VEGFA-VEGFR2 signaling (Homo sapiens)

From WikiPathways

Revision as of 08:00, 6 February 2020 by Prslab (Talk | contribs)
Jump to: navigation, search
27STAT3PROCK2PRKD2535327, 102MAPK3Y204T202MAPK1T185Y18758126, 129MAPK1Y187T185155214, 2712301236, 22, 2452544758, 234MAP2K3MAP2K6P24939MAPK9MAPK8Y185T183STAT3PMAPK3T183228MAPK3T202Y20418645, 123, 146, 173MAPK1Y185127PRKCZ128, 238PIK3R2ACACBNCF2MAPK12RAP1B33VEGFR2Y951Y996MeK1041Y1059Y1175Y1214Y105489201188, 214149AP1complexSoluble andcleaved FLT1may sequesterVEGFA fromVEGFR2PKC delta/ZetadependentEpoxyeicosatrienoicacid regioisomersEC proliferation,migration,tube formationand angiogenesisCYCell motilityand tube formationEC Migration andTube FormationABCF233, 11418FADDTCEB3FAF1FASBIN1BMXHDAC1TNFRSF10CHSPA1ASMARCA257DOK1PGAB1PReceptorPROTEINLigandProtein translocation LEGENDMultiple colored edges are introduced to distinguish the connecting nodesPhosphorylated form with/without site & residueEndosomeNucleusMitochondrionCytoplasmPlasma membraneMTEndoplasmic reticulumCYPMNUERENVEGFR2Y1054Y951Y1214Y801Y1059Y117530VEGFA259MAPK14P117, 190117F-actinreorganization117, 162117Stress fibreformationFocal adhesionassembly andcell migration117NCK1PFYNPPAK2P33STAT1PSTAT6P105, 137STAT1PSTAT6P137NUFRS2PCRKPPRKCI1515151533SRCY530Y4192087RAPGEF1186186RAP1AGTP186ITGAVITGB3Y773186BCAR1P17630, 187PLCG1Y783Ub16SHC1187, 213SHC218733, 127PTK2Y861Y576Y397S732Y407168IQGAP1PRAC1GTP133, 207149149Directed Cell migration135, 149, 215ITGB5ITGB1ITGAV1717, 811717222SH2D2A175175223VascularpermeabilityNAADP65TPCN2Ca2+Ca2+Ca2+Ca2+Ca2+Ca2+6565H+H+H+ATPADP656565Endolysosomalcalcium storeMAPKAPK2T33469, 190190190190PLAUPIP2IP3DAG274274274CAPN2138Ca2+Ca2+Ca2+166MYL2S20T19168Endothelial cellcontraction athigh VEGFA levels16851ROCK1P51, 75RHOAGTP35, 50, 51, 75, 119...207RHOCGTP3, 228Endothelial cellProliferationand migration228228MAP2K1S222S218188, 22822820, 163CBL163163163ITPR1274228PRKCBPRKCAS65790RAF1P6, 90, 254SPHK1PHRASGTP1927410PRKD1S738S742S9101551018, 155HDAC5S259S498155HDAC5S259S498PRKCDPRKCEPLA2G4AP66, 22PGI2HSPB1S78S82S1592150NRP1130, 201CAV1Y14878787CDH5106PTPN11106CSK10610610674PTK2BY402132128, 185HSP90AA1464646, 185267MLLT4210210FHL214014038PLCB3S1105S5372626CDC42GTP26WASF1NCF1PPAK1P140152152PTPN988PTPRZ160606060NCLMYH9NCL122122122122109AKT1T308S473109FOXO1S256AKT1T308S47323, 109, 202109FOXO1S256109, 249109106, 109, 250RELANFKBIA268P919163, 91, 165, 26191PLA2G5RPS6KA5P767676136, 154PIK3R1P73154, 202NOS3S1179S1141692, 138, 154NO154LIMK1S323CFL1S392162162150, 162VAV2Y1725050, 100FLNB9898, 20498PFN1Y12944G-actin bindingand actinpolymerization4At cellleadingedge1142, 234ATF2T71T69Promotes endothelial-leukocyte interactions23423458Endothelialcell survival58, 134GRB2P2020, 10046, 238PXNpY9, 128, 20336GJA1S279S368S255S282S262184ClathrinmediatedGap junctioninternalization123GJA1S262S282S368S255S279Stress fibreformation11PTPRJ250, 251250, 251250SHBP129129129129114, 235114, 235114185185ROCK1P185RPS6KB1T41256TXNIPACP1S-glutathionylation56, 131TXN5656, 131ONOO-5656109, 273Cysteineoxidationof VEGFR2and SRCPTPN6216216GRB10P5531, 152PRKAA1T183ROSMitochondrial21531CytosolicROS79Angiogenesis7979, 8549, 121, 246cGMP121, 164Angiogenesis49, 121, 246CREB1P68CAMKK285, 217ACACAP85, 20085, 217PRKAA2215ARHGEF156464RHOJGTP2576464126SHC1S36126, 213PDPK1S241214PIP2PIP3R1CTORMLST8MAPKAP1MTORS2481S2448199199MTORRAPTORMLST8214214214NRDG1T345mTORC2mTORC1142134, 227GSK3BS9202169, 214214AKT1S1T266271271271RPS6S236S235169, 271136RAPTORMTORMLST8mTORC1169ER stress-independentVEGF-UPR machinerymediated pathwayEIF2AK3ERN1PATF6EIF2AS51169169169GeneexpressionATF4169169DNAJB9HERPUD1169AKT1S4731693311CAPN2166EZR138138138TRPC1ITPR1171KL161161Ca2+Ca2+Ca2+Ca2+Ca2+161171Calciumreleasefrom ERPIK3CA210TXNIPVEGFR256PLCG1Y783RAB5ACDH5S665CTNND1S268S252CTNNB1CTNNA1S453MAP2K1S218S222MAP2K2243243VEGFR2Y1214Y1175Ub192Lysosomemediatedpartialproteosomaldegradation230 kDa160 kDaFBXW11192EEA12525SLC8A1Ca2+Ca2+Ca2+Ca2+232Na+Na+232232232232Mostlyclathrindependentinternalization25HGSY334VEGFR2UbY1214Y1175STAM8484GIPC1MYO6236PTPN1151, 236132272NRP1272272ClathrindependentinternalizationNRP1RAB11VEGFR2NRP1174VEGFR2recycling174239SRCY416Y527VAV2Y172RAC1133, 207GTPPAK2PARRB250, 23923950, 207, 239239239239239239CDH5S655CTNND1CTNNB1ARRB2239239239VE CadherinrecyclingEarly endosomes115115115115Regulation ofcell survivalRegulation ofchromatinremodellingRNA elongationby RNA Pol II115115115VCLS346464646, 18546, 185465Regulation ofendothelial cellsproutingCLTC192Involvedin the activationof VEGFR224MAPKAPK5T1822424NRP2MAP3K5S83MAP2K7PMAP2K4T261JUNS63393939AKT1T308S473CAV1Y1487ARF6275ARF6275ANXA1P265265208NFATC2dePNFATC2deP8, 16, 167, 225167NFATC1NFATC144, 86PTGS216EC Migration83RND1838, 237, 253EGR144, 77, 19844, 77, 198SRF44, 77, 198NR4A2NR4A344PPP3CACREB1P686, 228, 16, 167, 225, 237...Ca2+Ca2+Ca2+JAG1DKK1CCL2CXCL8AMOTBMP10237TEAD493, 1242, 82, 23712422554PKC delta/betadependentTEAD412454269EndosomeRegulation of receptor endocytosis and recyclingCYNUCYNUCYNUCYNUCYNUCYNUCYNUCYNUNUCYNFKB1RELANFKB1ICAM1SELE63Promotes endothelial-leukocyte interactions63165Endothelialcell survival105105FOXO4S197FOXO3249FOXO4FOXO3249249CYNUCYNU249Decreasedexpressionby nuclearexport ofFOXO1/3/4Endothelialcell survival249VEGFR2EndosomeRAB4A113RAB4A113ENPMHGSEPS15EPN1OCLNUbS490ITCHGap junctiondisruptionNa+Na+264156, 180, 264264264Tight junctiondisruption264Occludininternalizationand proteosomaldegradationHDAC7S397S194S479FLNBK1147204204YWHAE256HDAC7S397S479S194HDAC9S245S254HDAC4S467S 246CY196, 204, 256NUMEF2CCCND1228196, 204, 25654, 196, 204, 256RCAN2MMP10MMP14Activationof MEF2 by nuclearexport ofHDACsEC proliferation,migration,tube formationand angiogenesis196, 204, 25654MKNK1PMKNK1P254NUCYEIF4EP254ELK1160OCLNS490Ub45, 264PMENITGAVStimulationof tip cellfilopodiaPLAURPLAU141PLAUProActiveMMP224024012, 141, 252ITGAVITGB1PLAURPLAUCell migrationand invasion141PMENClathrinmediatedF3172NR4A1VCAM1BCL2L1CYP2C8SOD2ADAMTS1ACKR3EGR3172HBEGFRCAN1CDKN1BNUR4A1MEF2C172VCAM1172CCL2BCL2CTNNB1VEGFA SIGNALING PATHWAY IN ENDOTHELIAL CELLSCTNNB1Y142230230112, 230Adherensjunctiondisassembly230ATF2T69T71BCL2L158ERGS21510227NOTCH487ETS1AcT38S41177AA6, 22, 245245PTGS2S-nitrosylPTGS2242NOS3242T172PRKG1164121, 164ProteinComplexSmallmoleculesTranscriptional regulation of gene expression (multiple colours)Unique solid edges between receptor and other proteinsDirect protein-protein interactions associated with VEGFR2 phospho-Y1175Direct protein-protein interactions associated with VEGFR2 phospho-Y801Direct protein-protein interactions associated with VEGFR2 phospho-Y1214Direct protein-protein interactions associated with VEGFR2 phospho-Y951Direct protein interactions of VEGFR2 for which a specific VEGFR2 phosphosite involvement isnot reported AND also represents direct protein-protein interactions between other proteinsDirect phosphorylations by VEGFR2 AND also represents otherdirect kinase-substrate phosphorylation eventsGeneric edges between proteinsSolid edges Dashed edgesDirect protein-protein interactions or enzyme-substrate reactionsLeads to, through unknown or not reported intermediatesDirect dephosphorylation of substrates by phosphatasesDirect ubiquitination of substrates by E3 ubiquitin ligasesDirect protein cleavage of substrates by proteasesDirect inhibition of protein activityDissociation of direct protein-protein interactionsLeads to, through unknown ornot reported/studied intermediatesUbiquitinated form with/without site & residueMethylated form with/without site & residueGlutathionilated form with/without site & residuePTMsProtein transport across multiple cell compartmentsPIP2 PtdIns(4,5)P2PIP3 PtdIns(3,4,5)P3DAG DiacylglycerolIP3 Inositol triphosphateROS Reactive oxygen speciesONOO- PeroxynitriteNAADP Nicotinic acid adenine dinucleotide phosphateATP Adenosine triphosphateGTP Guanosine triphosphateADP Adenosine diphosphateNO Nitric OxidecGMP Cyclic GMPAA Arachidonic AcidPGI2 Prostaglandin I2S-nitrosilated formPROTEINmRNASmallmoleculesmRNAPROTEINModifiedformIncreasedexpressionDecreasedexpressionPI3K-AKT-MTOR ModuleP38 MAPKModuleJNKModulePLC-PKCModuleERKModuleNFKBModuleFAKModuleRACModuleSTATModuleRHOAModuleADAMTS121VEGFA-165aFGAMMRN2TNXBIGFBP7GPC1CTGF671111104144183PGF34FGBFGGVEGFA-145aVEGFA-145bVEGFA-111VEGFA-148VEGFA-165aVEGFA-165bVEGFA-121aVEGFA-121bVEGFA-183aVEGFA-183bVEGFA-162VEGFA-206VEGFA-189aVEGFA-189bMultiple VEGFA isoforms178178FLT1Y1213Y794Y1333Y116972, 9718218218218240, 95220RACK16161Direct protein-protein interactions associated with FLT1 phospho -Y794, -Y1169, -Y1213 & -Y1333VEGFAVEGFA-165a25914852BIRC5MDM2P52ADAM952ADAM10201S1PR1201AFDN21046, 21046, 21035, 50, 51, 75, 229SCUBE2195195ENGCDH5241PFGD5118147, 181181LMO2TAL1GATA2LDB2DLL4179GPX1GJA1159270CYCSMAP2K3CHAC1C15ORF39RAB37ADRB2TRAF3IP2DUSP5EPHA2FJX1TMEM170ASDF2L1SLC2A14IER5SLC39A14ZNF555HLXNRARPSLC25A25CCRL2PNPAPOLD1PIK3R1NDRG1FUT1DLL4SIAH2CASC10TRPC32828SLC7A1212212ArginineIntakeBRD4acetylated form103LARP7CREBBPMEF2C103CXCL8BMP2SEMA6DNR4A2ADAMTS9EGR3NR4A1IGFBP3103CYBBNOX4EPHB2SDCBPPromotesendocytosis120ABL114PRCAN1TNFRSF25255PTPN62247ACOT9ACTG1AKAP2ALBALDOAANXA1AP2A1AP2S1ARF4ARMCX1ARPC5LASCC3ATP6V0D1CSRP2CYR61DECR1DHX29DHX36DNAJA1DNAJB4DPM1DSC1EIF3DEIF3FEIF3HEIF4G1EIF4G2GRSF1HBDHMGB1HSP90AA1HSP90AB2PHTRA1HYOU1IDH2INPP5KIQGAP1KANK1KATNAL2LDHALMAN1P4HBPABPC1PBXIP1PDE4DIPPDIA6PFN1PGDPGK1PLOD3PPM1GPPP1CAPPP2CAPRDX2PRDX6PRKRARPL7RPLP2RPS11SARSSETSH3BGRL3SHROOM2SLC25A11SND1SPIRE1SRP54SRPK1SSR3SSR4STIP1ATP6V1E1BSGCACNA2D1CALRCALUCAPZBCCDC124CCT7CDC42BPBCGNL1CLIC1CNPCOPG1CRIP2CSRP1EPB41EPRSEWSR1FAM120AFARSBFGD5FHOD1FLIIFMNL3FN1FSCN1FXR2GAPDHGIGYF2GLUD1LRRC59LRRFIP2LUC7LMICAL2MOV10MYH11MYO1CMYO6NAP1L1NAPANCLNEXNNUMBOCRLP4HA2PRRC2CPSMD11PSMD4PTMAPTPN14QKIRBM39RCN1RPL10ARPL13ARPL18ARPL26RPL27RPL39P5RPL5SYNJ1TAOK2TBCATCEB1TFAMTFCP2TKTTMOD1TMOD3TMSB10TMSB4XTPM3TPP1TRIP4TUBA1CTUBB8TXNDC5UBAP2LUSP10VPS39YWHAEZC3H1577BCAR1interactome(10', 30', 60')


Description

Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is central to a number of physiological conditions, from embryogenesis to wound healing in adults and is a hallmark of pathological conditions such as tumorigenesis [1-3]. Angiogenesis is mediated by the coordinated action of a variety of growth factors, metabolites and cell adhesion molecules in endothelial cells [4-6]. Vascular endothelial growth factor (VEGF) is the principal angiogenic growth factor modulating neovascularization [7].

The biological effect of VEGF is mediated through specific VEGF receptors on endothelial cell surface. VEGFs (VEGF-A, VEGF-B, VEGF-C and VEGF-D) interact with VEGF receptors such as VEGFR1, VEGFR2 and VEGFR3. Among them, VEGFA/VEGFR2 signaling appears to mediate cellular responses involved in angiogenesis prominently. Further, VEGF/VEGFR1 signaling, though weak, converges to VEGFR2 signaling pathway. VEGFA binding to VEGFR2 at the surface of endothelial cells leads to dimerization and auto-phosphorylation of specific tyrosine residues in the cytoplasmic domain of VEGFR2. It leads to activation of multiple downstream signaling cascades and promotes endothelial cell proliferation, migration, and tube formation relevant to angiogenesis [8]. VEGFR2 dependent activation of PI3K-AKT-mTOR signaling regulates cell survival, cell proliferation, anti-apoptotic and cell permeability functions [9]. Another important pathway of VEGF mediated cell proliferation appears to be through PLCγ-mediated activation of PKC and downstream induction of the ERK and other PKC-dependent pathways [10]. Endothelial cell migration is induced by VEGFA/VEGFR2 signaling through activation of p38MAPK (actin polymerization) and FAK (focal adhesion turnover) which is particularly important in directed migration [11, 12]. Phosphosite specificity towards downstream signalling has also been documented. Phosphosite mapping documented seven phosphosites in VEGFR2 receptor: Y1054, Y1214, Y801, Y1175, Y951, Y1059 and Y996. Phosphorylation of Y1214 and Y1054 regulates signaling events involved in cell migration. Y801 phosphorylation regulates cell survival. Y1175 regulates both cell proliferation and migration. Y951 and Y1059 phosphorylation regulates cell survival, cell migration and cell proliferation.

VEGFA/VEGFR2 signaling network compiles data available in the literature with respect to VEGFA signaling (especially VEGFA-165) through VEGFR2 in endothelial cells. The signaling events involving these proteins were derived from experimentally validated data involving multiple experimental techniques and approaches. Individual signaling events in VEGFR2 signaling networks leading to cell proliferation, migration and survival were identified and categorized into protein-protein interactions, enzyme-catalyzed events, activation/inhibition reactions, transport of protein across subcellular compartments, and gene regulation events. Signaling molecules involved in VEGFA/VEGFR2 signaling were categorized to enzymes, receptors and transcription factors and the contextual activation/deactivation of these molecules downstream to VEGFA/ VEGFR2 signaling, in modulating angiogenesis, is documented.

VEGFA dependent angiogenesis pathway map depicts the integration of signaling pathways regulating cell survival, cell migration, cell proliferation, cellular interactions downstream of VEGFA/VEGFR2 signaling relevant to angiogenesis, regulation of VEGFR2, phosphosite specificity of VEGFR2 towards downstream signaling, post-translational modifications, molecular function-based information, cross-talks among proteins in the canonical signaling modules and the information on the compartmentalization of proteins. The map of VEGFA/VEGFR2 signaling network is interactive to help investigators to add new information as it becomes available in the future for analysis or representation.


VEGFA dependent angiogenesis pathway map may please be cited as:

1. Abhinand, C. S., Raju, R., Soumya, S. J., Arya, P. S., and Sudhakaran, P. R. (2016). VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis. Journal of cell communication and signaling, 10(4), 347-354.

2. Sunitha, P., Raju, R., Sajil, C.K., Abhinand, C.S., Nair, A.S., Oommen, O.V., Sugunan, V.S., and Sudhakaran, P.R. (2019). Temporal VEGFA responsive genes in HUVECs: Gene signatures and potential ligands/receptors fine-tuning angiogenesis. Journal of Cell Communication and Signaling, 13, 561 - 571.


References

1. Folkman J (1971). Tumor angiogenesis: therapeutic implications. N Engl J Med. 285:1182-1186.

2. Chatterjee S, Heukamp LC, Siobal M et al., 2013. Tumor VEGF: VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer. J Clin Invest. 123:1732-1740.

3. Shibuya M (2014). VEGF-VEGFR Signals in Health and Disease. BiomolTher (Seoul). 22:1-9.

4. Kumar VB, Binu S, Soumya SJ et al., 2014. Regulation of vascular endothelial growth factor by metabolic context of the cell. Glycoconj J. 31:427-434.

5. Kitazume S, Imamaki R, Ogawa K et al., 2014. Sweet role of platelet endothelial cell adhesion molecule in understanding angiogenesis. Glycobiology. 24:1260-1264.

6. Kunhiraman H, Edatt L, Thekkeveedu S et al., 2016. 2‐Deoxy Glucose Modulates Expression and Biological Activity of VEGF in a SIRT‐1 Dependent Mechanism. J Cell Biochem.

7. Lohela M, Bry M, Tammela T et al., 2009. VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell Biol. 21:154-165.

8. Koch S, Claesson-Welsh L, 2012. Signal transduction by vascular endothelial growth factor receptors. Cold Spring Harbor perspectives in medicine. 2(7):a006502.

9. Koch S, Tugues S, Li X et al., 2011. Signal transduction by vascular endothelial growth factor receptors. Biochem J.437:169-183.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Colladel R, Pellicani R, Andreuzzi E, Paulitti A, Tarticchio G, Todaro F, Colombatti A, Mongiat M; ''MULTIMERIN2 binds VEGF-A primarily via the carbohydrate chains exerting an angiostatic function and impairing tumor growth.''; Oncotarget, 2016 PubMed Europe PMC Scholia
  2. Minami T, Horiuchi K, Miura M, Abid MR, Takabe W, Noguchi N, Kohro T, Ge X, Aburatani H, Hamakubo T, Kodama T, Aird WC; ''Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  3. Hoeppner LH, Sinha S, Wang Y, Bhattacharya R, Dutta S, Gong X, Bedell VM, Suresh S, Chun C, Ramchandran R, Ekker SC, Mukhopadhyay D; ''RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells.''; J Cell Sci, 2015 PubMed Europe PMC Scholia
  4. Fan Y, Arif A, Gong Y, Jia J, Eswarappa SM, Willard B, Horowitz A, Graham LM, Penn MS, Fox PL; ''Stimulus-dependent phosphorylation of profilin-1 in angiogenesis.''; Nat Cell Biol, 2012 PubMed Europe PMC Scholia
  5. Kroll J, Epting D, Kern K, Dietz CT, Feng Y, Hammes HP, Wieland T, Augustin HG; ''Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis.''; Am J Physiol Heart Circ Physiol, 2009 PubMed Europe PMC Scholia
  6. Gliki G, Abu-Ghazaleh R, Jezequel S, Wheeler-Jones C, Zachary I; ''Vascular endothelial growth factor-induced prostacyclin production is mediated by a protein kinase C (PKC)-dependent activation of extracellular signal-regulated protein kinases 1 and 2 involving PKC-delta and by mobilization of intracellular Ca2+.''; Biochem J, 2001 PubMed Europe PMC Scholia
  7. ''''; , PubMed Europe PMC Scholia
  8. Johnson EN, Lee YM, Sander TL, Rabkin E, Schoen FJ, Kaushal S, Bischoff J; ''NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  9. Abedi H, Zachary I; ''Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  10. Shu X, Wu W, Mosteller RD, Broek D; ''''; , PubMed Europe PMC Scholia
  11. Lamalice L, Houle F, Jourdan G, Huot J; ''Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38.''; Oncogene, 2004 PubMed Europe PMC Scholia
  12. Uhrin P, Breuss JM; ''uPAR: a modulator of VEGF-induced angiogenesis.''; Cell Adh Migr, 2013 PubMed Europe PMC Scholia
  13. Caliceti C, Nigro P, Rizzo P, Ferrari R; ''''; , PubMed Europe PMC Scholia
  14. ''''; , PubMed Europe PMC Scholia
  15. Stoletov KV, Ratcliffe KE, Terman BI; ''''; , PubMed Europe PMC Scholia
  16. Fearnley GW, Bruns AF, Wheatcroft SB, Ponnambalam S; ''VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration.''; Biol Open, 2015 PubMed Europe PMC Scholia
  17. Lakshmikanthan S, Sobczak M, Chun C, Henschel A, Dargatz J, Ramchandran R, Chrzanowska-Wodnicka M; ''Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃.''; Blood, 2011 PubMed Europe PMC Scholia
  18. Wong C, Jin ZG; ''Protein kinase C-dependent protein kinase D activation modulates ERK signal pathway and endothelial cell proliferation by vascular endothelial growth factor.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  19. Meadows KN, Bryant P, Pumiglia K; ''Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  20. Meyer RD, Sacks DB, Rahimi N; ''''; , PubMed Europe PMC Scholia
  21. Luque A, Carpizo DR, Iruela-Arispe ML; ''ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  22. Wheeler-Jones C, Abu-Ghazaleh R, Cospedal R, Houliston RA, Martin J, Zachary I; ''Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase.''; FEBS Lett, 1997 PubMed Europe PMC Scholia
  23. Domigan CK, Warren CM, Antanesian V, Happel K, Ziyad S, Lee S, Krall A, Duan L, Torres-Collado AX, Castellani LW, Elashoff D, Christofk HR, van der Bliek AM, Potente M, Iruela-Arispe ML; ''Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy.''; J Cell Sci, 2015 PubMed Europe PMC Scholia
  24. Yoshizuka N, Chen RM, Xu Z, Liao R, Hong L, Hu WY, Yu G, Han J, Chen L, Sun P; ''A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis.''; Mol Cell Biol, 2012 PubMed Europe PMC Scholia
  25. Lampugnani MG, Orsenigo F, Gagliani MC, Tacchetti C, Dejana E; ''Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments.''; J Cell Biol, 2006 PubMed Europe PMC Scholia
  26. Bhattacharya R, Kwon J, Li X, Wang E, Patra S, Bida JP, Bajzer Z, Claesson-Welsh L, Mukhopadhyay D; ''Distinct role of PLCbeta3 in VEGF-mediated directional migration and vascular sprouting.''; J Cell Sci, 2009 PubMed Europe PMC Scholia
  27. Wythe JD, Dang LT, Devine WP, Boudreau E, Artap ST, He D, Schachterle W, Stainier DY, Oettgen P, Black BL, Bruneau BG, Fish JE; ''ETS factors regulate Vegf-dependent arterial specification.''; Dev Cell, 2013 PubMed Europe PMC Scholia
  28. ''''; , PubMed Europe PMC Scholia
  29. ''''; , PubMed Europe PMC Scholia
  30. Takahashi T, Yamaguchi S, Chida K, Shibuya M; ''A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells.''; EMBO J, 2001 PubMed Europe PMC Scholia
  31. Li SM, Zeng LW, Feng L, Chen DB; ''Rac1-dependent intracellular superoxide formation mediates vascular endothelial growth factor-induced placental angiogenesis in vitro.''; Endocrinology, 2010 PubMed Europe PMC Scholia
  32. Jin H, Garmy-Susini B, Avraamides CJ, Stoletov K, Klemke RL, Varner JA; ''''; , PubMed Europe PMC Scholia
  33. Lamalice L, Houle F, Huot J; ''Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  34. Inoki I, Shiomi T, Hashimoto G, Enomoto H, Nakamura H, Makino K, Ikeda E, Takata S, Kobayashi K, Okada Y; ''Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis.''; FASEB J, 2002 PubMed Europe PMC Scholia
  35. van Nieuw Amerongen GP, Koolwijk P, Versteilen A, van Hinsbergh VW; ''Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro.''; Arterioscler Thromb Vasc Biol, 2003 PubMed Europe PMC Scholia
  36. Qi JH, Claesson-Welsh L; ''VEGF-induced activation of phosphoinositide 3-kinase is dependent on focal adhesion kinase.''; Exp Cell Res, 2001 PubMed Europe PMC Scholia
  37. Bayraktutan U, Blayney L, Shah AM; ''Molecular characterization and localization of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells.''; Arterioscler Thromb Vasc Biol, 2000 PubMed Europe PMC Scholia
  38. Kaur S, Leszczynska K, Abraham S, Scarcia M, Hiltbrunner S, Marshall CJ, Mavria G, Bicknell R, Heath VL; ''RhoJ/TCL regulates endothelial motility and tube formation and modulates actomyosin contractility and focal adhesion numbers.''; Arterioscler Thromb Vasc Biol, 2011 PubMed Europe PMC Scholia
  39. Shen K, Ji L, Lu B, Wang Z; ''c-Jun N-terminal kinase mediated VEGFR2 sustained phosphorylation is critical for VEGFA-induced angiogenesis in vitro and in vivo.''; Cell Biochem Biophys, 2012 PubMed Europe PMC Scholia
  40. Cunningham SA, Waxham MN, Arrate PM, Brock TA; ''Interaction of the Flt-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositol 3-kinase. Mapping of a novel site involved in binding.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  41. Lim ST, Chen XL, Lim Y, Hanson DA, Vo TT, Howerton K, Larocque N, Fisher SJ, Schlaepfer DD, Ilic D; ''Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.''; Mol Cell, 2008 PubMed Europe PMC Scholia
  42. Zheng J, Bird IM, Melsaether AN, Magness RR; ''Activation of the mitogen-activated protein kinase cascade is necessary but not sufficient for basic fibroblast growth factor- and epidermal growth factor-stimulated expression of endothelial nitric oxide synthase in ovine fetoplacental artery endothelial cells.''; Endocrinology, 1999 PubMed Europe PMC Scholia
  43. Feng Z, Zhang H, Levine AJ, Jin S; ''The coordinate regulation of the p53 and mTOR pathways in cells.''; Proc Natl Acad Sci U S A, 2005 PubMed Europe PMC Scholia
  44. Liu D, Jia H, Holmes DI, Stannard A, Zachary I; ''Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1.''; Arterioscler Thromb Vasc Biol, 2003 PubMed Europe PMC Scholia
  45. Zhang L, Liu H, Peng YM, Dai YY, Liu FY; ''Vascular endothelial growth factor increases GEnC permeability by affecting the distributions of occludin, ZO-1 and tight juction assembly.''; Eur Rev Med Pharmacol Sci, 2015 PubMed Europe PMC Scholia
  46. Le Boeuf F, Houle F, Huot J; ''Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  47. Chai J, Jones MK, Tarnawski AS; ''Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis.''; FASEB J, 2004 PubMed Europe PMC Scholia
  48. Taylor JM, Macklem MM, Parsons JT; ''Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho.''; J Cell Sci, 1999 PubMed Europe PMC Scholia
  49. Ziche M, Morbidelli L, Choudhuri R, Zhang HT, Donnini S, Granger HJ, Bicknell R; ''Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis.''; J Clin Invest, 1997 PubMed Europe PMC Scholia
  50. Garrett TA, Van Buul JD, Burridge K; ''VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2.''; Exp Cell Res, 2007 PubMed Europe PMC Scholia
  51. Sun H, Breslin JW, Zhu J, Yuan SY, Wu MH; ''Rho and ROCK signaling in VEGF-induced microvascular endothelial hyperpermeability.''; Microcirculation, 2006 PubMed Europe PMC Scholia
  52. ''''; , PubMed Europe PMC Scholia
  53. Wu G, Luo J, Rana JS, Laham R, Sellke FW, Li J; ''Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells.''; Cardiovasc Res, 2006 PubMed Europe PMC Scholia
  54. Maiti D, Xu Z, Duh EJ; ''''; , PubMed Europe PMC Scholia
  55. Giorgetti-Peraldi S, Murdaca J, Mas JC, Van Obberghen E; ''The adapter protein, Grb10, is a positive regulator of vascular endothelial growth factor signaling.''; Oncogene, 2001 PubMed Europe PMC Scholia
  56. Abdelsaid MA, Matragoon S, El-Remessy AB; ''Thioredoxin-interacting protein expression is required for VEGF-mediated angiogenic signal in endothelial cells.''; Antioxid Redox Signal, 2013 PubMed Europe PMC Scholia
  57. Kashige N, Carpino N, Kobayashi R; ''''; , PubMed Europe PMC Scholia
  58. Salameh A, Galvagni F, Anselmi F, De Clemente C, Orlandini M, Oliviero S; ''Growth factor stimulation induces cell survival by c-Jun. ATF2-dependent activation of Bcl-XL.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  59. Schaller MD; ''''; , PubMed Europe PMC Scholia
  60. Koutsioumpa M, Poimenidi E, Pantazaka E, Theodoropoulou C, Skoura A, Megalooikonomou V, Kieffer N, Courty J, Mizumoto S, Sugahara K, Papadimitriou E; ''Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor.''; Mol Cancer, 2015 PubMed Europe PMC Scholia
  61. Wang F, Yamauchi M, Muramatsu M, Osawa T, Tsuchida R, Shibuya M; ''RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3K/Akt pathway.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  62. Sjöqvist M, Antfolk D, Ferraris S, Rraklli V, Haga C, Antila C, Mutvei A, Imanishi SY, Holmberg J, Jin S, Eriksson JE, Lendahl U, Sahlgren C; ''PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner.''; Cell Res, 2014 PubMed Europe PMC Scholia
  63. Kim I, Moon SO, Kim SH, Kim HJ, Koh YS, Koh GY; ''Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  64. Kusuhara S, Fukushima Y, Fukuhara S, Jakt LM, Okada M, Shimizu Y, Hata M, Nishida K, Negi A, Hirashima M, Mochizuki N, Nishikawa S, Uemura A; ''Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells.''; PLoS One, 2012 PubMed Europe PMC Scholia
  65. Favia A, Desideri M, Gambara G, D'Alessio A, Ruas M, Esposito B, Del Bufalo D, Parrington J, Ziparo E, Palombi F, Galione A, Filippini A; ''VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling.''; Proc Natl Acad Sci U S A, 2014 PubMed Europe PMC Scholia
  66. Koh W, Sachidanandam K, Stratman AN, Sacharidou A, Mayo AM, Murphy EA, Cheresh DA, Davis GE; ''''; , PubMed Europe PMC Scholia
  67. Sahni A, Francis CW; ''Vascular endothelial growth factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation.''; Blood, 2000 PubMed Europe PMC Scholia
  68. Mayo LD, Kessler KM, Pincheira R, Warren RS, Donner DB; ''Vascular endothelial cell growth factor activates CRE-binding protein by signaling through the KDR receptor tyrosine kinase.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  69. Bernatchez PN, Allen BG, Gélinas DS, Guillemette G, Sirois MG; ''Regulation of VEGF-induced endothelial cell PAF synthesis: role of p42/44 MAPK, p38 MAPK and PI3K pathways.''; Br J Pharmacol, 2001 PubMed Europe PMC Scholia
  70. Dodd KM, Yang J, Shen MH, Sampson JR, Tee AR; ''mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3.''; Oncogene, 2015 PubMed Europe PMC Scholia
  71. Moon DO, Kim MO, Kang SH, Choi YH, Kim GY; ''''; , PubMed Europe PMC Scholia
  72. Sawano A, Takahashi T, Yamaguchi S, Shibuya M; ''The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma.''; Biochem Biophys Res Commun, 1997 PubMed Europe PMC Scholia
  73. Guo D, Jia Q, Song HY, Warren RS, Donner DB; ''Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  74. Abu-Ghazaleh R, Kabir J, Jia H, Lobo M, Zachary I; ''Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells.''; Biochem J, 2001 PubMed Europe PMC Scholia
  75. Bryan BA, Dennstedt E, Mitchell DC, Walshe TE, Noma K, Loureiro R, Saint-Geniez M, Campaigniac JP, Liao JK, D'Amore PA; ''''; , PubMed Europe PMC Scholia
  76. Marchand C, Favier J, Sirois MG; ''Role of MSK1 in the signaling pathway leading to VEGF-mediated PAF synthesis in endothelial cells.''; J Cell Biochem, 2006 PubMed Europe PMC Scholia
  77. Suehiro J, Hamakubo T, Kodama T, Aird WC, Minami T; ''Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3.''; Blood, 2010 PubMed Europe PMC Scholia
  78. Cébe Suarez S, Pieren M, Cariolato L, Arn S, Hoffmann U, Bogucki A, Manlius C, Wood J, Ballmer-Hofer K; ''A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2.''; Cell Mol Life Sci, 2006 PubMed Europe PMC Scholia
  79. Webler AC, Michaelis UR, Popp R, Barbosa-Sicard E, Murugan A, Falck JR, Fisslthaler B, Fleming I; ''Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis.''; Am J Physiol Cell Physiol, 2008 PubMed Europe PMC Scholia
  80. Tran J, Rak J, Sheehan C, Saibil SD, LaCasse E, Korneluk RG, Kerbel RS; ''Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells.''; Biochem Biophys Res Commun, 1999 PubMed Europe PMC Scholia
  81. Stoletov KV, Gong C, Terman BI; ''Nck and Crk mediate distinct VEGF-induced signaling pathways that serve overlapping functions in focal adhesion turnover and integrin activation.''; Exp Cell Res, 2004 PubMed Europe PMC Scholia
  82. Hesser BA, Liang XH, Camenisch G, Yang S, Lewin DA, Scheller R, Ferrara N, Gerber HP; ''Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells.''; Blood, 2004 PubMed Europe PMC Scholia
  83. Suehiro J, Kanki Y, Makihara C, Schadler K, Miura M, Manabe Y, Aburatani H, Kodama T, Minami T; ''Genome-wide approaches reveal functional vascular endothelial growth factor (VEGF)-inducible nuclear factor ofactivated T cells (NFAT) c1 binding to angiogenesis-related genes in the endothelium.''; J Biol Chem, 2014 PubMed Europe PMC Scholia
  84. Ewan LC, Jopling HM, Jia H, Mittar S, Bagherzadeh A, Howell GJ, Walker JH, Zachary IC, Ponnambalam S; ''Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells.''; Traffic, 2006 PubMed Europe PMC Scholia
  85. Stahmann N, Woods A, Spengler K, Heslegrave A, Bauer R, Krause S, Viollet B, Carling D, Heller R; ''Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  86. Oller J, Alfranca A, Méndez-Barbero N, Villahoz S, Lozano-Vidal N, Martín-Alonso M, Arroyo AG, Escolano A, Armesilla AL, Campanero MR, Redondo JM; ''C/EBPβ and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling.''; Mol Cell Biol, 2015 PubMed Europe PMC Scholia
  87. Labrecque L, Royal I, Surprenant DS, Patterson C, Gingras D, Béliveau R; ''''; , PubMed Europe PMC Scholia
  88. Hao Q, Samten B, Ji HL, Zhao ZJ, Tang H; ''Tyrosine phosphatase PTP-MEG2 negatively regulates vascular endothelial growth factor receptor signaling and function in endothelial cells.''; Am J Physiol Cell Physiol, 2012 PubMed Europe PMC Scholia
  89. Hartsough EJ, Meyer RD, Chitalia V, Jiang Y, Marquez VE, Zhdanova IV, Weinberg J, Costello CE, Rahimi N; ''''; , PubMed Europe PMC Scholia
  90. Takahashi T, Ueno H, Shibuya M; ''VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells.''; Oncogene, 1999 PubMed Europe PMC Scholia
  91. Abid MR, Schoots IG, Spokes KC, Wu SQ, Mawhinney C, Aird WC; ''Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  92. Liao WX, Feng L, Zheng J, Chen DB; ''Deciphering mechanisms controlling placental artery endothelial cell migration stimulated by vascular endothelial growth factor.''; Endocrinology, 2010 PubMed Europe PMC Scholia
  93. Liu X, Zhao D, Qin L, Li J, Zeng H; ''Transcription enhancer factor 3 (TEF3) mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells.''; J Biol Chem, 2008 PubMed Europe PMC Scholia
  94. Gu Y, Filippi MD, Cancelas JA, Siefring JE, Williams EP, Jasti AC, Harris CE, Lee AW, Prabhakar R, Atkinson SJ, Kwiatkowski DJ, Williams DA; ''Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases.''; Science, 2003 PubMed Europe PMC Scholia
  95. ''''; , PubMed Europe PMC Scholia
  96. Benedito R, Roca C, Sörensen I, Adams S, Gossler A, Fruttiger M, Adams RH; ''The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis.''; Cell, 2009 PubMed Europe PMC Scholia
  97. Cunningham SA, Arrate MP, Brock TA, Waxham MN; ''Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites.''; Biochem Biophys Res Commun, 1997 PubMed Europe PMC Scholia
  98. Del Valle-Pérez B, Martínez VG, Lacasa-Salavert C, Figueras A, Shapiro SS, Takafuta T, Casanovas O, Capellà G, Ventura F, Viñals F; ''Filamin B plays a key role in vascular endothelial growth factor-induced endothelial cell motility through its interaction with Rac-1 and Vav-2.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  99. Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M, Cao Y, Shujath J, Gawlak S, Eveleigh D, Rowley B, Liu L, Adnane L, Lynch M, Auclair D, Taylor I, Gedrich R, Voznesensky A, Riedl B, Post LE, Bollag G, Trail PA; ''BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.''; Cancer Res, 2004 PubMed Europe PMC Scholia
  100. ''''; , PubMed Europe PMC Scholia
  101. Kikuchi A, Yamamoto H, Sato A, Matsumoto S; ''''; , PubMed Europe PMC Scholia
  102. ''''; , PubMed Europe PMC Scholia
  103. ''''; , PubMed Europe PMC Scholia
  104. Usui T, Murai T, Tanaka T, Yamaguchi K, Nagakubo D, Lee CM, Kiyomi M, Tamura S, Matsuzawa Y, Miyasaka M; ''Characterization of mac25/angiomodulin expression by high endothelial venule cells in lymphoid tissues and its identification as an inducible marker for activated endothelial cells.''; Int Immunol, 2002 PubMed Europe PMC Scholia
  105. Chen SH, Murphy DA, Lassoued W, Thurston G, Feldman MD, Lee WM; ''Activated STAT3 is a mediator and biomarker of VEGF endothelial activation.''; Cancer Biol Ther, 2008 PubMed Europe PMC Scholia
  106. Ha CH, Bennett AM, Jin ZG; ''A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factor.''; J Biol Chem, 2008 PubMed Europe PMC Scholia
  107. Rusnak F, Mertz P; ''''; , PubMed Europe PMC Scholia
  108. Serrels B, Serrels A, Brunton VG, Holt M, McLean GW, Gray CH, Jones GE, Frame MC; ''Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex.''; Nat Cell Biol, 2007 PubMed Europe PMC Scholia
  109. Abid MR, Spokes KC, Shih SC, Aird WC; ''NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  110. Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J; ''Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.''; Proc Natl Acad Sci U S A, 2004 PubMed Europe PMC Scholia
  111. Ikuta T, Ariga H, Matsumoto K; ''Extracellular matrix tenascin-X in combination with vascular endothelial growth factor B enhances endothelial cell proliferation.''; Genes Cells, 2000 PubMed Europe PMC Scholia
  112. Ali N, Yoshizumi M, Yano S, Sone S, Ohnishi H, Ishizawa K, Kanematsu Y, Tsuchiya K, Tamaki T; ''The novel Src kinase inhibitor M475271 inhibits VEGF-induced vascular endothelial-cadherin and beta-catenin phosphorylation but increases their association.''; J Pharmacol Sci, 2006 PubMed Europe PMC Scholia
  113. Jopling HM, Odell AF, Pellet-Many C, Latham AM, Frankel P, Sivaprasadarao A, Walker JH, Zachary IC, Ponnambalam S; ''Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel Formation.''; Cells, 2014 PubMed Europe PMC Scholia
  114. Laramée M, Chabot C, Cloutier M, Stenne R, Holgado-Madruga M, Wong AJ, Royal I; ''The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  115. Stoletov KV, Terman BI; ''''; , PubMed Europe PMC Scholia
  116. Sacco F, Tinti M, Palma A, Ferrari E, Nardozza AP, Hooft van Huijsduijnen R, Takahashi T, Castagnoli L, Cesareni G; ''''; , PubMed Europe PMC Scholia
  117. Rousseau S, Houle F, Landry J, Huot J; ''''; , PubMed Europe PMC Scholia
  118. ''''; , PubMed Europe PMC Scholia
  119. ''''; , PubMed Europe PMC Scholia
  120. ''''; , PubMed Europe PMC Scholia
  121. Parenti A, Morbidelli L, Cui XL, Douglas JG, Hood JD, Granger HJ, Ledda F, Ziche M; ''Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  122. Huang Y, Shi H, Zhou H, Song X, Yuan S, Luo Y; ''The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin.''; Blood, 2006 PubMed Europe PMC Scholia
  123. Nimlamool W, Andrews RM, Falk MM; ''Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization.''; Mol Biol Cell, 2015 PubMed Europe PMC Scholia
  124. Liu X, Zhao D, James L, Li J, Zeng H; ''Requirement of the nuclear localization of transcription enhancer factor 3 for proliferation, migration, tube formation, and angiogenesis induced by vascular endothelial growth factor.''; FASEB J, 2011 PubMed Europe PMC Scholia
  125. Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, Kaelin WG Jr; ''Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.''; Genes Dev, 2004 PubMed Europe PMC Scholia
  126. Oshikawa J, Kim SJ, Furuta E, Caliceti C, Chen GF, McKinney RD, Kuhr F, Levitan I, Fukai T, Ushio-Fukai M; ''Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells.''; Am J Physiol Heart Circ Physiol, 2012 PubMed Europe PMC Scholia
  127. Stoletov KV, Ratcliffe KE, Spring SC, Terman BI; ''''; , PubMed Europe PMC Scholia
  128. Avraham HK, Lee TH, Koh Y, Kim TA, Jiang S, Sussman M, Samarel AM, Avraham S; ''Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  129. Holmqvist K, Cross MJ, Rolny C, Hägerkvist R, Rahimi N, Matsumoto T, Claesson-Welsh L, Welsh M; ''The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  130. Herzog B, Pellet-Many C, Britton G, Hartzoulakis B, Zachary IC; ''VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation.''; Mol Biol Cell, 2011 PubMed Europe PMC Scholia
  131. Abdelsaid MA, El-Remessy AB; ''S-glutathionylation of LMW-PTP regulates VEGF-mediated FAK activation and endothelial cell migration.''; J Cell Sci, 2012 PubMed Europe PMC Scholia
  132. Wang Y, Yan F, Ye Q, Wu X, Jiang F; ''PTP1B inhibitor promotes endothelial cell motility by activating the DOCK180/Rac1 pathway.''; Sci Rep, 2016 PubMed Europe PMC Scholia
  133. Eriksson A, Cao R, Roy J, Tritsaris K, Wahlestedt C, Dissing S, Thyberg J, Cao Y; ''Small GTP-binding protein Rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations and vascular permeability.''; Circulation, 2003 PubMed Europe PMC Scholia
  134. Fujio Y, Walsh K; ''Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  135. Colavitti R, Pani G, Bedogni B, Anzevino R, Borrello S, Waltenberger J, Galeotti T; ''Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  136. Dayanir V, Meyer RD, Lashkari K, Rahimi N; ''''; , PubMed Europe PMC Scholia
  137. Bartoli M, Gu X, Tsai NT, Venema RC, Brooks SE, Marrero MB, Caldwell RB; ''''; , PubMed Europe PMC Scholia
  138. Youn JY, Wang T, Cai H; ''An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production.''; Circ Res, 2009 PubMed Europe PMC Scholia
  139. Hao T, Rockwell P; ''''; , PubMed Europe PMC Scholia
  140. Hayashi H, Nakagami H, Takami Y, Koriyama H, Mori M, Tamai K, Sun J, Nagao K, Morishita R, Kaneda Y; ''FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1.''; Arterioscler Thromb Vasc Biol, 2009 PubMed Europe PMC Scholia
  141. Alexander RA, Prager GW, Mihaly-Bison J, Uhrin P, Sunzenauer S, Binder BR, Schütz GJ, Freissmuth M, Breuss JM; ''VEGF-induced endothelial cell migration requires urokinase receptor (uPAR)-dependent integrin redistribution.''; Cardiovasc Res, 2012 PubMed Europe PMC Scholia
  142. García-Cardeña G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A, Sessa WC; ''Dynamic activation of endothelial nitric oxide synthase by Hsp90.''; Nature, 1998 PubMed Europe PMC Scholia
  143. ''''; , PubMed Europe PMC Scholia
  144. Gengrinovitch S, Berman B, David G, Witte L, Neufeld G, Ron D; ''Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  145. Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC; ''''; , PubMed Europe PMC Scholia
  146. Thuringer D; ''The vascular endothelial growth factor-induced disruption of gap junctions is relayed by an autocrine communication via ATP release in coronary capillary endothelium.''; Ann N Y Acad Sci, 2004 PubMed Europe PMC Scholia
  147. ''''; , PubMed Europe PMC Scholia
  148. Wiesmann C, Fuh G, Christinger HW, Eigenbrot C, Wells JA, de Vos AM; ''Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.''; Cell, 1997 PubMed Europe PMC Scholia
  149. Yamaoka-Tojo M, Ushio-Fukai M, Hilenski L, Dikalov SI, Chen YE, Tojo T, Fukai T, Fujimoto M, Patrushev NA, Wang N, Kontos CD, Bloom GS, Alexander RW; ''IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation.''; Circ Res, 2004 PubMed Europe PMC Scholia
  150. Evans IM, Britton G, Zachary IC; ''Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase.''; Cell Signal, 2008 PubMed Europe PMC Scholia
  151. Nakamura Y, Patrushev N, Inomata H, Mehta D, Urao N, Kim HW, Razvi M, Kini V, Mahadev K, Goldstein BJ, McKinney R, Fukai T, Ushio-Fukai M; ''Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cells.''; Circ Res, 2008 PubMed Europe PMC Scholia
  152. Wu RF, Gu Y, Xu YC, Nwariaku FE, Terada LS; ''Vascular endothelial growth factor causes translocation of p47phox to membrane ruffles through WAVE1.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  153. Koch S, Claesson-Welsh L; ''''; , PubMed Europe PMC Scholia
  154. Blanes MG, Oubaha M, Rautureau Y, Gratton JP; ''Phosphorylation of tyrosine 801 of vascular endothelial growth factor receptor-2 is necessary for Akt-dependent endothelial nitric-oxide synthase activation and nitric oxide release from endothelial cells.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  155. Ha CH, Wang W, Jhun BS, Wong C, Hausser A, Pfizenmaier K, McKinsey TA, Olson EN, Jin ZG; ''''; , PubMed Europe PMC Scholia
  156. Murakami T, Frey T, Lin C, Antonetti DA; ''Protein kinase cβ phosphorylates occludin regulating tight junction trafficking in vascular endothelial growth factor-induced permeability in vivo.''; Diabetes, 2012 PubMed Europe PMC Scholia
  157. Koch S, Tugues S, Li X, Gualandi L, Claesson-Welsh L; ''''; , PubMed Europe PMC Scholia
  158. Inoki K, Zhu T, Guan KL; ''TSC2 mediates cellular energy response to control cell growth and survival.''; Cell, 2003 PubMed Europe PMC Scholia
  159. ''''; , PubMed Europe PMC Scholia
  160. Liu J, Razani B, Tang S, Terman BI, Ware JA, Lisanti MP; ''Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  161. Kusaba T, Okigaki M, Matui A, Murakami M, Ishikawa K, Kimura T, Sonomura K, Adachi Y, Shibuya M, Shirayama T, Tanda S, Hatta T, Sasaki S, Mori Y, Matsubara H; ''Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+ channel to maintain endothelial integrity.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  162. Kobayashi M, Nishita M, Mishima T, Ohashi K, Mizuno K; ''''; , PubMed Europe PMC Scholia
  163. Singh AJ, Meyer RD, Navruzbekov G, Shelke R, Duan L, Band H, Leeman SE, Rahimi N; ''A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  164. Koika V, Zhou Z, Vasileiadis I, Roussos C, Finetti F, Monti M, Morbidelli L, Papapetropoulos A; ''PKG-I inhibition attenuates vascular endothelial growth factor-stimulated angiogenesis.''; Vascul Pharmacol, 2010 PubMed Europe PMC Scholia
  165. Marumo T, Schini-Kerth VB, Busse R; ''Vascular endothelial growth factor activates nuclear factor-kappaB and induces monocyte chemoattractant protein-1 in bovine retinal endothelial cells.''; Diabetes, 1999 PubMed Europe PMC Scholia
  166. Bodnar RJ, Yates CC, Wells A; ''IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain.''; Circ Res, 2006 PubMed Europe PMC Scholia
  167. Zaichuk TA, Shroff EH, Emmanuel R, Filleur S, Nelius T, Volpert OV; ''Nuclear factor of activated T cells balances angiogenesis activation and inhibition.''; J Exp Med, 2004 PubMed Europe PMC Scholia
  168. Mirzapoiazova T, Kolosova I, Usatyuk PV, Natarajan V, Verin AD; ''Diverse effects of vascular endothelial growth factor on human pulmonary endothelial barrier and migration.''; Am J Physiol Lung Cell Mol Physiol, 2006 PubMed Europe PMC Scholia
  169. Karali E, Bellou S, Stellas D, Klinakis A, Murphy C, Fotsis T; ''VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress.''; Mol Cell, 2014 PubMed Europe PMC Scholia
  170. Narasimhan P, Liu J, Song YS, Massengale JL, Chan PH; ''''; , PubMed Europe PMC Scholia
  171. Jho D, Mehta D, Ahmmed G, Gao XP, Tiruppathi C, Broman M, Malik AB; ''Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2 influx.''; Circ Res, 2005 PubMed Europe PMC Scholia
  172. Schweighofer B, Testori J, Sturtzel C, Sattler S, Mayer H, Wagner O, Bilban M, Hofer E; ''The VEGF-induced transcriptional response comprises gene clusters at the crossroad of angiogenesis and inflammation.''; Thromb Haemost, 2009 PubMed Europe PMC Scholia
  173. Suarez S, Ballmer-Hofer K; ''VEGF transiently disrupts gap junctional communication in endothelial cells.''; J Cell Sci, 2001 PubMed Europe PMC Scholia
  174. Ballmer-Hofer K, Andersson AE, Ratcliffe LE, Berger P; ''Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output.''; Blood, 2011 PubMed Europe PMC Scholia
  175. Sun Z, Li X, Massena S, Kutschera S, Padhan N, Gualandi L, Sundvold-Gjerstad V, Gustafsson K, Choy WW, Zang G, Quach M, Jansson L, Phillipson M, Abid MR, Spurkland A, Claesson-Welsh L; ''VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd.''; J Exp Med, 2012 PubMed Europe PMC Scholia
  176. ''''; , PubMed Europe PMC Scholia
  177. Heo SH, Choi YJ, Ryoo HM, Cho JY; ''Expression profiling of ETS and MMP factors in VEGF-activated endothelial cells: role of MMP-10 in VEGF-induced angiogenesis.''; J Cell Physiol, 2010 PubMed Europe PMC Scholia
  178. Arcondéguy T, Lacazette E, Millevoi S, Prats H, Touriol C; ''VEGF-A mRNA processing, stability and translation: a paradigm for intricate regulation of gene expression at the post-transcriptional level.''; Nucleic Acids Res, 2013 PubMed Europe PMC Scholia
  179. ''''; , PubMed Europe PMC Scholia
  180. Harhaj NS, Felinski EA, Wolpert EB, Sundstrom JM, Gardner TW, Antonetti DA; ''VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability.''; Invest Ophthalmol Vis Sci, 2006 PubMed Europe PMC Scholia
  181. ''''; , PubMed Europe PMC Scholia
  182. Ito N, Wernstedt C, Engström U, Claesson-Welsh L; ''Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  183. Eriksson A, Cao R, Pawliuk R, Berg SM, Tsang M, Zhou D, Fleet C, Tritsaris K, Dissing S, Leboulch P, Cao Y; ''Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers.''; Cancer Cell, 2002 PubMed Europe PMC Scholia
  184. Chidiac R, Zhang Y, Tessier S, Faubert D, Delisle C, Gratton JP; ''Comparative Phosphoproteomics Analysis of VEGF and Angiopoietin-1 Signaling Reveals ZO-1 as a Critical Regulator of Endothelial Cell Proliferation.''; Mol Cell Proteomics, 2016 PubMed Europe PMC Scholia
  185. Le Boeuf F, Houle F, Sussman M, Huot J; ''Phosphorylation of focal adhesion kinase (FAK) on Ser732 is induced by rho-dependent kinase and is essential for proline-rich tyrosine kinase-2-mediated phosphorylation of FAK on Tyr407 in response to vascular endothelial growth factor.''; Mol Biol Cell, 2006 PubMed Europe PMC Scholia
  186. Stoletov KV, Gong C, Terman BI; ''''; , PubMed Europe PMC Scholia
  187. Ratcliffe KE, Tao Q, Yavuz B, Stoletov KV, Spring SC, Terman BI; ''Sck is expressed in endothelial cells and participates in vascular endothelial growth factor-induced signaling.''; Oncogene, 2002 PubMed Europe PMC Scholia
  188. Yu Y, Sato JD; ''MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor.''; J Cell Physiol, 1999 PubMed Europe PMC Scholia
  189. Ren XR, Du QS, Huang YZ, Ao SZ, Mei L, Xiong WC; ''Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein.''; J Cell Biol, 2001 PubMed Europe PMC Scholia
  190. Yu J, Bian D, Mahanivong C, Cheng RK, Zhou W, Huang S; ''p38 Mitogen-activated protein kinase regulation of endothelial cell migration depends on urokinase plasminogen activator expression.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  191. Haddad P, Dussault S, Groleau J, Turgeon J, Maingrette F, Rivard A; ''Nox2-derived reactive oxygen species contribute to hypercholesterolemia-induced inhibition of neovascularization: effects on endothelial progenitor cells and mature endothelial cells.''; Atherosclerosis, 2011 PubMed Europe PMC Scholia
  192. Bruns AF, Herbert SP, Odell AF, Jopling HM, Hooper NM, Zachary IC, Walker JH, Ponnambalam S; ''''; ,
  193. Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A; ''''; , PubMed Europe PMC Scholia
  194. Zhou Y, Yan H, Guo M, Zhu J, Xiao Q, Zhang L; ''''; , PubMed Europe PMC Scholia
  195. ''''; , PubMed Europe PMC Scholia
  196. Wang S, Li X, Parra M, Verdin E, Bassel-Duby R, Olson EN; ''Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7.''; Proc Natl Acad Sci U S A, 2008 PubMed Europe PMC Scholia
  197. Dudley AC, Thomas D, Best J, Jenkins A; ''''; , PubMed Europe PMC Scholia
  198. Liu D, Evans I, Britton G, Zachary I; ''The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis.''; Oncogene, 2008 PubMed Europe PMC Scholia
  199. Pang X, Zhang L, Wu Y, Lin L, Li J, Qu W, Safe S, Liu M; ''Methyl 2-cyano-3,11-dioxo-18-olean-1,12-dien-30-oate (CDODA-Me), a derivative of glycyrrhetinic acid, functions as a potent angiogenesis inhibitor.''; J Pharmacol Exp Ther, 2010 PubMed Europe PMC Scholia
  200. Levine YC, Li GK, Michel T; ''Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathway.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  201. ''''; , PubMed Europe PMC Scholia
  202. Primo L, di Blasio L, Roca C, Droetto S, Piva R, Schaffhausen B, Bussolino F; ''Essential role of PDK1 in regulating endothelial cell migration.''; J Cell Biol, 2007 PubMed Europe PMC Scholia
  203. Dougher M, Terman BI; ''Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization.''; Oncogene, 1999 PubMed Europe PMC Scholia
  204. Su YT, Gao C, Liu Y, Guo S, Wang A, Wang B, Erdjument-Bromage H, Miyagi M, Tempst P, Kao HY; ''Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7.''; Mol Cell Biol, 2013 PubMed Europe PMC Scholia
  205. Kawamura H, Li X, Harper SJ, Bates DO, Claesson-Welsh L; ''Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity.''; Cancer Res, 2008 PubMed Europe PMC Scholia
  206. ''''; , PubMed Europe PMC Scholia
  207. Soga N, Namba N, McAllister S, Cornelius L, Teitelbaum SL, Dowdy SF, Kawamura J, Hruska KA; ''Rho family GTPases regulate VEGF-stimulated endothelial cell motility.''; Exp Cell Res, 2001 PubMed Europe PMC Scholia
  208. Pin AL, Houle F, Fournier P, Guillonneau M, Paquet ÉR, Simard MJ, Royal I, Huot J; ''Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression.''; J Biol Chem, 2012 PubMed Europe PMC Scholia
  209. Jiang BH, Liu LZ; ''''; , PubMed Europe PMC Scholia
  210. Tawa H, Rikitake Y, Takahashi M, Amano H, Miyata M, Satomi-Kobayashi S, Kinugasa M, Nagamatsu Y, Majima T, Ogita H, Miyoshi J, Hirata K, Takai Y; ''Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis.''; Circ Res, 2010 PubMed Europe PMC Scholia
  211. Guertin DA, Sabatini DM; ''''; , PubMed Europe PMC Scholia
  212. ''''; , PubMed Europe PMC Scholia
  213. ''''; , PubMed Europe PMC Scholia
  214. Wang S, Amato KR, Song W, Youngblood V, Lee K, Boothby M, Brantley-Sieders DM, Chen J; ''Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways.''; Mol Cell Biol, 2015 PubMed Europe PMC Scholia
  215. Wang Y, Zang QS, Liu Z, Wu Q, Maass D, Dulan G, Shaul PW, Melito L, Frantz DE, Kilgore JA, Williams NS, Terada LS, Nwariaku FE; ''Regulation of VEGF-induced endothelial cell migration by mitochondrial reactive oxygen species.''; Am J Physiol Cell Physiol, 2011 PubMed Europe PMC Scholia
  216. Bhattacharya R, Kwon J, Wang E, Mukherjee P, Mukhopadhyay D; ''Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration*.''; J Mol Signal, 2008 PubMed Europe PMC Scholia
  217. Reihill JA, Ewart MA, Hardie DG, Salt IP; ''AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production.''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC Scholia
  218. Kroll J, Waltenberger J; ''The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  219. Zhao ZS, Manser E; ''''; , PubMed Europe PMC Scholia
  220. Raikwar NS, Liu KZ, Thomas CP; ''N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain.''; PLoS One, 2014 PubMed Europe PMC Scholia
  221. Tahir SA, Park S, Thompson TC; ''Caveolin-1 regulates VEGF-stimulated angiogenic activities in prostate cancer and endothelial cells.''; Cancer Biol Ther, 2009 PubMed Europe PMC Scholia
  222. Chrzanowska-Wodnicka M, Kraus AE, Gale D, White GC 2nd, Vansluys J; ''Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice.''; Blood, 2008 PubMed Europe PMC Scholia
  223. Issbrücker K, Marti HH, Hippenstiel S, Springmann G, Voswinckel R, Gaumann A, Breier G, Drexler HC, Suttorp N, Clauss M; ''p38 MAP kinase--a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability.''; FASEB J, 2003 PubMed Europe PMC Scholia
  224. ''''; , PubMed Europe PMC Scholia
  225. Armesilla AL, Lorenzo E, Gómez del Arco P, Martínez-Martínez S, Alfranca A, Redondo JM; ''Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: a role for tissue factor gene expression.''; Mol Cell Biol, 1999 PubMed Europe PMC Scholia
  226. Lal BK, Varma S, Pappas PJ, Hobson RW 2nd, Durán WN; ''VEGF increases permeability of the endothelial cell monolayer by activation of PKB/akt, endothelial nitric-oxide synthase, and MAP kinase pathways.''; Microvasc Res, 2001 PubMed Europe PMC Scholia
  227. Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V, Ferrara N; ''Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  228. Hoeppner LH, Sinha S, Wang Y, Bhattacharya R, Dutta S, Gong X, Bedell VM, Suresh S, Chun C, Ramchandran R, Ekker SC, Mukhopadhyay D; ''RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells.''; J Cell Sci, 2015 PubMed Europe PMC Scholia
  229. Zeng H, Zhao D, Mukhopadhyay D; ''KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoA.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  230. Chen XL, Nam JO, Jean C, Lawson C, Walsh CT, Goka E, Lim ST, Tomar A, Tancioni I, Uryu S, Guan JL, Acevedo LM, Weis SM, Cheresh DA, Schlaepfer DD; ''VEGF-induced vascular permeability is mediated by FAK.''; Dev Cell, 2012 PubMed Europe PMC Scholia
  231. Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J; ''Rheb binds and regulates the mTOR kinase.''; Curr Biol, 2005 PubMed Europe PMC Scholia
  232. Andrikopoulos P, Baba A, Matsuda T, Djamgoz MB, Yaqoob MM, Eccles SA; ''Ca2+ influx through reverse mode Na+/Ca2+ exchange is critical for vascular endothelial growth factor-mediated extracellular signal-regulated kinase (ERK) 1/2 activation and angiogenic functions of human endothelial cells.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  233. Oshikawa J, Urao N, Kim HW, Kaplan N, Razvi M, McKinney R, Poole LB, Fukai T, Ushio-Fukai M; ''Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in mice.''; PLoS One, 2010 PubMed Europe PMC Scholia
  234. Fearnley GW, Odell AF, Latham AM, Mughal NA, Bruns AF, Burgoyne NJ, Homer-Vanniasinkam S, Zachary IC, Hollstein MC, Wheatcroft SB, Ponnambalam S; ''VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions.''; Mol Biol Cell, 2014 PubMed Europe PMC Scholia
  235. Dance M, Montagner A, Yart A, Masri B, Audigier Y, Perret B, Salles JP, Raynal P; ''The adaptor protein Gab1 couples the stimulation of vascular endothelial growth factor receptor-2 to the activation of phosphoinositide 3-kinase.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  236. Lanahan AA, Hermans K, Claes F, Kerley-Hamilton JS, Zhuang ZW, Giordano FJ, Carmeliet P, Simons M; ''VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis.''; Dev Cell, 2010 PubMed Europe PMC Scholia
  237. Jang GH, Park IS, Yang JH, Bischoff J, Lee YM; ''Differential functions of genes regulated by VEGF-NFATc1 signaling pathway in the migration of pulmonary valve endothelial cells.''; FEBS Lett, 2010 PubMed Europe PMC Scholia
  238. Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, Sheppard D, Cheresh DA; ''Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling.''; J Cell Biol, 2002 PubMed Europe PMC Scholia
  239. Gavard J, Gutkind JS; ''VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin.''; Nat Cell Biol, 2006 PubMed Europe PMC Scholia
  240. Prager GW, Breuss JM, Steurer S, Mihaly J, Binder BR; ''Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells.''; Blood, 2004 PubMed Europe PMC Scholia
  241. ''''; , PubMed Europe PMC Scholia
  242. ''''; , PubMed Europe PMC Scholia
  243. Gourlaouen M, Welti JC, Vasudev NS, Reynolds AR; ''Essential role for endocytosis in the growth factor-stimulated activation of ERK1/2 in endothelial cells.''; J Biol Chem, 2013 PubMed Europe PMC Scholia
  244. Rao A, Luo C, Hogan PG; ''''; , PubMed Europe PMC Scholia
  245. Neagoe PE, Lemieux C, Sirois MG; ''Vascular endothelial growth factor (VEGF)-A165-induced prostacyclin synthesis requires the activation of VEGF receptor-1 and -2 heterodimer.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  246. Morbidelli L, Chang CH, Douglas JG, Granger HJ, Ledda F, Ziche M; ''Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium.''; Am J Physiol, 1996 PubMed Europe PMC Scholia
  247. Zhang Z, Neiva KG, Lingen MW, Ellis LM, Nör JE; ''VEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2.''; Cell Death Differ, 2010 PubMed Europe PMC Scholia
  248. Kim SF, Huri DA, Snyder SH; ''''; , PubMed Europe PMC Scholia
  249. Abid MR, Guo S, Minami T, Spokes KC, Ueki K, Skurk C, Walsh K, Aird WC; ''Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells.''; Arterioscler Thromb Vasc Biol, 2004 PubMed Europe PMC Scholia
  250. Chabot C, Spring K, Gratton JP, Elchebly M, Royal I; ''New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival.''; Mol Cell Biol, 2009 PubMed Europe PMC Scholia
  251. Grazia Lampugnani M, Zanetti A, Corada M, Takahashi T, Balconi G, Breviario F, Orsenigo F, Cattelino A, Kemler R, Daniel TO, Dejana E; ''Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148.''; J Cell Biol, 2003 PubMed Europe PMC Scholia
  252. Prager GW, Breuss JM, Steurer S, Olcaydu D, Mihaly J, Brunner PM, Stockinger H, Binder BR; ''Vascular endothelial growth factor receptor-2-induced initial endothelial cell migration depends on the presence of the urokinase receptor.''; Circ Res, 2004 PubMed Europe PMC Scholia
  253. Combs MD, Yutzey KE; ''VEGF and RANKL regulation of NFATc1 in heart valve development.''; Circ Res, 2009 PubMed Europe PMC Scholia
  254. Mariappan MM, Senthil D, Natarajan KS, Choudhury GG, Kasinath BS; ''Phospholipase Cgamma-Erk Axis in vascular endothelial growth factor-induced eukaryotic initiation factor 4E phosphorylation and protein synthesis in renal epithelial cells.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  255. ''''; , PubMed Europe PMC Scholia
  256. Ha CH, Jhun BS, Kao HY, Jin ZG; ''VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis.''; Arterioscler Thromb Vasc Biol, 2008 PubMed Europe PMC Scholia
  257. Leszczynska K, Kaur S, Wilson E, Bicknell R, Heath VL; ''The role of RhoJ in endothelial cell biology and angiogenesis.''; Biochem Soc Trans, 2011 PubMed Europe PMC Scholia
  258. Liao HL, Zhu Y, Wang N, Verna L, Stemerman MB; ''''; , PubMed Europe PMC Scholia
  259. ''''; , PubMed Europe PMC Scholia
  260. Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, Sakakibara A, Adams S, Davy A, Deutsch U, Lüthi U, Barberis A, Benjamin LE, Mäkinen T, Nobes CD, Adams RH; ''Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.''; Nature, 2010 PubMed Europe PMC Scholia
  261. Dikov MM, Oyama T, Cheng P, Takahashi T, Takahashi K, Sepetavec T, Edwards B, Adachi Y, Nadaf S, Daniel T, Gabrilovich DI, Carbone DP; ''Vascular endothelial growth factor effects on nuclear factor-kappaB activation in hematopoietic progenitor cells.''; Cancer Res, 2001 PubMed Europe PMC Scholia
  262. Luo SW, Zhang C, Zhang B, Kim CH, Qiu YZ, Du QS, Mei L, Xiong WC; ''Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2.''; EMBO J, 2009 PubMed Europe PMC Scholia
  263. Julien LA, Carriere A, Moreau J, Roux PP; ''mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.''; Mol Cell Biol, 2010 PubMed Europe PMC Scholia
  264. Murakami T, Felinski EA, Antonetti DA; ''Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  265. Côté MC, Lavoie JR, Houle F, Poirier A, Rousseau S, Huot J; ''Regulation of vascular endothelial growth factor-induced endothelial cell migration by LIM kinase 1-mediated phosphorylation of annexin 1.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  266. Kobayashi S, Sawano A, Nojima Y, Shibuya M, Maru Y; ''The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1).''; FASEB J, 2004 PubMed Europe PMC Scholia
  267. Carmona G, Göttig S, Orlandi A, Scheele J, Bäuerle T, Jugold M, Kiessling F, Henschler R, Zeiher AM, Dimmeler S, Chavakis E; ''Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis.''; Blood, 2009 PubMed Europe PMC Scholia
  268. Dragoni S, Laforenza U, Bonetti E, Lodola F, Bottino C, Berra-Romani R, Carlo Bongio G, Cinelli MP, Guerra G, Pedrazzoli P, Rosti V, Tanzi F, Moccia F; ''Vascular endothelial growth factor stimulates endothelial colony forming cells proliferation and tubulogenesis by inducing oscillations in intracellular Ca2+ concentration.''; Stem Cells, 2011 PubMed Europe PMC Scholia
  269. Pedram A, Razandi M, Levin ER; ''Extracellular signal-regulated protein kinase/Jun kinase cross-talk underlies vascular endothelial cell growth factor-induced endothelial cell proliferation.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  270. ''''; , PubMed Europe PMC Scholia
  271. Zhuang G, Yu K, Jiang Z, Chung A, Yao J, Ha C, Toy K, Soriano R, Haley B, Blackwood E, Sampath D, Bais C, Lill JR, Ferrara N; ''Phosphoproteomic analysis implicates the mTORC2-FoxO1 axis in VEGF signaling and feedback activation of receptor tyrosine kinases.''; Sci Signal, 2013 PubMed Europe PMC Scholia
  272. Salikhova A, Wang L, Lanahan AA, Liu M, Simons M, Leenders WP, Mukhopadhyay D, Horowitz A; ''Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways.''; Circ Res, 2008 PubMed Europe PMC Scholia
  273. Lee M, Choy WC, Abid MR; ''Direct sensing of endothelial oxidants by vascular endothelial growth factor receptor-2 and c-Src.''; PLoS One, 2011 PubMed Europe PMC Scholia
  274. Holmes K, Roberts OL, Thomas AM, Cross MJ; ''''; , PubMed Europe PMC Scholia
  275. Ikeda S, Ushio-Fukai M, Zuo L, Tojo T, Dikalov S, Patrushev NA, Alexander RW; ''''; , PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126337view06:12, 22 April 2023EgonwLicense is CCZero
124848view21:27, 14 December 2022EweitzModified title
116782view09:53, 14 May 2021EweitzModified title
115530view10:00, 26 February 2021DeSlAdded database name for BMX
108912view12:37, 6 February 2020PrslabModified description
108911view12:20, 6 February 2020PrslabModified description
108910view12:19, 6 February 2020PrslabModified description
108909view08:00, 6 February 2020PrslabModified description
108905view06:18, 6 February 2020PrslabModified description
108904view06:17, 6 February 2020PrslabModified description
108903view05:57, 6 February 2020PrslabModified description
108902view05:57, 6 February 2020PrslabModified description
108901view05:56, 6 February 2020PrslabModified description
108900view05:55, 6 February 2020PrslabModified description
108899view05:54, 6 February 2020PrslabModified description
108895view03:24, 5 February 2020PrslabModified description
108894view03:21, 5 February 2020PrslabModified description
108893view03:18, 5 February 2020PrslabModified description
108892view03:17, 5 February 2020PrslabModified description
108891view03:15, 5 February 2020PrslabModified description
108890view03:14, 5 February 2020PrslabModified description
108889view03:13, 5 February 2020PrslabModified description
108888view03:12, 5 February 2020PrslabModified description
108796view07:05, 30 January 2020PrslabModified description
108795view06:38, 30 January 2020PrslabModified title
108463view11:59, 21 December 2019PrslabModified description
108462view11:57, 21 December 2019PrslabModified description
108339view06:06, 9 December 2019EgonwReplaced a weblink by its PubMed identifier.
108332view10:56, 7 December 2019EgonwModified title
108313view06:05, 5 December 2019PrslabModified title
108312view01:06, 5 December 2019MaintBotupdated with GPML provided by author
108252view07:20, 3 December 2019PrslabModified title
108251view07:13, 3 December 2019PrslabModified title
108249view06:59, 3 December 2019Prslab2019 Update version of VEGFA-VEGFR2
106441view23:30, 28 August 2019KhanspersModified description
105478view05:24, 8 August 2019KhanspersModified description
102004view15:48, 23 November 2018EgonwMoved a non-pubmed ID to a comment.
90000view09:56, 7 October 2016PrslabModified description
89999view09:54, 7 October 2016PrslabModified description
89998view09:27, 7 October 2016PrslabModified description
89997view09:18, 7 October 2016PrslabModified description
89996view09:17, 7 October 2016PrslabModified description
89396view19:22, 10 September 2016AlexanderPicoModified title
89247view16:06, 25 August 2016KhanspersOntology Term : 'endothelial cell' added !
89246view16:01, 25 August 2016KhanspersReverted to version '06:50, 25 August 2016' by Khanspers
89245view15:55, 25 August 2016Khansperstest
89242view06:50, 25 August 2016PrslabOntology Term : 'vascular endothelial growth factor signaling pathway' added !
89241view06:38, 25 August 2016PrslabModified title
89240view06:34, 25 August 2016PrslabNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCF2GeneProduct10061 (Entrez Gene)
ABL1Protein25 (Entrez Gene)
ACACAProtein31 (Entrez Gene)
ACACBProtein32 (Entrez Gene)
ACKR3Protein57007 (Entrez Gene)
ACOT9GeneProduct23597 (Entrez Gene)
ACP1Protein52 (Entrez Gene)
ACTG1GeneProduct71 (Entrez Gene)
ADAM10Protein102 (Entrez Gene)
ADAM9Protein8754 (Entrez Gene)
ADAMTS1Protein9510 (Entrez Gene)
ADAMTS9Protein56999 (Entrez Gene)
ADRB2Protein154 (Entrez Gene)
AFDNProtein4301 (Entrez Gene)
AKAP2GeneProduct11217 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
AKT1S1Protein84335 (Entrez Gene)
ALBGeneProduct213 (Entrez Gene)
ALDOAGeneProduct226 (Entrez Gene)
AMOTProtein154796 (Entrez Gene)
ANXA1GeneProduct301 (Entrez Gene)
AP2A1GeneProduct160 (Entrez Gene)
AP2S1GeneProduct1175 (Entrez Gene)
APOLD1Protein81575 (Entrez Gene)
ARF4GeneProduct378 (Entrez Gene)
ARF6Protein382 (Entrez Gene)
ARHGEF15Protein22899 (Entrez Gene)
ARMCX1GeneProduct51309 (Entrez Gene)
ARPC5LGeneProduct81873 (Entrez Gene)
ARRB2Protein409 (Entrez Gene)
ASCC3GeneProduct10973 (Entrez Gene)
ATF2Protein1386 (Entrez Gene)
ATF4Protein468 (Entrez Gene)
ATF6Protein22926 (Entrez Gene)
ATP6V0D1GeneProduct9114 (Entrez Gene)
ATP6V1E1GeneProduct529 (Entrez Gene)
BCAR1Protein9564 (Entrez Gene)
BCL2Protein596 (Entrez Gene)
BCL2L1Protein598 (Entrez Gene)
BIN1Protein274 (Entrez Gene)
BIRC5Protein332 (Entrez Gene)
BMP10Protein27302 (Entrez Gene)
BMP2Protein650 (Entrez Gene)
BMXProtein660
BRD4Protein23476 (Entrez Gene)
BSGGeneProduct682 (Entrez Gene)
C15ORF39Protein56905 (Entrez Gene)
CACNA2D1GeneProduct781 (Entrez Gene)
CALRGeneProduct811 (Entrez Gene)
CALUGeneProduct813 (Entrez Gene)
CAMKK2Protein10645 (Entrez Gene)
CAPN2Protein824 (Entrez Gene)
CAPZBGeneProduct832 (Entrez Gene)
CASC10Protein399726 (Entrez Gene)
CAV1 Protein857 (Entrez Gene)
CBLProtein867 (Entrez Gene)
CCDC124GeneProduct115098 (Entrez Gene)
CCL2Protein6347 (Entrez Gene)
CCND1Protein595 (Entrez Gene)
CCRL2Protein9034 (Entrez Gene)
CCT7GeneProduct10574 (Entrez Gene)
CDC42Protein998 (Entrez Gene)
CDC42BPBGeneProduct9578 (Entrez Gene)
CDH5Protein1003 (Entrez Gene)
CDKN1BProtein8013 (Entrez Gene)
CFL1Protein1072 (Entrez Gene)
CGNL1GeneProduct84952 (Entrez Gene)
CHAC1Protein79094 (Entrez Gene)
CLIC1GeneProduct1192 (Entrez Gene)
CLTCProtein1213 (Entrez Gene)
CNPGeneProduct1267 (Entrez Gene)
COPG1GeneProduct22820 (Entrez Gene)
CREB1Protein1385 (Entrez Gene)
CREBBPProtein1387 (Entrez Gene)
CRIP2GeneProduct1397 (Entrez Gene)
CRKProtein1398 (Entrez Gene)
CSKProtein1445 (Entrez Gene)
CSRP1GeneProduct1465 (Entrez Gene)
CSRP2GeneProduct1466 (Entrez Gene)
CTGFProtein1490 (Entrez Gene)
CTNNA1Protein1495 (Entrez Gene)
CTNNB1Protein1499 (Entrez Gene)
CTNND1Protein1500 (Entrez Gene)
CXCL8Protein3576 (Entrez Gene)
CYBBProtein1536 (Entrez Gene)
CYCSProtein54205 (Entrez Gene)
CYP2C8 Protein1558 (Entrez Gene)
CYR61GeneProduct3491 (Entrez Gene)
DECR1GeneProduct1666 (Entrez Gene)
DHX29GeneProduct54505 (Entrez Gene)
DHX36GeneProduct170506 (Entrez Gene)
DKK1Protein22943 (Entrez Gene)
DLL4Protein54567 (Entrez Gene)
DNAJA1GeneProduct3301 (Entrez Gene)
DNAJB4GeneProduct11080 (Entrez Gene)
DNAJB9Protein4189 (Entrez Gene)
DOK1 Protein1796 (Entrez Gene)
DPM1GeneProduct8813 (Entrez Gene)
DSC1GeneProduct1823 (Entrez Gene)
DUSP5Protein1847 (Entrez Gene)
EEA1Protein8411 (Entrez Gene)
EGR1Protein1958 (Entrez Gene)
EGR3Protein1960 (Entrez Gene)
EIF2AProtein83939 (Entrez Gene)
EIF2AK3Protein9451 (Entrez Gene)
EIF3DGeneProduct8664 (Entrez Gene)
EIF3FGeneProduct8665 (Entrez Gene)
EIF3HGeneProduct8667 (Entrez Gene)
EIF4EProtein1977 (Entrez Gene)
EIF4G1GeneProduct1981 (Entrez Gene)
EIF4G2GeneProduct1982 (Entrez Gene)
ELK1Protein2002 (Entrez Gene)
ENGProtein2022 (Entrez Gene)
EPB41GeneProduct2035 (Entrez Gene)
EPHA2Protein1969 (Entrez Gene)
EPHB2Protein2048 (Entrez Gene)
EPN1Protein29924 (Entrez Gene)
EPRSGeneProduct2058 (Entrez Gene)
EPS15Protein2060 (Entrez Gene)
ERGProtein2078 (Entrez Gene)
ERN1Protein2081 (Entrez Gene)
ETS1Protein2113 (Entrez Gene)
EWSR1GeneProduct2130 (Entrez Gene)
EZRProtein7430 (Entrez Gene)
F3Protein2152 (Entrez Gene)
FADDProtein8772 (Entrez Gene)
FAF1Protein11124 (Entrez Gene)
FAM120AGeneProduct23196 (Entrez Gene)
FARSBGeneProduct10056 (Entrez Gene)
FASProtein355 (Entrez Gene)
FBXW11Protein23291 (Entrez Gene)
FGAProtein2243 (Entrez Gene)
FGBProtein2244 (Entrez Gene)
FGD5GeneProduct152273 (Entrez Gene)
FGGProtein2266 (Entrez Gene)
FHL2Protein2274 (Entrez Gene)
FHOD1GeneProduct29109 (Entrez Gene)
FJX1Protein24147 (Entrez Gene)
FLIIGeneProduct2314 (Entrez Gene)
FLNBProtein2317 (Entrez Gene)
FLT1Protein2321 (Entrez Gene)
FMNL3GeneProduct91010 (Entrez Gene)
FN1GeneProduct2335 (Entrez Gene)
FOXO1Protein2308 (Entrez Gene)
FOXO3Protein2309 (Entrez Gene)
FOXO4Protein4303 (Entrez Gene)
FRS2Protein10818 (Entrez Gene)
FSCN1GeneProduct6624 (Entrez Gene)
FUT1Protein2523 (Entrez Gene)
FXR2GeneProduct9513 (Entrez Gene)
FYN Protein2534 (Entrez Gene)
GAB1Protein2549 (Entrez Gene)
GAPDHGeneProduct2597 (Entrez Gene)
GATA2Protein2624 (Entrez Gene)
GIGYF2GeneProduct26058 (Entrez Gene)
GIPC1Protein10755 (Entrez Gene)
GJA1Protein2697 (Entrez Gene)
GLUD1GeneProduct2746 (Entrez Gene)
GPC1Protein2817 (Entrez Gene)
GPX1Protein2876 (Entrez Gene)
GRB10Protein2887 (Entrez Gene)
GRB2Protein2885 (Entrez Gene)
GRSF1GeneProduct2926 (Entrez Gene)
GSK3BProtein2932 (Entrez Gene)
HBDGeneProduct3045 (Entrez Gene)
HBEGFProtein1839 (Entrez Gene)
HDAC1Protein3065 (Entrez Gene)
HDAC4Protein9759 (Entrez Gene)
HDAC5Protein10014 (Entrez Gene)
HDAC7Protein51564 (Entrez Gene)
HDAC9Protein9734 (Entrez Gene)
HERPUD1Protein9709 (Entrez Gene)
HGSProtein9146 (Entrez Gene)
HLXProtein3142 (Entrez Gene)
HMGB1GeneProduct3146 (Entrez Gene)
HRASProtein3265 (Entrez Gene)
HSP90AA1GeneProduct3320 (Entrez Gene)
HSP90AB2PGeneProduct391634 (Entrez Gene)
HSPA1AProtein3303 (Entrez Gene)
HSPB1Protein3315 (Entrez Gene)
HTRA1GeneProduct5654 (Entrez Gene)
HYOU1GeneProduct10525 (Entrez Gene)
ICAM1Protein3383 (Entrez Gene)
IDH2GeneProduct3418 (Entrez Gene)
IER5Protein51278 (Entrez Gene)
IGFBP3Protein3486 (Entrez Gene)
IGFBP7Protein3490 (Entrez Gene)
INPP5KGeneProduct51763 (Entrez Gene)
IQGAP1GeneProduct8826 (Entrez Gene)
ITCHProtein83737 (Entrez Gene)
ITGAVProtein3685 (Entrez Gene)
ITGB1Protein3688 (Entrez Gene)
ITGB3Protein3690 (Entrez Gene)
ITGB5Protein3693 (Entrez Gene)
ITPR1Protein3748 (Entrez Gene)
JAG1Protein182 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
KANK1GeneProduct23189 (Entrez Gene)
KATNAL2GeneProduct83473 (Entrez Gene)
KLProtein9365 (Entrez Gene)
LARP7Protein51574 (Entrez Gene)
LDB2Protein9079 (Entrez Gene)
LDHAGeneProduct3939 (Entrez Gene)
LIMK1Protein3984 (Entrez Gene)
LMAN1GeneProduct3998 (Entrez Gene)
LMO2Protein405 (Entrez Gene)
LRRC59GeneProduct55379 (Entrez Gene)
LRRFIP2GeneProduct9209 (Entrez Gene)
LUC7LGeneProduct55692 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
MAP2K2Protein5605 (Entrez Gene)
MAP2K3Protein5606 (Entrez Gene)
MAP2K4Protein6416 (Entrez Gene)
MAP2K6Protein5608 (Entrez Gene)
MAP2K7Protein5609 (Entrez Gene)
MAP3K5Protein4217 (Entrez Gene)
MAPK12Protein6300 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MAPKAP1Protein79109 (Entrez Gene)
MAPKAPK2Protein9261 (Entrez Gene)
MAPKAPK5Protein8550 (Entrez Gene)
MDM2Protein4193 (Entrez Gene)
MEF2CProtein4208 (Entrez Gene)
MICAL2GeneProduct9645 (Entrez Gene)
MKNK1Protein8569 (Entrez Gene)
MLLT4Protein4301 (Entrez Gene)
MLST8Protein64223 (Entrez Gene)
MMP10Protein4319 (Entrez Gene)
MMP14Protein4323 (Entrez Gene)
MMP2Protein4313 (Entrez Gene)
MMRN2Protein79812 (Entrez Gene)
MOV10GeneProduct4343 (Entrez Gene)
MTORProtein2475 (Entrez Gene)
MYH11GeneProduct4629 (Entrez Gene)
MYH9Protein4627 (Entrez Gene)
MYL2Protein4633 (Entrez Gene)
MYO1CGeneProduct4641 (Entrez Gene)
MYO6GeneProduct4646 (Entrez Gene)
NAP1L1GeneProduct4673 (Entrez Gene)
NAPAGeneProduct8775 (Entrez Gene)
NCF1Protein653361 (Entrez Gene)
NCF2Protein4688 (Entrez Gene)
NCK1Protein4690 (Entrez Gene)
NCLGeneProduct4691 (Entrez Gene)
NDRG1Protein10397 (Entrez Gene)
NEXNGeneProduct91624 (Entrez Gene)
NFATC1Protein4772 (Entrez Gene)
NFATC2Protein4773 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NFKBIAProtein4792 (Entrez Gene)
NOS3Protein4846 (Entrez Gene)
NOTCH4Protein4855 (Entrez Gene)
NOX4Protein50507 (Entrez Gene)
NR4A1Protein3164 (Entrez Gene)
NR4A2Protein4929 (Entrez Gene)
NR4A3Protein8013 (Entrez Gene)
NRARPProtein441478 (Entrez Gene)
NRDG1Protein10397 (Entrez Gene)
NRP1Protein8821 (Entrez Gene)
NRP2Protein8828 (Entrez Gene)
NUMBGeneProduct8650 (Entrez Gene)
NUR4A1Protein3164 (Entrez Gene)
OCLNProtein100506658 (Entrez Gene)
OCRLGeneProduct4952 (Entrez Gene)
P4HA2GeneProduct8974 (Entrez Gene)
P4HBGeneProduct5034 (Entrez Gene)
PABPC1GeneProduct26986 (Entrez Gene)
PAK1Protein5058 (Entrez Gene)
PAK2Protein5062 (Entrez Gene)
PBXIP1GeneProduct57326 (Entrez Gene)
PDE4DIPGeneProduct9659 (Entrez Gene)
PDIA6GeneProduct10130 (Entrez Gene)
PDPK1Protein5170 (Entrez Gene)
PFN1GeneProduct5216 (Entrez Gene)
PGDGeneProduct5226 (Entrez Gene)
PGFProtein5228 (Entrez Gene)
PGK1GeneProduct5230 (Entrez Gene)
PIK3CAProtein5290 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PIK3R2Protein5296 (Entrez Gene)
PLA2G4AProtein5321 (Entrez Gene)
PLA2G5Protein5322 (Entrez Gene)
PLAUProtein5328 (Entrez Gene)
PLAURProtein5329 (Entrez Gene)
PLCB3Protein5331 (Entrez Gene)
PLCG1Protein5335 (Entrez Gene)
PLOD3GeneProduct8985 (Entrez Gene)
PNPProtein4860 (Entrez Gene)
PPM1GGeneProduct5496 (Entrez Gene)
PPP1CAGeneProduct5499 (Entrez Gene)
PPP2CAGeneProduct5515 (Entrez Gene)
PPP3CAProtein5530 (Entrez Gene)
PRDX2GeneProduct7001 (Entrez Gene)
PRDX6GeneProduct9588 (Entrez Gene)
PRKAA1Protein5562 (Entrez Gene)
PRKAA2Protein5563 (Entrez Gene)
PRKCAProtein5578 (Entrez Gene)
PRKCBProtein5579 (Entrez Gene)
PRKCDProtein5580 (Entrez Gene)
PRKCEProtein5581 (Entrez Gene)
PRKCIProtein5584 (Entrez Gene)
PRKCZProtein5590 (Entrez Gene)
PRKD1Protein5587 (Entrez Gene)
PRKD2Protein25865 (Entrez Gene)
PRKG1Protein5592 (Entrez Gene)
PRKRAGeneProduct8575 (Entrez Gene)
PRRC2CGeneProduct23215 (Entrez Gene)
PSMD11GeneProduct5717 (Entrez Gene)
PSMD4GeneProduct5710 (Entrez Gene)
PTGS2Protein5743 (Entrez Gene)
PTK2Protein5747 (Entrez Gene)
PTK2BProtein2185 (Entrez Gene)
PTMAGeneProduct5757 (Entrez Gene)
PTPN11Protein5781 (Entrez Gene)
PTPN14GeneProduct5784 (Entrez Gene)
PTPN1Protein5770 (Entrez Gene)
PTPN6Protein5777 (Entrez Gene)
PTPN9Protein5780 (Entrez Gene)
PTPRJProtein5795 (Entrez Gene)
PTPRZ1Protein5803 (Entrez Gene)
PXNProtein5829 (Entrez Gene)
QKIGeneProduct9444 (Entrez Gene)
R1CTOR Protein253260 (Entrez Gene)
RAB11Protein8766 (Entrez Gene)
RAB37Protein326624 (Entrez Gene)
RAB4AProtein5867 (Entrez Gene)
RAB5AProtein5868 (Entrez Gene)
RAC1Protein5879 (Entrez Gene)
RACK1Protein10399 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RAP1AProtein5906 (Entrez Gene)
RAP1BProtein5908 (Entrez Gene)
RAPGEF1Protein2889 (Entrez Gene)
RAPTORProtein253260 (Entrez Gene)
RBM39GeneProduct9584 (Entrez Gene)
RCAN1Protein1827 (Entrez Gene)
RCAN2Protein10231 (Entrez Gene)
RCN1GeneProduct5954 (Entrez Gene)
RELAProtein5970 (Entrez Gene)
RHOAProtein387 (Entrez Gene)
RHOCProtein389 (Entrez Gene)
RHOJProtein57381 (Entrez Gene)
RND1Protein27289 (Entrez Gene)
ROCK1Protein6093 (Entrez Gene)
ROCK2Protein9475 (Entrez Gene)
RPL10AGeneProduct4736 (Entrez Gene)
RPL13AGeneProduct23521 (Entrez Gene)
RPL18AGeneProduct6142 (Entrez Gene)
RPL26GeneProduct6154 (Entrez Gene)
RPL27GeneProduct6155 (Entrez Gene)
RPL39P5GeneProduct553117 (Entrez Gene)
RPL5GeneProduct6125 (Entrez Gene)
RPL7GeneProduct6129 (Entrez Gene)
RPLP2GeneProduct6181 (Entrez Gene)
RPS11GeneProduct6205 (Entrez Gene)
RPS6Protein6194 (Entrez Gene)
RPS6KA5Protein9252 (Entrez Gene)
RPS6KB1Protein6198 (Entrez Gene)
S1PR1Protein1901 (Entrez Gene)
SARSGeneProduct6301 (Entrez Gene)
SCUBE2Protein57758 (Entrez Gene)
SDCBPProtein6386 (Entrez Gene)
SDF2L1Protein23753 (Entrez Gene)
SELEProtein6401 (Entrez Gene)
SEMA6DProtein80031 (Entrez Gene)
SETGeneProduct6418 (Entrez Gene)
SH2D2AProtein9047 (Entrez Gene)
SH3BGRL3GeneProduct83442 (Entrez Gene)
SHBProtein6461 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
SHC2Protein25759 (Entrez Gene)
SHROOM2GeneProduct357 (Entrez Gene)
SIAH2Protein6478 (Entrez Gene)
SLC25A11GeneProduct8402 (Entrez Gene)
SLC25A25Protein114789 (Entrez Gene)
SLC2A14Protein144195 (Entrez Gene)
SLC39A14Protein21356 (Entrez Gene)
SLC7A1Protein6541 (Entrez Gene)
SLC8A1Protein6546 (Entrez Gene)
SMARCA2Protein6595 (Entrez Gene)
SND1GeneProduct27044 (Entrez Gene)
SOD2Protein6648 (Entrez Gene)
SPHK1Protein55872 (Entrez Gene)
SPIRE1GeneProduct56907 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
SRFProtein6722 (Entrez Gene)
SRP54GeneProduct6729 (Entrez Gene)
SRPK1GeneProduct6732 (Entrez Gene)
SSR3GeneProduct6747 (Entrez Gene)
SSR4GeneProduct6748 (Entrez Gene)
STAMProtein8027 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT6Protein6778 (Entrez Gene)
STIP1GeneProduct10963 (Entrez Gene)
SYNJ1GeneProduct8867 (Entrez Gene)
TAL1Protein6886 (Entrez Gene)
TAOK2GeneProduct9344 (Entrez Gene)
TBCAGeneProduct6902 (Entrez Gene)
TCEB1GeneProduct6921 (Entrez Gene)
TCEB3Protein6924 (Entrez Gene)
TEAD4Protein7004 (Entrez Gene)
TFAMGeneProduct7019 (Entrez Gene)
TFCP2GeneProduct7024 (Entrez Gene)
TKTGeneProduct7086 (Entrez Gene)
TMEM170AProtein124491 (Entrez Gene)
TMOD1GeneProduct7111 (Entrez Gene)
TMOD3GeneProduct29766 (Entrez Gene)
TMSB10GeneProduct9168 (Entrez Gene)
TMSB4XGeneProduct7114 (Entrez Gene)
TNFRSF10CProtein8794 (Entrez Gene)
TNFRSF25Protein8718 (Entrez Gene)
TNXBProtein7148 (Entrez Gene)
TPCN2Protein219931 (Entrez Gene)
TPM3GeneProduct7170 (Entrez Gene)
TPP1GeneProduct1200 (Entrez Gene)
TRAF3IP2Protein10758 (Entrez Gene)
TRIP4GeneProduct9325 (Entrez Gene)
TRPC1Protein7220 (Entrez Gene)
TRPC3Protein7222 (Entrez Gene)
TUBA1CGeneProduct84790 (Entrez Gene)
TUBB8GeneProduct347688 (Entrez Gene)
TXNProtein7295 (Entrez Gene)
TXNDC5GeneProduct81567 (Entrez Gene)
TXNIPProtein10628 (Entrez Gene)
UBAP2LGeneProduct9898 (Entrez Gene)
USP10GeneProduct9100 (Entrez Gene)
VAV2Protein7410 (Entrez Gene)
VCAM1Protein5328 (Entrez Gene)
VCLProtein7414 (Entrez Gene)
VEGFAProtein7422 (Entrez Gene)
VEGFR2Protein3791 (Entrez Gene)
VPS39GeneProduct23339 (Entrez Gene)
WASF1Protein8936 (Entrez Gene)
YWHAEGeneProduct7531 (Entrez Gene)
ZC3H15GeneProduct55854 (Entrez Gene)
ZNF555Protein148254 (Entrez Gene)

Annotated Interactions

No annotated interactions

Personal tools