Fatty acid biosynthesis (Caenorhabditis elegans)

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1Malonyl-ACPPalmitoyl-ACPButyryl-ACPAcetyl-synthaseAcetoacetyl-ACPTriacylglyceride SynthesisFatty acyl CoAMitochondrionTCA CycleCrotonoyl-ACPless than 6 iterations6 iterationsAcetyl-ACPAcyl-CoA (n+2)CytosolLong-Chain fatty acidECHDC23-ketoacyl-CoAF54C8.1fat-5D1005.1F32H2.5F32H2.5ech-6Y65B4BL.5Malonyl-CoAACSL5C36A4.9F32H2.5W09H1.5oxaloacetateF32H2.5ACACAPalmitateY25C1A.13F53C11.3Acetyl-CoAbeta-hydroxybutyrylcitrateThiolasespyruvateacs-17pyc-1C32E8.9ech-2F32H2.5F32H2.5F32H2.5F37C12.7PECRACACB3-L-Hydroxyacyl-CoAF32H2.5trans-delta2-enoyl-CoAACSL6


Description

The fatty acid synthesis of the roundworm C. Elegans is a highly conserved pathway evolutionary. This pathways is therefore of great importance to understand fat synthesis and nutrient sensing in adiposity regulation, which is key to understand the molecular mechanism behind obesity.

Comments

GenMAPP notes 
Updated from Kam Dahlquists original by Magali Jaillard, Marijke Vermeer, Michiel Adrieans, Ron Schormans and Chris Evelo

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Quality Tags

Ontology Terms

 

Bibliography

  1. Watts JL; ''Fat synthesis and adiposityregulation in Caenorhabditis elegans.''; Trends Endocrinol Metab, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125346view19:40, 3 February 2023AlexanderPicoremoved old genmapp comments
118560view11:57, 28 May 2021DeSlModified description
118559view11:54, 28 May 2021DeSlReconnected some proteins
118558view11:53, 28 May 2021DeSlAdded lit. ref., cleaned up comments in description
118557view11:51, 28 May 2021DeSlAdded PW DataNode IDs, converted textlabels to metabolites
118450view14:54, 27 May 2021Fehrhartconnected line, added metabolite identifiers and proper catalysis and anchors
118126view10:33, 25 May 2021EweitzModified title
109400view16:44, 16 March 2020L DupuisFixed interactions
73759view00:09, 22 February 2014MaintBotupdating schema
67240view10:25, 26 June 2013Christine ChichesterOntology Term : 'fatty acid biosynthetic pathway' added !
53642view10:54, 10 November 2012EgonwConnected more dots
53592view20:58, 9 November 2012EgonwConnecting dots...
53591view20:56, 9 November 2012EgonwReplaced multiple general nodes by Metabolite DataNode's.
40643view19:58, 1 March 2011MaintBotRemoved redundant pathway information and comments
20757view11:29, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:Fatty Acid Synthesis BiGCaT]] moved to [[Pathway:WP38]]: Moved to stable identifier
8564view14:03, 7 January 2008MaintBotAdded to category $category
19458view14:03, 7 January 2008EveloUploaded new pathway
8562view14:03, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3-L-Hydroxyacyl-CoAMetabolite
3-ketoacyl-CoAMetaboliteCHEBI:57347 (ChEBI)
ACACAGeneProduct
ACACBGeneProduct
ACSL5GeneProduct
ACSL6GeneProduct
Acetoacetyl-ACPMetabolite
Acetyl-ACPMetabolite
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
Acetyl-synthaseMetabolite
Acyl-CoA (n+2)Metabolite
Butyryl-ACPMetabolite
C32E8.9GeneProduct171951 (Entrez Gene)
C36A4.9GeneProduct175500 (Entrez Gene)
Crotonoyl-ACPMetabolite
D1005.1GeneProduct180485 (Entrez Gene)
ECHDC2GeneProduct
F32H2.5GeneProduct172715 (Entrez Gene)
F37C12.7GeneProduct176005 (Entrez Gene)
F53C11.3GeneProduct179872 (Entrez Gene)
F54C8.1GeneProduct186222 (Entrez Gene)
Fatty acyl CoAMetabolite
Long-Chain fatty acidMetabolite
Malonyl-ACPMetabolite
Malonyl-CoAMetaboliteHMDB01175 (HMDB)
PECRGeneProduct
PalmitateMetaboliteCHEBI:15756 (ChEBI)
Palmitoyl-ACPMetabolite
TCA CyclePathwayWP76 (WikiPathways)
ThiolasesGeneProduct176756 (Entrez Gene)
Triacylglyceride SynthesisPathwayWP212 (WikiPathways)
W09H1.5GeneProduct174963 (Entrez Gene)
Y25C1A.13GeneProduct173657 (Entrez Gene)
Y65B4BL.5GeneProduct171643 (Entrez Gene)
acs-17GeneProduct180859 (Entrez Gene)
beta-hydroxybutyrylMetabolite
citrateMetaboliteCHEBI:133748 (ChEBI)
ech-2GeneProduct3564942 (Entrez Gene)
ech-6GeneProduct176376 (Entrez Gene)
fat-5GeneProduct180162 (Entrez Gene)
oxaloacetateMetaboliteCHEBI:16452 (ChEBI)
pyc-1GeneProduct179616 (Entrez Gene)
pyruvateMetaboliteCHEBI:15361 (ChEBI)
trans-delta2-enoyl-CoAMetabolite

Annotated Interactions

No annotated interactions
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