COVID-19 structural coverage map (Homo sapiens)

Revision as of 23:21, 29 November 2021 by Eweitz (Talk | contribs)

Description

This pathway summarizes the structural relationships (mimicking or hijacking) between COVID-19 (SARS-CoV-2) viral proteins and human proteins.

View approved pathways at the new wikipathways.org.

Moustaqil M, Ollivier E, Chiu HP, Van Tol S, Rudolffi-Soto P, Stevens C, Bhumkar A, Hunter DJB, Freiberg AN, Jacques D, Lee B, Sierecki E, Gambin Y; ''SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species.''; Emerg Microbes Infect, 2021 PubMed Europe PMC Scholia
Ahmad B, Batool M, Ain QU, Kim MS, Choi S; ''Exploring the Binding Mechanism of PF-07321332 SARS-CoV-2 Protease Inhibitor through Molecular Dynamics and Binding Free Energy Simulations.''; Int J Mol Sci, 2021 PubMed Europe PMC Scholia
O'Donoghue SI, Schafferhans A, Sikta N, Stolte C, Kaur S, Ho BK, Anderson S, Procter JB, Dallago C, Bordin N, Adcock M, Rost B; ''SARS-CoV-2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms.''; Mol Syst Biol, 2021 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
124659	view	13:35, 18 November 2022	NhungP	update viral proteins shapes
124628	view	12:18, 18 November 2022	NhungP	change viral proteins labels
120433	view	15:04, 1 December 2021	Egonw	Fixed the data source for a complex
120375	view	23:21, 29 November 2021	Eweitz	Modified title
120335	view	18:13, 26 November 2021	NhungP	Remove weird anchor
120334	view	18:12, 26 November 2021	NhungP	Adjust layout
120333	view	18:09, 26 November 2021	NhungP	Add nsp5 (3CL-Protease), its target host proteins (TAB1 & NLRP12) and the target drug
120327	view	15:50, 26 November 2021	Mkutmon	added complexes for 40S 43S and 80S
120326	view	15:42, 26 November 2021	Mkutmon	Ontology Term : 'infectious disease pathway' added !
120325	view	15:41, 26 November 2021	Mkutmon	Ontology Term : 'COVID-19' added !
120324	view	15:40, 26 November 2021	Mkutmon	New pathway

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Name	Type	Database reference
40S	Complex	CPX-5223 (ChEBI)
43S	Complex
80S	Complex
ACE2	Protein	Q9BYF1 (Uniprot-TrEMBL)
APOA1	Protein	P02647 (Uniprot-TrEMBL)
AQR	Protein	O60306 (Uniprot-TrEMBL)
CMTR1	Protein	Q8N1G2 (Uniprot-TrEMBL)
E	Protein	P0DTC4 (Uniprot-TrEMBL)
GDAP2	Protein	Q9NXN4 (Uniprot-TrEMBL)
IGHMBP2	Protein	P38935 (Uniprot-TrEMBL)
ISG15	Protein	P05161 (Uniprot-TrEMBL)
MACROD1	Protein	Q9BQ69 (Uniprot-TrEMBL)
MACROD2	Protein	A1Z1Q3 (Uniprot-TrEMBL)
MACROH2A1	Protein	O75367 (Uniprot-TrEMBL)
MACROH2A1	Protein	Q9P0M6 (Uniprot-TrEMBL)
MPP5	Protein	Q8N3R9 (Uniprot-TrEMBL)
MRM2	Protein	Q9UI43 (Uniprot-TrEMBL)
NLRP12	Protein	P59046 (Uniprot-TrEMBL)
NRP1	Protein	O14786 (Uniprot-TrEMBL)
Nsp13	Protein	YP_009725308 (NCBI Protein)
Nsp16	Protein	YP_009725311 (NCBI Protein)
Nsp1	Protein	YP_009725297 (NCBI Protein)
Nsp3	Protein	YP_009725299 (NCBI Protein)
Nsp5	Protein	YP_009725301 (NCBI Protein)
Orf3a	Protein	P0DTC6 (Uniprot-TrEMBL)
Orf9B	Protein	P0DTD2 (Uniprot-TrEMBL)
PAIP1	Protein	Q9H074 (Uniprot-TrEMBL)
PARP14	Protein	Q460N5 (Uniprot-TrEMBL)
PARP9	Protein	Q8IXQ6 (Uniprot-TrEMBL)
PF-07321332 (Pfizer PAXLOVID)	Metabolite	DB16691 (DrugBank)
SLC6A19	Protein	Q695T7 (Uniprot-TrEMBL)
Spike	Protein	P0DTC2 (Uniprot-TrEMBL)
TAB1	Protein	Q15750 (Uniprot-TrEMBL)
TOMM70	Protein	O94826 (Uniprot-TrEMBL)
UBA52	Protein	P62987 (Uniprot-TrEMBL)
UBB	Protein	P0CG47 (Uniprot-TrEMBL)
UBC	Protein	P0CG48 (Uniprot-TrEMBL)
UPF1	Protein	Q92900 (Uniprot-TrEMBL)
UPF2	Protein	Q9HAU5 (Uniprot-TrEMBL)

No annotated interactions