RuMP cycle, oxidative branch of the pentose phosphate pathway and formaldehyde assimilation (Saccharomyces cerevisiae)

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1-34-64, 64-6All metabolites in pink circle are part of the "Oxidative Branch of the Pentose Phosphate Pathway"formateSFA1D-arabino-3-Hexulose 6-phosphateS-formylglutathione hydrolaseZWF1S-hydroxymethylglutathioneNADHformaldehydeGND2ribulose-5-phosphatefructose-6-phosphateFDH1NADHS-formylglutathioneCO2NADPHSOL4SOL3H2OglutathioneGND1glucose-6-phosphate6-phospho-D-gluconateNADPH6-phosphono-D-glucono-lactoneNADCO2NADPH+NADPHH+H+H+NADPglutathioneH2O


Description

The reactions of the oxidative branch of the pentose phosphate pathway occur in the cytosol and are important for generating NADPH through the oxidative reduction of NADP+. NADPH is an important source of the reducing energy required by many enzymes in central biosynthetic pathways. Although there are other biochemical pathways that generate NADPH in yeast, the pentose phosphate pathway is considered the major source of NADPH, and insufficient NADPH probably contributes to the fitness defects seen in mutants of the oxidative branch of the pentose phosphate pathway.

Comments

GenMAPP remarks 
Based on http://pathway.yeastgenome.org/biocyc/

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Ontology Terms

 

Bibliography

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  1. Grey M, Schmidt M, Brendel M; ''Overexpression of ADH1 confers hyper-resistance to formaldehyde in Saccharomyces cerevisiae.''; Curr Genet, 1996 PubMed Europe PMC Scholia
  2. Degrassi G, Uotila L, Klima R, Venturi V; ''Purification and properties of an esterase from the yeast Saccharomyces cerevisiae and identification of the encoding gene.''; Appl Environ Microbiol, 1999 PubMed Europe PMC Scholia
  3. Achkor H, Díaz M, Fernández MR, Biosca JA, Parés X, Martínez MC; ''Enhanced formaldehyde detoxification by overexpression of glutathione-dependent formaldehyde dehydrogenase from Arabidopsis.''; Plant Physiol, 2003 PubMed Europe PMC Scholia
  4. Sinha A, Maitra PK; ''Induction of specific enzymes of the oxidative pentose phosphate pathway by glucono-delta-lactone in Saccharomyces cerevisiae.''; J Gen Microbiol, 1992 PubMed Europe PMC Scholia
  5. Stanford DR, Whitney ML, Hurto RL, Eisaman DM, Shen WC, Hopper AK; ''Division of labor among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism.''; Genetics, 2004 PubMed Europe PMC Scholia
  6. Nogae I, Johnston M; ''Isolation and characterization of the ZWF1 gene of Saccharomyces cerevisiae, encoding glucose-6-phosphate dehydrogenase.''; Gene, 1990 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
111625view04:34, 31 August 2020EgonwModified title
96437view07:53, 15 March 2018EgonwReplaced another secondary ChEBI identifier with a primary identifier.
96370view09:28, 10 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
94154view13:21, 24 August 2017DeSlAdded lit. refs from PW417 to this PW
94153view13:17, 24 August 2017DeSlOntology Term : 'pentose phosphate pathway - oxidative phase' added !
94152view13:16, 24 August 2017DeSlAdded visualisation for Oxidative Branch of the Pentose Phosphate Pathway, in order to remove double content from WP417
94151view13:14, 24 August 2017DeSlModified title
94147view11:59, 24 August 2017DeSlAnnotated last missing node (CO2)
94146view11:57, 24 August 2017DeSlAdded missing IDs
94145view11:47, 24 August 2017DeSlModified description
94144view11:45, 24 August 2017DeSlAdded node for 6-phosphone-D-glucono-lactone in cycle, which was missing before. Added literature references. Combined two lose PWs into one. Added nodes between formaldehyde and formate reaction, which where missing before.
89664view05:47, 24 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
71344view18:01, 17 October 2013MaintBotAutomated update of data sources
71015view19:37, 22 September 2013EgonwConverted metabolite Labelss into DataNodes and added a few ChemSpider IDs.
69855view17:13, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69614view20:33, 8 July 2013MaintBotUpdated to 2013 gpml schema
67631view11:35, 26 June 2013DdiglesOntology Term : 'RuMP pathway of formaldehyde assimilation' added !
41847view04:50, 2 March 2011MaintBotRemoved redundant pathway information and comments
21377view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:RuMP cycle Formaldehyde Assimilation]] moved to [[Pathway:WP332]]: Moved to stable identifier
12836view08:04, 17 May 2008MaintBotautomated metabolite conversion
8912view14:12, 7 January 2008MaintBotAdded to category $category
8910view14:12, 7 January 2008J.HeckmanUploaded new pathway

External references

DataNodes

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NameTypeDatabase referenceComment
6-phospho-D-gluconateMetaboliteCHEBI:58759 (ChEBI)
6-phosphono-D-glucono-lactoneMetaboliteCHEBI:16938 (ChEBI)
CO2MetaboliteCHEBI:16526 (ChEBI)
D-arabino-3-Hexulose 6-phosphateMetaboliteCHEBI:27973 (ChEBI)
FDH1GeneProductS000005915 (SGD)
GND1GeneProductS000001226 (SGD)
GND2GeneProductS000003488 (SGD)
H+Metabolite1010 (Chemspider)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
NADMetaboliteCHEBI:13389 (ChEBI)
NADHMetabolite53-84-9 (CAS)
NADPMetaboliteCHEBI:44409 (ChEBI)
NADPHMetabolite53-57-6 (CAS)
NADPHMetaboliteCHEBI:16474 (ChEBI)
S-formylglutathione hydrolaseProteinP40363 (Uniprot-TrEMBL)
S-formylglutathioneMetaboliteCHEBI:16225 (ChEBI)
S-hydroxymethylglutathioneMetaboliteCHEBI:48926 (ChEBI)
SFA1GeneProductYDL168W (Ensembl)
SOL3GeneProductYHR163W (Ensembl)
SOL4GeneProductYGR248W (Ensembl)
ZWF1GeneProductYNL241C (Ensembl)
formaldehydeMetabolite50-00-0 (CAS)
formateMetaboliteCHEBI:15740 (ChEBI)
fructose-6-phosphateMetabolite643-13-0 (CAS)
glucose-6-phosphateMetabolite59-56-3 (CAS)
glutathioneMetaboliteCHEBI:57925 (ChEBI)
ribulose-5-phosphateMetabolite4151-19-3 (CAS)

Annotated Interactions

No annotated interactions
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