Network map of SARS-CoV-2 signaling (Homo sapiens)
From WikiPathways
Description
A schematic representation of the SARS-CoV-2 signaling pathway. The pathway map represents protein-protein interactions and the downstream molecular events regulated by SARS-CoV-2 including molecular association, catalysis, and gene regulation events. Each events are color coded as described in the pathway legend. Information pertaining to site and residue of post-translational modification are also included in the pathway map.
Quality Tags
Ontology Terms
Bibliography
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- Schmoldt A, Benthe HF, Haberland G, Jallon JM, Risler Y, Iwatsubo M; ''Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH.''; Biochem Biophys Res Commun, 1975 DOI Scholia
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History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
A1BG | GeneProduct | ENSG00000121410 (Ensembl) | |
ACE2 | GeneProduct | ENSG00000130234 (Ensembl) | |
ACTB | GeneProduct | ENSG00000075624 (Ensembl) | |
ACTG1 | GeneProduct | ENSG00000184009 (Ensembl) | |
ADAM9 | GeneProduct | ADAM9 | |
AGT | GeneProduct | AGT (HGNC) | |
AHR | GeneProduct | AHR (HGNC) | |
AKT1 | Protein | P31749 (Uniprot-TrEMBL) | |
ALB | GeneProduct | ALB (HGNC) | |
APOA1 | GeneProduct | APOA1 (HGNC) | |
APOA2 | GeneProduct | APOA2 (HGNC) | |
APOC1 | GeneProduct | APOC1 (HGNC) | |
APOD | GeneProduct | APOD (HGNC) | |
APOH | GeneProduct | APOH (HGNC) | |
APOL1 | GeneProduct | APOL1 (HGNC) | |
APOM | GeneProduct | APOM (HGNC) | |
ATE1 | GeneProduct | ATE1 | |
ATG13 | Protein | 9776 (Entrez Gene) | |
ATP13A3 | GeneProduct | ATP13A3 | |
ATP6AP1 | GeneProduct | ATP6AP1 | |
BID | Protein | 637 (Entrez Gene) | |
BIRC5 | GeneProduct | BIRC5 (HGNC) | |
BST2 | GeneProduct | BST2 (HGNC) | |
BTN3A1 | GeneProduct | BTN3A1 (HGNC) | |
C1QBP | GeneProduct | C1QBP (HGNC) | |
C1R | GeneProduct | ENSG00000159403 (Ensembl) | |
C1S | GeneProduct | ENSG00000182326 (Ensembl) | |
C8A | GeneProduct | ENSG00000157131 (Ensembl) | |
CALC1 | GeneProduct | CALC1 (HGNC) | |
CAMK4 | GeneProduct | CAMK4 (HGNC) | |
CARD11 | GeneProduct | CARD11 (HGNC) | |
CASP3 | GeneProduct | ENSG00000164305 (Ensembl) | |
CASP5 | GeneProduct | CASP5 (HGNC) | |
CASP8 | GeneProduct | CASP8 (HGNC) | |
CASP9 | GeneProduct | CASP9 (HGNC) | |
CCL11 | GeneProduct | CCL11 (HGNC) | |
CCL15 | GeneProduct | CCL15 (HGNC) | |
CCL1 | GeneProduct | CCL1 (HGNC) | |
CCL20 | GeneProduct | CCL20 (HGNC) | |
CCL21 | GeneProduct | CCL21 (HGNC) | |
CCL22 | GeneProduct | CCL22 (HGNC) | |
CCL26 | GeneProduct | CCL26 (HGNC) | |
CCL27 | GeneProduct | CCL27 (HGNC) | |
CCL2 | GeneProduct | CCL2 (HGNC) | |
CCL2 | GeneProduct | ENSG00000108691 (Ensembl) | |
CCL3 | GeneProduct | CCL3 (HGNC) | |
CCL4 | GeneProduct | CCL4 (HGNC) | |
CCL5 | GeneProduct | CCL5 (HGNC) | |
CCL8 | GeneProduct | CCL8 (HGNC) | |
CCNB1 | GeneProduct | CCNB1 (HGNC) | |
CCNB2 | GeneProduct | CCNB2 (HGNC) | |
CCR5 | GeneProduct | CCR5 (HGNC) | |
CCR6 | GeneProduct | CCR6 (HGNC) | |
CD14 | GeneProduct | ENSG00000170458 (Ensembl) | |
CD163 | GeneProduct | CD163 (HGNC) | |
CD226 | GeneProduct | CD226 (HGNC) | |
CD247 | GeneProduct | 919 (Entrez Gene) | |
CD2 | GeneProduct | 914 (Entrez Gene) | |
CD3E | GeneProduct | 916 (Entrez Gene) | |
CD3G | GeneProduct | 917 (Entrez Gene) | |
CD4 | GeneProduct | 920 (Entrez Gene) | |
CD8A | GeneProduct | 925 (Entrez Gene) | |
CD8A | GeneProduct | 926 (Entrez Gene) | |
CDK1 | GeneProduct | CDK1 (HGNC) | |
CEBPB | GeneProduct | CEBPB (HGNC) | |
CFB | GeneProduct | ENSG00000243649 (Ensembl) | |
CFH | GeneProduct | ENSG00000000971 (Ensembl) | |
CFI | GeneProduct | ENSG00000205403 (Ensembl) | |
CFP | GeneProduct | CFP (HGNC) | |
CLCC1 | GeneProduct | ||
COL7A1 | GeneProduct | COL7A1 (HGNC) | |
COQ8B | GeneProduct | COQ8B | |
CPN1 | GeneProduct | CPN1 (HGNC) | |
CRP | GeneProduct | 1401 (Entrez Gene) | |
CRP | GeneProduct | CRP (HGNC) | |
CRP | GeneProduct | ENSG00000132693 (Ensembl) | |
CTSB | GeneProduct | CTSB (HGNC) | |
CTSD | GeneProduct | CTSD (HGNC) | |
CTSL | GeneProduct | CTSL (HGNC) | |
CTSZ | GeneProduct | CTSZ (HGNC) | |
CXCL10 | GeneProduct | CXCL10 (HGNC) | |
CXCL12 | GeneProduct | CXCL12 (HGNC) | |
CXCL13 | GeneProduct | CXCL13 (HGNC) | |
CXCL16 | GeneProduct | CXCL16 (HGNC) | |
CXCL1 | GeneProduct | CXCL1 (HGNC) | |
CXCL2 | GeneProduct | CXCL2 (HGNC) | |
CXCL3 | GeneProduct | CXCL3 (HGNC) | |
CXCL5 | GeneProduct | CXCL5 (HGNC) | |
CXCL6 | GeneProduct | CXCL6 (HGNC) | |
CXCL8 | GeneProduct | CXCL8 (HGNC) | |
CXCL8 | GeneProduct | CXCL8 (HGNC) | |
CXCL9 | GeneProduct | CXCL9 (HGNC) | |
CXCR1 | GeneProduct | CXCR1 (HGNC) | |
CXCR2 | GeneProduct | CXCR2 (HGNC) | |
CXCR7 | GeneProduct | CXCR7 (HGNC) | |
Cytochrome C | Metabolite | 18070 (ChEBI) | |
DDIT4 | GeneProduct | DDIT4 (HGNC) | |
DDX58 | GeneProduct | DDX58 (HGNC) | |
DEPTOR | Protein | 64798 (Entrez Gene) | |
DUSP1 | GeneProduct | DUSP1 (HGNC) | |
EGR1 | GeneProduct | EGR1 (HGNC) | |
EIF4A2 | GeneProduct | EIF4A2 (HGNC) | |
EIF4EBP1 | GeneProduct | 1978 (Entrez Gene) | |
EIF4E | Protein | EIF4E (HGNC) | |
ERLEC1 | GeneProduct | ERLEC1 | |
FAM83A | GeneProduct | FAM83A (HGNC) | |
FAM98A | GeneProduct | FAM98A | |
FGA | GeneProduct | ENSG00000171560 (Ensembl) | |
FGB | GeneProduct | ENSG00000171564 (Ensembl) | |
FGB | GeneProduct | FGB (HGNC) | |
FGF2 | GeneProduct | FGF2 (HGNC) | |
FGG | GeneProduct | ENSG00000171557 (Ensembl) | |
FGG | GeneProduct | FGG (HGNC) | |
FN1 | GeneProduct | FN1 (HGNC) | |
FOS | GeneProduct | FOS (HGNC) | |
FYN | GeneProduct | 2534 (Entrez Gene) | |
FYN | GeneProduct | FYN (HGNC) | |
G3BP1 | GeneProduct | G3BP1 | |
G3BP2 | GeneProduct | G3BP2 | |
GABARAPL2 | Protein | 11345 (Entrez Gene) | |
GCSF | GeneProduct | GCSF (HGNC) | |
GGH | GeneProduct | GGH | |
GMCSF | GeneProduct | GMCSF (HGNC) | |
GP1BA | GeneProduct | GP1BA (HGNC) | |
GSN | GeneProduct | GSN (HGNC) | |
GTF2F2 | GeneProduct | GTF2F2 | |
GTSE1 | GeneProduct | GTSE1 (HGNC) | |
HBB | GeneProduct | HBB (HGNC) | |
HBD | GeneProduct | HBD (HGNC) | |
GeneProduct | |||
HIF1A | GeneProduct | 3091 (Entrez Gene) | |
HLA-DRA | GeneProduct | 3122 (Entrez Gene) | |
HLA-DRB1 | GeneProduct | 3123 (Entrez Gene) | |
HLA-DRB4 | GeneProduct | 3126 (Entrez Gene) | |
HLA-DRB5 | GeneProduct | 3127 (Entrez Gene) | |
HP | GeneProduct | ENSG00000257017 (Ensembl) | |
HRG | GeneProduct | HRG (HGNC) | |
HSPA8 | GeneProduct | HSPA8 (HGNC) | |
IFI27 | GeneProduct | IFI27 (HGNC) | |
IFI44L | GeneProduct | IFI44L (HGNC) | |
IFI6 | GeneProduct | IFI6 (HGNC) | |
IFIH1 | GeneProduct | IFIH1 (HGNC) | |
IFIT1 | GeneProduct | IFIT1 (HGNC) | |
IFITM1 | GeneProduct | IFITM1 (HGNC) | |
IFITM3 | GeneProduct | ENSG00000142089 (Ensembl) | |
IFITM3 | GeneProduct | IFITM3 (HGNC) | |
IFN1 | Protein | IFN1 (Uniprot-TrEMBL) | |
IFNA | GeneProduct | IFNA (HGNC) | |
IFNB1 | Protein | P01574 (Uniprot-TrEMBL) | |
IFNG | GeneProduct | IFNG (HGNC) | |
IGFBP3 | GeneProduct | IGFBP3 (HGNC) | |
IGHE | GeneProduct | 3497 (Entrez Gene) | |
IGHG1 | GeneProduct | 3500 (Entrez Gene) | |
IGHG2 | GeneProduct | 3501 (Entrez Gene) | |
IGHG4 | GeneProduct | 3503 (Entrez Gene) | |
IGLC2 | GeneProduct | 3538 (Entrez Gene) | |
IGLL1 | GeneProduct | 3543 (Entrez Gene) | |
IKBKG | Protein | 8517 (Entrez Gene) | |
IL10 | GeneProduct | IL10 (HGNC) | |
IL12A | GeneProduct | IL12A (HGNC) | |
IL13 | GeneProduct | IL13 (HGNC) | |
IL16 | GeneProduct | IL16 (HGNC) | |
IL17A | GeneProduct | IL17A (HGNC) | |
IL18 | GeneProduct | IL18 (HGNC) | |
IL18RAP | GeneProduct | IL18RAP (HGNC) | |
IL1A | GeneProduct | IL1A (HGNC) | |
IL1B | GeneProduct | ENSG00000125538 (Ensembl) | |
IL1B | GeneProduct | IL1B (HGNC) | |
IL1R2 | GeneProduct | IL1R2 (HGNC) | |
IL1RA | GeneProduct | IL1RA (HGNC) | |
IL21 | GeneProduct | IL21 (HGNC) | |
IL22 | GeneProduct | IL22 (HGNC) | |
IL23 | GeneProduct | IL23 (HGNC) | |
IL2B | GeneProduct | IL2B (HGNC) | |
IL2R | GeneProduct | IL2R (HGNC) | |
IL33 | GeneProduct | IL33 (HGNC) | |
IL4 | GeneProduct | IL4 (HGNC) | |
IL5 | GeneProduct | IL5 (HGNC) | |
IL6 | GeneProduct | 3569 (Entrez Gene) | |
IL6 | GeneProduct | ENSG00000136244 (Ensembl) | |
IL6 | GeneProduct | IL6 (HGNC) | |
IL7 | GeneProduct | IL7 (HGNC) | |
IL8 | GeneProduct | 3576 (Entrez Gene) | |
IL8 | GeneProduct | IL8 (HGNC) | |
IL9 | GeneProduct | IL9 (HGNC) | |
INTS4 | GeneProduct | INTS4 | |
IP10 | GeneProduct | IP10 (HGNC) | |
IRAK1 | GeneProduct | 3654 (Entrez Gene) | |
IRF27 | GeneProduct | IRF27 (HGNC) | |
IRF3 | GeneProduct | IRF3 (HGNC) | |
IRF9 | GeneProduct | IRF9 (HGNC) | |
ISG56 | GeneProduct | ISG56 (HGNC) | |
ISRE | GeneProduct | ISRE (HGNC) | |
ITCH | GeneProduct | ITCH (HGNC) | |
ITGA3 | GeneProduct | ITGA3 (HGNC) | |
ITIH3 | GeneProduct | ENSG00000162267 (Ensembl) | |
ITIH4 | GeneProduct | ENSG00000055955 (Ensembl) | |
JAK1 | GeneProduct | JAK1 (HGNC) | |
JAK2 | GeneProduct | JAK2 (HGNC) | |
JUNB | GeneProduct | JUNB (HGNC) | |
JUN | GeneProduct | JUN (HGNC) | |
LARP1 | GeneProduct | 23367 (Entrez Gene) | |
LARP1 | GeneProduct | LARP1 | |
LBP | GeneProduct | 3929 (Entrez Gene) | |
LBP | GeneProduct | ENSG00000129988 (Ensembl) | |
LCK | GeneProduct | 3932 (Entrez Gene) | |
LCK | GeneProduct | LCK (HGNC) | |
LDH | GeneProduct | LDH (HGNC) | |
LGALS3BP | GeneProduct | ENSG00000108679 (Ensembl) | |
LRG1 | GeneProduct | ENSG00000171236 (Ensembl) | |
MAP1LC3B | GeneProduct | 81631 (Entrez Gene) | |
MAPK14 | Protein | NP_001306.1 (NCBI Protein) | |
MAPK1 | Protein | NP_002736.3 (NCBI Protein) | |
MAPK3 | Protein | NP_002737.2 (NCBI Protein) | |
MAPK8 | GeneProduct | MAPK8 (HGNC) | |
MAPK8 | Protein | NP_001310259.1 (NCBI Protein) | |
MARK2 | GeneProduct | MARK2 | |
MAVS | GeneProduct | ENSG00000088888 (Ensembl) | |
M | Protein | BCD58756 (NCBI Protein) | |
MCP1 | GeneProduct | MCP1 (HGNC) | |
MDN1 | GeneProduct | MDN1 | |
MIB1 | GeneProduct | MIB1 | |
MIP1A | GeneProduct | MIP1A (HGNC) | |
MIP1B | GeneProduct | MIP1B (HGNC) | |
MLST8 | Protein | 64223 (Entrez Gene) | |
MMP25 | GeneProduct | 64386 (Entrez Gene) | |
MOV10 | GeneProduct | MOV10 | |
MTOR | Protein | 2475 (Entrez Gene) | |
MX1 | GeneProduct | MX1 (HGNC) | |
MYD88 | GeneProduct | MYD88 (HGNC) | |
NBR1 | Protein | NBR1 (NCBI Protein) | |
NEK9 | GeneProduct | NEK9 | |
NFATC3 | GeneProduct | NFATC3 (HGNC) | |
NFKB2 | Protein | 4791 (Entrez Gene) | |
NKRF | GeneProduct | 55922 (Entrez Gene) | |
NLRP1 | GeneProduct | 22861 (Entrez Gene) | |
NLRP3 | GeneProduct | NLRP3 (HGNC) | |
N | Protein | N (NCBI Protein) | |
NPTX1 | GeneProduct | NPTX1 | |
NSP10 | Protein | YP_009725306 (NCBI Protein) | |
NSP13 | Protein | NSP13 (NCBI Protein) | |
NSP2 | Protein | YP_009725298 (NCBI Protein) | |
NSP6 | Protein | YP_009725302 (NCBI Protein) | |
NSP8 | Protein | NSP8 (NCBI Protein) | |
NSP9 | Protein | YP_009725305 (NCBI Protein) | |
NTRK1 | GeneProduct | NTRK1 (HGNC) | |
OAS2 | GeneProduct | OAS2 (HGNC) | |
ORF3a | Protein | BCD58754 (NCBI Protein) | |
ORF6 | Protein | BCD58757 (NCBI Protein) | |
ORF7a | Protein | ORF7a (NCBI Protein) | |
ORF7b | Protein | BCD58759 (NCBI Protein) | |
ORF8 | Protein | ORF8 (NCBI Protein) | |
ORF9b | Protein | ORF9b (NCBI Protein) | |
OS9 | GeneProduct | OS9 | |
PARP2 | GeneProduct | PARP2 (HGNC) | |
PDGF | GeneProduct | PDGF (HGNC) | |
PF4 | GeneProduct | PF4 (HGNC) | |
PI3K | Protein | P31749 (Uniprot-TrEMBL) | |
PIAS1 | GeneProduct | PIAS1 (HGNC) | |
PITRM1 | GeneProduct | PITRM1 | |
PLA2G4A | Protein | NP_077734.1 (NCBI Protein) | |
PMPCB | GeneProduct | PMPCB | |
PRAS40 | GeneProduct | ENSG00000204673 (Ensembl) | |
PRG3 | GeneProduct | 10394 (Entrez Gene) | |
PRKCQ | GeneProduct | PRKCQ (HGNC) | |
PTGS2 | GeneProduct | PTGS2 (HGNC) | |
PTPN6 | GeneProduct | PTPN6 (HGNC) | |
RAC1 | GeneProduct | RAC1 (HGNC) | |
RAP1GDS1 | GeneProduct | ||
RHEB | Protein | 6009 (Entrez Gene) | |
RPS6KB1 | Protein | NP_003152.1 (NCBI Protein) | |
RPS6 | GeneProduct | RPS6 (HGNC) | |
RPTOR | Protein | 57521 (Entrez Gene) | |
RRAS | GeneProduct | RRAS (HGNC) | |
RRM2 | GeneProduct | RRM2 (HGNC) | |
RTN4 | GeneProduct | RTN4 | |
SAA1 | GeneProduct | ENSG00000173432 (Ensembl) | |
SAA2 | GeneProduct | ENSG00000134339 (Ensembl) | |
SARS-CoV-2 | Pathway | WP4846 (WikiPathways) | |
S | Protein | BCD58753 (NCBI Protein) | |
SDF2 | GeneProduct | SDF2 | |
SELP | GeneProduct | ENSG00000174175 (Ensembl) | |
SERPINA10 | GeneProduct | ENSG00000140093 (Ensembl) | |
SERPINA5 | GeneProduct | SERPINA5 (HGNC) | |
SERPINE1 | GeneProduct | SERPINE1 (HGNC) | |
SIGMAR1 | GeneProduct | SIGMAR1 | |
SKAP1 | GeneProduct | SKAP1 (HGNC) | |
SMAD1 | GeneProduct | 4086 (Entrez Gene) | |
SMAD5 | GeneProduct | 4090 (Entrez Gene) | |
SQSTM1 | Protein | NP_003891.1 (NCBI Protein) | |
SRP19 | GeneProduct | SRP19 | |
SRP54 | GeneProduct | SRP54 | |
SRP72 | GeneProduct | SRP72 | |
STAT1 | GeneProduct | STAT1 (HGNC) | |
STEAP3 | GeneProduct | STEAP3 (HGNC) | |
TANK | GeneProduct | TANK (EMBL) | |
TAX1BP1 | Protein | TAX1BP1 (NCBI Protein) | |
TBK1 | GeneProduct | 29110 (Entrez Gene) | |
TBKBP1 | GeneProduct | TBKBP1 | |
TF | GeneProduct | TF (HGNC) | |
TGFBR2 | Protein | TGFBR2 (HGNC) | |
TLE1 | GeneProduct | TLE1 | |
TLE3 | GeneProduct | TLE3 | |
TLE5 | GeneProduct | TLE5 | |
TLRs | GeneProduct | ||
TMPRSS2 | Protein | 7226 (Entrez Gene) | |
TNFSF10 | GeneProduct | TNFSF10 (HGNC) | |
TNF | GeneProduct | TNF (HGNC) | |
TOMM70 | GeneProduct | TOMM70 | |
TP53I3 | GeneProduct | TP53I3 (HGNC) | |
TPO | GeneProduct | TPO (HGNC) | |
TRAC | GeneProduct | 28755 (Entrez Gene) | |
TRAF2 | GeneProduct | TRAF2 (HGNC) | |
TRAF3 | GeneProduct | ENSG00000131323 (Ensembl) | |
TRAF6 | GeneProduct | 7189 (Entrez Gene) | |
TRBC1 | GeneProduct | 28639 (Entrez Gene) | |
TRIM59 | GeneProduct | ||
TRO | GeneProduct | TRO (HGNC) | |
TSC2 | Protein | P31749 (Uniprot-TrEMBL) | |
UGGT2 | GeneProduct | UGGT2 | |
ULK1 | GeneProduct | 8408 (Entrez Gene) | |
UPF1 | GeneProduct | UPF1 | |
VEGFA | GeneProduct | ||
VPS11 | Protein | 55823 (Entrez Gene) | |
VPS16 | Protein | 64601 (Entrez Gene) | |
VPS18 | GeneProduct | VPS18 (HGNC) | |
VPS33A | Protein | 65082 (Entrez Gene) | |
VPS36 | Protein | 51028 (Entrez Gene) | |
VPS41 | Protein | 27072 (Entrez Gene) | |
WDR74 | GeneProduct | WDR74 (HGNC) | |
ZAP70 | GeneProduct | 7535 (Entrez Gene) |
Annotated Interactions
No annotated interactions