VEGFA-VEGFR2 signaling (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

View all...

1. Colladel R, Pellicani R, Andreuzzi E, Paulitti A, Tarticchio G, Todaro F, Colombatti A, Mongiat M; ''MULTIMERIN2 binds VEGF-A primarily via the carbohydrate chains exerting an angiostatic function and impairing tumor growth.''; Oncotarget, 2016 PubMed Europe PMC Scholia
2. Minami T, Horiuchi K, Miura M, Abid MR, Takabe W, Noguchi N, Kohro T, Ge X, Aburatani H, Hamakubo T, Kodama T, Aird WC; ''Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
3. Hoeppner LH, Sinha S, Wang Y, Bhattacharya R, Dutta S, Gong X, Bedell VM, Suresh S, Chun C, Ramchandran R, Ekker SC, Mukhopadhyay D; ''RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells.''; J Cell Sci, 2015 PubMed Europe PMC Scholia
4. Fan Y, Arif A, Gong Y, Jia J, Eswarappa SM, Willard B, Horowitz A, Graham LM, Penn MS, Fox PL; ''Stimulus-dependent phosphorylation of profilin-1 in angiogenesis.''; Nat Cell Biol, 2012 PubMed Europe PMC Scholia
5. Kroll J, Epting D, Kern K, Dietz CT, Feng Y, Hammes HP, Wieland T, Augustin HG; ''Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis.''; Am J Physiol Heart Circ Physiol, 2009 PubMed Europe PMC Scholia
6. Gliki G, Abu-Ghazaleh R, Jezequel S, Wheeler-Jones C, Zachary I; ''Vascular endothelial growth factor-induced prostacyclin production is mediated by a protein kinase C (PKC)-dependent activation of extracellular signal-regulated protein kinases 1 and 2 involving PKC-delta and by mobilization of intracellular Ca2+.''; Biochem J, 2001 PubMed Europe PMC Scholia
7. ''''; , PubMed Europe PMC Scholia
8. Johnson EN, Lee YM, Sander TL, Rabkin E, Schoen FJ, Kaushal S, Bischoff J; ''NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
9. Abedi H, Zachary I; ''Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
10. Shu X, Wu W, Mosteller RD, Broek D; ''''; , PubMed Europe PMC Scholia
11. Lamalice L, Houle F, Jourdan G, Huot J; ''Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38.''; Oncogene, 2004 PubMed Europe PMC Scholia
12. Uhrin P, Breuss JM; ''uPAR: a modulator of VEGF-induced angiogenesis.''; Cell Adh Migr, 2013 PubMed Europe PMC Scholia
13. Caliceti C, Nigro P, Rizzo P, Ferrari R; ''''; , PubMed Europe PMC Scholia
14. ''''; , PubMed Europe PMC Scholia
15. Stoletov KV, Ratcliffe KE, Terman BI; ''''; , PubMed Europe PMC Scholia
16. Fearnley GW, Bruns AF, Wheatcroft SB, Ponnambalam S; ''VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration.''; Biol Open, 2015 PubMed Europe PMC Scholia
17. Lakshmikanthan S, Sobczak M, Chun C, Henschel A, Dargatz J, Ramchandran R, Chrzanowska-Wodnicka M; ''Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃.''; Blood, 2011 PubMed Europe PMC Scholia
18. Wong C, Jin ZG; ''Protein kinase C-dependent protein kinase D activation modulates ERK signal pathway and endothelial cell proliferation by vascular endothelial growth factor.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
19. Meadows KN, Bryant P, Pumiglia K; ''Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
20. Meyer RD, Sacks DB, Rahimi N; ''''; , PubMed Europe PMC Scholia
21. Luque A, Carpizo DR, Iruela-Arispe ML; ''ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
22. Wheeler-Jones C, Abu-Ghazaleh R, Cospedal R, Houliston RA, Martin J, Zachary I; ''Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase.''; FEBS Lett, 1997 PubMed Europe PMC Scholia
23. Domigan CK, Warren CM, Antanesian V, Happel K, Ziyad S, Lee S, Krall A, Duan L, Torres-Collado AX, Castellani LW, Elashoff D, Christofk HR, van der Bliek AM, Potente M, Iruela-Arispe ML; ''Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy.''; J Cell Sci, 2015 PubMed Europe PMC Scholia
24. Yoshizuka N, Chen RM, Xu Z, Liao R, Hong L, Hu WY, Yu G, Han J, Chen L, Sun P; ''A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis.''; Mol Cell Biol, 2012 PubMed Europe PMC Scholia
25. Lampugnani MG, Orsenigo F, Gagliani MC, Tacchetti C, Dejana E; ''Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments.''; J Cell Biol, 2006 PubMed Europe PMC Scholia
26. Bhattacharya R, Kwon J, Li X, Wang E, Patra S, Bida JP, Bajzer Z, Claesson-Welsh L, Mukhopadhyay D; ''Distinct role of PLCbeta3 in VEGF-mediated directional migration and vascular sprouting.''; J Cell Sci, 2009 PubMed Europe PMC Scholia
27. Wythe JD, Dang LT, Devine WP, Boudreau E, Artap ST, He D, Schachterle W, Stainier DY, Oettgen P, Black BL, Bruneau BG, Fish JE; ''ETS factors regulate Vegf-dependent arterial specification.''; Dev Cell, 2013 PubMed Europe PMC Scholia
28. ''''; , PubMed Europe PMC Scholia
29. ''''; , PubMed Europe PMC Scholia
30. Takahashi T, Yamaguchi S, Chida K, Shibuya M; ''A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells.''; EMBO J, 2001 PubMed Europe PMC Scholia
31. Li SM, Zeng LW, Feng L, Chen DB; ''Rac1-dependent intracellular superoxide formation mediates vascular endothelial growth factor-induced placental angiogenesis in vitro.''; Endocrinology, 2010 PubMed Europe PMC Scholia
32. Jin H, Garmy-Susini B, Avraamides CJ, Stoletov K, Klemke RL, Varner JA; ''''; , PubMed Europe PMC Scholia
33. Lamalice L, Houle F, Huot J; ''Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
34. Inoki I, Shiomi T, Hashimoto G, Enomoto H, Nakamura H, Makino K, Ikeda E, Takata S, Kobayashi K, Okada Y; ''Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis.''; FASEB J, 2002 PubMed Europe PMC Scholia
35. van Nieuw Amerongen GP, Koolwijk P, Versteilen A, van Hinsbergh VW; ''Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro.''; Arterioscler Thromb Vasc Biol, 2003 PubMed Europe PMC Scholia
36. Qi JH, Claesson-Welsh L; ''VEGF-induced activation of phosphoinositide 3-kinase is dependent on focal adhesion kinase.''; Exp Cell Res, 2001 PubMed Europe PMC Scholia
37. Bayraktutan U, Blayney L, Shah AM; ''Molecular characterization and localization of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells.''; Arterioscler Thromb Vasc Biol, 2000 PubMed Europe PMC Scholia
38. Kaur S, Leszczynska K, Abraham S, Scarcia M, Hiltbrunner S, Marshall CJ, Mavria G, Bicknell R, Heath VL; ''RhoJ/TCL regulates endothelial motility and tube formation and modulates actomyosin contractility and focal adhesion numbers.''; Arterioscler Thromb Vasc Biol, 2011 PubMed Europe PMC Scholia
39. Shen K, Ji L, Lu B, Wang Z; ''c-Jun N-terminal kinase mediated VEGFR2 sustained phosphorylation is critical for VEGFA-induced angiogenesis in vitro and in vivo.''; Cell Biochem Biophys, 2012 PubMed Europe PMC Scholia
40. Cunningham SA, Waxham MN, Arrate PM, Brock TA; ''Interaction of the Flt-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositol 3-kinase. Mapping of a novel site involved in binding.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
41. Lim ST, Chen XL, Lim Y, Hanson DA, Vo TT, Howerton K, Larocque N, Fisher SJ, Schlaepfer DD, Ilic D; ''Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.''; Mol Cell, 2008 PubMed Europe PMC Scholia
42. Zheng J, Bird IM, Melsaether AN, Magness RR; ''Activation of the mitogen-activated protein kinase cascade is necessary but not sufficient for basic fibroblast growth factor- and epidermal growth factor-stimulated expression of endothelial nitric oxide synthase in ovine fetoplacental artery endothelial cells.''; Endocrinology, 1999 PubMed Europe PMC Scholia
43. Feng Z, Zhang H, Levine AJ, Jin S; ''The coordinate regulation of the p53 and mTOR pathways in cells.''; Proc Natl Acad Sci U S A, 2005 PubMed Europe PMC Scholia
44. Liu D, Jia H, Holmes DI, Stannard A, Zachary I; ''Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1.''; Arterioscler Thromb Vasc Biol, 2003 PubMed Europe PMC Scholia
45. Zhang L, Liu H, Peng YM, Dai YY, Liu FY; ''Vascular endothelial growth factor increases GEnC permeability by affecting the distributions of occludin, ZO-1 and tight juction assembly.''; Eur Rev Med Pharmacol Sci, 2015 PubMed Europe PMC Scholia
46. Le Boeuf F, Houle F, Huot J; ''Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
47. Chai J, Jones MK, Tarnawski AS; ''Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis.''; FASEB J, 2004 PubMed Europe PMC Scholia
48. Taylor JM, Macklem MM, Parsons JT; ''Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho.''; J Cell Sci, 1999 PubMed Europe PMC Scholia
49. Ziche M, Morbidelli L, Choudhuri R, Zhang HT, Donnini S, Granger HJ, Bicknell R; ''Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis.''; J Clin Invest, 1997 PubMed Europe PMC Scholia
50. Garrett TA, Van Buul JD, Burridge K; ''VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2.''; Exp Cell Res, 2007 PubMed Europe PMC Scholia
51. Sun H, Breslin JW, Zhu J, Yuan SY, Wu MH; ''Rho and ROCK signaling in VEGF-induced microvascular endothelial hyperpermeability.''; Microcirculation, 2006 PubMed Europe PMC Scholia
52. ''''; , PubMed Europe PMC Scholia
53. Wu G, Luo J, Rana JS, Laham R, Sellke FW, Li J; ''Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells.''; Cardiovasc Res, 2006 PubMed Europe PMC Scholia
54. Maiti D, Xu Z, Duh EJ; ''''; , PubMed Europe PMC Scholia
55. Giorgetti-Peraldi S, Murdaca J, Mas JC, Van Obberghen E; ''The adapter protein, Grb10, is a positive regulator of vascular endothelial growth factor signaling.''; Oncogene, 2001 PubMed Europe PMC Scholia
56. Abdelsaid MA, Matragoon S, El-Remessy AB; ''Thioredoxin-interacting protein expression is required for VEGF-mediated angiogenic signal in endothelial cells.''; Antioxid Redox Signal, 2013 PubMed Europe PMC Scholia
57. Kashige N, Carpino N, Kobayashi R; ''''; , PubMed Europe PMC Scholia
58. Salameh A, Galvagni F, Anselmi F, De Clemente C, Orlandini M, Oliviero S; ''Growth factor stimulation induces cell survival by c-Jun. ATF2-dependent activation of Bcl-XL.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
59. Schaller MD; ''''; , PubMed Europe PMC Scholia
60. Koutsioumpa M, Poimenidi E, Pantazaka E, Theodoropoulou C, Skoura A, Megalooikonomou V, Kieffer N, Courty J, Mizumoto S, Sugahara K, Papadimitriou E; ''Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor.''; Mol Cancer, 2015 PubMed Europe PMC Scholia
61. Wang F, Yamauchi M, Muramatsu M, Osawa T, Tsuchida R, Shibuya M; ''RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3K/Akt pathway.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
62. Sjöqvist M, Antfolk D, Ferraris S, Rraklli V, Haga C, Antila C, Mutvei A, Imanishi SY, Holmberg J, Jin S, Eriksson JE, Lendahl U, Sahlgren C; ''PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner.''; Cell Res, 2014 PubMed Europe PMC Scholia
63. Kim I, Moon SO, Kim SH, Kim HJ, Koh YS, Koh GY; ''Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
64. Kusuhara S, Fukushima Y, Fukuhara S, Jakt LM, Okada M, Shimizu Y, Hata M, Nishida K, Negi A, Hirashima M, Mochizuki N, Nishikawa S, Uemura A; ''Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells.''; PLoS One, 2012 PubMed Europe PMC Scholia
65. Favia A, Desideri M, Gambara G, D'Alessio A, Ruas M, Esposito B, Del Bufalo D, Parrington J, Ziparo E, Palombi F, Galione A, Filippini A; ''VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling.''; Proc Natl Acad Sci U S A, 2014 PubMed Europe PMC Scholia
66. Koh W, Sachidanandam K, Stratman AN, Sacharidou A, Mayo AM, Murphy EA, Cheresh DA, Davis GE; ''''; , PubMed Europe PMC Scholia
67. Sahni A, Francis CW; ''Vascular endothelial growth factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation.''; Blood, 2000 PubMed Europe PMC Scholia
68. Mayo LD, Kessler KM, Pincheira R, Warren RS, Donner DB; ''Vascular endothelial cell growth factor activates CRE-binding protein by signaling through the KDR receptor tyrosine kinase.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
69. Bernatchez PN, Allen BG, Gélinas DS, Guillemette G, Sirois MG; ''Regulation of VEGF-induced endothelial cell PAF synthesis: role of p42/44 MAPK, p38 MAPK and PI3K pathways.''; Br J Pharmacol, 2001 PubMed Europe PMC Scholia
70. Dodd KM, Yang J, Shen MH, Sampson JR, Tee AR; ''mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3.''; Oncogene, 2015 PubMed Europe PMC Scholia
71. Moon DO, Kim MO, Kang SH, Choi YH, Kim GY; ''''; , PubMed Europe PMC Scholia
72. Sawano A, Takahashi T, Yamaguchi S, Shibuya M; ''The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma.''; Biochem Biophys Res Commun, 1997 PubMed Europe PMC Scholia
73. Guo D, Jia Q, Song HY, Warren RS, Donner DB; ''Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
74. Abu-Ghazaleh R, Kabir J, Jia H, Lobo M, Zachary I; ''Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells.''; Biochem J, 2001 PubMed Europe PMC Scholia
75. Bryan BA, Dennstedt E, Mitchell DC, Walshe TE, Noma K, Loureiro R, Saint-Geniez M, Campaigniac JP, Liao JK, D'Amore PA; ''''; , PubMed Europe PMC Scholia
76. Marchand C, Favier J, Sirois MG; ''Role of MSK1 in the signaling pathway leading to VEGF-mediated PAF synthesis in endothelial cells.''; J Cell Biochem, 2006 PubMed Europe PMC Scholia
77. Suehiro J, Hamakubo T, Kodama T, Aird WC, Minami T; ''Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3.''; Blood, 2010 PubMed Europe PMC Scholia
78. Cébe Suarez S, Pieren M, Cariolato L, Arn S, Hoffmann U, Bogucki A, Manlius C, Wood J, Ballmer-Hofer K; ''A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2.''; Cell Mol Life Sci, 2006 PubMed Europe PMC Scholia
79. Webler AC, Michaelis UR, Popp R, Barbosa-Sicard E, Murugan A, Falck JR, Fisslthaler B, Fleming I; ''Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis.''; Am J Physiol Cell Physiol, 2008 PubMed Europe PMC Scholia
80. Tran J, Rak J, Sheehan C, Saibil SD, LaCasse E, Korneluk RG, Kerbel RS; ''Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells.''; Biochem Biophys Res Commun, 1999 PubMed Europe PMC Scholia
81. Stoletov KV, Gong C, Terman BI; ''Nck and Crk mediate distinct VEGF-induced signaling pathways that serve overlapping functions in focal adhesion turnover and integrin activation.''; Exp Cell Res, 2004 PubMed Europe PMC Scholia
82. Hesser BA, Liang XH, Camenisch G, Yang S, Lewin DA, Scheller R, Ferrara N, Gerber HP; ''Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells.''; Blood, 2004 PubMed Europe PMC Scholia
83. Suehiro J, Kanki Y, Makihara C, Schadler K, Miura M, Manabe Y, Aburatani H, Kodama T, Minami T; ''Genome-wide approaches reveal functional vascular endothelial growth factor (VEGF)-inducible nuclear factor ofactivated T cells (NFAT) c1 binding to angiogenesis-related genes in the endothelium.''; J Biol Chem, 2014 PubMed Europe PMC Scholia
84. Ewan LC, Jopling HM, Jia H, Mittar S, Bagherzadeh A, Howell GJ, Walker JH, Zachary IC, Ponnambalam S; ''Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells.''; Traffic, 2006 PubMed Europe PMC Scholia
85. Stahmann N, Woods A, Spengler K, Heslegrave A, Bauer R, Krause S, Viollet B, Carling D, Heller R; ''Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
86. Oller J, Alfranca A, Méndez-Barbero N, Villahoz S, Lozano-Vidal N, Martín-Alonso M, Arroyo AG, Escolano A, Armesilla AL, Campanero MR, Redondo JM; ''C/EBPβ and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling.''; Mol Cell Biol, 2015 PubMed Europe PMC Scholia
87. Labrecque L, Royal I, Surprenant DS, Patterson C, Gingras D, Béliveau R; ''''; , PubMed Europe PMC Scholia
88. Hao Q, Samten B, Ji HL, Zhao ZJ, Tang H; ''Tyrosine phosphatase PTP-MEG2 negatively regulates vascular endothelial growth factor receptor signaling and function in endothelial cells.''; Am J Physiol Cell Physiol, 2012 PubMed Europe PMC Scholia
89. Hartsough EJ, Meyer RD, Chitalia V, Jiang Y, Marquez VE, Zhdanova IV, Weinberg J, Costello CE, Rahimi N; ''''; , PubMed Europe PMC Scholia
90. Takahashi T, Ueno H, Shibuya M; ''VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells.''; Oncogene, 1999 PubMed Europe PMC Scholia
91. Abid MR, Schoots IG, Spokes KC, Wu SQ, Mawhinney C, Aird WC; ''Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
92. Liao WX, Feng L, Zheng J, Chen DB; ''Deciphering mechanisms controlling placental artery endothelial cell migration stimulated by vascular endothelial growth factor.''; Endocrinology, 2010 PubMed Europe PMC Scholia
93. Liu X, Zhao D, Qin L, Li J, Zeng H; ''Transcription enhancer factor 3 (TEF3) mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells.''; J Biol Chem, 2008 PubMed Europe PMC Scholia
94. Gu Y, Filippi MD, Cancelas JA, Siefring JE, Williams EP, Jasti AC, Harris CE, Lee AW, Prabhakar R, Atkinson SJ, Kwiatkowski DJ, Williams DA; ''Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases.''; Science, 2003 PubMed Europe PMC Scholia
95. ''''; , PubMed Europe PMC Scholia
96. Benedito R, Roca C, Sörensen I, Adams S, Gossler A, Fruttiger M, Adams RH; ''The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis.''; Cell, 2009 PubMed Europe PMC Scholia
97. Cunningham SA, Arrate MP, Brock TA, Waxham MN; ''Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites.''; Biochem Biophys Res Commun, 1997 PubMed Europe PMC Scholia
98. Del Valle-Pérez B, Martínez VG, Lacasa-Salavert C, Figueras A, Shapiro SS, Takafuta T, Casanovas O, Capellà G, Ventura F, Viñals F; ''Filamin B plays a key role in vascular endothelial growth factor-induced endothelial cell motility through its interaction with Rac-1 and Vav-2.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
99. Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M, Cao Y, Shujath J, Gawlak S, Eveleigh D, Rowley B, Liu L, Adnane L, Lynch M, Auclair D, Taylor I, Gedrich R, Voznesensky A, Riedl B, Post LE, Bollag G, Trail PA; ''BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.''; Cancer Res, 2004 PubMed Europe PMC Scholia
100. ''''; , PubMed Europe PMC Scholia
101. Kikuchi A, Yamamoto H, Sato A, Matsumoto S; ''''; , PubMed Europe PMC Scholia
102. ''''; , PubMed Europe PMC Scholia
103. ''''; , PubMed Europe PMC Scholia
104. Usui T, Murai T, Tanaka T, Yamaguchi K, Nagakubo D, Lee CM, Kiyomi M, Tamura S, Matsuzawa Y, Miyasaka M; ''Characterization of mac25/angiomodulin expression by high endothelial venule cells in lymphoid tissues and its identification as an inducible marker for activated endothelial cells.''; Int Immunol, 2002 PubMed Europe PMC Scholia
105. Chen SH, Murphy DA, Lassoued W, Thurston G, Feldman MD, Lee WM; ''Activated STAT3 is a mediator and biomarker of VEGF endothelial activation.''; Cancer Biol Ther, 2008 PubMed Europe PMC Scholia
106. Ha CH, Bennett AM, Jin ZG; ''A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factor.''; J Biol Chem, 2008 PubMed Europe PMC Scholia
107. Rusnak F, Mertz P; ''''; , PubMed Europe PMC Scholia
108. Serrels B, Serrels A, Brunton VG, Holt M, McLean GW, Gray CH, Jones GE, Frame MC; ''Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex.''; Nat Cell Biol, 2007 PubMed Europe PMC Scholia
109. Abid MR, Spokes KC, Shih SC, Aird WC; ''NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
110. Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J; ''Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.''; Proc Natl Acad Sci U S A, 2004 PubMed Europe PMC Scholia
111. Ikuta T, Ariga H, Matsumoto K; ''Extracellular matrix tenascin-X in combination with vascular endothelial growth factor B enhances endothelial cell proliferation.''; Genes Cells, 2000 PubMed Europe PMC Scholia
112. Ali N, Yoshizumi M, Yano S, Sone S, Ohnishi H, Ishizawa K, Kanematsu Y, Tsuchiya K, Tamaki T; ''The novel Src kinase inhibitor M475271 inhibits VEGF-induced vascular endothelial-cadherin and beta-catenin phosphorylation but increases their association.''; J Pharmacol Sci, 2006 PubMed Europe PMC Scholia
113. Jopling HM, Odell AF, Pellet-Many C, Latham AM, Frankel P, Sivaprasadarao A, Walker JH, Zachary IC, Ponnambalam S; ''Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel Formation.''; Cells, 2014 PubMed Europe PMC Scholia
114. Laramée M, Chabot C, Cloutier M, Stenne R, Holgado-Madruga M, Wong AJ, Royal I; ''The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
115. Stoletov KV, Terman BI; ''''; , PubMed Europe PMC Scholia
116. Sacco F, Tinti M, Palma A, Ferrari E, Nardozza AP, Hooft van Huijsduijnen R, Takahashi T, Castagnoli L, Cesareni G; ''''; , PubMed Europe PMC Scholia
117. Rousseau S, Houle F, Landry J, Huot J; ''''; , PubMed Europe PMC Scholia
118. ''''; , PubMed Europe PMC Scholia
119. ''''; , PubMed Europe PMC Scholia
120. ''''; , PubMed Europe PMC Scholia
121. Parenti A, Morbidelli L, Cui XL, Douglas JG, Hood JD, Granger HJ, Ledda F, Ziche M; ''Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
122. Huang Y, Shi H, Zhou H, Song X, Yuan S, Luo Y; ''The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin.''; Blood, 2006 PubMed Europe PMC Scholia
123. Nimlamool W, Andrews RM, Falk MM; ''Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization.''; Mol Biol Cell, 2015 PubMed Europe PMC Scholia
124. Liu X, Zhao D, James L, Li J, Zeng H; ''Requirement of the nuclear localization of transcription enhancer factor 3 for proliferation, migration, tube formation, and angiogenesis induced by vascular endothelial growth factor.''; FASEB J, 2011 PubMed Europe PMC Scholia
125. Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, Kaelin WG Jr; ''Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.''; Genes Dev, 2004 PubMed Europe PMC Scholia
126. Oshikawa J, Kim SJ, Furuta E, Caliceti C, Chen GF, McKinney RD, Kuhr F, Levitan I, Fukai T, Ushio-Fukai M; ''Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells.''; Am J Physiol Heart Circ Physiol, 2012 PubMed Europe PMC Scholia
127. Stoletov KV, Ratcliffe KE, Spring SC, Terman BI; ''''; , PubMed Europe PMC Scholia
128. Avraham HK, Lee TH, Koh Y, Kim TA, Jiang S, Sussman M, Samarel AM, Avraham S; ''Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
129. Holmqvist K, Cross MJ, Rolny C, Hägerkvist R, Rahimi N, Matsumoto T, Claesson-Welsh L, Welsh M; ''The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
130. Herzog B, Pellet-Many C, Britton G, Hartzoulakis B, Zachary IC; ''VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation.''; Mol Biol Cell, 2011 PubMed Europe PMC Scholia
131. Abdelsaid MA, El-Remessy AB; ''S-glutathionylation of LMW-PTP regulates VEGF-mediated FAK activation and endothelial cell migration.''; J Cell Sci, 2012 PubMed Europe PMC Scholia
132. Wang Y, Yan F, Ye Q, Wu X, Jiang F; ''PTP1B inhibitor promotes endothelial cell motility by activating the DOCK180/Rac1 pathway.''; Sci Rep, 2016 PubMed Europe PMC Scholia
133. Eriksson A, Cao R, Roy J, Tritsaris K, Wahlestedt C, Dissing S, Thyberg J, Cao Y; ''Small GTP-binding protein Rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations and vascular permeability.''; Circulation, 2003 PubMed Europe PMC Scholia
134. Fujio Y, Walsh K; ''Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
135. Colavitti R, Pani G, Bedogni B, Anzevino R, Borrello S, Waltenberger J, Galeotti T; ''Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
136. Dayanir V, Meyer RD, Lashkari K, Rahimi N; ''''; , PubMed Europe PMC Scholia
137. Bartoli M, Gu X, Tsai NT, Venema RC, Brooks SE, Marrero MB, Caldwell RB; ''''; , PubMed Europe PMC Scholia
138. Youn JY, Wang T, Cai H; ''An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production.''; Circ Res, 2009 PubMed Europe PMC Scholia
139. Hao T, Rockwell P; ''''; , PubMed Europe PMC Scholia
140. Hayashi H, Nakagami H, Takami Y, Koriyama H, Mori M, Tamai K, Sun J, Nagao K, Morishita R, Kaneda Y; ''FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1.''; Arterioscler Thromb Vasc Biol, 2009 PubMed Europe PMC Scholia
141. Alexander RA, Prager GW, Mihaly-Bison J, Uhrin P, Sunzenauer S, Binder BR, Schütz GJ, Freissmuth M, Breuss JM; ''VEGF-induced endothelial cell migration requires urokinase receptor (uPAR)-dependent integrin redistribution.''; Cardiovasc Res, 2012 PubMed Europe PMC Scholia
142. García-Cardeña G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A, Sessa WC; ''Dynamic activation of endothelial nitric oxide synthase by Hsp90.''; Nature, 1998 PubMed Europe PMC Scholia
143. ''''; , PubMed Europe PMC Scholia
144. Gengrinovitch S, Berman B, David G, Witte L, Neufeld G, Ron D; ''Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
145. Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC; ''''; , PubMed Europe PMC Scholia
146. Thuringer D; ''The vascular endothelial growth factor-induced disruption of gap junctions is relayed by an autocrine communication via ATP release in coronary capillary endothelium.''; Ann N Y Acad Sci, 2004 PubMed Europe PMC Scholia
147. ''''; , PubMed Europe PMC Scholia
148. Wiesmann C, Fuh G, Christinger HW, Eigenbrot C, Wells JA, de Vos AM; ''Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.''; Cell, 1997 PubMed Europe PMC Scholia
149. Yamaoka-Tojo M, Ushio-Fukai M, Hilenski L, Dikalov SI, Chen YE, Tojo T, Fukai T, Fujimoto M, Patrushev NA, Wang N, Kontos CD, Bloom GS, Alexander RW; ''IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation.''; Circ Res, 2004 PubMed Europe PMC Scholia
150. Evans IM, Britton G, Zachary IC; ''Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase.''; Cell Signal, 2008 PubMed Europe PMC Scholia
151. Nakamura Y, Patrushev N, Inomata H, Mehta D, Urao N, Kim HW, Razvi M, Kini V, Mahadev K, Goldstein BJ, McKinney R, Fukai T, Ushio-Fukai M; ''Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cells.''; Circ Res, 2008 PubMed Europe PMC Scholia
152. Wu RF, Gu Y, Xu YC, Nwariaku FE, Terada LS; ''Vascular endothelial growth factor causes translocation of p47phox to membrane ruffles through WAVE1.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
153. Koch S, Claesson-Welsh L; ''''; , PubMed Europe PMC Scholia
154. Blanes MG, Oubaha M, Rautureau Y, Gratton JP; ''Phosphorylation of tyrosine 801 of vascular endothelial growth factor receptor-2 is necessary for Akt-dependent endothelial nitric-oxide synthase activation and nitric oxide release from endothelial cells.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
155. Ha CH, Wang W, Jhun BS, Wong C, Hausser A, Pfizenmaier K, McKinsey TA, Olson EN, Jin ZG; ''''; , PubMed Europe PMC Scholia
156. Murakami T, Frey T, Lin C, Antonetti DA; ''Protein kinase cβ phosphorylates occludin regulating tight junction trafficking in vascular endothelial growth factor-induced permeability in vivo.''; Diabetes, 2012 PubMed Europe PMC Scholia
157. Koch S, Tugues S, Li X, Gualandi L, Claesson-Welsh L; ''''; , PubMed Europe PMC Scholia
158. Inoki K, Zhu T, Guan KL; ''TSC2 mediates cellular energy response to control cell growth and survival.''; Cell, 2003 PubMed Europe PMC Scholia
159. ''''; , PubMed Europe PMC Scholia
160. Liu J, Razani B, Tang S, Terman BI, Ware JA, Lisanti MP; ''Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
161. Kusaba T, Okigaki M, Matui A, Murakami M, Ishikawa K, Kimura T, Sonomura K, Adachi Y, Shibuya M, Shirayama T, Tanda S, Hatta T, Sasaki S, Mori Y, Matsubara H; ''Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+ channel to maintain endothelial integrity.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
162. Kobayashi M, Nishita M, Mishima T, Ohashi K, Mizuno K; ''''; , PubMed Europe PMC Scholia
163. Singh AJ, Meyer RD, Navruzbekov G, Shelke R, Duan L, Band H, Leeman SE, Rahimi N; ''A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
164. Koika V, Zhou Z, Vasileiadis I, Roussos C, Finetti F, Monti M, Morbidelli L, Papapetropoulos A; ''PKG-I inhibition attenuates vascular endothelial growth factor-stimulated angiogenesis.''; Vascul Pharmacol, 2010 PubMed Europe PMC Scholia
165. Marumo T, Schini-Kerth VB, Busse R; ''Vascular endothelial growth factor activates nuclear factor-kappaB and induces monocyte chemoattractant protein-1 in bovine retinal endothelial cells.''; Diabetes, 1999 PubMed Europe PMC Scholia
166. Bodnar RJ, Yates CC, Wells A; ''IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain.''; Circ Res, 2006 PubMed Europe PMC Scholia
167. Zaichuk TA, Shroff EH, Emmanuel R, Filleur S, Nelius T, Volpert OV; ''Nuclear factor of activated T cells balances angiogenesis activation and inhibition.''; J Exp Med, 2004 PubMed Europe PMC Scholia
168. Mirzapoiazova T, Kolosova I, Usatyuk PV, Natarajan V, Verin AD; ''Diverse effects of vascular endothelial growth factor on human pulmonary endothelial barrier and migration.''; Am J Physiol Lung Cell Mol Physiol, 2006 PubMed Europe PMC Scholia
169. Karali E, Bellou S, Stellas D, Klinakis A, Murphy C, Fotsis T; ''VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress.''; Mol Cell, 2014 PubMed Europe PMC Scholia
170. Narasimhan P, Liu J, Song YS, Massengale JL, Chan PH; ''''; , PubMed Europe PMC Scholia
171. Jho D, Mehta D, Ahmmed G, Gao XP, Tiruppathi C, Broman M, Malik AB; ''Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2 influx.''; Circ Res, 2005 PubMed Europe PMC Scholia
172. Schweighofer B, Testori J, Sturtzel C, Sattler S, Mayer H, Wagner O, Bilban M, Hofer E; ''The VEGF-induced transcriptional response comprises gene clusters at the crossroad of angiogenesis and inflammation.''; Thromb Haemost, 2009 PubMed Europe PMC Scholia
173. Suarez S, Ballmer-Hofer K; ''VEGF transiently disrupts gap junctional communication in endothelial cells.''; J Cell Sci, 2001 PubMed Europe PMC Scholia
174. Ballmer-Hofer K, Andersson AE, Ratcliffe LE, Berger P; ''Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output.''; Blood, 2011 PubMed Europe PMC Scholia
175. Sun Z, Li X, Massena S, Kutschera S, Padhan N, Gualandi L, Sundvold-Gjerstad V, Gustafsson K, Choy WW, Zang G, Quach M, Jansson L, Phillipson M, Abid MR, Spurkland A, Claesson-Welsh L; ''VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd.''; J Exp Med, 2012 PubMed Europe PMC Scholia
176. ''''; , PubMed Europe PMC Scholia
177. Heo SH, Choi YJ, Ryoo HM, Cho JY; ''Expression profiling of ETS and MMP factors in VEGF-activated endothelial cells: role of MMP-10 in VEGF-induced angiogenesis.''; J Cell Physiol, 2010 PubMed Europe PMC Scholia
178. Arcondéguy T, Lacazette E, Millevoi S, Prats H, Touriol C; ''VEGF-A mRNA processing, stability and translation: a paradigm for intricate regulation of gene expression at the post-transcriptional level.''; Nucleic Acids Res, 2013 PubMed Europe PMC Scholia
179. ''''; , PubMed Europe PMC Scholia
180. Harhaj NS, Felinski EA, Wolpert EB, Sundstrom JM, Gardner TW, Antonetti DA; ''VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability.''; Invest Ophthalmol Vis Sci, 2006 PubMed Europe PMC Scholia
181. ''''; , PubMed Europe PMC Scholia
182. Ito N, Wernstedt C, Engström U, Claesson-Welsh L; ''Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
183. Eriksson A, Cao R, Pawliuk R, Berg SM, Tsang M, Zhou D, Fleet C, Tritsaris K, Dissing S, Leboulch P, Cao Y; ''Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers.''; Cancer Cell, 2002 PubMed Europe PMC Scholia
184. Chidiac R, Zhang Y, Tessier S, Faubert D, Delisle C, Gratton JP; ''Comparative Phosphoproteomics Analysis of VEGF and Angiopoietin-1 Signaling Reveals ZO-1 as a Critical Regulator of Endothelial Cell Proliferation.''; Mol Cell Proteomics, 2016 PubMed Europe PMC Scholia
185. Le Boeuf F, Houle F, Sussman M, Huot J; ''Phosphorylation of focal adhesion kinase (FAK) on Ser732 is induced by rho-dependent kinase and is essential for proline-rich tyrosine kinase-2-mediated phosphorylation of FAK on Tyr407 in response to vascular endothelial growth factor.''; Mol Biol Cell, 2006 PubMed Europe PMC Scholia
186. Stoletov KV, Gong C, Terman BI; ''''; , PubMed Europe PMC Scholia
187. Ratcliffe KE, Tao Q, Yavuz B, Stoletov KV, Spring SC, Terman BI; ''Sck is expressed in endothelial cells and participates in vascular endothelial growth factor-induced signaling.''; Oncogene, 2002 PubMed Europe PMC Scholia
188. Yu Y, Sato JD; ''MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor.''; J Cell Physiol, 1999 PubMed Europe PMC Scholia
189. Ren XR, Du QS, Huang YZ, Ao SZ, Mei L, Xiong WC; ''Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein.''; J Cell Biol, 2001 PubMed Europe PMC Scholia
190. Yu J, Bian D, Mahanivong C, Cheng RK, Zhou W, Huang S; ''p38 Mitogen-activated protein kinase regulation of endothelial cell migration depends on urokinase plasminogen activator expression.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
191. Haddad P, Dussault S, Groleau J, Turgeon J, Maingrette F, Rivard A; ''Nox2-derived reactive oxygen species contribute to hypercholesterolemia-induced inhibition of neovascularization: effects on endothelial progenitor cells and mature endothelial cells.''; Atherosclerosis, 2011 PubMed Europe PMC Scholia
192. Bruns AF, Herbert SP, Odell AF, Jopling HM, Hooper NM, Zachary IC, Walker JH, Ponnambalam S; ''''; ,
193. Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A; ''''; , PubMed Europe PMC Scholia
194. Zhou Y, Yan H, Guo M, Zhu J, Xiao Q, Zhang L; ''''; , PubMed Europe PMC Scholia
195. ''''; , PubMed Europe PMC Scholia
196. Wang S, Li X, Parra M, Verdin E, Bassel-Duby R, Olson EN; ''Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7.''; Proc Natl Acad Sci U S A, 2008 PubMed Europe PMC Scholia
197. Dudley AC, Thomas D, Best J, Jenkins A; ''''; , PubMed Europe PMC Scholia
198. Liu D, Evans I, Britton G, Zachary I; ''The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis.''; Oncogene, 2008 PubMed Europe PMC Scholia
199. Pang X, Zhang L, Wu Y, Lin L, Li J, Qu W, Safe S, Liu M; ''Methyl 2-cyano-3,11-dioxo-18-olean-1,12-dien-30-oate (CDODA-Me), a derivative of glycyrrhetinic acid, functions as a potent angiogenesis inhibitor.''; J Pharmacol Exp Ther, 2010 PubMed Europe PMC Scholia
200. Levine YC, Li GK, Michel T; ''Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathway.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
201. ''''; , PubMed Europe PMC Scholia
202. Primo L, di Blasio L, Roca C, Droetto S, Piva R, Schaffhausen B, Bussolino F; ''Essential role of PDK1 in regulating endothelial cell migration.''; J Cell Biol, 2007 PubMed Europe PMC Scholia
203. Dougher M, Terman BI; ''Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization.''; Oncogene, 1999 PubMed Europe PMC Scholia
204. Su YT, Gao C, Liu Y, Guo S, Wang A, Wang B, Erdjument-Bromage H, Miyagi M, Tempst P, Kao HY; ''Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7.''; Mol Cell Biol, 2013 PubMed Europe PMC Scholia
205. Kawamura H, Li X, Harper SJ, Bates DO, Claesson-Welsh L; ''Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity.''; Cancer Res, 2008 PubMed Europe PMC Scholia
206. ''''; , PubMed Europe PMC Scholia
207. Soga N, Namba N, McAllister S, Cornelius L, Teitelbaum SL, Dowdy SF, Kawamura J, Hruska KA; ''Rho family GTPases regulate VEGF-stimulated endothelial cell motility.''; Exp Cell Res, 2001 PubMed Europe PMC Scholia
208. Pin AL, Houle F, Fournier P, Guillonneau M, Paquet ÉR, Simard MJ, Royal I, Huot J; ''Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression.''; J Biol Chem, 2012 PubMed Europe PMC Scholia
209. Jiang BH, Liu LZ; ''''; , PubMed Europe PMC Scholia
210. Tawa H, Rikitake Y, Takahashi M, Amano H, Miyata M, Satomi-Kobayashi S, Kinugasa M, Nagamatsu Y, Majima T, Ogita H, Miyoshi J, Hirata K, Takai Y; ''Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis.''; Circ Res, 2010 PubMed Europe PMC Scholia
211. Guertin DA, Sabatini DM; ''''; , PubMed Europe PMC Scholia
212. ''''; , PubMed Europe PMC Scholia
213. ''''; , PubMed Europe PMC Scholia
214. Wang S, Amato KR, Song W, Youngblood V, Lee K, Boothby M, Brantley-Sieders DM, Chen J; ''Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways.''; Mol Cell Biol, 2015 PubMed Europe PMC Scholia
215. Wang Y, Zang QS, Liu Z, Wu Q, Maass D, Dulan G, Shaul PW, Melito L, Frantz DE, Kilgore JA, Williams NS, Terada LS, Nwariaku FE; ''Regulation of VEGF-induced endothelial cell migration by mitochondrial reactive oxygen species.''; Am J Physiol Cell Physiol, 2011 PubMed Europe PMC Scholia
216. Bhattacharya R, Kwon J, Wang E, Mukherjee P, Mukhopadhyay D; ''Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration*.''; J Mol Signal, 2008 PubMed Europe PMC Scholia
217. Reihill JA, Ewart MA, Hardie DG, Salt IP; ''AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production.''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC Scholia
218. Kroll J, Waltenberger J; ''The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
219. Zhao ZS, Manser E; ''''; , PubMed Europe PMC Scholia
220. Raikwar NS, Liu KZ, Thomas CP; ''N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain.''; PLoS One, 2014 PubMed Europe PMC Scholia
221. Tahir SA, Park S, Thompson TC; ''Caveolin-1 regulates VEGF-stimulated angiogenic activities in prostate cancer and endothelial cells.''; Cancer Biol Ther, 2009 PubMed Europe PMC Scholia
222. Chrzanowska-Wodnicka M, Kraus AE, Gale D, White GC 2nd, Vansluys J; ''Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice.''; Blood, 2008 PubMed Europe PMC Scholia
223. Issbrücker K, Marti HH, Hippenstiel S, Springmann G, Voswinckel R, Gaumann A, Breier G, Drexler HC, Suttorp N, Clauss M; ''p38 MAP kinase--a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability.''; FASEB J, 2003 PubMed Europe PMC Scholia
224. ''''; , PubMed Europe PMC Scholia
225. Armesilla AL, Lorenzo E, Gómez del Arco P, Martínez-Martínez S, Alfranca A, Redondo JM; ''Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: a role for tissue factor gene expression.''; Mol Cell Biol, 1999 PubMed Europe PMC Scholia
226. Lal BK, Varma S, Pappas PJ, Hobson RW 2nd, Durán WN; ''VEGF increases permeability of the endothelial cell monolayer by activation of PKB/akt, endothelial nitric-oxide synthase, and MAP kinase pathways.''; Microvasc Res, 2001 PubMed Europe PMC Scholia
227. Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V, Ferrara N; ''Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
228. Hoeppner LH, Sinha S, Wang Y, Bhattacharya R, Dutta S, Gong X, Bedell VM, Suresh S, Chun C, Ramchandran R, Ekker SC, Mukhopadhyay D; ''RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells.''; J Cell Sci, 2015 PubMed Europe PMC Scholia
229. Zeng H, Zhao D, Mukhopadhyay D; ''KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoA.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
230. Chen XL, Nam JO, Jean C, Lawson C, Walsh CT, Goka E, Lim ST, Tomar A, Tancioni I, Uryu S, Guan JL, Acevedo LM, Weis SM, Cheresh DA, Schlaepfer DD; ''VEGF-induced vascular permeability is mediated by FAK.''; Dev Cell, 2012 PubMed Europe PMC Scholia
231. Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J; ''Rheb binds and regulates the mTOR kinase.''; Curr Biol, 2005 PubMed Europe PMC Scholia
232. Andrikopoulos P, Baba A, Matsuda T, Djamgoz MB, Yaqoob MM, Eccles SA; ''Ca2+ influx through reverse mode Na+/Ca2+ exchange is critical for vascular endothelial growth factor-mediated extracellular signal-regulated kinase (ERK) 1/2 activation and angiogenic functions of human endothelial cells.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
233. Oshikawa J, Urao N, Kim HW, Kaplan N, Razvi M, McKinney R, Poole LB, Fukai T, Ushio-Fukai M; ''Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in mice.''; PLoS One, 2010 PubMed Europe PMC Scholia
234. Fearnley GW, Odell AF, Latham AM, Mughal NA, Bruns AF, Burgoyne NJ, Homer-Vanniasinkam S, Zachary IC, Hollstein MC, Wheatcroft SB, Ponnambalam S; ''VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions.''; Mol Biol Cell, 2014 PubMed Europe PMC Scholia
235. Dance M, Montagner A, Yart A, Masri B, Audigier Y, Perret B, Salles JP, Raynal P; ''The adaptor protein Gab1 couples the stimulation of vascular endothelial growth factor receptor-2 to the activation of phosphoinositide 3-kinase.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
236. Lanahan AA, Hermans K, Claes F, Kerley-Hamilton JS, Zhuang ZW, Giordano FJ, Carmeliet P, Simons M; ''VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis.''; Dev Cell, 2010 PubMed Europe PMC Scholia
237. Jang GH, Park IS, Yang JH, Bischoff J, Lee YM; ''Differential functions of genes regulated by VEGF-NFATc1 signaling pathway in the migration of pulmonary valve endothelial cells.''; FEBS Lett, 2010 PubMed Europe PMC Scholia
238. Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, Sheppard D, Cheresh DA; ''Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling.''; J Cell Biol, 2002 PubMed Europe PMC Scholia
239. Gavard J, Gutkind JS; ''VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin.''; Nat Cell Biol, 2006 PubMed Europe PMC Scholia
240. Prager GW, Breuss JM, Steurer S, Mihaly J, Binder BR; ''Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells.''; Blood, 2004 PubMed Europe PMC Scholia
241. ''''; , PubMed Europe PMC Scholia
242. ''''; , PubMed Europe PMC Scholia
243. Gourlaouen M, Welti JC, Vasudev NS, Reynolds AR; ''Essential role for endocytosis in the growth factor-stimulated activation of ERK1/2 in endothelial cells.''; J Biol Chem, 2013 PubMed Europe PMC Scholia
244. Rao A, Luo C, Hogan PG; ''''; , PubMed Europe PMC Scholia
245. Neagoe PE, Lemieux C, Sirois MG; ''Vascular endothelial growth factor (VEGF)-A165-induced prostacyclin synthesis requires the activation of VEGF receptor-1 and -2 heterodimer.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
246. Morbidelli L, Chang CH, Douglas JG, Granger HJ, Ledda F, Ziche M; ''Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium.''; Am J Physiol, 1996 PubMed Europe PMC Scholia
247. Zhang Z, Neiva KG, Lingen MW, Ellis LM, Nör JE; ''VEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2.''; Cell Death Differ, 2010 PubMed Europe PMC Scholia
248. Kim SF, Huri DA, Snyder SH; ''''; , PubMed Europe PMC Scholia
249. Abid MR, Guo S, Minami T, Spokes KC, Ueki K, Skurk C, Walsh K, Aird WC; ''Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells.''; Arterioscler Thromb Vasc Biol, 2004 PubMed Europe PMC Scholia
250. Chabot C, Spring K, Gratton JP, Elchebly M, Royal I; ''New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival.''; Mol Cell Biol, 2009 PubMed Europe PMC Scholia
251. Grazia Lampugnani M, Zanetti A, Corada M, Takahashi T, Balconi G, Breviario F, Orsenigo F, Cattelino A, Kemler R, Daniel TO, Dejana E; ''Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148.''; J Cell Biol, 2003 PubMed Europe PMC Scholia
252. Prager GW, Breuss JM, Steurer S, Olcaydu D, Mihaly J, Brunner PM, Stockinger H, Binder BR; ''Vascular endothelial growth factor receptor-2-induced initial endothelial cell migration depends on the presence of the urokinase receptor.''; Circ Res, 2004 PubMed Europe PMC Scholia
253. Combs MD, Yutzey KE; ''VEGF and RANKL regulation of NFATc1 in heart valve development.''; Circ Res, 2009 PubMed Europe PMC Scholia
254. Mariappan MM, Senthil D, Natarajan KS, Choudhury GG, Kasinath BS; ''Phospholipase Cgamma-Erk Axis in vascular endothelial growth factor-induced eukaryotic initiation factor 4E phosphorylation and protein synthesis in renal epithelial cells.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
255. ''''; , PubMed Europe PMC Scholia
256. Ha CH, Jhun BS, Kao HY, Jin ZG; ''VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis.''; Arterioscler Thromb Vasc Biol, 2008 PubMed Europe PMC Scholia
257. Leszczynska K, Kaur S, Wilson E, Bicknell R, Heath VL; ''The role of RhoJ in endothelial cell biology and angiogenesis.''; Biochem Soc Trans, 2011 PubMed Europe PMC Scholia
258. Liao HL, Zhu Y, Wang N, Verna L, Stemerman MB; ''''; , PubMed Europe PMC Scholia
259. ''''; , PubMed Europe PMC Scholia
260. Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, Sakakibara A, Adams S, Davy A, Deutsch U, Lüthi U, Barberis A, Benjamin LE, Mäkinen T, Nobes CD, Adams RH; ''Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.''; Nature, 2010 PubMed Europe PMC Scholia
261. Dikov MM, Oyama T, Cheng P, Takahashi T, Takahashi K, Sepetavec T, Edwards B, Adachi Y, Nadaf S, Daniel T, Gabrilovich DI, Carbone DP; ''Vascular endothelial growth factor effects on nuclear factor-kappaB activation in hematopoietic progenitor cells.''; Cancer Res, 2001 PubMed Europe PMC Scholia
262. Luo SW, Zhang C, Zhang B, Kim CH, Qiu YZ, Du QS, Mei L, Xiong WC; ''Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2.''; EMBO J, 2009 PubMed Europe PMC Scholia
263. Julien LA, Carriere A, Moreau J, Roux PP; ''mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.''; Mol Cell Biol, 2010 PubMed Europe PMC Scholia
264. Murakami T, Felinski EA, Antonetti DA; ''Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
265. Côté MC, Lavoie JR, Houle F, Poirier A, Rousseau S, Huot J; ''Regulation of vascular endothelial growth factor-induced endothelial cell migration by LIM kinase 1-mediated phosphorylation of annexin 1.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
266. Kobayashi S, Sawano A, Nojima Y, Shibuya M, Maru Y; ''The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1).''; FASEB J, 2004 PubMed Europe PMC Scholia
267. Carmona G, Göttig S, Orlandi A, Scheele J, Bäuerle T, Jugold M, Kiessling F, Henschler R, Zeiher AM, Dimmeler S, Chavakis E; ''Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis.''; Blood, 2009 PubMed Europe PMC Scholia
268. Dragoni S, Laforenza U, Bonetti E, Lodola F, Bottino C, Berra-Romani R, Carlo Bongio G, Cinelli MP, Guerra G, Pedrazzoli P, Rosti V, Tanzi F, Moccia F; ''Vascular endothelial growth factor stimulates endothelial colony forming cells proliferation and tubulogenesis by inducing oscillations in intracellular Ca2+ concentration.''; Stem Cells, 2011 PubMed Europe PMC Scholia
269. Pedram A, Razandi M, Levin ER; ''Extracellular signal-regulated protein kinase/Jun kinase cross-talk underlies vascular endothelial cell growth factor-induced endothelial cell proliferation.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
270. ''''; , PubMed Europe PMC Scholia
271. Zhuang G, Yu K, Jiang Z, Chung A, Yao J, Ha C, Toy K, Soriano R, Haley B, Blackwood E, Sampath D, Bais C, Lill JR, Ferrara N; ''Phosphoproteomic analysis implicates the mTORC2-FoxO1 axis in VEGF signaling and feedback activation of receptor tyrosine kinases.''; Sci Signal, 2013 PubMed Europe PMC Scholia
272. Salikhova A, Wang L, Lanahan AA, Liu M, Simons M, Leenders WP, Mukhopadhyay D, Horowitz A; ''Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways.''; Circ Res, 2008 PubMed Europe PMC Scholia
273. Lee M, Choy WC, Abid MR; ''Direct sensing of endothelial oxidants by vascular endothelial growth factor receptor-2 and c-Src.''; PLoS One, 2011 PubMed Europe PMC Scholia
274. Holmes K, Roberts OL, Thomas AM, Cross MJ; ''''; , PubMed Europe PMC Scholia
275. Ikeda S, Ushio-Fukai M, Zuo L, Tojo T, Dikalov S, Patrushev NA, Alexander RW; ''''; , PubMed Europe PMC Scholia

History

View all...

Compare	Revision	Action	Time	User	Comment
	126337	view	06:12, 22 April 2023	Egonw	License is CCZero
	124848	view	21:27, 14 December 2022	Eweitz	Modified title
	116782	view	09:53, 14 May 2021	Eweitz	Modified title
	115530	view	10:00, 26 February 2021	DeSl	Added database name for BMX
	108912	view	12:37, 6 February 2020	Prslab	Modified description
	108911	view	12:20, 6 February 2020	Prslab	Modified description
	108910	view	12:19, 6 February 2020	Prslab	Modified description
	108909	view	08:00, 6 February 2020	Prslab	Modified description
	108905	view	06:18, 6 February 2020	Prslab	Modified description
	108904	view	06:17, 6 February 2020	Prslab	Modified description
	108903	view	05:57, 6 February 2020	Prslab	Modified description
	108902	view	05:57, 6 February 2020	Prslab	Modified description
	108901	view	05:56, 6 February 2020	Prslab	Modified description
	108900	view	05:55, 6 February 2020	Prslab	Modified description
	108899	view	05:54, 6 February 2020	Prslab	Modified description
	108895	view	03:24, 5 February 2020	Prslab	Modified description
	108894	view	03:21, 5 February 2020	Prslab	Modified description
	108893	view	03:18, 5 February 2020	Prslab	Modified description
	108892	view	03:17, 5 February 2020	Prslab	Modified description
	108891	view	03:15, 5 February 2020	Prslab	Modified description
	108890	view	03:14, 5 February 2020	Prslab	Modified description
	108889	view	03:13, 5 February 2020	Prslab	Modified description
	108888	view	03:12, 5 February 2020	Prslab	Modified description
	108796	view	07:05, 30 January 2020	Prslab	Modified description
	108795	view	06:38, 30 January 2020	Prslab	Modified title
	108463	view	11:59, 21 December 2019	Prslab	Modified description
	108462	view	11:57, 21 December 2019	Prslab	Modified description
	108339	view	06:06, 9 December 2019	Egonw	Replaced a weblink by its PubMed identifier.
	108332	view	10:56, 7 December 2019	Egonw	Modified title
	108313	view	06:05, 5 December 2019	Prslab	Modified title
	108312	view	01:06, 5 December 2019	MaintBot	updated with GPML provided by author
	108252	view	07:20, 3 December 2019	Prslab	Modified title
	108251	view	07:13, 3 December 2019	Prslab	Modified title
	108249	view	06:59, 3 December 2019	Prslab	2019 Update version of VEGFA-VEGFR2
	106441	view	23:30, 28 August 2019	Khanspers	Modified description
	105478	view	05:24, 8 August 2019	Khanspers	Modified description
	102004	view	15:48, 23 November 2018	Egonw	Moved a non-pubmed ID to a comment.
	90000	view	09:56, 7 October 2016	Prslab	Modified description
	89999	view	09:54, 7 October 2016	Prslab	Modified description
	89998	view	09:27, 7 October 2016	Prslab	Modified description
	89997	view	09:18, 7 October 2016	Prslab	Modified description
	89996	view	09:17, 7 October 2016	Prslab	Modified description
	89396	view	19:22, 10 September 2016	AlexanderPico	Modified title
	89247	view	16:06, 25 August 2016	Khanspers	Ontology Term : 'endothelial cell' added !
	89246	view	16:01, 25 August 2016	Khanspers	Reverted to version '06:50, 25 August 2016' by Khanspers
	89245	view	15:55, 25 August 2016	Khanspers	test
	89242	view	06:50, 25 August 2016	Prslab	Ontology Term : 'vascular endothelial growth factor signaling pathway' added !
	89241	view	06:38, 25 August 2016	Prslab	Modified title
	89240	view	06:34, 25 August 2016	Prslab	New pathway

External references

DataNodes

View all...

Name	Type	Database reference	Comment
ABCF2	GeneProduct	10061 (Entrez Gene)
ABL1	Protein	25 (Entrez Gene)
ACACA	Protein	31 (Entrez Gene)
ACACB	Protein	32 (Entrez Gene)
ACKR3	Protein	57007 (Entrez Gene)
ACOT9	GeneProduct	23597 (Entrez Gene)
ACP1	Protein	52 (Entrez Gene)
ACTG1	GeneProduct	71 (Entrez Gene)
ADAM10	Protein	102 (Entrez Gene)
ADAM9	Protein	8754 (Entrez Gene)
ADAMTS1	Protein	9510 (Entrez Gene)
ADAMTS9	Protein	56999 (Entrez Gene)
ADRB2	Protein	154 (Entrez Gene)
AFDN	Protein	4301 (Entrez Gene)
AKAP2	GeneProduct	11217 (Entrez Gene)
AKT1	Protein	207 (Entrez Gene)
AKT1S1	Protein	84335 (Entrez Gene)
ALB	GeneProduct	213 (Entrez Gene)
ALDOA	GeneProduct	226 (Entrez Gene)
AMOT	Protein	154796 (Entrez Gene)
ANXA1	GeneProduct	301 (Entrez Gene)
AP2A1	GeneProduct	160 (Entrez Gene)
AP2S1	GeneProduct	1175 (Entrez Gene)
APOLD1	Protein	81575 (Entrez Gene)
ARF4	GeneProduct	378 (Entrez Gene)
ARF6	Protein	382 (Entrez Gene)
ARHGEF15	Protein	22899 (Entrez Gene)
ARMCX1	GeneProduct	51309 (Entrez Gene)
ARPC5L	GeneProduct	81873 (Entrez Gene)
ARRB2	Protein	409 (Entrez Gene)
ASCC3	GeneProduct	10973 (Entrez Gene)
ATF2	Protein	1386 (Entrez Gene)
ATF4	Protein	468 (Entrez Gene)
ATF6	Protein	22926 (Entrez Gene)
ATP6V0D1	GeneProduct	9114 (Entrez Gene)
ATP6V1E1	GeneProduct	529 (Entrez Gene)
BCAR1	Protein	9564 (Entrez Gene)
BCL2	Protein	596 (Entrez Gene)
BCL2L1	Protein	598 (Entrez Gene)
BIN1	Protein	274 (Entrez Gene)
BIRC5	Protein	332 (Entrez Gene)
BMP10	Protein	27302 (Entrez Gene)
BMP2	Protein	650 (Entrez Gene)
BMX	Protein	660
BRD4	Protein	23476 (Entrez Gene)
BSG	GeneProduct	682 (Entrez Gene)
C15ORF39	Protein	56905 (Entrez Gene)
CACNA2D1	GeneProduct	781 (Entrez Gene)
CALR	GeneProduct	811 (Entrez Gene)
CALU	GeneProduct	813 (Entrez Gene)
CAMKK2	Protein	10645 (Entrez Gene)
CAPN2	Protein	824 (Entrez Gene)
CAPZB	GeneProduct	832 (Entrez Gene)
CASC10	Protein	399726 (Entrez Gene)
CAV1	Protein	857 (Entrez Gene)
CBL	Protein	867 (Entrez Gene)
CCDC124	GeneProduct	115098 (Entrez Gene)
CCL2	Protein	6347 (Entrez Gene)
CCND1	Protein	595 (Entrez Gene)
CCRL2	Protein	9034 (Entrez Gene)
CCT7	GeneProduct	10574 (Entrez Gene)
CDC42	Protein	998 (Entrez Gene)
CDC42BPB	GeneProduct	9578 (Entrez Gene)
CDH5	Protein	1003 (Entrez Gene)
CDKN1B	Protein	8013 (Entrez Gene)
CFL1	Protein	1072 (Entrez Gene)
CGNL1	GeneProduct	84952 (Entrez Gene)
CHAC1	Protein	79094 (Entrez Gene)
CLIC1	GeneProduct	1192 (Entrez Gene)
CLTC	Protein	1213 (Entrez Gene)
CNP	GeneProduct	1267 (Entrez Gene)
COPG1	GeneProduct	22820 (Entrez Gene)
CREB1	Protein	1385 (Entrez Gene)
CREBBP	Protein	1387 (Entrez Gene)
CRIP2	GeneProduct	1397 (Entrez Gene)
CRK	Protein	1398 (Entrez Gene)
CSK	Protein	1445 (Entrez Gene)
CSRP1	GeneProduct	1465 (Entrez Gene)
CSRP2	GeneProduct	1466 (Entrez Gene)
CTGF	Protein	1490 (Entrez Gene)
CTNNA1	Protein	1495 (Entrez Gene)
CTNNB1	Protein	1499 (Entrez Gene)
CTNND1	Protein	1500 (Entrez Gene)
CXCL8	Protein	3576 (Entrez Gene)
CYBB	Protein	1536 (Entrez Gene)
CYCS	Protein	54205 (Entrez Gene)
CYP2C8	Protein	1558 (Entrez Gene)
CYR61	GeneProduct	3491 (Entrez Gene)
DECR1	GeneProduct	1666 (Entrez Gene)
DHX29	GeneProduct	54505 (Entrez Gene)
DHX36	GeneProduct	170506 (Entrez Gene)
DKK1	Protein	22943 (Entrez Gene)
DLL4	Protein	54567 (Entrez Gene)
DNAJA1	GeneProduct	3301 (Entrez Gene)
DNAJB4	GeneProduct	11080 (Entrez Gene)
DNAJB9	Protein	4189 (Entrez Gene)
DOK1	Protein	1796 (Entrez Gene)
DPM1	GeneProduct	8813 (Entrez Gene)
DSC1	GeneProduct	1823 (Entrez Gene)
DUSP5	Protein	1847 (Entrez Gene)
EEA1	Protein	8411 (Entrez Gene)
EGR1	Protein	1958 (Entrez Gene)
EGR3	Protein	1960 (Entrez Gene)
EIF2A	Protein	83939 (Entrez Gene)
EIF2AK3	Protein	9451 (Entrez Gene)
EIF3D	GeneProduct	8664 (Entrez Gene)
EIF3F	GeneProduct	8665 (Entrez Gene)
EIF3H	GeneProduct	8667 (Entrez Gene)
EIF4E	Protein	1977 (Entrez Gene)
EIF4G1	GeneProduct	1981 (Entrez Gene)
EIF4G2	GeneProduct	1982 (Entrez Gene)
ELK1	Protein	2002 (Entrez Gene)
ENG	Protein	2022 (Entrez Gene)
EPB41	GeneProduct	2035 (Entrez Gene)
EPHA2	Protein	1969 (Entrez Gene)
EPHB2	Protein	2048 (Entrez Gene)
EPN1	Protein	29924 (Entrez Gene)
EPRS	GeneProduct	2058 (Entrez Gene)
EPS15	Protein	2060 (Entrez Gene)
ERG	Protein	2078 (Entrez Gene)
ERN1	Protein	2081 (Entrez Gene)
ETS1	Protein	2113 (Entrez Gene)
EWSR1	GeneProduct	2130 (Entrez Gene)
EZR	Protein	7430 (Entrez Gene)
F3	Protein	2152 (Entrez Gene)
FADD	Protein	8772 (Entrez Gene)
FAF1	Protein	11124 (Entrez Gene)
FAM120A	GeneProduct	23196 (Entrez Gene)
FARSB	GeneProduct	10056 (Entrez Gene)
FAS	Protein	355 (Entrez Gene)
FBXW11	Protein	23291 (Entrez Gene)
FGA	Protein	2243 (Entrez Gene)
FGB	Protein	2244 (Entrez Gene)
FGD5	GeneProduct	152273 (Entrez Gene)
FGG	Protein	2266 (Entrez Gene)
FHL2	Protein	2274 (Entrez Gene)
FHOD1	GeneProduct	29109 (Entrez Gene)
FJX1	Protein	24147 (Entrez Gene)
FLII	GeneProduct	2314 (Entrez Gene)
FLNB	Protein	2317 (Entrez Gene)
FLT1	Protein	2321 (Entrez Gene)
FMNL3	GeneProduct	91010 (Entrez Gene)
FN1	GeneProduct	2335 (Entrez Gene)
FOXO1	Protein	2308 (Entrez Gene)
FOXO3	Protein	2309 (Entrez Gene)
FOXO4	Protein	4303 (Entrez Gene)
FRS2	Protein	10818 (Entrez Gene)
FSCN1	GeneProduct	6624 (Entrez Gene)
FUT1	Protein	2523 (Entrez Gene)
FXR2	GeneProduct	9513 (Entrez Gene)
FYN	Protein	2534 (Entrez Gene)
GAB1	Protein	2549 (Entrez Gene)
GAPDH	GeneProduct	2597 (Entrez Gene)
GATA2	Protein	2624 (Entrez Gene)
GIGYF2	GeneProduct	26058 (Entrez Gene)
GIPC1	Protein	10755 (Entrez Gene)
GJA1	Protein	2697 (Entrez Gene)
GLUD1	GeneProduct	2746 (Entrez Gene)
GPC1	Protein	2817 (Entrez Gene)
GPX1	Protein	2876 (Entrez Gene)
GRB10	Protein	2887 (Entrez Gene)
GRB2	Protein	2885 (Entrez Gene)
GRSF1	GeneProduct	2926 (Entrez Gene)
GSK3B	Protein	2932 (Entrez Gene)
HBD	GeneProduct	3045 (Entrez Gene)
HBEGF	Protein	1839 (Entrez Gene)
HDAC1	Protein	3065 (Entrez Gene)
HDAC4	Protein	9759 (Entrez Gene)
HDAC5	Protein	10014 (Entrez Gene)
HDAC7	Protein	51564 (Entrez Gene)
HDAC9	Protein	9734 (Entrez Gene)
HERPUD1	Protein	9709 (Entrez Gene)
HGS	Protein	9146 (Entrez Gene)
HLX	Protein	3142 (Entrez Gene)
HMGB1	GeneProduct	3146 (Entrez Gene)
HRAS	Protein	3265 (Entrez Gene)
HSP90AA1	GeneProduct	3320 (Entrez Gene)
HSP90AB2P	GeneProduct	391634 (Entrez Gene)
HSPA1A	Protein	3303 (Entrez Gene)
HSPB1	Protein	3315 (Entrez Gene)
HTRA1	GeneProduct	5654 (Entrez Gene)
HYOU1	GeneProduct	10525 (Entrez Gene)
ICAM1	Protein	3383 (Entrez Gene)
IDH2	GeneProduct	3418 (Entrez Gene)
IER5	Protein	51278 (Entrez Gene)
IGFBP3	Protein	3486 (Entrez Gene)
IGFBP7	Protein	3490 (Entrez Gene)
INPP5K	GeneProduct	51763 (Entrez Gene)
IQGAP1	GeneProduct	8826 (Entrez Gene)
ITCH	Protein	83737 (Entrez Gene)
ITGAV	Protein	3685 (Entrez Gene)
ITGB1	Protein	3688 (Entrez Gene)
ITGB3	Protein	3690 (Entrez Gene)
ITGB5	Protein	3693 (Entrez Gene)
ITPR1	Protein	3748 (Entrez Gene)
JAG1	Protein	182 (Entrez Gene)
JUN	Protein	3725 (Entrez Gene)
KANK1	GeneProduct	23189 (Entrez Gene)
KATNAL2	GeneProduct	83473 (Entrez Gene)
KL	Protein	9365 (Entrez Gene)
LARP7	Protein	51574 (Entrez Gene)
LDB2	Protein	9079 (Entrez Gene)
LDHA	GeneProduct	3939 (Entrez Gene)
LIMK1	Protein	3984 (Entrez Gene)
LMAN1	GeneProduct	3998 (Entrez Gene)
LMO2	Protein	405 (Entrez Gene)
LRRC59	GeneProduct	55379 (Entrez Gene)
LRRFIP2	GeneProduct	9209 (Entrez Gene)
LUC7L	GeneProduct	55692 (Entrez Gene)
MAP2K1	Protein	5604 (Entrez Gene)
MAP2K2	Protein	5605 (Entrez Gene)
MAP2K3	Protein	5606 (Entrez Gene)
MAP2K4	Protein	6416 (Entrez Gene)
MAP2K6	Protein	5608 (Entrez Gene)
MAP2K7	Protein	5609 (Entrez Gene)
MAP3K5	Protein	4217 (Entrez Gene)
MAPK12	Protein	6300 (Entrez Gene)
MAPK14	Protein	1432 (Entrez Gene)
MAPK1	Protein	5594 (Entrez Gene)
MAPK3	Protein	5595 (Entrez Gene)
MAPK8	Protein	5599 (Entrez Gene)
MAPK9	Protein	5601 (Entrez Gene)
MAPKAP1	Protein	79109 (Entrez Gene)
MAPKAPK2	Protein	9261 (Entrez Gene)
MAPKAPK5	Protein	8550 (Entrez Gene)
MDM2	Protein	4193 (Entrez Gene)
MEF2C	Protein	4208 (Entrez Gene)
MICAL2	GeneProduct	9645 (Entrez Gene)
MKNK1	Protein	8569 (Entrez Gene)
MLLT4	Protein	4301 (Entrez Gene)
MLST8	Protein	64223 (Entrez Gene)
MMP10	Protein	4319 (Entrez Gene)
MMP14	Protein	4323 (Entrez Gene)
MMP2	Protein	4313 (Entrez Gene)
MMRN2	Protein	79812 (Entrez Gene)
MOV10	GeneProduct	4343 (Entrez Gene)
MTOR	Protein	2475 (Entrez Gene)
MYH11	GeneProduct	4629 (Entrez Gene)
MYH9	Protein	4627 (Entrez Gene)
MYL2	Protein	4633 (Entrez Gene)
MYO1C	GeneProduct	4641 (Entrez Gene)
MYO6	GeneProduct	4646 (Entrez Gene)
NAP1L1	GeneProduct	4673 (Entrez Gene)
NAPA	GeneProduct	8775 (Entrez Gene)
NCF1	Protein	653361 (Entrez Gene)
NCF2	Protein	4688 (Entrez Gene)
NCK1	Protein	4690 (Entrez Gene)
NCL	GeneProduct	4691 (Entrez Gene)
NDRG1	Protein	10397 (Entrez Gene)
NEXN	GeneProduct	91624 (Entrez Gene)
NFATC1	Protein	4772 (Entrez Gene)
NFATC2	Protein	4773 (Entrez Gene)
NFKB1	Protein	4790 (Entrez Gene)
NFKBIA	Protein	4792 (Entrez Gene)
NOS3	Protein	4846 (Entrez Gene)
NOTCH4	Protein	4855 (Entrez Gene)
NOX4	Protein	50507 (Entrez Gene)
NR4A1	Protein	3164 (Entrez Gene)
NR4A2	Protein	4929 (Entrez Gene)
NR4A3	Protein	8013 (Entrez Gene)
NRARP	Protein	441478 (Entrez Gene)
NRDG1	Protein	10397 (Entrez Gene)
NRP1	Protein	8821 (Entrez Gene)
NRP2	Protein	8828 (Entrez Gene)
NUMB	GeneProduct	8650 (Entrez Gene)
NUR4A1	Protein	3164 (Entrez Gene)
OCLN	Protein	100506658 (Entrez Gene)
OCRL	GeneProduct	4952 (Entrez Gene)
P4HA2	GeneProduct	8974 (Entrez Gene)
P4HB	GeneProduct	5034 (Entrez Gene)
PABPC1	GeneProduct	26986 (Entrez Gene)
PAK1	Protein	5058 (Entrez Gene)
PAK2	Protein	5062 (Entrez Gene)
PBXIP1	GeneProduct	57326 (Entrez Gene)
PDE4DIP	GeneProduct	9659 (Entrez Gene)
PDIA6	GeneProduct	10130 (Entrez Gene)
PDPK1	Protein	5170 (Entrez Gene)
PFN1	GeneProduct	5216 (Entrez Gene)
PGD	GeneProduct	5226 (Entrez Gene)
PGF	Protein	5228 (Entrez Gene)
PGK1	GeneProduct	5230 (Entrez Gene)
PIK3CA	Protein	5290 (Entrez Gene)
PIK3R1	Protein	5295 (Entrez Gene)
PIK3R2	Protein	5296 (Entrez Gene)
PLA2G4A	Protein	5321 (Entrez Gene)
PLA2G5	Protein	5322 (Entrez Gene)
PLAU	Protein	5328 (Entrez Gene)
PLAUR	Protein	5329 (Entrez Gene)
PLCB3	Protein	5331 (Entrez Gene)
PLCG1	Protein	5335 (Entrez Gene)
PLOD3	GeneProduct	8985 (Entrez Gene)
PNP	Protein	4860 (Entrez Gene)
PPM1G	GeneProduct	5496 (Entrez Gene)
PPP1CA	GeneProduct	5499 (Entrez Gene)
PPP2CA	GeneProduct	5515 (Entrez Gene)
PPP3CA	Protein	5530 (Entrez Gene)
PRDX2	GeneProduct	7001 (Entrez Gene)
PRDX6	GeneProduct	9588 (Entrez Gene)
PRKAA1	Protein	5562 (Entrez Gene)
PRKAA2	Protein	5563 (Entrez Gene)
PRKCA	Protein	5578 (Entrez Gene)
PRKCB	Protein	5579 (Entrez Gene)
PRKCD	Protein	5580 (Entrez Gene)
PRKCE	Protein	5581 (Entrez Gene)
PRKCI	Protein	5584 (Entrez Gene)
PRKCZ	Protein	5590 (Entrez Gene)
PRKD1	Protein	5587 (Entrez Gene)
PRKD2	Protein	25865 (Entrez Gene)
PRKG1	Protein	5592 (Entrez Gene)
PRKRA	GeneProduct	8575 (Entrez Gene)
PRRC2C	GeneProduct	23215 (Entrez Gene)
PSMD11	GeneProduct	5717 (Entrez Gene)
PSMD4	GeneProduct	5710 (Entrez Gene)
PTGS2	Protein	5743 (Entrez Gene)
PTK2	Protein	5747 (Entrez Gene)
PTK2B	Protein	2185 (Entrez Gene)
PTMA	GeneProduct	5757 (Entrez Gene)
PTPN11	Protein	5781 (Entrez Gene)
PTPN14	GeneProduct	5784 (Entrez Gene)
PTPN1	Protein	5770 (Entrez Gene)
PTPN6	Protein	5777 (Entrez Gene)
PTPN9	Protein	5780 (Entrez Gene)
PTPRJ	Protein	5795 (Entrez Gene)
PTPRZ1	Protein	5803 (Entrez Gene)
PXN	Protein	5829 (Entrez Gene)
QKI	GeneProduct	9444 (Entrez Gene)
R1CTOR	Protein	253260 (Entrez Gene)
RAB11	Protein	8766 (Entrez Gene)
RAB37	Protein	326624 (Entrez Gene)
RAB4A	Protein	5867 (Entrez Gene)
RAB5A	Protein	5868 (Entrez Gene)
RAC1	Protein	5879 (Entrez Gene)
RACK1	Protein	10399 (Entrez Gene)
RAF1	Protein	5894 (Entrez Gene)
RAP1A	Protein	5906 (Entrez Gene)
RAP1B	Protein	5908 (Entrez Gene)
RAPGEF1	Protein	2889 (Entrez Gene)
RAPTOR	Protein	253260 (Entrez Gene)
RBM39	GeneProduct	9584 (Entrez Gene)
RCAN1	Protein	1827 (Entrez Gene)
RCAN2	Protein	10231 (Entrez Gene)
RCN1	GeneProduct	5954 (Entrez Gene)
RELA	Protein	5970 (Entrez Gene)
RHOA	Protein	387 (Entrez Gene)
RHOC	Protein	389 (Entrez Gene)
RHOJ	Protein	57381 (Entrez Gene)
RND1	Protein	27289 (Entrez Gene)
ROCK1	Protein	6093 (Entrez Gene)
ROCK2	Protein	9475 (Entrez Gene)
RPL10A	GeneProduct	4736 (Entrez Gene)
RPL13A	GeneProduct	23521 (Entrez Gene)
RPL18A	GeneProduct	6142 (Entrez Gene)
RPL26	GeneProduct	6154 (Entrez Gene)
RPL27	GeneProduct	6155 (Entrez Gene)
RPL39P5	GeneProduct	553117 (Entrez Gene)
RPL5	GeneProduct	6125 (Entrez Gene)
RPL7	GeneProduct	6129 (Entrez Gene)
RPLP2	GeneProduct	6181 (Entrez Gene)
RPS11	GeneProduct	6205 (Entrez Gene)
RPS6	Protein	6194 (Entrez Gene)
RPS6KA5	Protein	9252 (Entrez Gene)
RPS6KB1	Protein	6198 (Entrez Gene)
S1PR1	Protein	1901 (Entrez Gene)
SARS	GeneProduct	6301 (Entrez Gene)
SCUBE2	Protein	57758 (Entrez Gene)
SDCBP	Protein	6386 (Entrez Gene)
SDF2L1	Protein	23753 (Entrez Gene)
SELE	Protein	6401 (Entrez Gene)
SEMA6D	Protein	80031 (Entrez Gene)
SET	GeneProduct	6418 (Entrez Gene)
SH2D2A	Protein	9047 (Entrez Gene)
SH3BGRL3	GeneProduct	83442 (Entrez Gene)
SHB	Protein	6461 (Entrez Gene)
SHC1	Protein	6464 (Entrez Gene)
SHC2	Protein	25759 (Entrez Gene)
SHROOM2	GeneProduct	357 (Entrez Gene)
SIAH2	Protein	6478 (Entrez Gene)
SLC25A11	GeneProduct	8402 (Entrez Gene)
SLC25A25	Protein	114789 (Entrez Gene)
SLC2A14	Protein	144195 (Entrez Gene)
SLC39A14	Protein	21356 (Entrez Gene)
SLC7A1	Protein	6541 (Entrez Gene)
SLC8A1	Protein	6546 (Entrez Gene)
SMARCA2	Protein	6595 (Entrez Gene)
SND1	GeneProduct	27044 (Entrez Gene)
SOD2	Protein	6648 (Entrez Gene)
SPHK1	Protein	55872 (Entrez Gene)
SPIRE1	GeneProduct	56907 (Entrez Gene)
SRC	Protein	6714 (Entrez Gene)
SRF	Protein	6722 (Entrez Gene)
SRP54	GeneProduct	6729 (Entrez Gene)
SRPK1	GeneProduct	6732 (Entrez Gene)
SSR3	GeneProduct	6747 (Entrez Gene)
SSR4	GeneProduct	6748 (Entrez Gene)
STAM	Protein	8027 (Entrez Gene)
STAT1	Protein	6772 (Entrez Gene)
STAT3	Protein	6774 (Entrez Gene)
STAT6	Protein	6778 (Entrez Gene)
STIP1	GeneProduct	10963 (Entrez Gene)
SYNJ1	GeneProduct	8867 (Entrez Gene)
TAL1	Protein	6886 (Entrez Gene)
TAOK2	GeneProduct	9344 (Entrez Gene)
TBCA	GeneProduct	6902 (Entrez Gene)
TCEB1	GeneProduct	6921 (Entrez Gene)
TCEB3	Protein	6924 (Entrez Gene)
TEAD4	Protein	7004 (Entrez Gene)
TFAM	GeneProduct	7019 (Entrez Gene)
TFCP2	GeneProduct	7024 (Entrez Gene)
TKT	GeneProduct	7086 (Entrez Gene)
TMEM170A	Protein	124491 (Entrez Gene)
TMOD1	GeneProduct	7111 (Entrez Gene)
TMOD3	GeneProduct	29766 (Entrez Gene)
TMSB10	GeneProduct	9168 (Entrez Gene)
TMSB4X	GeneProduct	7114 (Entrez Gene)
TNFRSF10C	Protein	8794 (Entrez Gene)
TNFRSF25	Protein	8718 (Entrez Gene)
TNXB	Protein	7148 (Entrez Gene)
TPCN2	Protein	219931 (Entrez Gene)
TPM3	GeneProduct	7170 (Entrez Gene)
TPP1	GeneProduct	1200 (Entrez Gene)
TRAF3IP2	Protein	10758 (Entrez Gene)
TRIP4	GeneProduct	9325 (Entrez Gene)
TRPC1	Protein	7220 (Entrez Gene)
TRPC3	Protein	7222 (Entrez Gene)
TUBA1C	GeneProduct	84790 (Entrez Gene)
TUBB8	GeneProduct	347688 (Entrez Gene)
TXN	Protein	7295 (Entrez Gene)
TXNDC5	GeneProduct	81567 (Entrez Gene)
TXNIP	Protein	10628 (Entrez Gene)
UBAP2L	GeneProduct	9898 (Entrez Gene)
USP10	GeneProduct	9100 (Entrez Gene)
VAV2	Protein	7410 (Entrez Gene)
VCAM1	Protein	5328 (Entrez Gene)
VCL	Protein	7414 (Entrez Gene)
VEGFA	Protein	7422 (Entrez Gene)
VEGFR2	Protein	3791 (Entrez Gene)
VPS39	GeneProduct	23339 (Entrez Gene)
WASF1	Protein	8936 (Entrez Gene)
YWHAE	GeneProduct	7531 (Entrez Gene)
ZC3H15	GeneProduct	55854 (Entrez Gene)
ZNF555	Protein	148254 (Entrez Gene)

Annotated Interactions

No annotated interactions