Hypoxia-dependent differentiation of myoblasts (Mus musculus)

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Notch-pathwayMYHPHD2MYOGHIF1ANCDKN1A24122166MYF5HIF1AMyotube survivalHypoxiamiR210TP53MYF6VEGFWNT canoncialpathwayCDNK1BBHLHE40MAPK143097021422006022309702142200602230970214220060222646827626468276264682762520831197211361972113677917892314821015104534, 28901388, 116412741829957817395396HGF


Description

HIF1A modulates myogenic differentiation in hypoxia. Black arrow: activation of the signaling pathway/ protein/ molecule. Blunt red arrow: inhibition of the signaling path-way/ protein/ molecule. Round blue arrow: Interaction between two pathways.

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Ontology Terms

 

Bibliography

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  1. Flann KL, Rathbone CR, Cole LC, Liu X, Allen RE, Rhoads RP; ''''; , PubMed Europe PMC Scholia
  2. Li Y, Liu Y, Lu Y, Zhao B; ''''; , PubMed Europe PMC Scholia
  3. Li X, Zhu L, Chen X, Fan M; ''''; , PubMed Europe PMC Scholia
  4. Wang C, Liu W, Liu Z, Chen L, Liu X, Kuang S; ''''; , PubMed Europe PMC Scholia
  5. Guo K, Wang J, Andrés V, Smith RC, Walsh K; ''''; , PubMed Europe PMC Scholia
  6. Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, Jelkmann W, Jaakkola P, Metzen E; ''''; , PubMed Europe PMC Scholia
  7. Kim HW, Haider HK, Jiang S, Ashraf M; ''''; , PubMed Europe PMC Scholia
  8. Majmundar AJ, Skuli N, Mesquita RC, Kim MN, Yodh AG, Nguyen-McCarty M, Simon MC; ''''; , PubMed Europe PMC Scholia
  9. Cicchillitti L, Di Stefano V, Isaia E, Crimaldi L, Fasanaro P, Ambrosino V, Antonini A, Capogrossi MC, Gaetano C, Piaggio G, Martelli F; ''''; , PubMed Europe PMC Scholia
  10. Mahon PC, Hirota K, Semenza GL; ''''; , PubMed Europe PMC Scholia
  11. Sinha KM, Tseng C, Guo P, Lu A, Pan H, Gao X, Andrews R, Eltzschig H, Huard J; ''''; , PubMed Europe PMC Scholia
  12. Zheng X, Linke S, Dias JM, Gradin K, Wallis TP, Hamilton BR, Gustafsson M, Ruas JL, Wilkins S, Bilton RL, Brismar K, Whitelaw ML, Pereira T, Gorman JJ, Ericson J, Peet DJ, Lendahl U, Poellinger L; ''''; , PubMed Europe PMC Scholia
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History

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CompareRevisionActionTimeUserComment
128730view02:53, 21 February 2024EweitzUpgrade disease node, economize layout, standardize case
126537view09:50, 29 May 2023EgonwTyped two datanodes
119057view23:50, 13 June 2021KhanspersOntology Term : 'Wnt signaling pathway' added !
119056view23:50, 13 June 2021KhanspersOntology Term : 'Notch signaling pathway' added !
118849view09:43, 2 June 2021ExperiMedadded full references
118822view08:36, 2 June 2021ExperiMedmoved PMID as references to the interactions
117897view10:25, 23 May 2021EweitzModified title
117896view10:24, 23 May 2021EweitzOntology Term : 'myoblast' added !
115691view13:20, 4 March 2021DeSlOntology Term : 'regulatory pathway' added !
114005view14:47, 17 December 2020LaurentConnected lines
113997view12:57, 16 December 2020ExperiMedNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
15104534, 28901388, 11641274
30970214 22006022
BHLHE40GeneProduct20893 (Entrez Gene)
CDKN1AGeneProduct12575 (Entrez Gene)
CDNK1BGeneProduct12576 (Entrez Gene)
HGFGeneProduct17928 (Entrez Gene)
HIF1AGeneProduct15251 (Entrez Gene)
HIF1ANGeneProduct319594 (Entrez Gene)
Hypoxia
MAPK14GeneProduct26416 (Entrez Gene)
MYF5GeneProduct17877 (Entrez Gene)
MYF6GeneProduct17878 (Entrez Gene)
MYHGeneProduct17879 (Entrez Gene)
MYOGGeneProduct17928 (Entrez Gene)
Myotube survival
Notch-pathwayGeneProduct18128 (Entrez Gene)
PHD2GeneProduct112405 (Entrez Gene)
TP53GeneProduct
VEGFGeneProduct22339 (Entrez Gene)
WNT canoncial pathwayPathway
miR210Rna
2520831
7791789
17395396
18299578
19721136
23148210
24122166
26468276

Annotated Interactions

No annotated interactions

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