Glucocorticoid and mineralcorticoid metabolism (Bos taurus)

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11b,17a 21-Trihydroxy-5bPregnane 3,20-dione5b-Pregnane-3,20-dione3a-OH-5b-Pregnane-20-oneGlucocorticoidsChemical structures shownfor metabolites in tealUrocortisolProgesterone Degradation17a,21-Dihydroxy-5b-17a,21-Dihydroxy-5b-Pregnane-3,11,20-trioneO11b, 21-Dihydroxy-3,20-5b-Pregnan-18-alGlucuronides11-DeoxycortisolUrocortisone3a,11b,21-Trihydroxy-20-Oxo-5b-Pregnan-18-alCorticosterone(R)20-hydroxysteroid DhCholesterol BiosynthesisCorticosterone 18-Monooxy17-OH-progesteroneCYP11A13-Oxo-5b-Steroid DhHSD3BCYP17A1Androgen Synthesis and MetabolismCYP21A2CortoloneHSD3B20b-Hydroxysteroid DhProgesteroneHSD11B23B-OH-delta-Steroid Dh11-DeoxycorticosteroneHSD11B1CYP11B2Steroid Hormone SignalingCortisone beta-reductaseCortisonePregnanediol17a-OH-pregnenoloneCholesterol18-HydroxycorticosteroneCortisolPregnenoloneHSD3BCYP17A1Cortisol3a-Hydroxysteroid Dh3a-Hydroxysteroid DhAldosterone


Description

Pathway should be updated after Human version is curated.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP237(78497) with a 55.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
118583view13:41, 28 May 2021EweitzModified title
113601view14:03, 4 November 2020DeSlUpdating IDs for cortisol to avoid duplicate mappings (2x)
113001view15:23, 29 October 2020DeSlModified description
113000view15:22, 29 October 2020DeSlReplaced character in title; removed structural drawings
105951view11:48, 16 August 2019MaintBotHMDB identifier normalization
80752view15:24, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(R)20-hydroxysteroid DhGeneProduct1.1.1.53, similiar SP:2BHD STREX
11-DeoxycorticosteroneMetabolite64-85-7 (CAS)
17-OH-progesteroneMetaboliteHMDB0000374 (HMDB)
17a-OH-pregnenoloneMetaboliteHMDB0000363 (HMDB)
18-HydroxycorticosteroneMetaboliteHMDB0000319 (HMDB)
20b-Hydroxysteroid DhGeneProduct1.1.1.53, similiar SP:2BHD STREX
3-Oxo-5b-Steroid DhGeneProduct
3B-OH-delta-Steroid DhGeneProduct
3a-Hydroxysteroid DhGeneProductSPs:DIDH RAT
AldosteroneMetabolite52-39-1 (CAS)
Androgen Synthesis and MetabolismPathwayWP496 (WikiPathways)
CYP11A1GeneProductENSBTAG00000006934 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1583
CYP11B2GeneProductENSBTAG00000004596 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1585
CYP17A1GeneProductENSBTAG00000014335 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1586
CYP21A2GeneProductENSBTAG00000047039 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1589
Cholesterol BiosynthesisPathwayWP197 (WikiPathways)
CholesterolMetabolite57-88-5 (CAS)
Corticosterone 18-MonooxyGeneProductEC number: 1.14.15.5
CorticosteroneMetabolite50-22-6 (CAS)
CortisolMetaboliteQ190875 (Wikidata)
Cortisone beta-reductaseGeneProduct1.3.1.3
CortisoneMetaboliteHMDB0002802 (HMDB)
CortoloneMetabolite516-42-7 (CAS)
HSD11B1GeneProductENSBTAG00000015086 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3290
HSD11B2GeneProductENSBTAG00000005685 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3291
HSD3BGeneProductENSBTAG00000006769 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3284
PregnanediolMetabolite80-92-2 (CAS)
PregnenoloneMetabolite145-13-1 (CAS)
ProgesteroneMetabolite57-83-0 (CAS)
Steroid Hormone SignalingPathwayWP496 (WikiPathways)

Annotated Interactions

No annotated interactions
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