Hepatocyte growth factor receptor signaling (Gallus gallus)

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AP-1PExtracellularCDC42pathwayPTranscriptionActinAKT PathwayPRHOpathwayTranscriptionof Cox2RAC1pathwayCytoplasmTrancriptionAnoikisChanges in Cytoskeletonand Cell mobilityELK1SOS1HGFPTENPXNCRKLCRKMAPK3JUNGAB1MetITGB1PTK2DOCK1RAPGEF1STAT3PTPN11PAK1GRB2RAF1RAP1BRASA1MAP4K1SRCPXNPTK2MAP2K2FOSRAP1APIK3CASRCMAP2K1HRASMAPK1MAPK8ITGA1PTK2BPTK2B


Description

Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion.

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP313(r21339) with a 78% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Organ SL, Tsao MS; ''An overview of the c-MET signaling pathway.''; Ther Adv Med Oncol, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118803view07:47, 2 June 2021DeSlConverted "P" textlabels to states
118802view07:46, 2 June 2021DeSlConverted ReceptorSquare to MIM binding with lit. ref.
118801view07:44, 2 June 2021DeSlRemoved textLabel
118800view07:44, 2 June 2021DeSlOntology Term : 'hepatocyte' added !
118799view07:43, 2 June 2021DeSlOntology Term : 'Rho/Rac/Cdc42 mediated signaling pathway' added !
118798view07:43, 2 June 2021DeSlAdded description from WP313
118039view11:50, 23 May 2021EweitzModified title
109466view10:53, 18 March 2020L DupuisConverted interaction lines representing membrane to graphical lines
87669view08:55, 25 July 2016LindarieswijkOntology Term : 'scatter factor/hepatocyte growth factor signaling pathway' added !
68877view17:22, 8 July 2013MaintBotUpdated to 2013 gpml schema
41018view22:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
33939view18:13, 9 December 2009MaintBotAutomatic update of empty xrefs
33484view15:08, 30 November 2009MaintBotRemoved group label
31534view21:45, 13 August 2009MaintBotFixed text labels
30379view21:02, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CRKGeneProduct417553 (Entrez Gene)
CRKLGeneProduct416939 (Entrez Gene)
DOCK1GeneProduct423960 (Entrez Gene) Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
ELK1GeneProduct
FOSGeneProduct396512 (Entrez Gene)
GAB1GeneProduct422456 (Entrez Gene)
GRB2GeneProduct386572 (Entrez Gene)
HGFGeneProduct395941 (Entrez Gene)
HRASGeneProduct396229 (Entrez Gene)
ITGA1GeneProduct395951 (Entrez Gene)
ITGB1GeneProduct374058 (Entrez Gene)
JUNGeneProduct424673 (Entrez Gene)
MAP2K1GeneProduct415549 (Entrez Gene)
MAP2K2GeneProduct396349 (Entrez Gene)
MAP4K1GeneProduct
MAPK1GeneProduct373953 (Entrez Gene)
MAPK3GeneProduct
MAPK8GeneProduct423778 (Entrez Gene)
MetGeneProduct396134 (Entrez Gene)
PAK1GeneProduct419083 (Entrez Gene)
PIK3CAGeneProduct424971 (Entrez Gene)
PTENGeneProduct423675 (Entrez Gene)
PTK2GeneProduct396416 (Entrez Gene)
PTK2BGeneProduct421998 (Entrez Gene)
PTPN11GeneProduct395815 (Entrez Gene)
PXNGeneProduct395832 (Entrez Gene)
RAF1GeneProduct396245 (Entrez Gene)
RAP1AGeneProduct419867 (Entrez Gene)
RAP1BGeneProduct417840 (Entrez Gene)
RAPGEF1GeneProduct417173 (Entrez Gene)
RASA1GeneProduct427327 (Entrez Gene)
SOS1GeneProduct425964 (Entrez Gene) Son of sevenless homolog 1 (Drosophila) (predicted)
SRCGeneProduct396442 (Entrez Gene)
STAT3GeneProduct420027 (Entrez Gene)

Annotated Interactions

No annotated interactions
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