Hepatocyte growth factor receptor signaling (Gallus gallus)
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L Dupuis
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Extracellular
RAC1
pathway
Transcription
Cytoplasm
Changes in Cytoskeleton
and Cell mobility
Right Click for Comments
AP-1
Actin
RHO
pathway
Trancription
Anoikis
P
Transcription
of Cox2
P
CDC42
pathway
P
AKT Pathway
PAK1
GRB2
PTK2B
RASA1
SRC
SOS1
GAB1
ITGB1
MAP2K2
ITGA1
PXN
PXN
MAPK3
JUN
RAPGEF1
FOS
CRKL
PTPN11
PTK2
CRK
Met
SRC
PTK2B
HGF
DOCK1
MAP4K1
MAPK8
HRAS
RAP1A
ELK1
RAF1
PTK2
RAP1B
PIK3CA
STAT3
MAPK1
PTEN
MAP2K1
Description
No description
Comments
GenMAPP remarks
Converted to human by GenMAPP.org
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP313(r21339)
with a 78% conversion rate.
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Quality Tags
Ontology Terms
Saving...
No Tags!
Bibliography
Organ SL, Tsao MS; ''An overview of the c-MET signaling pathway.''; Ther Adv Med Oncol, 2011
PubMed
Europe PMC
Scholia
History
View all...
Compare
Revision
Action
Time
User
Comment
118803
view
07:47, 2 June 2021
DeSl
Converted "P" textlabels to states
118802
view
07:46, 2 June 2021
DeSl
Converted ReceptorSquare to MIM binding with lit. ref.
118801
view
07:44, 2 June 2021
DeSl
Removed textLabel
118800
view
07:44, 2 June 2021
DeSl
Ontology Term : 'hepatocyte' added !
118799
view
07:43, 2 June 2021
DeSl
Ontology Term : 'Rho/Rac/Cdc42 mediated signaling pathway' added !
118798
view
07:43, 2 June 2021
DeSl
Added description from WP313
118039
view
11:50, 23 May 2021
Eweitz
Modified title
109466
view
10:53, 18 March 2020
L Dupuis
Converted interaction lines representing membrane to graphical lines
87669
view
08:55, 25 July 2016
Lindarieswijk
Ontology Term : 'scatter factor/hepatocyte growth factor signaling pathway' added !
68877
view
17:22, 8 July 2013
MaintBot
Updated to 2013 gpml schema
41018
view
22:57, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33939
view
18:13, 9 December 2009
MaintBot
Automatic update of empty xrefs
33484
view
15:08, 30 November 2009
MaintBot
Removed group label
31534
view
21:45, 13 August 2009
MaintBot
Fixed text labels
30379
view
21:02, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
CRK
GeneProduct
417553 (Entrez Gene)
CRKL
GeneProduct
416939 (Entrez Gene)
DOCK1
GeneProduct
423960 (Entrez Gene)
Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
ELK1
GeneProduct
FOS
GeneProduct
396512 (Entrez Gene)
GAB1
GeneProduct
422456 (Entrez Gene)
GRB2
GeneProduct
386572 (Entrez Gene)
HGF
GeneProduct
395941 (Entrez Gene)
HRAS
GeneProduct
396229 (Entrez Gene)
ITGA1
GeneProduct
395951 (Entrez Gene)
ITGB1
GeneProduct
374058 (Entrez Gene)
JUN
GeneProduct
424673 (Entrez Gene)
MAP2K1
GeneProduct
415549 (Entrez Gene)
MAP2K2
GeneProduct
396349 (Entrez Gene)
MAP4K1
GeneProduct
MAPK1
GeneProduct
373953 (Entrez Gene)
MAPK3
GeneProduct
MAPK8
GeneProduct
423778 (Entrez Gene)
Met
GeneProduct
396134 (Entrez Gene)
PAK1
GeneProduct
419083 (Entrez Gene)
PIK3CA
GeneProduct
424971 (Entrez Gene)
PTEN
GeneProduct
423675 (Entrez Gene)
PTK2
GeneProduct
396416 (Entrez Gene)
PTK2B
GeneProduct
421998 (Entrez Gene)
PTPN11
GeneProduct
395815 (Entrez Gene)
PXN
GeneProduct
395832 (Entrez Gene)
RAF1
GeneProduct
396245 (Entrez Gene)
RAP1A
GeneProduct
419867 (Entrez Gene)
RAP1B
GeneProduct
417840 (Entrez Gene)
RAPGEF1
GeneProduct
417173 (Entrez Gene)
RASA1
GeneProduct
427327 (Entrez Gene)
SOS1
GeneProduct
425964 (Entrez Gene)
Son of sevenless homolog 1 (Drosophila) (predicted)
SRC
GeneProduct
396442 (Entrez Gene)
STAT3
GeneProduct
420027 (Entrez Gene)
Annotated Interactions
No annotated interactions
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Discussion
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DataNodes
Annotated Interactions
No annotated interactions