Oxidative damage response (Homo sapiens)

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Cell survivalC4aActivator of Cell DeathC4b/2aGSHCell lysis and clearanceFormation of apoptotic bodiesInhibitor of Cell DeathProteasomeC3b/4b, C3b, C3dAdaptive response in liverROSC3bMembrane lysis complexNf-kB pathwayComplement activationMuscle contraction,Chemotaxis,Phagocyte recruitment,Inflammation etcInduction of antioxidant genes(classical pathway)Mitochondrial pathwayC5aStressC3-convertaseC3aLiver regenerationROSMAP2K4BAK1CDC42DNA ReplicationCYCSTDP2CASP3MAP3K9NFKBIEMAPK13CDKN1BTRAF3C1STNFTNK2C5TRAF1C3AR1NFKB1APAF1CDKN1AC2CR2C1QAMAPK10TRAF6C5AR1PCNATRAF2CDKN1CCyctBADMAP3K1Oxidative stressGADD45AApoptosisC4BBCL2C1QCTNFRSF1BC1QBC1RBAG4CASP9


Description

This pathway shows how tissue is damaged when oxygen levels are not balanced and become too high.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "Oxidative Damage", WP1496 revision 90169, with a 97.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
128368view23:29, 2 February 2024EweitzUpgrade legend
128367view23:04, 2 February 2024EweitzLicense is CC0
128366view23:03, 2 February 2024EweitzEnlarge tiny text, economize layout, standardize case
123242view18:42, 6 July 2022EgonwMade three pathways clickable
117040view14:12, 16 May 2021EweitzModified title
106568view21:15, 6 September 2019KhanspersModified description
105771view19:39, 15 August 2019KhanspersModified description
94696view23:22, 4 October 2017KhanspersModified description
94695view23:22, 4 October 2017Khanspersremoved GenMAPP notes
90810view18:32, 14 December 2016KhanspersOntology Term : 'oxidative stress response pathway' added !
90809view18:30, 14 December 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APAF1GeneProductENSG00000120868 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11783
ApoptosisPathwayWP1254 (WikiPathways)
BADGeneProductENSG00000002330 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12015
BAG4GeneProductENSG00000156735 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67384
BAK1GeneProductENSG00000030110 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12018
BCL2GeneProductENSG00000171791 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12043
C1QAGeneProductENSG00000173372 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12259
C1QBGeneProductENSG00000173369 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12260
C1QCGeneProductENSG00000159189 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12262
C1RGeneProductENSG00000159403 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50909
C1SGeneProductENSG00000182326 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50908
C2GeneProductENSG00000166278 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12263
C3AR1GeneProductENSG00000171860 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12267
C4BGeneProductENSG00000224389 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12268
C5AR1GeneProductENSG00000197405 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12273
C5GeneProductENSG00000106804 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15139
CASP3GeneProductENSG00000164305 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12367
CASP9GeneProductENSG00000132906 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12371
CDC42GeneProductENSG00000070831 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12540
CDKN1AGeneProductENSG00000124762 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12575
CDKN1BGeneProductENSG00000111276 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12576
CDKN1CGeneProductENSG00000129757 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12577
CR2GeneProductENSG00000117322 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12902
CYCSGeneProductENSG00000172115 (Ensembl)
  • Rel,Nup93,Nrf1,Them2,Syap1,Zfp259,2700059L22Rik,,Cotl1
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13063
CyctGeneProductNo homologues found for original id L:13067
DNA ReplicationPathwayWP150 (WikiPathways)
GADD45AGeneProductENSG00000116717 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13197
MAP2K4GeneProductENSG00000065559 (Ensembl)
  • Xbp1,Mapk10,Klhl8,Mapk10
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26398
MAP3K1GeneProductENSG00000095015 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26401
MAP3K9GeneProductENSG00000006432 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:338372
MAPK10GeneProductENSG00000109339 (Ensembl)
  • Map2k4,Nlk,Fos,Fzd7,Jund1,ORF19,Map2k4,Dhodh,Map3k7,Dvl3,Eda,Rac1,Jup,Mllt4,Mink1,Myef2,Dusp10,Rala,Etv6,Frk,Wee1,Rexo1
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26414
MAPK13GeneProductENSG00000156711 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26415
NFKB1GeneProductENSG00000109320 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18033
NFKBIEGeneProductENSG00000146232 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18037
Oxidative stressPathwayWP412 (WikiPathways)
PCNAGeneProductENSG00000132646 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18538
TDP2GeneProductENSG00000111802 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56196
TNFGeneProductENSG00000232810 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21926
TNFRSF1BGeneProductENSG00000028137 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21938
TNK2GeneProductENSG00000061938 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:51789
TRAF1GeneProductENSG00000056558 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22029
TRAF2GeneProductENSG00000127191 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22030
TRAF3GeneProductENSG00000131323 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22031
TRAF6GeneProductENSG00000175104 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22034

Annotated Interactions

No annotated interactions
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