Hepatocyte growth factor receptor signaling (Bos taurus)

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TrancriptionAKT PathwayTranscriptionof Cox2CytoplasmRAC1pathwayChanges in Cytoskeletonand Cell mobilityActinRight Click for CommentsAP-1ExtracellularTranscriptionAnoikisRHOpathwayCDC42pathwayPPPFOSPTPN11ELK1MAP4K1PXNMAPK1PIK3CAPAK1GRB2PXNMAPK8C-METPTK2BJUNSRCRAP1BCRKLGAB1SRCHRASSTAT3CRKPTENMAP2K2RAF1PTK2RAPGEF1RASA1MAPK3RAP1AMAP2K1ITGB1PTK2DOCK1HGFPTK2BITGA1SOS1


Description

Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion.

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP313(79946) with a 100.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Organ SL, Tsao MS; ''An overview of the c-MET signaling pathway.''; Ther Adv Med Oncol, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118734view10:48, 1 June 2021DeSlConverted 2 lines to GraphicalLine
118733view10:47, 1 June 2021DeSlAdded states iso textlabel P
118732view10:46, 1 June 2021DeSlConverted ReceptorSquare to MIMbinding with lit ref
118731view10:43, 1 June 2021DeSlAdded description from WP313
117607view11:38, 21 May 2021EweitzModified title
80800view15:26, 30 June 2015Mkutmonhomology conversion
63315view21:05, 9 May 2013MaintBotUpdated to 2013 gpml schema
40496view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
33740view23:55, 8 December 2009MaintBotAutomatic update of empty xrefs
32511view12:52, 17 August 2009MaintBotFixed text labels
32199view12:37, 15 August 2009MaintBotFixed text labels
31681view11:44, 14 August 2009MaintBotFixed group labels
31209view19:36, 13 August 2009MaintBotFixed text labels
30615view22:20, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
C-METGeneProductENSBTAG00000006161 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4233
CRKGeneProductENSBTAG00000005665 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1398
CRKLGeneProductENSBTAG00000045548 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1399
DOCK1GeneProductENSBTAG00000031890 (Ensembl)
  • Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1793
ELK1GeneProductENSBTAG00000015817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002
FOSGeneProductENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
GAB1GeneProductENSBTAG00000002813 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2549
GRB2GeneProductENSBTAG00000004736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
HGFGeneProductENSBTAG00000017664 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3082
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
ITGA1GeneProductENSBTAG00000016525 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3672
ITGB1GeneProductENSBTAG00000015910 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3688
JUNGeneProductENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
MAP2K1GeneProductENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2GeneProductENSBTAG00000024450 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAP4K1GeneProductENSBTAG00000021145 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11184
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3GeneProductENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MAPK8GeneProductENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
PAK1GeneProductENSBTAG00000010191 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5058
PIK3CAGeneProductENSBTAG00000009232 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
PTENGeneProductENSBTAG00000009498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5728
PTK2BGeneProductENSBTAG00000005958 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2185
PTK2GeneProductENSBTAG00000009578 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5747
PTPN11GeneProductENSBTAG00000002048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781
PXNGeneProductENSBTAG00000018108 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5829
RAF1GeneProductENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RAP1AGeneProductENSBTAG00000014710 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906
RAP1BGeneProductENSBTAG00000008967 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5908
RAPGEF1GeneProductENSBTAG00000020791 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2889
RASA1GeneProductENSBTAG00000009565 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5921
SOS1GeneProductENSBTAG00000011643 (Ensembl)
  • Son of sevenless homolog 1 (Drosophila) (predicted)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654
SRCGeneProductENSBTAG00000008938 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
STAT3GeneProductENSBTAG00000021523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1046"
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