Steroid biosynthesis (Homo sapiens)

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1***** Estradiol-17-beta DH = DHB* 3-beta-OH-delta-steroid DH & Steroid isomerase =**EstroneProgesteroneHSD3B1AndrostenediolHSD3B1Steroid-19-HydroxylaseDihydrotestosteroneHSD3B1Hydroxyprogesterone aldolaseHSD3B1HSD3B2CholesterolEstradioldehydroepiandrosteroneCYP17A1HSD3B1HSD3B1PregnenoloneHSD3B2HSD3B1HSD3B117-alpha-OH-PregnenoloneHSD17B3TestosteroneAndrostenedioneHSD17B7HSD17B4F13BCYP17A1HSD3B1HSD3B2HSD3B1HSD3B1HSD3B2HSD3B1HSD3B1HSD3B1HSD3B1Hydroxyprogesterone aldolaseHSD3B1HSD3B1Mineralocortocoid SynthesisGlucocortocoid SynthesisHSD3B1HSD3B117-alpha-OH-ProgesteroneHSD3B1HSD3B1HSD17B1HSD17B2Steroid-19-Hydroxylase


Description

Steroidogenesis is the biological process by which steroids are generated from cholesterol and transformed into other steroids. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Häggström M, Stannered, Hoffmeier, Settersr, Richfield, D; ''Diagram of the pathways of human steroidogenesis. doi:10.15347/wjm/2014.005''; WikiJournal of Medicine, 2014 DOI Scholia

History

View all...
CompareRevisionActionTimeUserComment
128960view19:56, 25 February 2024EweitzEconomize layout, standardize line style, case
119106view10:06, 17 June 2021FinterlyAdded DOI to PublicationXref
117831view15:09, 22 May 2021EweitzModified title
117281view10:46, 20 May 2021DeSlUpdated Shape around PW Nodes
115214view10:04, 5 February 2021EgonwWP237 was used twice, actually
115212view06:48, 5 February 2021EgonwUpdated a link to a now deleted pathway to a replacing existing pathway
106152view12:04, 16 August 2019MaintBotHMDB identifier normalization
105823view23:03, 15 August 2019KhanspersModified description
96053view16:22, 15 February 2018Mkutmonremoved old pathway attributes
96051view16:21, 15 February 2018Mkutmonadded literature reference
96050view16:19, 15 February 2018MkutmonModified description
69016view17:47, 8 July 2013MaintBotUpdated to 2013 gpml schema
59804view07:02, 8 March 2013EgonwFixed the metabolite name, to match the identifier (and not be a enzyme name)
59201view19:14, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
46559view00:16, 17 February 2012AlexanderPicoReverted to version '18:32, 6 October 2011' by AlexanderPico
46556view17:52, 16 February 2012AnatolymikutinSpecify description
46555view17:52, 16 February 2012AnatolymikutinSpecify description
46554view17:49, 16 February 2012AnatolymikutinPeriodical save, work in progress
45151view01:32, 7 October 2011AlexanderPicofixed db refs
45113view23:18, 6 October 2011KhanspersOntology Term : 'steroid hormone biosynthetic pathway' added !
41189view23:43, 1 March 2011MaintBotRemoved redundant pathway information and comments
38848view17:49, 24 September 2010Khanspers
38743view22:10, 23 September 2010KhanspersChanged layout
38742view22:09, 23 September 2010KhanspersPeriodical save, work in progress
34455view18:24, 10 December 2009MaintBotAutomatic update of empty xrefs
32448view17:20, 15 August 2009MaintBotFixed text labels
32122view13:52, 14 August 2009MaintBotFixed group labels
21722view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Steroid Biosynthesis]] moved to [[Pathway:WP496]]: Moved to stable identifier
14081view10:35, 21 May 2008MartijnVanIersellinked up, added metabolites
13121view11:17, 17 May 2008MaintBotautomated metabolite conversion
8408view13:46, 7 January 2008MaintBot[[Pathway:Human:Steroid Biosynthesis]] moved to [[Pathway:Homo sapiens:Steroid Biosynthesis]]: Renaming species
7821view16:20, 18 December 2007MaintBotfixed category names
7398view12:42, 4 November 2007MaintBotAdded categories to GPML
6393view22:18, 22 May 2007A.Kwagpml file for [[Human:Steroid_Biosynthesis]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
17-alpha-OH-PregnenoloneMetaboliteHMDB0000363 (HMDB)
17-alpha-OH-ProgesteroneMetaboliteHMDB0000374 (HMDB)
AndrostenediolMetaboliteHMDB0005849 (HMDB)
AndrostenedioneMetabolite63-05-8 (CAS)
CYP17A1GeneProduct1586 (Entrez Gene)
CholesterolMetabolite57-88-5 (CAS)
DihydrotestosteroneMetaboliteHMDB0002961 (HMDB)
EstradiolMetabolite57-91-0 (CAS)
EstroneMetabolite53-16-7 (CAS)
F13BGeneProduct2165 (Entrez Gene)
Glucocortocoid SynthesisPathwayWP4523 (WikiPathways)
HSD17B1GeneProduct3292 (Entrez Gene)
HSD17B2GeneProduct3294 (Entrez Gene)
HSD17B3GeneProduct3293 (Entrez Gene)
HSD17B4GeneProduct3295 (Entrez Gene)
HSD17B7GeneProduct51478 (Entrez Gene)
HSD3B1GeneProduct3283 (Entrez Gene)
HSD3B2GeneProduct3284 (Entrez Gene)
Hydroxyprogesterone aldolaseGeneProduct4.1.2.30 (Enzyme Nomenclature)
Mineralocortocoid SynthesisPathwayWP4523 (WikiPathways)
PregnenoloneMetabolite145-13-1 (CAS)
ProgesteroneMetabolite57-83-0 (CAS)
Steroid-19-HydroxylaseGeneProductENSG00000120054 (Ensembl)
TestosteroneMetabolite58-22-0 (CAS)
dehydroepiandrosteroneMetabolite53-43-0 (CAS)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP496"
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