Host-pathogen interaction of human coronaviruses - apoptosis (Homo sapiens)

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Description

Apoptosis induction by human corona virus infection.

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Ontology Terms

Pathway Ontology : cholesterol biosynthetic pathway cholesterol metabolic pathway cholesterol transport pathway

Cell Type : hepatocyte enterocyte

Bibliography

Li H, Zhu H, Xu CJ, Yuan J; ''Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.''; Cell, 1998 PubMed Europe PMC Scholia
Fung TS, Liu DX; ''Human Coronavirus: Host-Pathogen Interaction.''; Annu Rev Microbiol, 2019 PubMed Europe PMC Scholia

History

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Revision	Action	Time	User	Comment
124634	view	12:40, 18 November 2022	NhungP	update viral protein shapes
124632	view	12:33, 18 November 2022	NhungP	change viral proteins shapes
116596	view	19:12, 8 May 2021	Eweitz	Modified title
113801	view	09:33, 25 November 2020	NhungP	Annotated protein 8a and updated protein S and N identifiers
111622	view	18:17, 30 August 2020	Egonw
111365	view	05:33, 3 August 2020	Egonw	Converted two interacting Label's to DataNode's.
110821	view	07:59, 10 June 2020	Fehrhart	Modified description
110242	view	17:35, 29 April 2020	Egonw	Replaced a secondary ChEBI identifiers with a primary identifier.
110205	view	10:49, 24 April 2020	Fehrhart	updated legend and labels
110200	view	20:39, 23 April 2020	Egonw	Typed proteins as Type="Protein"
109973	view	18:18, 8 April 2020	AlexanderPico	updated sars nodes per #covidpathways guidelines
109950	view	18:21, 7 April 2020	MaintBot	Added two more identifiers.
109876	view	10:08, 3 April 2020	Fehrhart	added information about tBID
109849	view	11:36, 2 April 2020	Fehrhart	changed virus protein visualization
109819	view	14:57, 1 April 2020	Fehrhart	added protein ID for M
109818	view	14:56, 1 April 2020	Fehrhart	added some virus protein IDs
109639	view	19:00, 27 March 2020	Fehrhart	Ontology Term : 'apoptotic cell death pathway' added !
109638	view	18:59, 27 March 2020	Fehrhart	Ontology Term : 'disease pathway' added !
109637	view	18:59, 27 March 2020	Fehrhart	Ontology Term : 'viral infectious disease' added !
109636	view	18:59, 27 March 2020	Fehrhart	Ontology Term : 'severe acute respiratory syndrome' added !
109635	view	18:56, 27 March 2020	Fehrhart	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
3a	GeneProduct	P59632 (Uniprot-TrEMBL)
3b	GeneProduct	P59633 (Uniprot-TrEMBL)
6	GeneProduct	P59634 (Uniprot-TrEMBL)
7a	GeneProduct	P59635 (Uniprot-TrEMBL)
8a	GeneProduct
9b	GeneProduct	P59636 (Uniprot-TrEMBL)
AKT1	GeneProduct	207 (Entrez Gene)
APAF1	GeneProduct	ENSG00000120868 (Ensembl)
BAD	GeneProduct	ENSG00000002330 (Ensembl)
BAX	GeneProduct	ENSG00000087088 (Ensembl)
BBC3	GeneProduct	ENSG00000105327 (Ensembl)	PUMA
BCL2	GeneProduct	ENSG00000171791 (Ensembl)
BCL2L11	GeneProduct	ENSG00000153094 (Ensembl)	BIM
BCL2L1	GeneProduct	ENSG00000171552 (Ensembl)
BID	GeneProduct	ENSG00000015475 (Ensembl)
CASP3	GeneProduct	ENSG00000164305 (Ensembl)
CASP7	GeneProduct	ENSG00000165806 (Ensembl)
CASP8	GeneProduct	ENSG00000064012 (Ensembl)
CASP9	GeneProduct	ENSG00000132906 (Ensembl)
Cytochrome C	Metabolite	CHEBI:4062 (ChEBI)
E	GeneProduct	P59637 (Uniprot-TrEMBL)
FADD	GeneProduct	ENSG00000168040 (Ensembl)
FASLG	GeneProduct	ENSG00000117560 (Ensembl)
MAPK11	GeneProduct	ENSG00000185386 (Ensembl)
MAPK12	GeneProduct	ENSG00000188130 (Ensembl)
MAPK13	GeneProduct	ENSG00000156711 (Ensembl)
MAPK14	GeneProduct	ENSG00000112062 (Ensembl)
MCL1	GeneProduct	ENSG00000143384 (Ensembl)
M	GeneProduct	P59596 (Uniprot-TrEMBL)
N	GeneProduct	Q89457519 (Wikidata)
S	GeneProduct	Q89458416 (Wikidata)
TNF	GeneProduct	ENSG00000232810 (Ensembl)
tBID	GeneProduct	PRO_0000223233 (Uniprot-TrEMBL)	BH3-interacting domain death agonist, truncated, p15