Adverse outcome pathway for mitochondrial complex 1 (C1) inhibition (Homo sapiens)
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Description
Adverse Outcome Pathway (AOP) network for mitochondrial Complex 1 (C1) inhibition leading to adverse outcomes in kidney, brain and liver.
Adverse Outcome Pathways (AOPs), in general, are defined as a sequence of key events that begins with a molecular initiating event (MIE) and leads to an Adverse Outcome. At that level, AOPs are described in the AOPWiki. This AOP network is based on 3 AOPs: AOPwiki:3, AOPwiki:273 and AOPwiki:276.
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Ontology Terms
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| Apoptosis | Pathway | WP1772 (WikiPathways)  | |
| Autophagy | Pathway | WP4923 (WikiPathways) | |
| Decreased mitochondrial oxidative phosphorylation | Pathway | WP111 (WikiPathways) | |
| Decreased proximal tubule vectorial transport | Pathway | WP4917 (WikiPathways) | |
| Degeneration of DA neurons of nigrostratial pathway | Pathway | WP2855 (WikiPathways) | |
| Deguelin | Metabolite | CHEBI:4357 (ChEBI) | |
| Ferroptosis | Pathway | WP4313 (WikiPathways) | |
| Impaired proteostasis | Pathway | WP4918 (WikiPathways) | |
| Increased ROS | Pathway | WP3941 (WikiPathways) | |
| Inhibition of mitochondrial Complex I | Pathway | WP4324 (WikiPathways) | |
| Necrosis | Pathway | WP3383 (WikiPathways) | |
| Neuroinflammation | Pathway | WP4919 (WikiPathways) | |
| Parkinsonian motor deficits | Pathway | WP2371 (WikiPathways) | |
| Rotenone | Metabolite | CHEBI:28201 (ChEBI) | |
| UPR | Pathway | WP4925 (WikiPathways) |
Annotated Interactions
No annotated interactions
