Acute viral myocarditis (Homo sapiens)

From WikiPathways

Revision as of 13:58, 28 May 2020 by Fehrhart (Talk | contribs)
Jump to: navigation, search
4213732Formation ofcaveosomesfor CVB3 uptake17, 28, 3926, 29CAR/DAF complexCVB1DegradationIncreased expr.AD2Adjacent CardiomyocytesDystrophin deficiency leads to loss of the sarcoglycan complexpre-cursor to DCMApoptosis type I & IICVB3HIV triggered immunemediated myocarditisDegenerationSarcomerPrimary profibrotic cytokinePhosphorylated dimersmove to nucleusstimulate gene expressionExtracellular Matrix21396, 11, 25, 413940beta catenin pathwayB CellViral genomic RNA30Max. release ofprogeny virionMyocyte NecrosisFibrosisMyocyte atrophieType I induced apoptosisOverproduction of fibrofatty tissue in myocardiumDNA FragmentationCD8*T cellViral replication, inactivation of p21ras32CVB 1 3 5 can all bind to both CAR and DAFViral progeny releaseNucleusCoxsackie B virusUbiquitin-Proteasome SystemMatrix degradation23SarcoplasmHIV-143AutoreactiveantibodiesHost protein synthesis shutoffinduction of CPE27, 31Apoptotic cardiomyocyteERSarcolemmaEnterovirus-induced Cardiomyopathy39Type II induced apoptosisVirus-specific antibodiesMyocyte dysfunctionDystrophinDecreased force transmissionIncreased cell permeabilitySarcoglycan complexAdeno Viruscell cycle arrestCellular activationSuppresses cytopathic effectsLoss of mechanicalstability of the cell38chaoticApoptosis and/or necrosisMyosinActin ReorganizationViral replicationDNA fragmentationwithin nucleusmitochondrionCD4*T Cellantigen presenting cellCalcium pumpMyocyteInflammationAD2 and 5 solely bind the CARHIV-2T cell receptorsignalling pathwayImmune-mediatedmyocyte damage24t-Bid29Symptomatic arrhythmiasSTAT1IL10JAK1ganglioside GM1Endothelin-1Nitric oxide synthaseIL6SOCS1STAT3IFNGEIF4G2TGFB1ECM-receptor interaction740CASP8ACTBprostaglandin E232BAX2ATF-2SGCBILKCD47, 163C^PROFYNMMP9DAFRAC2ABL1BCL2L12RAF-1CASP2MK2pro-IL-1betaCASP6Tyrosine KinaseCASP7NOD235CCR5TLR3CYCS23, 29MEK 1/2PTCRAp53TNF-a9, 22BH3 Bid29peptidoglycan muramyl dipeptide15Catenin beta-1IgGHerbimycin Aglycophosphatidylinositol23, 34antigenPro-IL-18IL1CHRAC1MKK 3/6Ca2+AIF114CCND1JNK123TICAM1SOS1MAPK1RASA132SRC4, 8SGCATNFRSM5DFFB-45GSK3BAKT1MHCIIMHC-1CD55CARCXADRViral entryCVB32, 37T cell receptor alpha chain V regionSGCDHLA-DMAENDOG19, 23TLR4IL1PYCARDDFFA/ICADhsp27c-JunPerforin-1PIK323Cd28HIV12ITGALLAMA2CREB11, 20CXCR4ITGB2mature secreted forms5NFkB23CASP310, 36matrix metalloproteinasesIL12AKRT83MYH6IL2RAC3cardiac antigensDMD135 S A-particleBCL22DAP522A^PRODAG1-BTLR5T-cell receptor beta chain V regionstriated muscle contractionNLRP3CASP9MKK 4/7CCR3DystrophinDAG1-aMacrophage7viral antigensEIF4G12, 27SGCGCD40LGBNIP2PARMyocarditisABL2reactive oxygen species generatorsNF-kBMAPK3CD80CAV1IgGcd86glycophosphatidylinositol34BH3 Bid2, 29Ca2+NucleusantigenPTCRADecreased expr.Increased expr.? Promotes tissue fibrosis ?CAAP123PARP1PABPC1ProteasomeMAPK1IL12B


Description

Viral Myocarditis is a rare cardiac disease associated with the inflammation and injury of the myocardium. The downstream effects are a product of cooperation between viral processes and both the adaptive as innate host's immune response. Acute appearance of myocarditis is mostly idiopathic (=of unknown origin). Primarily established on clinical observation and limited epidemiologic studies. Most studied cases are coxsackie, adeno and human immunodeficiency virus. Grey compartments describe extracellular matrix. Direct lines indicate downstream effects and dashed lines indicate speculative research.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Knowlton KU; ''CVB infection and mechanisms of viral cardiomyopathy.''; Curr Top Microbiol Immunol, 2008 PubMed Europe PMC Scholia
  2. Chau DH, Yuan J, Zhang H, Cheung P, Lim T, Liu Z, Sall A, Yang D; ''Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondrial injury and cleavage of eIF4GI but not DAP5/p97/NAT1.''; Apoptosis, 2007 PubMed Europe PMC Scholia
  3. Muckelbauer JK, Kremer M, Minor I, Diana G, Dutko FJ, Groarke J, Pevear DC, Rossmann MG; ''The structure of coxsackievirus B3 at 3.5 A resolution.''; Structure, 1995 PubMed Europe PMC Scholia
  4. Fiala M, Popik W, Qiao JH, Lossinsky AS, Alce T, Tran K, Yang W, Roos KP, Arthos J; ''HIV-1 induces cardiomyopathyby cardiomyocyte invasion and gp120, Tat, and cytokine apoptotic signaling.''; Cardiovasc Toxicol, 2004 PubMed Europe PMC Scholia
  5. Li H, Zhu H, Xu CJ, Yuan J; ''Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.''; Cell, 1998 PubMed Europe PMC Scholia
  6. Huber M, Selinka HC, Kandolf R; ''Tyrosine phosphorylation events during coxsackievirus B3 replication.''; J Virol, 1997 PubMed Europe PMC Scholia
  7. Garcia-Dorado, D., Andres-Villarreal, M., Ruiz-Meana, M., Inserte, J., Barba, I.; ''Myocardial edema: A translational view''; ScienceDirect, 2011 DOI Scholia
  8. Barbaro G, Di Lorenzo G, Grisorio B, Barbarini G; ''Incidence of dilated cardiomyopathy and detection of HIV in myocardial cells of HIV-positive patients. Gruppo Italiano per lo Studio Cardiologico dei Pazienti Affetti da AIDS.''; N Engl J Med, 1998 PubMed Europe PMC Scholia
  9. Esfandiarei M, McManus BM; ''Molecular biology and pathogenesis of viral myocarditis.''; Annu Rev Pathol, 2008 PubMed Europe PMC Scholia
  10. Henke A, Launhardt H, Klement K, Stelzner A, Zell R, Munder T; ''Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva.''; J Virol, 2000 PubMed Europe PMC Scholia
  11. Sabbah A, Chang TH, Harnack R, Frohlich V, Tominaga K, Dube PH, Xiang Y, Bose S; ''Activation of innate immune antiviral responses by Nod2.''; Nat Immunol, 2009 PubMed Europe PMC Scholia
  12. Kania G, Blyszczuk P, Eriksson U; ''Mechanisms of cardiac fibrosis in inflammatory heart disease.''; Trends Cardiovasc Med, 2009 PubMed Europe PMC Scholia
  13. Iizuka N, Kuge S, Nomoto A; ''Complete nucleotide sequence of the genome of coxsackievirus B1.''; Virology, 1987 PubMed Europe PMC Scholia
  14. Zhang HM, Yanagawa B, Cheung P, Luo H, Yuan J, Chau D, Wang A, Bohunek L, Wilson JE, McManus BM, Yang D; ''Nip21 gene expression reduces coxsackievirus B3 replication by promoting apoptotic cell death via a mitochondria-dependent pathway.''; Circ Res, 2002 PubMed Europe PMC Scholia
  15. Barbaro G, Lipshultz SE; ''Pathogenesis of HIV-associated cardiomyopathy.''; Ann N Y Acad Sci, 2001 PubMed Europe PMC Scholia
  16. Vařecha M, Potěšilová M, Matula P, Kozubek M; ''Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis.''; Mol Cell Biochem, 2012 PubMed Europe PMC Scholia
  17. Barbaro G; ''HIV-associated cardiomyopathy etiopathogenesis and clinical aspects.''; Herz, 2005 PubMed Europe PMC Scholia
  18. Badorff C, Lee GH, Knowlton KU; ''Enteroviral cardiomyopathy: bad news for the dystrophin-glycoprotein complex.''; Herz, 2000 PubMed Europe PMC Scholia
  19. Blyszczuk P, Kania G, Dieterle T, Marty RR, Valaperti A, Berthonneche C, Pedrazzini T, Berger CT, Dirnhofer S, Matter CM, Penninger JM, Lüscher TF, Eriksson U; ''Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy.''; Circ Res, 2009 PubMed Europe PMC Scholia
  20. Yu SW, Andrabi SA, Wang H, Kim NS, Poirier GG, Dawson TM, Dawson VL; ''Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  21. Marash L, Kimchi A; ''DAP5 and IRES-mediated translation during programmed cell death.''; Cell Death Differ, 2005 PubMed Europe PMC Scholia
  22. Holcik M, Sonenberg N; ''Translational control in stress and apoptosis.''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  23. Chau, D., Yuan, J., Zhang, H., et al.; ''''; , 2007 PubMed Europe PMC Scholia
  24. ''Detection of Coxsackie-B-virus-specific RNA sequences in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy.''; Lancet, 1986 PubMed Europe PMC Scholia
  25. Twu C, Liu NQ, Popik W, Bukrinsky M, Sayre J, Roberts J, Rania S, Bramhandam V, Roos KP, MacLellan WR, Fiala M; ''Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC Scholia
  26. Zhang Y, Schneider RJ; ''Adenovirus inhibition of cell translation facilitates release of virus particles and enhances degradation of the cytokeratin network.''; J Virol, 1994 PubMed Europe PMC Scholia
  27. Tschöpe C, Müller I, Xia Y, Savvatis K, Pappritz K, Pinkert S, Lassner D, Heimesaat MM, Spillmann F, Miteva K, Bereswill S, Schultheiss HP, Fechner H, Pieske B, Kühl U, Van Linthout S; ''NOD2 (Nucleotide-Binding Oligomerization Domain 2) Is a Major Pathogenic Mediator of Coxsackievirus B3-Induced Myocarditis.''; Circ Heart Fail, 2017 PubMed Europe PMC Scholia
  28. Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL, Finberg RW; ''Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5.''; Science, 1997 PubMed Europe PMC Scholia
  29. Fentzke RC, Korcarz CE, Lang RM, Lin H, Leiden JM; ''Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart.''; J Clin Invest, 1998 PubMed Europe PMC Scholia
  30. Leiden JM; ''The genetics of dilated cardiomyopathy--emerging clues to the puzzle.''; N Engl J Med, 1997 PubMed Europe PMC Scholia
  31. Barry WH; ''Mechanisms of immune-mediated myocyte injury.''; Circulation, 1994 PubMed Europe PMC Scholia
  32. Liu X, Zou H, Slaughter C, Wang X; ''DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis.''; Cell, 1997 PubMed Europe PMC Scholia
  33. Sutterwala FS, Haasken S, Cassel SL; ''Mechanism of NLRP3 inflammasome activation.''; Ann N Y Acad Sci, 2014 PubMed Europe PMC Scholia
  34. Calandria, C., Irurzun, A., Barco, A., Carrasco, L.; ''''; , 2004 PubMed Europe PMC Scholia
  35. Seipelt J, Liebig HD, Sommergruber W, Gerner C, Kuechler E; ''2A proteinase of human rhinovirus cleaves cytokeratin 8 in infected HeLa cells.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  36. Afanasyeva M, Georgakopoulos D, Rose NR; ''Autoimmune myocarditis: cellular mediators of cardiac dysfunction.''; Autoimmun Rev, 2004 PubMed Europe PMC Scholia
  37. Wang, X., Bergelson, J.M.; ''Coxsackievirus and adenovirus receptor cytoplasmic and transmembrane domains are not essential for coxsackievirus and adenovirus infection.''; J. Virol, 1999 PubMed Europe PMC Scholia
  38. Huber M, Watson KA, Selinka HC, Carthy CM, Klingel K, McManus BM, Kandolf R; ''Cleavage of RasGAP and phosphorylation of mitogen-activated protein kinase in the course of coxsackievirus B3 replication.''; J Virol, 1999 PubMed Europe PMC Scholia
  39. Wu X, Deng Y; ''Bax and BH3-domain-only proteins in p53-mediated apoptosis.''; Front Biosci, 2002 PubMed Europe PMC Scholia
  40. Esfandiarei, M., McManus, B.M.; ''Molecular Biology and Pathogenesis of Viral Myocarditis; Annual Review of Pathology ''; Mechanisms of Disease, 2008 PubMed Europe PMC Scholia
  41. Liu QN, Reddy S, Sayre JW, Pop V, Graves MC, Fiala M; ''Essential role of HIV type 1-infected and cyclooxygenase 2-activated macrophages and T cells in HIV type 1 myocarditis.''; AIDS Res Hum Retroviruses, 2001 PubMed Europe PMC Scholia
  42. Bewley MC, Springer K, Zhang YB, Freimuth P, Flanagan JM; ''Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR.''; Science, 1999 PubMed Europe PMC Scholia
  43. He Y, Chipman PR, Howitt J, Bator CM, Whitt MA, Baker TS, Kuhn RJ, Anderson CW, Freimuth P, Rossmann MG; ''Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor.''; Nat Struct Biol, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134291view05:51, 20 July 2024EgonwRemoved template comments
128817view22:15, 22 February 2024EweitzOntology Term : 'CD4-positive, alpha-beta T cell' added !
128816view22:14, 22 February 2024EweitzOntology Term : 'CD8-positive, alpha-beta T cell' added !
128815view22:13, 22 February 2024EweitzOntology Term : 'professional antigen presenting cell' added !
128814view22:13, 22 February 2024EweitzOntology Term : 'B cell' added !
123508view05:00, 29 July 2022EgonwMade a pathway clickable
121698view03:38, 26 February 2022EweitzFix gene symbol
120527view02:02, 11 December 2021EweitzModified description
120524view00:19, 11 December 2021EweitzRefine graphics and labels
119226view18:37, 22 June 2021Finterlyadded PMID and DOI
116591view16:29, 8 May 2021EweitzModified title
110705view14:12, 28 May 2020Fehrhartadded label instead of node for mature secreted forms
110701view14:09, 28 May 2020Fehrhartreplaced antigen nodes with labels
110696view13:58, 28 May 2020Fehrhartupdated virus labels
110235view14:00, 29 April 2020EgonwNot a mim-conversion
109212view15:10, 27 February 2020FehrhartILK identifier
109211view15:01, 27 February 2020Fehrhartadeno virus particle
109209view14:34, 27 February 2020Marvin M2Converted line to graphical line
107305view14:37, 19 September 2019EgonwRemove an empty ChEBI identifier
107166view14:25, 17 September 2019MaintBotChEBI identifier normalization
106151view12:04, 16 August 2019MaintBotHMDB identifier normalization
98082view18:38, 17 July 2018Khanspersone more author name
98081view18:36, 17 July 2018Khanspersremoved empty comment field
98080view18:31, 17 July 2018Khanspersone more author name
98079view18:30, 17 July 2018Khanspersfixing faulty rendering of author names
98072view15:15, 16 July 2018Fehrhartadded some annotations
98071view14:37, 16 July 2018FehrhartModified description
97885view18:39, 17 June 2018Olivier.traetsupdated mim-interactions
97880view10:01, 14 June 2018Olivier.traetsUpdated cascade annotations
97878view09:19, 13 June 2018Olivier.traetsModified description
97845view20:59, 10 June 2018Olivier.traetsupdated secondary to primary identifier
97844view19:52, 10 June 2018Olivier.traetsUpdated cascade anotations
97843view19:39, 10 June 2018Olivier.traetsUpdated anotation
97842view19:33, 10 June 2018Olivier.traetsChanged a secundary to a primary identifier
97716view09:23, 7 June 2018Olivier.traetsAdditional data nodes
97711view21:25, 6 June 2018Olivier.traetsAdded complementary proteins
97708view13:56, 6 June 2018Olivier.traetsVisual update
97707view12:02, 6 June 2018Olivier.traetsVisual changes
97706view11:56, 6 June 2018Olivier.traetsVisual changes
97696view09:17, 3 June 2018EgonwModified title
97685view15:05, 1 June 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
97615view11:45, 30 May 2018FehrhartOntology Term : 'viral infectious disease' added !
97614view11:44, 30 May 2018FehrhartOntology Term : 'cardiac muscle cell' added !
97613view11:43, 30 May 2018FehrhartOntology Term : 'myocarditis' added !
97612view11:43, 30 May 2018FehrhartOntology Term : 'myocarditis pathway' added !
97611view11:42, 30 May 2018FehrhartOntology Term : 'cardiomyopathy pathway' added !
97610view11:41, 30 May 2018FehrhartOntology Term : 'disease pathway' added !
97597view15:56, 28 May 2018Olivier.traetsModified title
97596view15:56, 28 May 2018Olivier.traetsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
135 S A-particleRna
2A^PROGeneProductMulders MN, Lipskaya GY, van der Avoort HG, Koopmans MP, Kew OM, van Loon AM.

Molecular epidemiology of wild poliovirus type 1 in Europe, the Middle East, and the Indian subcontinent. J Infect Dis 1995;171:1399-1405. 34. Mulders MN, Salminen M, Kalkkinen N, Hovi T. Molecular epidemiology of coxsackievirus B4 and disclosure of the correct VP1/2A(pro) cleavage site: evidence for high genomic diversity and long-term endemicity of distinct genotypes. J Gen Virol 2000;81 Part 3:803-812. 35. Rico-Hesse R, Pallansch MA, Nottay BK, Kew OM. Geographic distribution of wild poliovirus

type 1 genotypes. Virology 1987;160:311-322.
3C^PROGeneProduct
ABL1GeneProductENSG00000097007 (Ensembl)
ABL2GeneProductENSG00000143322 (Ensembl)
ACTBGeneProductENSG00000075624 (Ensembl)
AIF1GeneProductENSG00000204472 (Ensembl)
AKT1GeneProductENSG00000142208 (Ensembl)
ATF-2ProteinP16951 (Uniprot-TrEMBL)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BCL2L1GeneProductENSG00000171552 (Ensembl) BCL-XL
BH3 BidProteinA8ASI8 (Uniprot-TrEMBL)
BNIP2GeneProductENSG00000140299 (Ensembl)
CAAP1GeneProductENSG00000120159 (Ensembl)
CAR CXADRProteinENSG00000154639 (Ensembl)
CASP2GeneProductENSG00000106144 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP6GeneProductENSG00000138794 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP8ProteinENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CAV1GeneProductENSG00000105974 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CCR3GeneProductENSG00000183625 (Ensembl)
CCR5GeneProductENSG00000160791 (Ensembl)
CD40LGGeneProductENSG00000102245 (Ensembl)
CD4GeneProductENSG00000010610 (Ensembl)
CD55GeneProductENSG00000196352 (Ensembl)
CD80GeneProductENSG00000121594 (Ensembl)
CHRAC1GeneProductENSG00000104472 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
CXCR4GeneProductENSG00000121966 (Ensembl)
CYCSGeneProductENSG00000172115 (Ensembl)
Ca2+MetaboliteHMDB0000464 (HMDB)
Catenin beta-1ProteinE9PW26 (Uniprot-TrEMBL)
Cd28GeneProduct12487 (Entrez Gene)
DAFProteinA0A1U8D6D6 (Uniprot-TrEMBL) Dispensible for productive replication
DAG1-BGeneProduct1605 (Entrez Gene)
DAG1-aGeneProductENSG00000173402 (Ensembl)
DAP5GeneProductENSG00000110321 (Ensembl)
DFFA/ICADGeneProductENSG00000160049 (Ensembl)
DFFB-45 GeneProductENSG00000169598 (Ensembl)
DMDGeneProductENSG00000198947 (Ensembl)
DystrophinProteinA2A9Z1 (Uniprot-TrEMBL)
ECM-receptor interactionPathwayhsa04512 (KEGG Pathway)
EIF4G1GeneProductENSG00000114867 (Ensembl)
EIF4G2GeneProductENSG00000110321 (Ensembl)
ENDOGGeneProductENSG00000167136 (Ensembl)
Endothelin-1ProteinP05305 (Uniprot-TrEMBL)
FYNGeneProductENSG00000010810 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
HIV
HLA-DMAGeneProductENSG00000204257 (Ensembl)
Herbimycin AMetaboliteCHEBI:5674 (ChEBI)
IFNGGeneProductENSG00000111537 (Ensembl)
IL10GeneProductENSG00000136634 (Ensembl)
IL12AGeneProductENSG00000168811 (Ensembl)
IL12BGeneProductENSG00000113302 (Ensembl)
IL1ProteinG3V169 (Uniprot-TrEMBL)
IL1GeneProductPF00340 (Pfam) IL1 protein family
IL2ProteinP60568 (Uniprot-TrEMBL)
IL6 GeneProductENSG00000136244 (Ensembl)
ILKGeneProductENSG00000166333 (Ensembl)
ITGALGeneProductENSG00000005844 (Ensembl)
ITGB2GeneProductENSG00000160255 (Ensembl)
IgGGeneProduct
JAK1GeneProductENSG00000162434 (Ensembl)
JNK1 ProteinA0A087WVY6 (Uniprot-TrEMBL)
KRT8GeneProductENSG00000170421 (Ensembl)
LAMA2GeneProductENSG00000196569 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl) alternative name ERK2
MAPK3GeneProductENSG00000102882 (Ensembl) alternative name ERK1
MEK 1/2Protein
MHC-1 ProteinA0A024RCL3 (Uniprot-TrEMBL)
MHCII Protein
MK2Protein
MKK 3/6Protein
MKK 4/7Protein
MMP9GeneProductENSG00000100985 (Ensembl)
MYH6GeneProductENSG00000197616 (Ensembl)
Macrophage GeneProduct
Myocarditis Pathwaymap05416 (KEGG Pathway)
NF-kBGeneProduct
NFkBGeneProductENSG00000077150 (Ensembl)
NLRP3GeneProduct
NOD2ProteinE9PLF7 (Uniprot-TrEMBL)
Nitric oxide synthaseProteinB3VK56 (Uniprot-TrEMBL)
PABPC1GeneProductENSG00000070756 (Ensembl)
PARMetabolite
PARP1GeneProductENSG00000143799 (Ensembl)
PIK3GeneProductENSG00000145675 (Ensembl)
PTCRAGeneProductENSG00000171611 (Ensembl)
PYCARDGeneProductENSG00000103490 (Ensembl) Adaptor protein ASC
Perforin-1ProteinP10820 (Uniprot-TrEMBL)
Pro-IL-18GeneProduct
ProteasomePathwayhsa03050 (KEGG Pathway)
RAC2GeneProductENSG00000128340 (Ensembl)
RAC3GeneProductENSG00000169750 (Ensembl)
RAF-1MetaboliteHMDB0003213 (HMDB)
RASA1GeneProductENSG00000145715 (Ensembl)
SGCAGeneProductENSG00000108823 (Ensembl)
SGCBGeneProductENSG00000163069 (Ensembl)
SGCDGeneProductENSG00000170624 (Ensembl)
SGCGGeneProductENSG00000102683 (Ensembl)
SOCS1GeneProductENSG00000185338 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SRCProteinENSG00000197122 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
T cell receptor alpha chain V regionGeneProduct
T-cell receptor beta chain V regionGeneProduct
TGFB1GeneProductENSG00000105329 (Ensembl)
TICAM1GeneProductTICAM1 (HGNC)
TLR3GeneProductENSG00000164342 (Ensembl)
  • low expression
  • Type your comment here
TLR4GeneProductENSG00000136869 (Ensembl)
  • low expression
  • Type your comment here
TLR5GeneProductENSG00000187554 (Ensembl)
  • high expression
  • Type your comment here
TNF-aProteinENSG00000232810 (Ensembl)
TNFRSM5ProteinP27512 (Uniprot-TrEMBL)
Tyrosine Kinase Protein
Viral entry CVB3GeneProduct
antigen
c-JunProteinQ9WVI9 (Uniprot-TrEMBL)
cardiac antigens
cd86 ProteinD3Z363 (Uniprot-TrEMBL)
ganglioside GM1MetaboliteCHEBI:18216 (ChEBI)
glycophosphatidylinositol
hsp27Protein
matrix metalloproteinasesProtein
mature secreted forms
p53ProteinA0A0R4J1K8 (Uniprot-TrEMBL)
peptidoglycan muramyl dipeptideGeneProduct
pro-IL-1betaGeneProduct
prostaglandin E2MetaboliteCHEBI:606564 (ChEBI)
reactive oxygen species generatorsMetaboliteCHEBI:70982 (ChEBI)
striated muscle contractionPathwayWP383 (WikiPathways)
viral antigens

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4298"
Personal tools