DNA replication (Anopheles gambiae)

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1, 2Cdt1Mcm5Orc complexOriginMcm10Orc3Mcm3Mcm7Orc complexMcm5Cdc6Ubiquitinated Orc1UbiquitinOrc2Mcm2Orc1RFC36Cdt1Degraded by proteasome in cytosolPre-replicative complexRFC38Cdc6RNA primer-DNA primer:origin duplex:PCNADNA polymerase alpha:primase: origin complexMcm 4,6,7 trimer forms andassociates with the replication forkCdt1Mcm2Phosphorylated Cdc6Cdc6Orc complexCdc6Pre-replicative complexDNAPolymerase ARFC37Mcm4Mcm7RNA primer-DNA primerCdt1RFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerOrc5Phosphorylation ofMcm 2-7 complexRNA primer-DNA primerRFC1401. Assembly of the pre-replicative complexp58Orc25. Leading/lagging strand synthesisp70RFC Heteropentamer:RNA primer-DNA primerMcm10UbiquitinMcm4Mcm6Orc2Phosphorylated Orc1Orc3Orc3Degraded byproteasomein cytosolOrc5Cdt1Ubiquitinated Cdc6RNA Primer3. DNA replication initiationp180Mcm6Orc5Processive complexp49GemininOrc42. Activation of the pre-replicative complexOrc complexPrimaseOrc24. Switching of origins to post-replicative stateRFC40Orc complexDNA polymerase alpha:primase: origin complexMcm3Orc3Orc4AgaP_AGAP007927ATPGMNNAgaP_AGAP001290GTPAgaP_AGAP004615ASKADPdGTPAgaP_AGAP007477AgaP_AGAP005176AgaP_AGAP001929AgaP_AGAP006065AgaP_AGAP010220CTPAgaP_AGAP008910AgaP_AGAP000474dUTPATPdCTPAgaP_AGAP010219AgaP_AGAP004408AgaP_AGAP010406AgaP_AGAP005144AgaP_AGAP004579AgaP_AGAP004614AgaP_AGAP009047AgaP_AGAP001971AgaP_AGAP005800AgaP_AGAP011246AgaP_AGAP001421AgaP_AGAP007063AgaP_AGAP004956RPA3UTPPOLD3AgaP_AGAP004392POLD1AgaP_AGAP004957AgaP_AGAP008332dATPATPAgaP_AGAP008723ADPAgaP_AGAP000978RPA4CDC7AgaP_AGAP011961AgaP_AGAP004275AgaP_AGAP001135AgaP_AGAP005321POLD4AgaP_AGAP006387ATPAgaP_AGAP003093


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 61% conversion rate.

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Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
119019view10:39, 10 June 2021FinterlyRestored Biopax PublicationXrefs which were lost in 2013 conversion
117220view09:29, 19 May 2021EweitzModified title
68760view15:14, 7 July 2013EgonwRemoved data source where no ID was given.
67158view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
63232view23:19, 8 May 2013AnweshaOpened to convert to GPML 2013
40462view18:46, 1 March 2011MaintBotRemoved redundant pathway information and comments
35223view15:55, 11 February 2010ThomasModified description
35222view15:54, 11 February 2010Thomasadded literature
33729view23:42, 8 December 2009MaintBotAutomatic update of empty xrefs
32282view13:08, 15 August 2009MaintBotFixed text labels
31830view12:26, 14 August 2009MaintBotFixed group labels
31310view20:13, 13 August 2009MaintBotFixed text labels
30792view23:40, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ASKGeneProduct
ATPMetabolite
AgaP_AGAP000474GeneProduct1271764 (Entrez Gene)
AgaP_AGAP000978GeneProduct1270475 (Entrez Gene)
AgaP_AGAP001135GeneProduct1282031 (Entrez Gene)
AgaP_AGAP001290GeneProduct1281887 (Entrez Gene)
AgaP_AGAP001421GeneProduct1281755 (Entrez Gene)
AgaP_AGAP001929GeneProduct1281195 (Entrez Gene)
AgaP_AGAP001971GeneProduct3290537 (Entrez Gene)
AgaP_AGAP003093GeneProduct1273769 (Entrez Gene)
AgaP_AGAP004275GeneProduct1274119 (Entrez Gene)
AgaP_AGAP004392GeneProduct1274537 (Entrez Gene)
AgaP_AGAP004408GeneProduct1274553 (Entrez Gene)
AgaP_AGAP004579GeneProduct3291042 (Entrez Gene)
AgaP_AGAP004614GeneProduct1275918 (Entrez Gene)
AgaP_AGAP004615GeneProduct1275917 (Entrez Gene)
AgaP_AGAP004956GeneProduct1275768 (Entrez Gene)
AgaP_AGAP004957GeneProduct1275769 (Entrez Gene)
AgaP_AGAP005144GeneProduct1274822 (Entrez Gene)
AgaP_AGAP005176GeneProduct1274882 (Entrez Gene)
AgaP_AGAP005321GeneProduct1276035 (Entrez Gene)
AgaP_AGAP005800GeneProduct1276468 (Entrez Gene)
AgaP_AGAP006065GeneProduct1276738 (Entrez Gene)
AgaP_AGAP006387GeneProduct1276999 (Entrez Gene)
AgaP_AGAP007063GeneProduct1270041 (Entrez Gene)
AgaP_AGAP007477GeneProduct1269746 (Entrez Gene)
AgaP_AGAP007927GeneProduct1278028 (Entrez Gene)
AgaP_AGAP008332GeneProduct1277651 (Entrez Gene)
AgaP_AGAP008723GeneProduct1275573 (Entrez Gene)
AgaP_AGAP008910GeneProduct1279877 (Entrez Gene)
AgaP_AGAP009047GeneProduct1280005 (Entrez Gene)
AgaP_AGAP010219GeneProduct1279642 (Entrez Gene)
AgaP_AGAP010220GeneProduct1279643 (Entrez Gene)
AgaP_AGAP010406GeneProduct1272643 (Entrez Gene)
AgaP_AGAP011246GeneProduct1270681 (Entrez Gene)
AgaP_AGAP011961GeneProduct1280711 (Entrez Gene)
CDC7GeneProduct
CTPMetabolite
GMNNGeneProduct
GTPMetabolite
POLD1GeneProduct
POLD3GeneProduct
POLD4GeneProduct
RPA3GeneProduct
RPA4GeneProduct
UTPMetabolite
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite

Annotated Interactions

No annotated interactions
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