DNA IR-damage and cellular response via ATR (Homo sapiens)

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89, 91, 240, 323, 409...243, 268, 5122612224551215, 296, 453, 498, 65028496137597126424, 456, 6235135684249569167376306260, 62332116583632, 6517351634, 64952660464266363, 651208137298623394187, 393307536126131552251246706287499, 458, 700673146155, 47534220848166308, 65199, 34226419, 60716401200, 594, 641248416639264282609107, 118, 238, 292, 444...293, 45231539321815061240948, 124, 126, 150, 164494404, 488, 713345652, 662, 703ATR-ATRIPcomplexLegendssDNADNA DSBsRecQ-like helicasesIonizing radiation (IR)173, 240, 260, 345, 525...237, 314, 332, 367, 505...2, 47, 86, 151, 205...TP53Intra-S-phasecheckpoint mediatedarrest of cell cycleprogressionIKPKBFANCIEEF1E1UB2D3E2F1SP1CLSPNBRCA1DCLRE1ACHK1TRIM28PLK1RPA2SMC1AFANCATP53BP1POLNBCL6RAD51RAD52USP1XRCC5EXO1PCNARAD9SMARCC2MDC1PRKDCRAD50RBBP8POLBRAD17M-phase progressionATRMCM2HERC2MUTL-ALPHAMLH1MRE11ABLMCLK2MCPH1CEP164MCPH1MDM2MSH2PPM1DBRCA2UPF1TDP1SMARCAL1XPARFWD3NBNCHK234, 175, 252, 441, 49529, 78, 108, 422, 468...610339, 506, 608, 666, 67140, 55, 59, 132, 246...17, 294, 38858, 273, 274, 311, 614...62, 64, 170, 438, 629445, 479, 52643, 64, 73, 100, 165...103, 352, 404, 435, 4622356, 185, 227, 318, 400...24, 368, 385, 439, 620...518, 675313, 496, 652, 662, 690...26, 231, 65871, 87, 158, 322, 346...46, 216, 281, 602, 697112, 146, 181, 236, 405...241, 254, 287, 428, 471...177, 293, 419, 680258, 399, 429, 483, 524...35, 60, 121, 166, 215...228, 280, 411111, 206, 326, 355, 375...50, 93, 386, 425, 463...202, 535, 556, 557, 615...169, 214, 371, 379, 461...3, 233, 578, 584, 71939, 277, 301107, 197, 310, 491, 59345, 65, 204, 242, 303...4, 44, 183, 421, 601...92, 147, 710201, 403, 440, 530188, 399, 508, 711213, 373, 454, 553, 586...105, 110, 267, 492286, 342, 53191, 138, 240, 409, 415...427, 431, 58225, 130, 21228, 63, 96, 102, 340...94, 266, 508, 711192, 336, 489, 501, 572358, 423, 6395, 54, 76, 88, 272...44, 119, 135, 160, 179...330, 564, 69853, 156, 162, 174, 265...404, 488, 71310, 14, 30, 84, 291...22, 101, 161, 224, 259...PATM4, 8, 81, 85, 211...H2AX270, 271, 377, 543, 592...DNA repair11, 32, 133, 171, 469RNF848, 126, 164Cell cyclecheckpoint activation120, 143, 180, 503, 688G2/M-phase checkpoint152, 365, 366Damage processingDNA Polymerasedelta tetramer232329, 466, 541CDC25C172, 369, 677MRE11ARAD50NBNGammaH2AXMDC1MRNcomplex104, 387, 417, 705FANCD2FANCD2BRCA213, 21, 83, 199, 221...83, 141, 217, 230, 326...UIMC118, 41, 144, 207, 234...TOPBP198, 260, 337, 348, 502...PMLRPA120, 77, 117, 127, 128, 134...6, 22, 49, 97, 161...BRIP1RAD182, 288, 499, 550, 636HUS155, 153, 276, 327, 45780, 246, 356, 457, 477...BARD1157, 225, 284, 437, 631BRCC3FAM175A61, 239, 537CDC45189, 245, 312, 378, 380...RECQL567, 247, 256, 406, 547...129, 222, 235, 338, 625...WRNRECQL431, 168, 269, 382, 402...33, 95, 163, 302, 350...RECQL72, 190, 193, 196, 283...RMI1TOP3A473, 687, 691279, 370, 389, 447, 467...PARP175, 115, 123, 139, 142...ssDNARPA1ATRIP173, 240, 345, 374, 474...RAD9RAD1HUS19-1-1complex55, 257, 317, 327, 356...66434393699304416SHFM1FOXM1113, 116, 226, 229, 244...PALB2195, 693, 707CycA1, 37, 519, 542, 546...27, 36, 90, 106, 140...Cdk238, 51, 52, 154, 191...CycB36, 106, 114, 125, 285...Cdc2109, 176, 191, 433, 451...G1/S boundary activationFEN1BARD142, 79, 122, 223, 656...UIMC1BRCA1UIMCI-BRCA1-BARD1complex393RBBP8112, 146, 181, 236, 405...BLMRMI1TOP3ABLMcomplexInhibition pathMember of the groupIntermediate paths not shownPath to processStimulation pathRelation to pathRelation to path(intermediate steps not shown)Translocation pathCycACdk2CycBCdc2ATRATRIPCellular responseto DNA damage


Description

In fission yeast, the rad3 gene product plays a critical role in sensing DNA structure defects and activating damage response pathways. A structural homologue of rad3 in humans has been identified based on sequence similarity in the protein kinase domain. ATR (for Ataxia Telangiectasia and Rad3-related) is considered the mammalian counterpart of yeast rad3, Mec1p, and fruit fly Mei-41, proteins involved in DNA damage responses.

The ATR protein is a member of the phosphoinositide 3-kinase related kinase family and plays an important role in UV-induced DNA damage checkpoint response and its role as a signal transducer in cell cycle checkpoint has been well established. Even though it is currently unclear whether ATR functions as a damage sensor, recent evidence shows that ATR may function as an initial sensor in the DNA damage checkpoint response. Moreover, it has been found that ATR is a DNA-binding protein with higher affinity to UV-damaged than undamaged DNA. In addition, damaged DNA stimulates the kinase activity of ATR to a significantly higher level than undamaged DNA. ATR is structurally related to ATM (for Ataxia Telangiectasia Mutated) as well as the yeast PIK family members Mec1p and Rad3. Mec1p and Rad3 participate in checkpoint pathways induced by DNA replication blocks, DNA strand breaks, and other chromosomal abnormalities, which implies that ATR performs similar functions in mammalian cells. Reports have demonstrated that overexpression of a catalytically inactive version of ATR (ATRki) in human fibroblasts caused hypersensitivity to gamma-radiation and hydroxyurea and abrogation of the radiation-induced G2 checkpoint. The checkpoint defects observed in ATR-overexpressing cells resemble those found in AT cells. Additionally, ATR functions as an upstream regulator of p53 phosphorylation in DNA-damaged cells. ATR phosphorylates p53 at both Ser-15 and Ser-37 in vitro, suggesting that ATR is directly involved in the modification of p53 in DNA-damaged cells. Recent reports concerning ATM, suggest that ATR and ATM play both overlapping and independent roles in the phosphorylation of p53 during cellular exposure to genotoxic stress. Atr is localized to the nuclei of primary spermatocytes, cells that are undergoing meiosis I. It has been demonstrated that both Atr and Atm proteins have associated protein kinase activity, consistent with their primary structures. Additionally, Atr and Atm show specific association with chromosomes in cells that are in early meiosis I as demonstrated by antibody localization on surface-spread spermatocytes. Both the Atr and Atm proteins are present at pairing forks in meiotic prophase as chromosomes synapse; however, they do not colocalize, instead they occupy complementary positions: Atr localizes along unsynapsed chromosome axes and Atm interacts with synapsed axes.

Meanwhile ATM is activated by damage-induced rapid intermolecular autophosphorylation prior relocalization to sites of DNA breaks, ATR activation seems to require single-stranded DNA (ssDNA) coated with replication protein A. The recruitment of ATR to damage sites appears to be mediated by an ATR-interacting protein that forms a stable complex with the vast majority of ATR in human cells.

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  1. Buisson R, Masson JY; ''PALB2 self-interaction controls homologous recombination.''; Nucleic Acids Res, 2012 PubMed Europe PMC Scholia
  2. Price A; ''The repair of ionising radiation-induced damage to DNA.''; Semin Cancer Biol, 1993 PubMed Europe PMC Scholia
  3. Chung U, Igarashi T, Nishishita T, Iwanari H, Iwamatsu A, Suwa A, Mimori T, Hata K, Ebisu S, Ogata E, Fujita T, Okazaki T; ''The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  4. Kass EM, Ahn J, Tanaka T, Freed-Pastor WA, Keezer S, Prives C; ''Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  5. Castro E, Eeles R.; ''The role of BRCA1 and BRCA2 in prostate cancer.''; Asian J Androl, 2012 PubMed Europe PMC Scholia
  6. Sleeth KM, Sørensen CS, Issaeva N, Dziegielewski J, Bartek J, Helleday T; ''RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells.''; J Mol Biol, 2007 PubMed Europe PMC Scholia
  7. Lupardus PJ, Cimprich KA; ''Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus.''; Mol Biol Cell, 2006 PubMed Europe PMC Scholia
  8. Platzer M, Rotman G, Bauer D, Uziel T, Savitsky K, Bar-Shira A, Gilad S, Shiloh Y, Rosenthal A; ''Ataxia-telangiectasia locus: sequence analysis of 184 kb of human genomic DNA containing the entire ATM gene.''; Genome Res, 1997 PubMed Europe PMC Scholia
  9. Peng G, Yim EK, Dai H, Jackson AP, Burgt Iv, Pan MR, Hu R, Li K, Lin SY; ''BRIT1/MCPH1 links chromatin remodelling to DNA damage response.''; Nat Cell Biol, 2009 PubMed Europe PMC Scholia
  10. Genschel J, Bazemore LR, Modrich P; ''Human exonuclease I is required for 5' and 3' mismatch repair.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  11. Liu VF, Boubnov NV, Weaver DT; ''Cell cycle checkpoints and repair of ionizing radiation damage.''; Stem Cells, 1995 PubMed Europe PMC Scholia
  12. Jackson P, Ridgway P, Rayner J, Noble J, Braithwaite A; ''Transcriptional regulation of the PCNA promoter by p53.''; Biochem Biophys Res Commun, 1994 PubMed Europe PMC Scholia
  13. Freie BW, Ciccone SL, Li X, Plett PA, Orschell CM, Srour EF, Hanenberg H, Schindler D, Lee SH, Clapp DW; ''A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  14. Dzantiev L, Constantin N, Genschel J, Iyer RR, Burgers PM, Modrich P; ''A defined human system that supports bidirectional mismatch-provoked excision.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  15. Harris SL, Levine AJ; ''The p53 pathway: positive and negative feedback loops.''; Oncogene, 2005 PubMed Europe PMC Scholia
  16. Yang J, Yu Y, Hamrick HE, Duerksen-Hughes PJ; ''ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses.''; Carcinogenesis, 2003 PubMed Europe PMC Scholia
  17. Eisenreich A, Bogdanov VY, Zakrzewicz A, Pries A, Antoniak S, Poller W, Schultheiss HP, Rauch U; ''Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.''; Circ Res, 2009 PubMed Europe PMC Scholia
  18. Shao G, Lilli DR, Patterson-Fortin J, Coleman KA, Morrissey DE, Greenberg RA; ''The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia
  19. Shell SM, Li Z, Shkriabai N, Kvaratskhelia M, Brosey C, Serrano MA, Chazin WJ, Musich PR, Zou Y; ''Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  20. McNally BA, Trgovcich J, Maul GG, Liu Y, Zheng P; ''A role for cytoplasmic PML in cellular resistance to viral infection.''; PLoS One, 2008 PubMed Europe PMC Scholia
  21. Taniguchi T, Garcia-Higuera I, Xu B, Andreassen PR, Gregory RC, Kim ST, Lane WS, Kastan MB, D'Andrea AD; ''Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways.''; Cell, 2002 PubMed Europe PMC Scholia
  22. DeMott MS, Zigman S, Bambara RA; ''Replication protein A stimulates long patch DNA base excision repair.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  23. Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J; ''SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.''; Genes Dev, 2002 PubMed Europe PMC Scholia
  24. Wang B, Matsuoka S, Carpenter PB, Elledge SJ; ''53BP1, a mediator of the DNA damage checkpoint.''; Science, 2002 PubMed Europe PMC Scholia
  25. Todorov IT, Pepperkok R, Philipova RN, Kearsey SE, Ansorge W, Werner D; ''A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division.''; J Cell Sci, 1994 PubMed Europe PMC Scholia
  26. Ciccia A, Bredemeyer AL, Sowa ME, Terret ME, Jallepalli PV, Harper JW, Elledge SJ; ''The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart.''; Genes Dev, 2009 PubMed Europe PMC Scholia
  27. Avedisov SN, Krasnoselskaya I, Mortin M, Thomas BJ; ''Roughex mediates G(1) arrest through a physical association with cyclin A.''; Mol Cell Biol, 2000 PubMed Europe PMC Scholia
  28. Iwahori S, Yasui Y, Kudoh A, Sato Y, Nakayama S, Murata T, Isomura H, Tsurumi T; ''Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites.''; Cell Signal, 2008 PubMed Europe PMC Scholia
  29. Zeng W, Xu M, Liu S, Sun L, Chen ZJ; ''Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3.''; Mol Cell, 2009 PubMed Europe PMC Scholia
  30. Lee BI, Wilson DM 3rd; ''The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  31. Zecevic A, Menard H, Gurel V, Hagan E, DeCaro R, Zhitkovich A; ''WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts.''; Cell Cycle, 2009 PubMed Europe PMC Scholia
  32. Gerlitz G; ''HMGNs, DNA repair and cancer.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  33. Kellermayer R; ''The versatile RECQL4.''; Genet Med, 2006 PubMed Europe PMC Scholia
  34. Sims AE, Spiteri E, Sims RJ 3rd, Arita AG, Lach FP, Landers T, Wurm M, Freund M, Neveling K, Hanenberg H, Auerbach AD, Huang TT; ''FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.''; Nat Struct Mol Biol, 2007 PubMed Europe PMC Scholia
  35. Yuan J, Eckerdt F, Bereiter-Hahn J, Kurunci-Csacsko E, Kaufmann M, Strebhardt K; ''Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1.''; Oncogene, 2002 PubMed Europe PMC Scholia
  36. Stiffler LA, Ji JY, Trautmann S, Trusty C, Schubiger G; ''Cyclin A and B functions in the early Drosophila embryo.''; Development, 1999 PubMed Europe PMC Scholia
  37. Buisson R, Dion-Côté AM, Coulombe Y, Launay H, Cai H, Stasiak AZ, Stasiak A, Xia B, Masson JY; ''Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 instimulating homologous recombination.''; Nat Struct Mol Biol, 2010 PubMed Europe PMC Scholia
  38. Harbour JW, Luo RX, Dei Santi A, Postigo AA, Dean DC; ''Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1.''; Cell, 1999 PubMed Europe PMC Scholia
  39. Franchitto A, Pichierri P; ''Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest.''; J Cell Biol, 2002 PubMed Europe PMC Scholia
  40. Rauen M, Burtelow MA, Dufault VM, Karnitz LM; ''The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  41. Kim H, Chen J, Yu X; ''Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.''; Science, 2007 PubMed Europe PMC Scholia
  42. Robins P, Pappin DJ, Wood RD, Lindahl T; ''Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I.''; J Biol Chem, 1994 PubMed Europe PMC Scholia
  43. Gradia S, Subramanian D, Wilson T, Acharya S, Makhov A, Griffith J, Fishel R; ''hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA.''; Mol Cell, 1999 PubMed Europe PMC Scholia
  44. Stevens C, Smith L, La Thangue NB; ''Chk2 activates E2F-1 in response to DNA damage.''; Nat Cell Biol, 2003 PubMed Europe PMC Scholia
  45. Garcia-Higuera I, Kuang Y, Näf D, Wasik J, D'Andrea AD; ''Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex.''; Mol Cell Biol, 1999 PubMed Europe PMC Scholia
  46. Ziv Y, Bielopolski D, Galanty Y, Lukas C, Taya Y, Schultz DC, Lukas J, Bekker-Jensen S, Bartek J, Shiloh Y; ''Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.''; Nat Cell Biol, 2006 PubMed Europe PMC Scholia
  47. Ruiz de Almodóvar JM, Bush C, Peacock JH, Steel GG, Whitaker SJ, McMillan TJ; ''Dose-rate effect for DNA damage induced by ionizing radiation in human tumor cells.''; Radiat Res, 1994 PubMed Europe PMC Scholia
  48. Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J; ''RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.''; Cell, 2007 PubMed Europe PMC Scholia
  49. Bochkareva E, Belegu V, Korolev S, Bochkarev A; ''Structure of the major single-stranded DNA-binding domain of replication protein A suggests a dynamic mechanism for DNA binding.''; EMBO J, 2001 PubMed Europe PMC Scholia
  50. Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, Elledge SJ; ''Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.''; Science, 1997 PubMed Europe PMC Scholia
  51. Okuda M, Horn HF, Tarapore P, Tokuyama Y, Smulian AG, Chan PK, Knudsen ES, Hofmann IA, Snyder JD, Bove KE, Fukasawa K; ''Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication.''; Cell, 2000 PubMed Europe PMC Scholia
  52. Hydbring P, Bahram F, Su Y, Tronnersjö S, Högstrand K, von der Lehr N, Sharifi HR, Lilischkis R, Hein N, Wu S, Vervoorts J, Henriksson M, Grandien A, Lüscher B, Larsson LG; ''Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  53. Phan RT, Saito M, Kitagawa Y, Means AR, Dalla-Favera R; ''Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells.''; Nat Immunol, 2007 PubMed Europe PMC Scholia
  54. Futreal PA, Liu Q, Shattuck-Eidens D, Cochran C, Harshman K, Tavtigian S, Bennett LM, Haugen-Strano A, Swensen J, Miki Y, et al.; ''BRCA1 mutations in primary breast and ovarian carcinomas.''; Science, 1994 PubMed Europe PMC Scholia
  55. Wu X, Shell SM, Zou Y; ''Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells.''; Oncogene, 2005 PubMed Europe PMC Scholia
  56. Phelan ML, Sif S, Narlikar GJ, Kingston RE; ''Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.''; Mol Cell, 1999 PubMed Europe PMC Scholia
  57. Lalioti V, Pulido D, Sandoval IV; ''Cdk5, the multifunctional surveyor.''; Cell Cycle, 2010 PubMed Europe PMC Scholia
  58. Chakrabarti S, Jayachandran U, Bonneau F, Fiorini F, Basquin C, Domcke S, Le Hir H, Conti E; ''Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2.''; Mol Cell, 2011 PubMed Europe PMC Scholia
  59. Bessho T, Sancar A; ''Human DNA damage checkpoint protein hRAD9 is a 3' to 5' exonuclease.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  60. Oshimori N, Ohsugi M, Yamamoto T; ''The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity.''; Nat Cell Biol, 2006 PubMed Europe PMC Scholia
  61. Chen X, Arciero CA, Wang C, Broccoli D, Godwin AK; ''BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation.''; Cancer Res, 2006 PubMed Europe PMC Scholia
  62. Drost M, Zonneveld Je, van Dijk L, Morreau H, Tops CM, Vasen HF, Wijnen JT, de Wind N; ''A cell-free assay for the functional analysis of variants of the mismatch repair protein MLH1.''; Hum Mutat, 2010 PubMed Europe PMC Scholia
  63. Courey AJ, Tjian R; ''Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif.''; Cell, 1988 PubMed Europe PMC Scholia
  64. Kansikas M, Kariola R, Nyström M; ''Verification of the three-step model in assessing the pathogenicity of mismatch repair gene variants.''; Hum Mutat, 2011 PubMed Europe PMC Scholia
  65. Meetei AR, Sechi S, Wallisch M, Yang D, Young MK, Joenje H, Hoatlin ME, Wang W; ''A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.''; Mol Cell Biol, 2003 PubMed Europe PMC Scholia
  66. Harper JW, Elledge SJ; ''The DNA damage response: ten years after.''; Mol Cell, 2007 PubMed Europe PMC Scholia
  67. Saha P, Thome KC, Yamaguchi R, Hou Z, Weremowicz S, Dutta A; ''The human homolog of Saccharomyces cerevisiae CDC45.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  68. Kwak Y, Jeong J, Lee S, Park YU, Lee SA, Han DH, Kim JH, Ohshima T, Mikoshiba K, Suh YH, Cho S, Park SK; ''Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation.''; J Biol Chem, 2013 PubMed Europe PMC Scholia
  69. Restle A, Janz C, Wiesmüller L; ''Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombination.''; Oncogene, 2005 PubMed Europe PMC Scholia
  70. Sabatel H, Pirlot C, Piette J, Habraken Y; ''Importance of PIKKs in NF-κB activation by genotoxic stress.''; Biochem Pharmacol, 2011 PubMed Europe PMC Scholia
  71. Kang T, Kwon NH, Lee JY, Park MC, Kang E, Kim HH, Kang TJ, Kim S; ''AIMP3/p18 controls translational initiation by mediating the delivery of charged initiator tRNA to initiation complex.''; J Mol Biol, 2012 PubMed Europe PMC Scholia
  72. Sharma S, Sommers JA, Choudhary S, Faulkner JK, Cui S, Andreoli L, Muzzolini L, Vindigni A, Brosh RM Jr; ''Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  73. Blackwell LJ, Bjornson KP, Modrich P; ''DNA-dependent activation of the hMutSalpha ATPase.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  74. Yan J, Yang XP, Kim YS, Jetten AM; ''RAP80 responds to DNA damage induced by both ionizing radiation and UV irradiation and is phosphorylated at Ser 205.''; Cancer Res, 2008 PubMed Europe PMC Scholia
  75. Ahel D, Horejsí Z, Wiechens N, Polo SE, Garcia-Wilson E, Ahel I, Flynn H, Skehel M, West SC, Jackson SP, Owen-Hughes T, Boulton SJ; ''Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.''; Science, 2009 PubMed Europe PMC Scholia
  76. Oluwagbemiga LA, Oluwole A, Kayode AA; ''Seventeen years after BRCA1: what is the BRCA mutation status of the breast cancer patients in Africa? - a systematic review.''; Springerplus, 2012 PubMed Europe PMC Scholia
  77. Fu C, Ahmed K, Ding H, Ding X, Lan J, Yang Z, Miao Y, Zhu Y, Shi Y, Zhu J, Huang H, Yao X; ''Stabilization of PML nuclear localization by conjugation and oligomerization of SUMO-3.''; Oncogene, 2005 PubMed Europe PMC Scholia
  78. Zhou H, Wertz I, O'Rourke K, Ultsch M, Seshagiri S, Eby M, Xiao W, Dixit VM; ''Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.''; Nature, 2004 PubMed Europe PMC Scholia
  79. Qiu J, Bimston DN, Partikian A, Shen B; ''Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  80. Hirai I, Sasaki T, Wang HG; ''Human hRad1 but not hRad9 protects hHus1 from ubiquitin-proteasomal degradation.''; Oncogene, 2004 PubMed Europe PMC Scholia
  81. Rasio D, Negrini M, Croce CM; ''Genomic organization of the ATM locus involved in ataxia-telangiectasia.''; Cancer Res, 1995 PubMed Europe PMC Scholia
  82. Bridge WL, Vandenberg CJ, Franklin RJ, Hiom K; ''The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair.''; Nat Genet, 2005 PubMed Europe PMC Scholia
  83. Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG; ''Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways.''; Hum Mol Genet, 2004 PubMed Europe PMC Scholia
  84. Wilson DM 3rd, Carney JP, Coleman MA, Adamson AW, Christensen M, Lamerdin JE; ''Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1.''; Nucleic Acids Res, 1998 PubMed Europe PMC Scholia
  85. Rotman G, Shiloh Y; ''ATM: from gene to function.''; Hum Mol Genet, 1998 PubMed Europe PMC Scholia
  86. Goodhead DT; ''The initial physical damage produced by ionizing radiations.''; Int J Radiat Biol, 1989 PubMed Europe PMC Scholia
  87. Guglielmi C, Cerri I, Evangelista M, Collavoli A, Tancredi M, Aretini P, Caligo MA; ''Identification of two novel BRCA1-partner genes in the DNA double-strand break repair pathway.''; Breast Cancer Res Treat, 2013 PubMed Europe PMC Scholia
  88. Deffenbaugh AM, Frank TS, Hoffman M, Cannon-Albright L, Neuhausen SL; ''Characterization of common BRCA1 and BRCA2 variants.''; Genet Test, 2002 PubMed Europe PMC Scholia
  89. Unsal-Kaçmaz K, Makhov AM, Griffith JD, Sancar A; ''Preferential binding of ATR protein to UV-damaged DNA.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC Scholia
  90. Kaspar M, Dienemann A, Schulze C, Sprenger F; ''Mitotic degradation of cyclin A is mediated by multiple and novel destruction signals.''; Curr Biol, 2001 PubMed Europe PMC Scholia
  91. Barr SM, Leung CG, Chang EE, Cimprich KA; ''ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation.''; Curr Biol, 2003 PubMed Europe PMC Scholia
  92. An H, Lu X, Liu D, Yarbrough WG; ''LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1).''; PLoS One, 2011 PubMed Europe PMC Scholia
  93. Xiao Z, Chen Z, Gunasekera AH, Sowin TJ, Rosenberg SH, Fesik S, Zhang H; ''Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  94. Trujillo KM, Yuan SS, Lee EY, Sung P; ''Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  95. Yin J, Kwon YT, Varshavsky A, Wang W; ''RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.''; Hum Mol Genet, 2004 PubMed Europe PMC Scholia
  96. Vicart A, Lefebvre T, Imbert J, Fernandez A, Kahn-Perlès B; ''Increased chromatin association of Sp1 in interphase cells by PP2A-mediated dephosphorylations.''; J Mol Biol, 2006 PubMed Europe PMC Scholia
  97. Erdile LF, Heyer WD, Kolodner R, Kelly TJ; ''Characterization of a cDNA encoding the 70-kDa single-stranded DNA-binding subunit of human replication protein A and the role of the protein in DNA replication.''; J Biol Chem, 1991 PubMed Europe PMC Scholia
  98. Cotta-Ramusino C, McDonald ER 3rd, Hurov K, Sowa ME, Harper JW, Elledge SJ; ''A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.''; Science, 2011 PubMed Europe PMC Scholia
  99. Mu JJ, Wang Y, Luo H, Leng M, Zhang J, Yang T, Besusso D, Jung SY, Qin J; ''A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  100. Iaccarino I, Marra G, Palombo F, Jiricny J; ''hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha.''; EMBO J, 1998 PubMed Europe PMC Scholia
  101. Weisshart K, Pestryakov P, Smith RW, Hartmann H, Kremmer E, Lavrik O, Nasheuer HP; ''Coordinated regulation of replication protein A activities by its subunits p14 and p32.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  102. Jochmann R, Thurau M, Jung S, Hofmann C, Naschberger E, Kremmer E, Harrer T, Miller M, Schaft N, Stürzl M; ''O-linked N-acetylglucosaminylation of Sp1 inhibits the human immunodeficiency virus type 1 promoter.''; J Virol, 2009 PubMed Europe PMC Scholia
  103. Shao Z, Li F, Sy SM, Yan W, Zhang Z, Gong D, Wen B, Huen MS, Gong Q, Wu J, Shi Y; ''Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure.''; J. Struct. Biol., 2012 PubMed Europe PMC Scholia
  104. Lavin MF, Kozlov S, Gatei M, Kijas AW; ''ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor.''; Biomolecules, 2015 PubMed Europe PMC Scholia
  105. Harris N, Brill E, Shohat O, Prokocimer M, Wolf D, Arai N, Rotter V; ''Molecular basis for heterogeneity of the human p53 protein.''; Mol Cell Biol, 1986 PubMed Europe PMC Scholia
  106. LaRocque JR, Jaklevic B, Su TT, Sekelsky J; ''Drosophila ATR in double-strand break repair.''; Genetics, 2007 PubMed Europe PMC Scholia
  107. Chini CC, Chen J; ''Human claspin is required for replication checkpoint control.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  108. Wu CJ, Conze DB, Li T, Srinivasula SM, Ashwell JD; ''Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected].''; Nat Cell Biol, 2006 PubMed Europe PMC Scholia
  109. Nakamura A, Naito M, Arai H, Fujita N; ''Mitotic phosphorylation of Aki1 at Ser208 by cyclin B1-Cdk1 complex.''; Biochem Biophys Res Commun, 2010 PubMed Europe PMC Scholia
  110. Lamb, P, Crawford, L; ''Characterization of the human p53 gene.''; Mol Cell Biol, 1986 PubMed Europe PMC Scholia
  111. Du Y, Zhou J, Fan J, Shen Z, Chen X; ''Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex.''; J Proteome Res, 2009 PubMed Europe PMC Scholia
  112. You Z, Shi LZ, Zhu Q, Wu P, Zhang YW, Basilio A, Tonnu N, Verma IM, Berns MW, Hunter T; ''CtIP links DNA double-strand break sensing to resection.''; Mol Cell, 2009 PubMed Europe PMC Scholia
  113. Marston NJ, Richards WJ, Hughes D, Bertwistle D, Marshall CJ, Ashworth A; ''Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals.''; Mol Cell Biol, 1999 PubMed Europe PMC Scholia
  114. Huang J, Raff JW; ''The disappearance of cyclin B at the end of mitosis is regulated spatially in Drosophila cells.''; EMBO J, 1999 PubMed Europe PMC Scholia
  115. Ahel I, Ahel D, Matsusaka T, Clark AJ, Pines J, Boulton SJ, West SC; ''Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins.''; Nature, 2008 PubMed Europe PMC Scholia
  116. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M; ''Towards a proteome-scale map of the human protein-protein interaction network.''; Nature, 2005 PubMed Europe PMC Scholia
  117. Regad T, Saib A, Lallemand-Breitenbach V, Pandolfi PP, de Thé H, Chelbi-Alix MK; ''PML mediates the interferon-induced antiviral state against a complex retrovirus via its association with the viral transactivator.''; EMBO J, 2001 PubMed Europe PMC Scholia
  118. Smits VA, Reaper PM, Jackson SP; ''Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.''; Curr Biol, 2006 PubMed Europe PMC Scholia
  119. Xu M, Sheppard KA, Peng CY, Yee AS, Piwnica-Worms H; ''Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.''; Mol Cel Biol, 1994 PubMed Europe PMC Scholia
  120. Finn K, Lowndes NF, Grenon M; ''Eukaryotic DNA damage checkpoint activation in response to double-strand breaks.''; Cell Mol Life Sci, 2012 PubMed Europe PMC Scholia
  121. Lindon C, Pines J; ''Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells.''; J Cell Biol, 2004 PubMed Europe PMC Scholia
  122. Guo Z, Qian L, Liu R, Dai H, Zhou M, Zheng L, Shen B; ''Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair.''; Mol Cell Biol, 2008 PubMed Europe PMC Scholia
  123. Reinemund J, Seidel K, Steckelings UM, Zaade D, Klare S, Rompe F, Katerbaum M, Schacherl J, Li Y, Menk M, Schefe JH, Goldin-Lang P, Szabo C, Olah G, Unger T, Funke-Kaiser H; ''Poly(ADP-ribose) polymerase-1 (PARP-1) transcriptionally regulates angiotensin AT2 receptor (AT2R) and AT2R binding protein (ATBP) genes.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia
  124. Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, Ellenberg J, Panier S, Durocher D, Bartek J, Lukas J, Lukas C; ''RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.''; Cell, 2009 PubMed Europe PMC Scholia
  125. Whitfield WG, Gonzalez C, Maldonado-Codina G, Glover DM; ''The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transition.''; EMBO J, 1990 PubMed Europe PMC Scholia
  126. Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, Lukas J; ''RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.''; Cell, 2007 PubMed Europe PMC Scholia
  127. Lin HK, Bergmann S, Pandolfi PP; ''Cytoplasmic PML function in TGF-beta signalling.''; Nature, 2004 PubMed Europe PMC Scholia
  128. Salomoni P, Dvorkina M, Michod D; ''Role of the promyelocytic leukaemia protein in cell death regulation.''; Cell Death Dis, 2012 PubMed Europe PMC Scholia
  129. Islam MN, Fox D 3rd, Guo R, Enomoto T, Wang W; ''RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase.''; Mol Cell Biol, 2010 PubMed Europe PMC Scholia
  130. Gao J, Wang Q, Dong C, Chen S, Qi Y, Liu Y; ''Whole Exome Sequencing Identified MCM2 as a Novel Causative Gene for Autosomal Dominant Nonsyndromic Deafness in a Chinese Family.''; PLoS One, 2015 PubMed Europe PMC Scholia
  131. Ho GP, Margossian S, Taniguchi T, D'Andrea AD; ''Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance.''; Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  132. Yoshida K, Komatsu K, Wang HG, Kufe D; ''c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage.''; Mol Cell Biol, 2002 PubMed Europe PMC Scholia
  133. Thompson LH; ''Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography.''; Mutat Res, 2012 PubMed Europe PMC Scholia
  134. Shimada N, Shinagawa T, Ishii S; ''Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein.''; Genes Cells, 2008 PubMed Europe PMC Scholia
  135. Kitagawa M, Higashi H, Suzuki-Takahashi I, Segawa K, Hanks SK, Taya Y, Nishimura S, Okuyama A; ''Phosphorylation of E2F-1 by cyclin A-cdk2.''; Oncogene, 1995 PubMed Europe PMC Scholia
  136. Bernardi R, Scaglioni PP, Bergmann S, Horn HF, Vousden KH, Pandolfi PP; ''PML regulates p53 stability by sequestering Mdm2 to the nucleolus.''; Nat Cell Biol, 2004 PubMed Europe PMC Scholia
  137. Riches LC, Lynch AM, Gooderham NJ; ''Early events in the mammalian response to DNA double-strand breaks.''; Mutagenesis, 2008 PubMed Europe PMC Scholia
  138. Keegan KS, Holtzman DA, Plug AW, Christenson ER, Brainerd EE, Flaggs G, Bentley NJ, Taylor EM, Meyn MS, Moss SB, Carr AM, Ashley T, Hoekstra MF; ''The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.''; Genes Dev, 1996 PubMed Europe PMC Scholia
  139. Kanno S, Kuzuoka H, Sasao S, Hong Z, Lan L, Nakajima S, Yasui A; ''A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.''; EMBO J, 2007 PubMed Europe PMC Scholia
  140. Lehner CF, Yakubovich N, O'Farrell PH; ''Exploring the role of Drosophila cyclin A in the regulation of S phase.''; Cold Spring Harb Symp Quant Biol, 1991 PubMed Europe PMC Scholia
  141. Wooster R, Bignell G, Lancaster J, Swift S, Seal S, Mangion J, Collins N, Gregory S, Gumbs C, Micklem G; ''Identification of the breast cancer susceptibility gene BRCA2.''; Nature, 1995 PubMed Europe PMC Scholia
  142. Gibbs-Seymour I, Fontana P, Rack JG, Ahel I; ''HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity.''; Mol Cell, 2016 PubMed Europe PMC Scholia
  143. Smits VA, Warmerdam DO, Martin Y, Freire R; ''Mechanisms of ATR-mediated checkpoint signalling.''; Front Biosci (Landmark Ed), 2010 PubMed Europe PMC Scholia
  144. Sobhian B, Shao G, Lilli DR, Culhane AC, Moreau LA, Xia B, Livingston DM, Greenberg RA; ''RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.''; Science, 2007 PubMed Europe PMC Scholia
  145. Musio A, Montagna C, Mariani T, Tilenni M, Focarelli ML, Brait L, Indino E, Benedetti PA, Chessa L, Albertini A, Ried T, Vezzoni P; ''SMC1 involvement in fragile site expression.''; Hum Mol Genet, 2005 PubMed Europe PMC Scholia
  146. Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP; ''Human CtIP promotes DNA end resection.''; Nature, 2007 PubMed Europe PMC Scholia
  147. Lu X, Nannenga B, Donehower LA; ''PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.''; Genes Dev, 2005 PubMed Europe PMC Scholia
  148. Hisanaga S, Endo R; ''Regulation and role of cyclin-dependent kinase activity in neuronal survival and death.''; J Neurochem, 2010 PubMed Europe PMC Scholia
  149. Brady ME, Ozanne DM, Gaughan L, Waite I, Cook S, Neal DE, Robson CN; ''Tip60 is a nuclear hormone receptor coactivator.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  150. Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D; ''Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.''; Science, 2007 PubMed Europe PMC Scholia
  151. Erzgräber G, Rosemann M, Regel K, Abel H; ''DNA structures and radiation injury.''; Adv Space Res, 1992 PubMed Europe PMC Scholia
  152. Kaufmann WK; ''Cell cycle checkpoints and DNA repair preserve the stability of the human genome.''; Cancer Metastasis Rev, 1995 PubMed Europe PMC Scholia
  153. Freire R, Murguía JR, Tarsounas M, Lowndes NF, Moens PB, Jackson SP; ''Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis.''; Genes Dev, 1998 PubMed Europe PMC Scholia
  154. Kumar S, Barthwal MK, Dikshit M; ''Cdk2 nitrosylation and loss of mitochondrial potential mediate NO-dependent biphasic effect on HL-60 cell cycle.''; Free Radic Biol Med, 2010 PubMed Europe PMC Scholia
  155. Calzone L, Gelay A, Zinovyev A, Radvanyi F, Barillot E; ''A comprehensive modular map of molecular interactions in RB/E2F pathway.''; Mol Syst Biol, 2008 PubMed Europe PMC Scholia
  156. Basso K, Schneider C, Shen Q, Holmes AB, Setty M, Leslie C, Dalla-Favera R; ''BCL6 positively regulates AID and germinal center gene expression via repression of miR-155.''; J Exp Med, 2012 PubMed Europe PMC Scholia
  157. Morris JR, Solomon E; ''BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair.''; Hum Mol Genet, 2004 PubMed Europe PMC Scholia
  158. Park BJ, Kang JW, Lee SW, Choi SJ, Shin YK, Ahn YH, Choi YH, Choi D, Lee KS, Kim S; ''The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR.''; Cell, 2005 PubMed Europe PMC Scholia
  159. Oh W, Ghim J, Lee EW, Yang MR, Kim ET, Ahn JH, Song J; ''PML-IV functions as a negative regulator of telomerase by interacting with TERT.''; J Cell Sci, 2009 PubMed Europe PMC Scholia
  160. Johnson DG, Ohtani K, Nevins JR; ''Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.''; Genes Dev, 1994 PubMed Europe PMC Scholia
  161. Haahr P, Hoffmann S, Tollenaere MA, Ho T, Toledo LI, Mann M, Bekker-Jensen S, Räschle M, Mailand N; ''Activation of the ATR kinase by the RPA-binding protein ETAA1.''; Nat Cell Biol, 2016 PubMed Europe PMC Scholia
  162. Bereshchenko OR, Gu W, Dalla-Favera R; ''Acetylation inactivates the transcriptional repressor BCL6.''; Nat Genet, 2002 PubMed Europe PMC Scholia
  163. Nishijo K, Nakayama T, Aoyama T, Okamoto T, Ishibe T, Yasura K, Shima Y, Shibata KR, Tsuboyama T, Nakamura T, Toguchida J; ''Mutation analysis of the RECQL4 gene in sporadic osteosarcomas.''; Int J Cancer, 2004 PubMed Europe PMC Scholia
  164. Peuscher MH, Jacobs JJ; ''DNA-damage response and repair activities at uncapped telomeres depend on RNF8.''; Nat Cell Biol, 2011 PubMed Europe PMC Scholia
  165. Yang Q, Zhang R, Wang XW, Linke SP, Sengupta S, Hickson ID, Pedrazzi G, Perrera C, Stagljar I, Littman SJ, Modrich P, Harris CC; ''The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase.''; Oncogene, 2004 PubMed Europe PMC Scholia
  166. Roshak AK, Capper EA, Imburgia C, Fornwald J, Scott G, Marshall LA; ''The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase.''; Cell Signal, 2000 PubMed Europe PMC Scholia
  167. Ranuncolo SM, Polo JM, Dierov J, Singer M, Kuo T, Greally J, Green R, Carroll M, Melnick A; ''Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR.''; Nat Immunol, 2007 PubMed Europe PMC Scholia
  168. Liu J, Song Y, Qian J, Liu B, Dong Y, Tian B, Sun Z; ''Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in γ-irradiation-induced DNA damage responses.''; Biochemistry (Mosc), 2011 PubMed Europe PMC Scholia
  169. Hammarsten O, Chu G; ''DNA-dependent protein kinase: DNA binding and activation in the absence of Ku.''; Proc Natl Acad Sci U S A, 1998 PubMed Europe PMC Scholia
  170. Sacho EJ, Kadyrov FA, Modrich P, Kunkel TA, Erie DA; ''Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha.''; Mol Cell, 2008 PubMed Europe PMC Scholia
  171. Jeggo PA, Geuting V, Lobrich M; ''The role of homologous recombination in radiation-induced double-strand break repair.''; Radiother Oncol, 2011 PubMed Europe PMC Scholia
  172. Sadhu K, Reed SI, Richardson H, Russell P; ''Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2.''; Proc Natl Acad Sci USA, 1990 PubMed Europe PMC Scholia
  173. Itakura E, Takai KK, Umeda K, Kimura M, Ohsumi M, Tamai K, Matsuura A; ''Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage.''; FEBS Lett, 2004 PubMed Europe PMC Scholia
  174. Shaffer AL, Yu X, He Y, Boldrick J, Chan EP, Staudt LM; ''BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.''; Immunity, 2000 PubMed Europe PMC Scholia
  175. Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER 3rd, Hurov KE, Luo J, Ballif BA, Gygi SP, Hofmann K, D'Andrea AD, Elledge SJ; ''Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.''; Cell, 2007 PubMed Europe PMC Scholia
  176. Malumbres M, Barbacid M; ''Mammalian cyclin-dependent kinases.''; Trends Biochem Sci, 2005 PubMed Europe PMC Scholia
  177. Mochan TA, Venere M, DiTullio RA Jr, Halazonetis TD; ''53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.''; Cancer Res, 2003 PubMed Europe PMC Scholia
  178. Liebl J, Weitensteiner SB, Vereb G, Takács L, Fürst R, Vollmar AM, Zahler S; ''Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  179. Wu X, Levine AJ; ''p53 and E2F-1 cooperate to mediate apoptosis.''; Proc Natl Acad Sci USA, 1994 PubMed Europe PMC Scholia
  180. Warmerdam DO, Kanaar R; ''Dealing with DNA damage: relationships between checkpoint and repair pathways.''; Mutat Res, 2010 PubMed Europe PMC Scholia
  181. Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, Lee EY, Lee WH; ''Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response.''; Nature, 2000 PubMed Europe PMC Scholia
  182. Takahisa M, Togashi S, Ueda R, Mikuni M, Tsurumura S, Kondo K, Miyake T; ''Structure of the Drosophila melanogaster gene encoding cyclin A.''; Gene, 1992 PubMed Europe PMC Scholia
  183. Matsuoka S, Huang M, Elledge SJ; ''Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.''; Science, 1998 PubMed Europe PMC Scholia
  184. Garcia-Cruz R, Brieño MA, Roig I, Grossmann M, Velilla E, Pujol A, Cabero L, Pessarrodona A, Barbero JL, Garcia Caldés M; ''Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes.''; Hum Reprod, 2010 PubMed Europe PMC Scholia
  185. Battaglioli E, Andrés ME, Rose DW, Chenoweth JG, Rosenfeld MG, Anderson ME, Mandel G; ''REST repression of neuronal genes requires components of the hSWI.SNF complex.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  186. Cuchet D, Sykes A, Nicolas A, Orr A, Murray J, Sirma H, Heeren J, Bartelt A, Everett RD; ''PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication.''; J Cell Sci, 2011 PubMed Europe PMC Scholia
  187. Stucki M, Jackson SP; ''gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes.''; DNA Repair (Amst), 2006 PubMed Europe PMC Scholia
  188. de Jager M, Wyman C, van Gent DC, Kanaar R; ''DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP.''; Nucleic Acids Res, 2002 PubMed Europe PMC Scholia
  189. Wang B, Hurov K, Hofmann K, Elledge SJ; ''NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.''; Genes Dev, 2009 PubMed Europe PMC Scholia
  190. Zhang AH, Xi X; ''Molecular cloning of a splicing variant of human RECQL helicase.''; Biochem Biophys Res Commun, 2002 PubMed Europe PMC Scholia
  191. Meijer L, Borgne A, Mulner O, Chong JP, Blow JJ, Inagaki N, Inagaki M, Delcros JG, Moulinoux JP; ''Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.''; Eur J Biochem, 1997 PubMed Europe PMC Scholia
  192. Davies DR, Interthal H, Champoux JJ, Hol WG; ''Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures.''; J Mol Biol, 2002 PubMed Europe PMC Scholia
  193. Puranam KL, Blackshear PJ; ''Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ.''; J Biol Chem, 1994 PubMed Europe PMC Scholia
  194. Neuman E, Sellers WR, McNeil JA, Lawrence JB, Kaelin WG Jr; ''Structure and partial genomic sequence of the human E2F1 gene.''; Gene, 1996 PubMed Europe PMC Scholia
  195. Littler DR, Alvarez-Fernández M, Stein A, Hibbert RG, Heidebrecht T, Aloy P, Medema RH, Perrakis A; ''Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence.''; Nucleic Acids Res, 2010 PubMed Europe PMC Scholia
  196. Doherty KM, Sharma S, Uzdilla LA, Wilson TM, Cui S, Vindigni A, Brosh RM Jr; ''RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  197. Sørensen CS, Syljuåsen RG, Lukas J, Bartek J; ''ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage.''; Cell Cycle, 2004 PubMed Europe PMC Scholia
  198. Potts PR, Porteus MH, Yu H; ''Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks.''; EMBO J, 2006 PubMed Europe PMC Scholia
  199. Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, Grompe M, D'Andrea AD; ''Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.''; Mol Cell, 2001 PubMed Europe PMC Scholia
  200. Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y, Ziv Y; ''Enhanced phosphorylation of p53 by ATM in response to DNA damage.''; Science, 1998 PubMed Europe PMC Scholia
  201. Sage JM, Gildemeister OS, Knight KL; ''Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  202. Almendral JM, Huebsch D, Blundell PA, Macdonald-Bravo H, Bravo R; ''Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins.''; Proc Natl Acad Sci USA, 1987 PubMed Europe PMC Scholia
  203. Ulbricht T, Alzrigat M, Horch A, Reuter N, von Mikecz A, Steimle V, Schmitt E, Krämer OH, Stamminger T, Hemmerich P; ''PML promotes MHC class II gene expression by stabilizing the class II transactivator.''; J Cell Biol, 2012 PubMed Europe PMC Scholia
  204. Folias A, Matkovic M, Bruun D, Reid S, Hejna J, Grompe M, D'Andrea A, Moses R; ''BRCA1 interacts directly with the Fanconi anemia protein FANCA.''; Hum Mol Genet, 2002 PubMed Europe PMC Scholia
  205. Liang Y, Yang G, Liu F, Wang Y; ''Monte Carlo simulation of ionizing radiation induced DNA strand breaks utilizing coarse grained high-order chromatin structures.''; Phys Med Biol, 2016 PubMed Europe PMC Scholia
  206. Muris DF, Bezzubova O, Buerstedde JM, Vreeken K, Balajee AS, Osgood CJ, Troelstra C, Hoeijmakers JH, Ostermann K, Schmidt H; ''Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination.''; Mutat Res, 1994 PubMed Europe PMC Scholia
  207. Yan J, Kim YS, Yang XP, Li LP, Liao G, Xia F, Jetten AM; ''The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.''; Cancer Res, 2007 PubMed Europe PMC Scholia
  208. Bekker-Jensen S, Rendtlew Danielsen J, Fugger K, Gromova I, Nerstedt A, Lukas C, Bartek J, Lukas J, Mailand N; ''HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes.''; Nat Cell Biol, 2010 PubMed Europe PMC Scholia
  209. Hahnfeldt P, Sachs RK, Hlatky LR; ''Evolution of DNA damage in irradiated cells.''; J Math Biol, 1992 PubMed Europe PMC Scholia
  210. Gregson HC, Van Hooser AA, Ball AR Jr, Brinkley BR, Yokomori K; ''Localization of human SMC1 protein at kinetochores.''; Chromosome Res, 2002 PubMed Europe PMC Scholia
  211. Vorechovský I, Rasio D, Luo L, Monaco C, Hammarström L, Webster AD, Zaloudik J, Barbanti-Brodani G, James M, Russo G, et al.; ''The ATM gene and susceptibility to breast cancer: analysis of 38 breast tumors reveals no evidence for mutation.''; Cancer Res, 1996 PubMed Europe PMC Scholia
  212. Tsuji T, Ficarro SB, Jiang W; ''Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.''; Mol Biol Cell, 2006 PubMed Europe PMC Scholia
  213. Polanowska J, Martin JS, Garcia-Muse T, Petalcorin MI, Boulton SJ; ''A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.''; EMBO J, 2006 PubMed Europe PMC Scholia
  214. Ma Y, Lu H, Tippin B, Goodman MF, Shimazaki N, Koiwai O, Hsieh CL, Schwarz K, Lieber MR; ''A biochemically defined system for mammalian nonhomologous DNA end joining.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  215. Lane HA, Nigg EA; ''Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.''; J Cell Biol, 1996 PubMed Europe PMC Scholia
  216. Friedman JR, Fredericks WJ, Jensen DE, Speicher DW, Huang XP, Neilson EG, Rauscher FJ 3rd; ''KAP-1, a novel corepressor for the highly conserved KRAB repression domain.''; Genes Dev, 1996 PubMed Europe PMC Scholia
  217. Miki Y, Katagiri T, Kasumi F, Yoshimoto T, Nakamura Y; ''Mutation analysis in the BRCA2 gene in primary breast cancers.''; Nat Genet, 1996 PubMed Europe PMC Scholia
  218. Yan S, Michael WM; ''TopBP1 and DNA polymerase alpha-mediated recruitment of the 9-1-1 complex to stalled replication forks: implications for a replication restart-based mechanism for ATR checkpoint activation.''; Cell Cycle, 2009 PubMed Europe PMC Scholia
  219. Ma Z, Lin M, Li K, Fu Y, Liu X, Yang D, Zhao Y, Zheng J, Sun B; ''Knocking down SMC1A inhibits growth and leads to G2/M arrest in human glioma cells.''; Int J Clin Exp Pathol, 2013 PubMed Europe PMC Scholia
  220. Pinton P, Giorgi C, Pandolfi PP; ''The role of PML in the control of apoptotic cell fate: a new key player at ER-mitochondria sites.''; Cell Death Differ, 2011 PubMed Europe PMC Scholia
  221. Ohashi A, Zdzienicka MZ, Chen J, Couch FJ; ''Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  222. Schwendener S, Raynard S, Paliwal S, Cheng A, Kanagaraj R, Shevelev I, Stark JM, Sung P, Janscak P; ''Physical interaction of RECQ5 helicase with RAD51 facilitates itsanti-recombinase activity.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  223. Tom S, Henricksen LA, Bambara RA; ''Mechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  224. Erdile LF, Wold MS, Kelly TJ; ''The primary structure of the 32-kDa subunit of human replication protein A.''; J Biol Chem, 1990 PubMed Europe PMC Scholia
  225. Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE; ''Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.''; Nat Struct Biol, 2001 PubMed Europe PMC Scholia
  226. Schweitzer A, Aufderheide A, Rudack T, Beck F, Pfeifer G, Plitzko JM, Sakata E, Schulten K, Förster F, Baumeister W; ''Structure of the human 26S proteasome at a resolution of 3.9 Å.''; Proc Natl Acad Sci U S A, 2016 PubMed Europe PMC Scholia
  227. Chen J, Archer TK; ''Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57.''; Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  228. Danielsen JR, Povlsen LK, Villumsen BH, Streicher W, Nilsson J, Wikström M, Bekker-Jensen S, Mailand N; ''DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger.''; J Cell Biol, 2012 PubMed Europe PMC Scholia
  229. Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng N, Chen PL, Lee WH, Pavletich NP; ''BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.''; Science, 2002 PubMed Europe PMC Scholia
  230. Wang X, Andreassen PR, D'Andrea AD; ''Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin.''; Mol Cell Biol, 2004 PubMed Europe PMC Scholia
  231. Yusufzai T, Kadonaga JT; ''HARP is an ATP-driven annealing helicase.''; Science, 2008 PubMed Europe PMC Scholia
  232. Dantzer F, Nasheuer HP, Vonesch JL, de Murcia G, Ménissier-de Murcia J; ''Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication.''; Nucleic Acids Res, 1998 PubMed Europe PMC Scholia
  233. Jensik PJ, Huggenvik JI, Collard MW; ''Deformed epidermal autoregulatory factor-1 (DEAF1) interacts with the Ku70 subunit of the DNA-dependent protein kinase complex.''; PLoS One, 2012 PubMed Europe PMC Scholia
  234. Anamika, Markin CJ, Rout MK, Spyracopoulos L; ''Molecular basis for impaired DNA damage response function associated with the RAP80 �E81 defect.''; J Biol Chem, 2014 PubMed Europe PMC Scholia
  235. Blundred R, Myers K, Helleday T, Goldman AS, Bryant HE; ''Human RECQL5 overcomes thymidine-induced replication stress.''; DNA Repair (Amst), 2010 PubMed Europe PMC Scholia
  236. Yu X, Chen J; ''DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains.''; Mol Cell Biol, 2004 PubMed Europe PMC Scholia
  237. Ward JF; ''DNA damage and repair.''; Basic Life Sci, 1991 PubMed Europe PMC Scholia
  238. Uto K, Inoue D, Shimuta K, Nakajo N, Sagata N; ''Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.''; EMBO J, 2004 PubMed Europe PMC Scholia
  239. Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, Shiekhattar R; ''Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.''; Mol Cell, 2003 PubMed Europe PMC Scholia
  240. Zou L, Elledge SJ; ''Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.''; Science, 2003 PubMed Europe PMC Scholia
  241. Yamanaka K, Minko IG, Takata K, Kolbanovskiy A, Kozekov ID, Wood RD, Rizzo CJ, Lloyd RS; ''Novel enzymatic function of DNA polymerase nu in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links.''; Chem Res Toxicol, 2010 PubMed Europe PMC Scholia
  242. Zhang X, Li J, Sejas DP, Rathbun KR, Bagby GC, Pang Q; ''The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR).''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  243. Nakamura AJ, Rao VA, Pommier Y, Bonner WM; ''The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks.''; Cell Cycle, 2010 PubMed Europe PMC Scholia
  244. Li J, Zou C, Bai Y, Wazer DE, Band V, Gao Q; ''DSS1 is required for the stability of BRCA2.''; Oncogene, 2006 PubMed Europe PMC Scholia
  245. Kim H, Huang J, Chen J; ''CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response.''; Nat Struct Mol Biol, 2007 PubMed Europe PMC Scholia
  246. Toueille M, El-Andaloussi N, Frouin I, Freire R, Funk D, Shevelev I, Friedrich-Heineken E, Villani G, Hottiger MO, Hübscher U; ''The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair.''; Nucleic Acids Res, 2004 PubMed Europe PMC Scholia
  247. Pollok S, Bauerschmidt C, Sänger J, Nasheuer HP, Grosse F; ''Human Cdc45 is a proliferation-associated antigen.''; FEBS J, 2007 PubMed Europe PMC Scholia
  248. Huang TT, D'Andrea AD; ''Regulation of DNA repair by ubiquitylation.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  249. Kemp MG, Mason AC, Carreira A, Reardon JT, Haring SJ, Borgstahl GE, Kowalczykowski SC, Sancar A, Wold MS; ''An alternative form of replication protein a expressed in normal human tissues supports DNA repair.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  250. Mihaylov IS, Kondo T, Jones L, Ryzhikov S, Tanaka J, Zheng J, Higa LA, Minamino N, Cooley L, Zhang H; ''Control of DNA replication and chromosome ploidy by geminin and cyclin A.''; Mol Cell Biol, 2002 PubMed Europe PMC Scholia
  251. Bekker-Jensen S, Lukas C, Melander F, Bartek J, Lukas J; ''Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1.''; J Cell Biol, 2005 PubMed Europe PMC Scholia
  252. Alpi AF, Pace PE, Babu MM, Patel KJ; ''Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI.''; Mol Cell, 2008 PubMed Europe PMC Scholia
  253. Tian B, Yang Q, Mao Z; ''Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death.''; Nat Cell Biol, 2009 PubMed Europe PMC Scholia
  254. Moldovan GL, Madhavan MV, Mirchandani KD, McCaffrey RM, Vinciguerra P, D'Andrea AD; ''DNA polymerase POLN participates in cross-link repair and homologous recombination.''; Mol Cell Biol, 2010 PubMed Europe PMC Scholia
  255. Lehner CF, O'Farrell PH; ''Expression and function of Drosophila cyclin A during embryonic cell cycle progression.''; Cell, 1989 PubMed Europe PMC Scholia
  256. Szambowska A, Tessmer I, Kursula P, Usskilat C, Prus P, Pospiech H, Grosse F; ''DNA binding properties of human Cdc45 suggest a function as molecular wedge for DNA unwinding.''; Nucleic Acids Res, 2014 PubMed Europe PMC Scholia
  257. Eichinger CS, Jentsch S; ''9-1-1: PCNA's specialized cousin.''; Trends Biochem Sci, 2011 PubMed Europe PMC Scholia
  258. Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates JR 3rd, Hays L, Morgan WF, Petrini JH; ''The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.''; Cell, 1998 PubMed Europe PMC Scholia
  259. He Z, Henricksen LA, Wold MS, Ingles CJ; ''RPA involvement in the damage-recognition and incision steps of nucleotide excision repair.''; Nature, 1995 PubMed Europe PMC Scholia
  260. Kumagai A, Lee J, Yoo HY, Dunphy WG; ''TopBP1 activates the ATR-ATRIP complex.''; Cell, 2006 PubMed Europe PMC Scholia
  261. Yamaguchi H, Durell SR, Chatterjee DK, Anderson CW, Appella E; ''The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases.''; Biochemistry, 2007 PubMed Europe PMC Scholia
  262. Sims JJ, Cohen RE; ''Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80.''; Mol Cell, 2009 PubMed Europe PMC Scholia
  263. Binz SK, Sheehan AM, Wold MS; ''Replication protein A phosphorylation and the cellular response to DNA damage.''; DNA Repair (Amst), 2004 PubMed Europe PMC Scholia
  264. Deming PB, Flores KG, Downes CS, Paules RS, Kaufmann WK; ''ATR enforces the topoisomerase II-dependent G2 checkpoint through inhibition of Plk1 kinase.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  265. Mendez LM, Polo JM, Yu JJ, Krupski M, Ding BB, Melnick A, Ye BH; ''CtBP is an essential corepressor for BCL6 autoregulation.''; Mol Cell Biol, 2008 PubMed Europe PMC Scholia
  266. Lee JH, Paull TT; ''Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.''; Science, 2004 PubMed Europe PMC Scholia
  267. Flaman JM, Waridel F, Estreicher A, Vannier A, Limacher JM, Gilbert D, Iggo R, Frebourg T; ''The human tumour suppressor gene p53 is alternatively spliced in normal cells.''; Oncogene, 1996 PubMed Europe PMC Scholia
  268. Kao J, Milano MT, Javaheri A, Garofalo MC, Chmura SJ, Weichselbaum RR, Kron SJ; ''gamma-H2AX as a therapeutic target for improving the efficacy of radiation therapy.''; Curr Cancer Drug Targets, 2006 PubMed Europe PMC Scholia
  269. Compton SA, Tolun G, Kamath-Loeb AS, Loeb LA, Griffith JD; ''The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.''; J Biol Chem, 2008 PubMed Europe PMC Scholia
  270. Dickey JS, Redon CE, Nakamura AJ, Baird BJ, Sedelnikova OA, Bonner WM; ''H2AX: functional roles and potential applications.''; Chromosoma, 2009 PubMed Europe PMC Scholia
  271. Tanaka T, Huang X, Halicka HD, Zhao H, Traganos F, Albino AP, Dai W, Darzynkiewicz Z; ''Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents.''; Cytometry A, 2007 PubMed Europe PMC Scholia
  272. Stolz A, Ertych N, Kienitz A, Vogel C, Schneider V, Fritz B, Jacob R, Dittmar G, Weichert W, Petersen I, Bastians H; ''The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells.''; Mat Cell Biol, 2010 PubMed Europe PMC Scholia
  273. Mullen TE, Marzluff WF; ''Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.''; Genes Dev, 2008 PubMed Europe PMC Scholia
  274. Bhattacharya A, Czaplinski K, Trifillis P, He F, Jacobson A, Peltz SW; ''Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.''; RNA, 2000 PubMed Europe PMC Scholia
  275. Yang X, Li H, Zhou Z, Wang WH, Deng A, Andrisani O, Liu X; ''Plk1-mediated phosphorylation of Topors regulates p53 stability.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  276. Marathi UK, Dahlen M, Sunnerhagen P, Romero AV, Ramagli LS, Siciliano MJ, Li L, Legerski RJ; ''RAD1, a human structural homolog of the Schizosaccharomyces pombe RAD1 cell cycle checkpoint gene.''; Genomics, 1998 PubMed Europe PMC Scholia
  277. Ellis NA, Groden J, Ye TZ, Straughen J, Lennon DJ, Ciocci S, Proytcheva M, German J; ''The Bloom's syndrome gene product is homologous to RecQ helicases.''; Cell, 1995 PubMed Europe PMC Scholia
  278. Neef R, Preisinger C, Sutcliffe J, Kopajtich R, Nigg EA, Mayer TU, Barr FA; ''Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis.''; J Cell Biol, 2003 PubMed Europe PMC Scholia
  279. Yang J, Bachrati CZ, Ou J, Hickson ID, Brown GW; ''Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  280. Eiberg H, Troelsen J, Nielsen M, Mikkelsen A, Mengel-From J, Kjaer KW, Hansen L; ''Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression.''; Hum Genet, 2008 PubMed Europe PMC Scholia
  281. Wang C, Rauscher FJ 3rd, Cress WD, Chen J; ''Regulation of E2F1 function by the nuclear corepressor KAP1.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  282. Hurley PJ, Bunz F; ''ATM and ATR: components of an integrated circuit.''; Cell Cycle, 2007 PubMed Europe PMC Scholia
  283. LeRoy G, Carroll R, Kyin S, Seki M, Cole MD; ''Identification of RecQL1 as a Holliday junction processing enzyme in human cell lines.''; Nucleic Acids Res, 2005 PubMed Europe PMC Scholia
  284. Wu-Baer F, Lagrazon K, Yuan W, Baer R; ''The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  285. Su TT, Walker J, Stumpff J; ''Activating the DNA damage checkpoint in a developmental context.''; Curr Biol, 2000 PubMed Europe PMC Scholia
  286. Fu X, Yucer N, Liu S, Li M, Yi P, Mu JJ, Yang T, Chu J, Jung SY, O'Malley BW, Gu W, Qin J, Wang Y; ''RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  287. Takata K, Shimizu T, Iwai S, Wood RD; ''Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  288. Litman R, Peng M, Jin Z, Zhang F, Zhang J, Powell S, Andreassen PR, Cantor SB; ''BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ.''; Cancer Cell, 2005 PubMed Europe PMC Scholia
  289. Rotman G, Shiloh Y; ''Ataxia-telangiectasia: is ATM a sensor of oxidative damage and stress?''; Bioessays, 1997 PubMed Europe PMC Scholia
  290. Gradia S, Acharya S, Fishel R; ''The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  291. Genschel J, Modrich P; ''Mechanism of 5'-directed excision in human mismatch repair.''; Mol Cell, 2003 PubMed Europe PMC Scholia
  292. Bartek J, Lukas J; ''Chk1 and Chk2 kinases in checkpoint control and cancer.''; Cancer Cell, 2003 PubMed Europe PMC Scholia
  293. Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S, Goldberg M, Lerenthal Y, Jackson SP, Bartek J, Lukas J; ''''; , PubMed Europe PMC Scholia
  294. Duncan PI, Stojdl DF, Marius RM, Scheit KH, Bell JC; ''The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing.''; Exp Cell Res, 1998 PubMed Europe PMC Scholia
  295. Muzzolini L, Beuron F, Patwardhan A, Popuri V, Cui S, Niccolini B, Rappas M, Freemont PS, Vindigni A; ''Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity.''; PLoS Biol, 2007 PubMed Europe PMC Scholia
  296. Poyurovsky MV, Katz C, Laptenko O, Beckerman R, Lokshin M, Ahn J, Byeon IJ, Gabizon R, Mattia M, Zupnick A, Brown LM, Friedler A, Prives C; ''The C terminus of p53 binds the N-terminal domain of MDM2.''; Nat Struct Mol Biol, 2010 PubMed Europe PMC Scholia
  297. Montes de Oca R, Andreassen PR, Margossian SP, Gregory RC, Taniguchi T, Wang X, Houghtaling S, Grompe M, D'Andrea AD; ''Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin.''; Blood, 2005 PubMed Europe PMC Scholia
  298. Jeffers LJ, Coull BJ, Stack SJ, Morrison CG; ''Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization.''; Oncogene, 2008 PubMed Europe PMC Scholia
  299. Kim SA, Yoon JH, Lee SH, Ahn SG; ''Polo-like kinase 1 phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  300. Sapountzi V, Logan IR, Robson CN; ''Cellular functions of TIP60.''; Int J Biochem Cell Biol, 2006 PubMed Europe PMC Scholia
  301. Kaneko H, Orii KO, Matsui E, Shimozawa N, Fukao T, Matsumoto T, Shimamoto A, Furuichi Y, Hayakawa S, Kasahara K, Kondo N; ''BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal.''; Biochem Biophys Res Commun, 1997 PubMed Europe PMC Scholia
  302. Kawabe T, Tsuyama N, Kitao S, Nishikawa K, Shimamoto A, Shiratori M, Matsumoto T, Anno K, Sato T, Mitsui Y, Seki M, Enomoto T, Goto M, Ellis NA, Ide T, Furuichi Y, Sugimoto M; ''Differential regulation of human RecQ family helicases in cell transformation and cell cycle.''; Oncogene, 2000 PubMed Europe PMC Scholia
  303. Medhurst AL, Huber PA, Waisfisz Q, de Winter JP, Mathew CG; ''Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway.''; Hum Mol Genet, 2001 PubMed Europe PMC Scholia
  304. Venere M, Snyder A, Zgheib O, Halazonetis TD; ''Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function.''; Cancer Res, 2007 PubMed Europe PMC Scholia
  305. Grudic A, Jul-Larsen A, Haring SJ, Wold MS, Lønning PE, Bjerkvig R, Bøe SO; ''Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres.''; Nucleic Acids Res, 2007 PubMed Europe PMC Scholia
  306. Langland G, Elliott J, Li Y, Creaney J, Dixon K, Groden J; ''The BLM helicase is necessary for normal DNA double-strand break repair.''; Cancer Res, 2002 PubMed Europe PMC Scholia
  307. Collins NB, Wilson JB, Bush T, Thomashevski A, Roberts KJ, Jones NJ, Kupfer GM; ''ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function.''; Blood, 2009 PubMed Europe PMC Scholia
  308. Yajima H, Lee KJ, Chen BP; ''ATR-dependent phosphorylation of DNA-dependent protein kinase catalytic subunit in response to UV-induced replication stress.''; Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  309. Sun X, Zheng L, Shen B; ''Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome.''; Cancer Res, 2002 PubMed Europe PMC Scholia
  310. Lin SY, Li K, Stewart GS, Elledge SJ; ''Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation.''; Proc Natl Acad Sci U S A, 2004 PubMed Europe PMC Scholia
  311. Lykke-Andersen J, Shu MD, Steitz JA; ''Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon.''; Cell, 2000 PubMed Europe PMC Scholia
  312. Solyom S, Aressy B, Pylkäs K, Patterson-Fortin J, Hartikainen JM, Kallioniemi A, Kauppila S, Nikkilä J, Kosma VM, Mannermaa A, Greenberg RA, Winqvist R; ''Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions.''; Sci Transl Med, 2012 PubMed Europe PMC Scholia
  313. Post SM, Tomkinson AE, Lee EY; ''The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon.''; Nucleic Acids Res, 2003 PubMed Europe PMC Scholia
  314. Lehman AR, Stevens S; ''The production and repair of double strand breaks in cells from normal humans and from patients with ataxia telangiectasia.''; Biochim Biophys Acta, 1977 PubMed Europe PMC Scholia
  315. Pabla N, Ma Z, McIlhatton MA, Fishel R, Dong Z; ''hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  316. Niiya F, Tatsumoto T, Lee KS, Miki T; ''Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA.''; Oncogene, 2006 PubMed Europe PMC Scholia
  317. Bermudez VP, Lindsey-Boltz LA, Cesare AJ, Maniwa Y, Griffith JD, Hurwitz J, Sancar A; ''Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro.''; Proc Natl Acad Sci U S A, 2003 PubMed Europe PMC Scholia
  318. Kadam S, McAlpine GS, Phelan ML, Kingston RE, Jones KA, Emerson BM; ''Functional selectivity of recombinant mammalian SWI/SNF subunits.''; Genes Dev, 2000 PubMed Europe PMC Scholia
  319. Floquet C, Deforges J, Rousset JP, Bidou L; ''Rescue of non-sense mutated p53 tumor suppressor gene by aminoglycosides.''; Nucleic Acids Res, 2011 PubMed Europe PMC Scholia
  320. Kamitani T, Nguyen HP, Kito K, Fukuda-Kamitani T, Yeh ET; ''Covalent modification of PML by the sentrin family of ubiquitin-like proteins.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  321. Yoshioka K, Yoshioka Y, Hsieh P; ''ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts.''; Mol Cell, 2006 PubMed Europe PMC Scholia
  322. Kim SS, Hur SY, Kim YR, Yoo NJ, Lee SH; ''Expression of AIMP1, 2 and 3, the scaffolds for the multi-tRNA synthetase complex, is downregulated in gastric and colorectal cancer.''; Tumori, 2011 PubMed Europe PMC Scholia
  323. Dart DA, Adams KE, Akerman I, Lakin ND; ''Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  324. Ramachandran V, Matzkies M, Dienemann A, Sprenger F; ''Cyclin A degradation employs preferentially used lysines and a cyclin box function other than Cdk1 binding.''; Cell Cycle, 2007 PubMed Europe PMC Scholia
  325. Park MS, Ludwig DL, Stigger E, Lee SH; ''Physical interaction between human RAD52 and RPA is required for homologous recombination in mammalian cells.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  326. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ; ''ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.''; Science, 2007 PubMed Europe PMC Scholia
  327. Xu M, Bai L, Gong Y, Xie W, Hang H, Jiang T; ''Structure and functional implications of the human rad9-hus1-rad1 cell cycle checkpoint complex.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  328. Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ; ''Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.''; Cell, 2000 PubMed Europe PMC Scholia
  329. Taleei R, Girard PM, Nikjoo H; ''''; , PubMed Europe PMC Scholia
  330. Ikegami T, Kuraoka I, Saijo M, Kodo N, Kyogoku Y, Morikawa K, Tanaka K, Shirakawa M; ''Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA.''; Nat Struct Biol, 1998 PubMed Europe PMC Scholia
  331. Lieberman HB; ''Rad9, an evolutionarily conserved gene with multiple functions for preserving genomic integrity.''; J Cell Biochem, 2006 PubMed Europe PMC Scholia
  332. Woods WG, Lopez M, Kalvonjian SL; ''Normal repair of gamma radiation-induced single-strand and double-strand DNA breaks in retinoblastoma fibroblasts.''; Biochim Biophys Acta, 1982 PubMed Europe PMC Scholia
  333. McMahon LW, Walsh CE, Lambert MW; ''Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  334. Jacobs HW, Keidel E, Lehner CF; ''A complex degradation signal in Cyclin A required for G1 arrest, and a C-terminal region for mitosis.''; EMBO J, 2001 PubMed Europe PMC Scholia
  335. Shen TH, Lin HK, Scaglioni PP, Yung TM, Pandolfi PP; ''The mechanisms of PML-nuclear body formation.''; Mol Cell, 2006 PubMed Europe PMC Scholia
  336. Inamdar KV, Pouliot JJ, Zhou T, Lees-Miller SP, Rasouli-Nia A, Povirk LF; ''Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  337. Yamane K, Chen J, Kinsella TJ; ''Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint.''; Cancer Res, 2003 PubMed Europe PMC Scholia
  338. Ramamoorthy M, Tadokoro T, Rybanska I, Ghosh AK, Wersto R, May A, Kulikowicz T, Sykora P, Croteau DL, Bohr VA; ''RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression.''; Nucleic Acids Res, 2012 PubMed Europe PMC Scholia
  339. Richie CT, Peterson C, Lu T, Hittelman WN, Carpenter PB, Legerski RJ; ''hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage.''; Mol Cell Biol, 2002 PubMed Europe PMC Scholia
  340. Infantino V, Convertini P, Iacobazzi F, Pisano I, Scarcia P, Iacobazzi V; ''Identification of a novel Sp1 splice variant as a strong transcriptional activator.''; Biochem Biophys Res Commun, 2011 PubMed Europe PMC Scholia
  341. Zhang J.; ''The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy.''; Cell Biosci, 2013 PubMed Europe PMC Scholia
  342. Liu S, Chu J, Yucer N, Leng M, Wang SY, Chen BP, Hittelman WN, Wang Y; ''RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  343. Ding H, Benotmane AM, Suske G, Collen D, Belayew A; ''Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  344. Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV; ''TRAF6 is a signal transducer for interleukin-1.''; Nature, 1996 PubMed Europe PMC Scholia
  345. Ball HL, Myers JS, Cortez D; ''ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation.''; Mol Biol Cell, 2005 PubMed Europe PMC Scholia
  346. Lee S, Yu KR, Ryu YS, Oh YS, Hong IS, Kim HS, Lee JY, Kim S, Seo KW, Kang KS; ''miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18.''; Age (Dordr), 2014 PubMed Europe PMC Scholia
  347. Bidou L, Allamand V, Rousset JP, Namy O; ''Sense from nonsense: therapies for premature stop codon diseases.''; Trends Mol Med, 2012 PubMed Europe PMC Scholia
  348. Yamane K, Kawabata M, Tsuruo T; ''A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator.''; Eur J Biochem, 1997 PubMed Europe PMC Scholia
  349. Filippini1 SE, Vega A; ''Breast cancer genes: beyond BRCA1 and BRCA2.''; Front Biosci, 2013 PubMed Europe PMC Scholia
  350. Kitao S, Lindor NM, Shiratori M, Furuichi Y, Shimamoto A; ''Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.''; Genomics, 1999 PubMed Europe PMC Scholia
  351. Lin WC, Lin FT, Nevins JR; ''Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.''; Genes Dev, 2001 PubMed Europe PMC Scholia
  352. Zhong X, Pfeifer GP, Xu X; ''Microcephalin encodes a centrosomal protein.''; Cell Cycle, 2006 PubMed Europe PMC Scholia
  353. St Onge RP, Besley BD, Pelley JL, Davey S; ''A role for the phosphorylation of hRad9 in checkpoint signaling.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  354. Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A; ''Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes.''; Genomics, 1998 PubMed Europe PMC Scholia
  355. Honda M, Okuno Y, Yoo J, Ha T, Spies M; ''Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding.''; EMBO J, 2011 PubMed Europe PMC Scholia
  356. Roos-Mattjus P, Vroman BT, Burtelow MA, Rauen M, Eapen AK, Karnitz LM; ''Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  357. Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du K, Singh S, Pike JW, Darnay BG, Choi Y, Wu H; ''Distinct molecular mechanism for initiating TRAF6 signalling.''; Nature, 2002 PubMed Europe PMC Scholia
  358. Tanos BE, Yang HJ, Soni R, Wang WJ, Macaluso FP, Asara JM, Tsou MF; ''Centriole distal appendages promote membrane docking, leading to cilia initiation.''; Genes Dev, 2013 PubMed Europe PMC Scholia
  359. Phan RT, Dalla-Favera R; ''The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells.''; Nature, 2004 PubMed Europe PMC Scholia
  360. Brandt PD, Helt CE, Keng PC, Bambara RA; ''The Rad9 protein enhances survival and promotes DNA repair following exposure to ionizing radiation.''; Biochem Biophys Res Commun, 2006 PubMed Europe PMC Scholia
  361. Terret ME, Sherwood R, Rahman S, Qin J, Jallepalli PV; ''Cohesin acetylation speeds the replication fork.''; Nature, 2009 PubMed Europe PMC Scholia
  362. Anne SL, Saudou F, Humbert S; ''Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.''; J Neurosci, 2007 PubMed Europe PMC Scholia
  363. Zhong H, Bryson A, Eckersdorff M, Ferguson DO; ''Rad50 depletion impacts upon ATR-dependent DNA damage responses.''; Hum Mol Genet, 2005 PubMed Europe PMC Scholia
  364. Thorslund T, McIlwraith MJ, Compton SA, Lekomtsev S, Petronczki M, Griffith JD, West SC; ''The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.''; Nat Struct Mol Biol, 2010 PubMed Europe PMC Scholia
  365. Allalunis-Turner J, Barron GM, Day RS 3rd; ''Intact G2-phase checkpoint in cells of a human cell line lacking DNA-dependent protein kinase activity.''; Radiat Res, 1997 PubMed Europe PMC Scholia
  366. Marini F, Nardo T, Giannattasio M, Minuzzo M, Stefanini M, Plevani P, Muzi Falconi M; ''DNA nucleotide excision repair-dependent signaling to checkpoint activation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  367. North P, Ganesh A, Thacker J; ''The rejoining of double-strand breaks in DNA by human cell extracts.''; Nucleic Acids Res, 1990 PubMed Europe PMC Scholia
  368. Iwabuchi K, Basu BP, Kysela B, Kurihara T, Shibata M, Guan D, Cao Y, Hamada T, Imamura K, Jeggo PA, Date T, Doherty AJ; ''Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  369. Turowski P, Franckhauser C, Morris MC, Vaglio P, Fernandez A, Lamb NJ; ''Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells.''; Mol Biol Cell, 2003 PubMed Europe PMC Scholia
  370. Hanai R, Caron PR, Wang JC; ''Human TOP3: a single-copy gene encoding DNA topoisomerase III.''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC Scholia
  371. Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE, Abraham RT; ''Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.''; Cancer Res, 1998 PubMed Europe PMC Scholia
  372. Yan Z, Kim YS, Jetten AM; ''RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  373. Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, Pagano M, Iwai K, Ciechanover A; ''Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  374. Liu S, Ho CK, Ouyang J, Zou L; ''Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.''; Proc Natl Acad Sci U S A, 2013 PubMed Europe PMC Scholia
  375. Tong D, Volm T, Eberhardt E, Krainer M, Leodolter S, Kreienberg R, Zeillinger R; ''Rad52 gene mutations in breast/ovarian cancer families and sporadic ovarian carcinoma patients.''; Oncol Rep, 2003 PubMed Europe PMC Scholia
  376. Göhler T, Sabbioneda S, Green CM, Lehmann AR; ''ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage.''; J Cell Biol, 2011 PubMed Europe PMC Scholia
  377. Srivastava N, Gochhait S, de Boer P, Bamezai RN; ''Role of H2AX in DNA damage response and human cancers.''; Mutat Res, 2009 PubMed Europe PMC Scholia
  378. Liu Z, Wu J, Yu X; ''CCDC98 targets BRCA1 to DNA damage sites.''; Nat Struct Mol Biol, 2007 PubMed Europe PMC Scholia
  379. Soubeyrand S, Pope L, Pakuts B, Haché RJ; ''Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation.''; Cancer Res, 2003 PubMed Europe PMC Scholia
  380. Wu Q, Paul A, Su D, Mehmood S, Foo TK, Ochi T, Bunting EL, Xia B, Robinson CV, Wang B, Blundell TL; ''Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites.''; Mol Cell, 2016 PubMed Europe PMC Scholia
  381. Luo H, Li Y, Mu JJ, Zhang J, Tonaka T, Hamamori Y, Jung SY, Wang Y, Qin J; ''Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3.''; J Biol Chem, 2008 PubMed Europe PMC Scholia
  382. Kamath-Loeb AS, Lan L, Nakajima S, Yasui A, Loeb LA; ''Werner syndrome protein interacts functionally with translesion DNA polymerases.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  383. Pérez-Ortín JE, Alepuz P, Chávez S, Choder M; ''Eukaryotic mRNA decay: methodologies, pathways, and links to other stages of gene expression.''; J Mol Biol, 2013 PubMed Europe PMC Scholia
  384. Waisfisz Q, de Winter JP, Kruyt FA, de Groot J, van der Weel L, Dijkmans LM, Zhi Y, Arwert F, Scheper RJ, Youssoufian H, Hoatlin ME, Joenje H; ''A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA.''; Proc Natl Acad Sci U S A, 1999 PubMed Europe PMC Scholia
  385. Rappold I, Iwabuchi K, Date T, Chen J; ''Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways.''; J Cell Biol, 2001 PubMed Europe PMC Scholia
  386. Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, Pascual J, Imamura S, Kishi S, Amatruda JF, Kanki JP, Green DR, D'Andrea AA, Look AT; ''Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.''; Cell, 2008 PubMed Europe PMC Scholia
  387. Lee JH, Mand MR, Deshpande RA, Kinoshita E, Yang SH, Wyman C, Paull TT; ''Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.''; J Biol Chem, 2013 PubMed Europe PMC Scholia
  388. Moeslein FM, Myers MP, Landreth GE; ''The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  389. Tsai HJ, Huang WH, Li TK, Tsai YL, Wu KJ, Tseng SF, Teng SC; ''Involvement of topoisomerase III in telomere-telomere recombination.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  390. Ji JY, Squirrell JM, Schubiger G; ''Both cyclin B levels and DNA-replication checkpoint control the early embryonic mitoses in Drosophila.''; Development, 2004 PubMed Europe PMC Scholia
  391. Bochkarev A, Pfuetzner RA, Edwards AM, Frappier L; ''Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA.''; Nature, 1997 PubMed Europe PMC Scholia
  392. Kito K, Wada H, Yeh ET, Kamitani T; ''Identification of novel isoforms of human RAD52.''; Biochim Biophys Acta, 1999 PubMed Europe PMC Scholia
  393. Branzei D, Foiani M; ''Regulation of DNA repair throughout the cell cycle.''; Nat Rev Mol Cell Biol, 2008 PubMed Europe PMC Scholia
  394. Zhang X, Succi J, Feng Z, Prithivirajsingh S, Story MD, Legerski RJ; ''Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.''; Mol Cell Biol, 2004 PubMed Europe PMC Scholia
  395. Chen G, Lee EYHP; ''The product of the ATM gene is a 370-kDa nuclear phosphoprotein.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  396. Casenghi M, Meraldi P, Weinhart U, Duncan PI, Körner R, Nigg EA; ''Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.''; Dev Cell, 2003 PubMed Europe PMC Scholia
  397. Kim MS, Jeong EG, Chung YJ, Yoo NJ, Lee SH; ''Absence of somatic mutation of a tumor suppressor gene eukaryotic translation elongation factor 1, epsilon-1 (EEF1E1), in common human cancers.''; APMIS, 2008 PubMed Europe PMC Scholia
  398. Li X, Wang W, Wang J, Malovannaya A, Xi Y, Li W, Guerra R, Hawke DH, Qin J, Chen J; ''Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.''; Mol Syst Biol, 2015 PubMed Europe PMC Scholia
  399. Zhu XD, Küster B, Mann M, Petrini JH, de Lange T; ''Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.''; Nat Genet, 2000 PubMed Europe PMC Scholia
  400. Kadoch C, Crabtree GR; ''Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma.''; Cell, 2013 PubMed Europe PMC Scholia
  401. Shiloh Y; ''ATM and related protein kinases: safeguarding genome integrity.''; Nat Rev Cancer, 2003 PubMed Europe PMC Scholia
  402. Xue Y, Ratcliff GC, Wang H, Davis-Searles PR, Gray MD, Erie DA, Redinbo MR; ''A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities.''; Biochemistry, 2002 PubMed Europe PMC Scholia
  403. Wang AT, Kim T, Wagner JE, Conti BA, Lach FP, Huang AL, Molina H, Sanborn EM, Zierhut H, Cornes BK, Abhyankar A, Sougnez C, Gabriel SB, Auerbach AD, Kowalczykowski SC, Smogorzewska A; ''A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination.''; Mol Cell, 2015 PubMed Europe PMC Scholia
  404. Xu X, Lee J, Stern DF; ''Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1.''; JBC, 2004 PubMed Europe PMC Scholia
  405. Kaidi A, Weinert BT, Choudhary C, Jackson SP; ''Human SIRT6 promotes DNA end resection through CtIP deacetylation.''; Science, 2010 PubMed Europe PMC Scholia
  406. Takaya J, Kusunoki S, Ishimi Y; ''Protein interaction and cellular localization of human CDC45.''; J Biochem, 2013 PubMed Europe PMC Scholia
  407. Qiu J, Qian Y, Chen V, Guan MX, Shen B; ''Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  408. De Boer L, Oakes V, Beamish H, Giles N, Stevens F, Somodevilla-Torres M, Desouza C, Gabrielli B; ''Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events.''; Oncogene, 2008 PubMed Europe PMC Scholia
  409. Tibbetts RS, Brumbaugh KM, Williams JM, Sarkaria JN, Cliby WA, Shieh SY, Taya Y, Prives C, Abraham RT; ''A role for ATR in the DNA damage-induced phosphorylation of p53.''; Genes Dev, 1999 PubMed Europe PMC Scholia
  410. Yang X, Su K, Roos MD, Chang Q, Paterson AJ, Kudlow JE; ''O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability.''; Proc Natl Acad Sci U S A, 2001 PubMed Europe PMC Scholia
  411. Kang TH, Lindsey-Boltz LA, Reardon JT, Sancar A; ''Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  412. Li M, Yu X; ''Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation.''; Cancer Cell, 2013 PubMed Europe PMC Scholia
  413. Wright JA, Keegan KS, Herendeen DR, Bentley NJ, Carr AM, Hoekstra MF, Concannon P; ''Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control.''; Proc Natl Acad Sci U S A, 1998 PubMed Europe PMC Scholia
  414. Besche HC, Sha Z, Kukushkin NV, Peth A, Hock EM, Kim W, Gygi S, Gutierrez JA, Liao H, Dick L, Goldberg AL; ''Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.''; EMBO J, 2014 PubMed Europe PMC Scholia
  415. Kim ST, Lim DS, Canman CE, Kastan MB; ''Substrate specificities and identification of putative substrates of ATM kinase family members.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  416. Kurumizaka H, Aihara H, Kagawa W, Shibata T, Yokoyama S; ''Human Rad51 amino acid residues required for Rad52 binding.''; J Mol Biol, 1999 PubMed Europe PMC Scholia
  417. Zhou Y, Paull TT; ''DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).''; J Biol Chem, 2013 PubMed Europe PMC Scholia
  418. Kagawa W, Kurumizaka H, Ishitani R, Fukai S, Nureki O, Shibata T, Yokoyama S; ''Crystal structure of the homologous-pairing domain from the human Rad52 recombinase in the undecameric form.''; Mol Cell, 2002 PubMed Europe PMC Scholia
  419. Lou Z, Chen BP, Asaithamby A, Minter-Dykhouse K, Chen DJ, Chen J; ''MDC1 regulates DNA-PK autophosphorylation in response to DNA damage.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  420. Phan RT, Saito M, Basso K, Niu H, Dalla-Favera R; ''BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells.''; Nat Immunol, 2005 PubMed Europe PMC Scholia
  421. Blasina A, de Weyer IV, Laus MC, Luyten WH, Parker AE, McGowan CH; ''A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase.''; Curr Biol, 1999 PubMed Europe PMC Scholia
  422. Cordier F, Grubisha O, Traincard F, Véron M, Delepierre M, Agou F; ''The zinc finger of NEMO is a functional ubiquitin-binding domain.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  423. Graser S, Stierhof YD, Lavoie SB, Gassner OS, Lamla S, Le Clech M, Nigg EA; ''Cep164, a novel centriole appendage protein required for primary cilium formation.''; J Cell Biol, 2007 PubMed Europe PMC Scholia
  424. Lee JH, Paull TT; ''Activation and regulation of ATM kinase activity in response to DNA double-strand breaks.''; Oncogene, 2007 PubMed Europe PMC Scholia
  425. Pichierri P, Rosselli F; ''The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways.''; EMBO J, 2004 PubMed Europe PMC Scholia
  426. Opresko PL, Sowd G, Wang H; ''The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation.''; PLoS One, 2009 PubMed Europe PMC Scholia
  427. Liang H, Atkins H, Abdel-Fattah R, Jones SN, Lunec J; ''Genomic organisation of the human MDM2 oncogene and relationship to its alternatively spliced mRNAs.''; Gene, 2004 PubMed Europe PMC Scholia
  428. Marini F, Kim N, Schuffert A, Wood RD; ''POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  429. Tauchi H, Matsuura S, Isomura M, Kinjo T, Nakamura A, Sakamoto S, Kondo N, Endo S, Komatsu K, Nakamura Y; ''Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1.''; Genomics, 1999 PubMed Europe PMC Scholia
  430. Kim SS, Kim MS, Yoo NJ, Lee SH; ''Frameshift mutations of a chromatin-remodeling gene SMARCC2 in gastric and colorectal cancers with microsatellite instability.''; APMIS, 2013 PubMed Europe PMC Scholia
  431. Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM; ''Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  432. Hölzel M, van Diest PJ, Bier P, Wallisch M, Hoatlin ME, Joenje H, de Winter JP; ''FANCD2 protein is expressed in proliferating cells of human tissues that are cancer-prone in Fanconi anaemia.''; J Pathol, 2003 PubMed Europe PMC Scholia
  433. Yuan Z, Becker EB, Merlo P, Yamada T, DiBacco S, Konishi Y, Schaefer EM, Bonni A; ''Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons.''; Science, 2008 PubMed Europe PMC Scholia
  434. Kagawa W, Kurumizaka H, Ikawa S, Yokoyama S, Shibata T; ''Homologous pairing promoted by the human Rad52 protein.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  435. Singh N, Basnet H, Wiltshire TD, Mohammad DH, Thompson JR, Héroux A, Botuyan MV, Yaffe MB, Couch FJ, Rosenfeld MG, Mer G; ''Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.''; PNAS, 2012 PubMed Europe PMC Scholia
  436. Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, Vanagaite L, Tagle DA, Smith S, Uziel T, Sfez S, Ashkenazi M, Pecker I, Frydman M, Harnik R, Patanjali SR, Simmons A, Clines GA, Sartiel A, Gatti RA, Chessa L, Sanal O, Lavin MF, Jaspers NG, Taylor AM, Arlett CF, Miki T, Weissman SM, Lovett M, Collins FS, Shiloh Y; ''A single ataxia telangiectasia gene with a product similar to PI-3 kinase.''; Science, 1995 PubMed Europe PMC Scholia
  437. Kleiman FE, Manley JL; ''Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50.''; Science, 1999 PubMed Europe PMC Scholia
  438. Wijnen J, Khan PM, Vasen H, van der Klift H, Mulder A, van Leeuwen-Cornelisse I, Bakker B, Losekoot M, Møller P, Fodde R; ''Hereditary nonpolyposis colorectal cancer families not complying with the Amsterdam criteria show extremely low frequency of mismatch-repair-gene mutations.''; Am J Hum Genet, 1997 PubMed Europe PMC Scholia
  439. DiTullio RA Jr, Mochan TA, Venere M, Bartkova J, Sehested M, Bartek J, Halazonetis TD; ''53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer.''; Nat Cell Biol, 2002 PubMed Europe PMC Scholia
  440. Park JY, Yoo HW, Kim BR, Park R, Choi SY, Kim Y; ''Identification of a novel human Rad51 variant that promotes DNA strand exchange.''; Nucleic Acids Res, 2008 PubMed Europe PMC Scholia
  441. Longerich S, San Filippo J, Liu D, Sung P; ''FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  442. Maréchal A, Li JM, Ji XY, Wu CS, Yazinski SA, Nguyen HD, Liu S, Jiménez AE, Jin J, Zou L; ''PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.''; Mol Cell, 2014 PubMed Europe PMC Scholia
  443. Sun Y, Xu Y, Roy K, Price BD; ''DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.''; Mol Cell Biol, 2007 PubMed Europe PMC Scholia
  444. Chen Y, Sanchez Y; ''Chk1 in the DNA damage response: conserved roles from yeasts to mammals.''; DNA Repair (Amst), 2004 PubMed Europe PMC Scholia
  445. Parsons JL, Dianova II, Khoronenkova SV, Edelmann MJ, Kessler BM, Dianov GL; ''USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β.''; Mol Cell, 2011 PubMed Europe PMC Scholia
  446. Deardorff MA, Kaur M, Yaeger D, Rampuria A, Korolev S, Pie J, Gil-Rodríguez C, Arnedo M, Loeys B, Kline AD, Wilson M, Lillquist K, Siu V, Ramos FJ, Musio A, Jackson LS, Dorsett D, Krantz ID; ''Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of cornelia de Lange syndrome with predominant mental retardation.''; Am J Hum Genet, 2007 PubMed Europe PMC Scholia
  447. Hsieh MY, Fan JR, Chang HW, Chen HC, Shen TL, Teng SC, Yeh YH, Li TK; ''DNA topoisomerase III alpha regulates p53-mediated tumor suppression.''; Clin Cancer Res, 2014 PubMed Europe PMC Scholia
  448. Lieberman HB, Hopkins KM, Nass M, Demetrick D, Davey S; ''A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene.''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC Scholia
  449. Liu F, Lee WH; ''CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression.''; Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  450. Fishel R, Ewel A, Lescoe MK; ''Purified human MSH2 protein binds to DNA containing mismatched nucleotides.''; Cancer Res, 1994 PubMed Europe PMC Scholia
  451. Fourest-Lieuvin A, Peris L, Gache V, Garcia-Saez I, Juillan-Binard C, Lantez V, Job D; ''Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1.''; Mol Biol Cell, 2006 PubMed Europe PMC Scholia
  452. Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP; ''MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.''; Cell, 2005 PubMed Europe PMC Scholia
  453. Zhang L, Zhang J, Hu C, Cao J, Zhou X, Hu Y, He Q, Yang B; ''Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction.''; Anticancer Drugs, 2009 PubMed Europe PMC Scholia
  454. Rajendra R, Malegaonkar D, Pungaliya P, Marshall H, Rasheed Z, Brownell J, Liu LF, Lutzker S, Saleem A, Rubin EH; ''Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  455. Zheng L, Kanagaraj R, Mihaljevic B, Schwendener S, Sartori AA, Gerrits B, Shevelev I, Janscak P; ''MRE11 complex links RECQ5 helicase to sites of DNA damage.''; Nucleic Acids Res, 2009 PubMed Europe PMC Scholia
  456. Lucena R, Cárdenas S, Gallego M, Valcárcel M; ''ATR-FT-IR membrane-based sensor for integrated microliquid-liquid extraction and detection.''; Anal Chem, 2005 PubMed Europe PMC Scholia
  457. St Onge RP, Udell CM, Casselman R, Davey S; ''The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1.''; Mol Biol Cell, 1999 PubMed Europe PMC Scholia
  458. Krum SA, la Rosa Dalugdugan Ed, Miranda-Carboni GA, Lane TF; ''BRCA1 Forms a Functional Complex with γ-H2AX as a Late Response to Genotoxic Stress.''; J Nucleic Acids, 2010 PubMed Europe PMC Scholia
  459. Sedukhina A, Fukuda T, Ohta T.; ''[BRCA1 and DNA damage response].''; Seikagaku, 2012 PubMed Europe PMC Scholia
  460. Sohn SY, Cho Y; ''Crystal structure of the human rad9-hus1-rad1 clamp.''; J Mol Biol, 2009 PubMed Europe PMC Scholia
  461. Wechsler T, Chen BP, Harper R, Morotomi-Yano K, Huang BC, Meek K, Cleaver JE, Chen DJ, Wabl M; ''DNA-PKcs function regulated specifically by protein phosphatase 5.''; Proc Natl Acad Sci U S A, 2004 PubMed Europe PMC Scholia
  462. Singh N, Wiltshire TD, Thompson JR, Mer G, Couch FJ; ''Molecular basis for the association of microcephalin (MCPH1) protein with the cell division cycle protein 27 (Cdc27) subunit of the anaphase-promoting complex.''; JBC, 2012 PubMed Europe PMC Scholia
  463. O'Neill T, Giarratani L, Chen P, Iyer L, Lee CH, Bobiak M, Kanai F, Zhou BB, Chung JH, Rathbun GA; ''Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  464. Morgan MA, Lawrence TS; ''Molecular Pathways: Overcoming Radiation Resistance by Targeting DNA Damage Response Pathways.''; Clin Cancer Res, 2015 PubMed Europe PMC Scholia
  465. Macůrek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH; ''Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.''; Nature, 2008 PubMed Europe PMC Scholia
  466. Vilenchik MM, Knudson AG; ''Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer.''; Proc Natl Acad Sci U S A, 2003 PubMed Europe PMC Scholia
  467. Wang Y, Lyu YL, Wang JC; ''Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC Scholia
  468. Ngadjeua F, Chiaravalli J, Traincard F, Raynal B, Fontan E, Agou F; ''Two-sided ubiquitin binding of NF-κB essential modulator (NEMO) zinc finger unveiled by a mutation associated with anhidrotic ectodermal dysplasia with immunodeficiency syndrome.''; J Biol Chem, 2013 PubMed Europe PMC Scholia
  469. Mladenov E, Iliakis G; ''Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways.''; Mutat Res, 2011 PubMed Europe PMC Scholia
  470. Khanna KK, Lavin MF; ''Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells.''; Oncogene, 1993 PubMed Europe PMC Scholia
  471. Arana ME, Takata K, Garcia-Diaz M, Wood RD, Kunkel TA; ''A unique error signature for human DNA polymerase nu.''; DNA Repair (Amst), 2007 PubMed Europe PMC Scholia
  472. Goodhead DT; ''Initial events in the cellular effects of ionizing radiations: clustered damage in DNA.''; Int J Radiat Biol, 1994 PubMed Europe PMC Scholia
  473. Raynard S, Bussen W, Sung P; ''A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  474. Itakura E, Umeda K, Sekoguchi E, Takata H, Ohsumi M, Matsuura A; ''ATR-dependent phosphorylation of ATRIP in response to genotoxic stress.''; Biochem Biophys Res Commun, 2004 PubMed Europe PMC Scholia
  475. Yang SZ, Lin FT, Lin WC; ''MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis.''; EMBO Rep, 2008 PubMed Europe PMC Scholia
  476. Cui S, Arosio D, Doherty KM, Brosh RM Jr, Falaschi A, Vindigni A; ''Analysis of the unwinding activity of the dimeric RECQ1 helicase in the presence of human replication protein A.''; Nucleic Acids Res, 2004 PubMed Europe PMC Scholia
  477. de la Torre J, Gil-Moreno A, García A, Rojo F, Xercavins J, Salido E, Freire R; ''Expression of DNA damage checkpoint protein Hus1 in epithelial ovarian tumors correlates with prognostic markers.''; Int J Gynecol Pathol, 2008 PubMed Europe PMC Scholia
  478. Cui S, Klima R, Ochem A, Arosio D, Falaschi A, Vindigni A; ''Characterization of the DNA-unwinding activity of human RECQ1, a helicase specifically stimulated by human replication protein A.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  479. Matsumoto Y, Kim K, Katz DS, Feng JA; ''Catalytic center of DNA polymerase beta for excision of deoxyribose phosphate groups.''; Biochemistry, 1998 PubMed Europe PMC Scholia
  480. Bradley MO; ''Double-strand breaks in DNA caused by repair of damage due to ultraviolet light.''; J Supramol Struct Cell Biochem, 1981 PubMed Europe PMC Scholia
  481. Strausfeld U, Fernandez A, Capony JP, Girard F, Lautredou N, Derancourt J, Labbe JC, Lamb NJ; ''Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis.''; J Biol Chem, 1994 PubMed Europe PMC Scholia
  482. Baynton K, Otterlei M, Bjørås M, von Kobbe C, Bohr VA, Seeberg E; ''WRN interacts physically and functionally with the recombination mediator protein RAD52.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  483. Stiff T, Reis C, Alderton GK, Woodbine L, O'Driscoll M, Jeggo PA; ''Nbs1 is required for ATR-dependent phosphorylation events.''; EMBO J, 2005 PubMed Europe PMC Scholia
  484. Zhong S, Salomoni P, Ronchetti S, Guo A, Ruggero D, Pandolfi PP; ''Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis.''; J Exp Med, 2000 PubMed Europe PMC Scholia
  485. Doré AS, Kilkenny ML, Rzechorzek NJ, Pearl LH; ''Crystal structure of the rad9-rad1-hus1 DNA damage checkpoint complex--implications for clamp loading and regulation.''; Mol Cell, 2009 PubMed Europe PMC Scholia
  486. Kumagai A, Dunphy WG; ''Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts.''; Mol Cell, 2000 PubMed Europe PMC Scholia
  487. Wong RW, Blobel G; ''Cohesin subunit SMC1 associates with mitotic microtubules at the spindle pole.''; Proc Natl Acad Sci USA, 2008 PubMed Europe PMC Scholia
  488. Trimborn M, Bell SM, Felix C, Rashid Y, Jafri H, Griffiths PD, Neumann LM, Krebs A, Reis A, Sperling K, Neitzel H, Jackson AP; ''Mutations in microcephalin cause aberrant regulation of chromosome condensation.''; Am J Hum Genet, 2004 PubMed Europe PMC Scholia
  489. Interthal H, Chen HJ, Champoux JJ; ''Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  490. Buheitel J, Stemmann O; ''Prophase pathway-dependent removal of cohesin from human chromosomes requires opening of the Smc3-Scc1 gate.''; EMBO J, 2013 PubMed Europe PMC Scholia
  491. Clarke CA, Clarke PR; ''DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system.''; Biochem J, 2005 PubMed Europe PMC Scholia
  492. Zakut-Houri R, Bienz-Tadmor B, Givol D, Oren M; ''Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells.''; EMBO J, 1985 PubMed Europe PMC Scholia
  493. Lee JH, Kim HS, Lee SJ, Kim KT; ''Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death.''; J Cell Sci, 2007 PubMed Europe PMC Scholia
  494. Chen K, Hu Z, Wang LE, Zhang W, El-Naggar AK, Sturgis EM, Wei Q; ''Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck.''; Clin Cancer Res, 2007 PubMed Europe PMC Scholia
  495. Dorsman JC, Levitus M, Rockx D, Rooimans MA, Oostra AB, Haitjema A, Bakker ST, Steltenpool J, Schuler D, Mohan S, Schindler D, Arwert F, Pals G, Mathew CG, Waisfisz Q, de Winter JP, Joenje H; ''Identification of the Fanconi anemia complementation group I gene, FANCI.''; Cell Oncol, 2007 PubMed Europe PMC Scholia
  496. Bao S, Tibbetts RS, Brumbaugh KM, Fang Y, Richardson DA, Ali A, Chen SM, Abraham RT, Wang XF; ''ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.''; Nature, 2001 PubMed Europe PMC Scholia
  497. Seifert M, Scherer SJ, Edelmann W, Böhm M, Meineke V, Löbrich M, Tilgen W, Reichrath J; ''The DNA-mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cells.''; J Invest Dermatol, 2008 PubMed Europe PMC Scholia
  498. Blattner C, Hay T, Meek DW, Lane DP; ''Hypophosphorylation of Mdm2 augments p53 stability.''; 2002, Mol Cell Biol PubMed Europe PMC Scholia
  499. Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, Grossman S, Wahrer DC, Sgroi DC, Lane WS, Haber DA, Livingston DM; ''BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.''; Cell, 2001 PubMed Europe PMC Scholia
  500. Timmers C, Taniguchi T, Hejna J, Reifsteck C, Lucas L, Bruun D, Thayer M, Cox B, Olson S, D'Andrea AD, Moses R, Grompe M; ''Positional cloning of a novel Fanconi anemia gene, FANCD2.''; Mol Cell, 2001 PubMed Europe PMC Scholia
  501. Raymond AC, Staker BL, Burgin AB Jr; ''Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1).''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  502. Mäkiniemi M, Hillukkala T, Tuusa J, Reini K, Vaara M, Huang D, Pospiech H, Majuri I, Westerling T, Mäkelä TP, Syväoja JE; ''BRCT domain-containing protein TopBP1 functions in DNA replication and damage response.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  503. Medema RH, Macůrek L; ''Checkpoint control and cancer.''; Oncogene, 2012 PubMed Europe PMC Scholia
  504. Lin YL, Shivji MK, Chen C, Kolodner R, Wood RD, Dutta A; ''The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repair.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  505. LeMotte PK, Little JB; ''DNA damage induced in human diploid cells by decay of incorporated radionuclides.''; Cancer Res, 1984 PubMed Europe PMC Scholia
  506. Allerston CK, Lee SY, Newman JA, Schofield CJ, McHugh PJ, Gileadi O; ''The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
  507. Yamane K, Tsuruo T; ''Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA.''; Oncogene, 1999 PubMed Europe PMC Scholia
  508. Paull TT, Gellert M; ''The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.''; Mol Cell, 1998 PubMed Europe PMC Scholia
  509. Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Maratos-Flier E, Richardson AL, Schafer ZT, Pandolfi PP; ''A metabolic prosurvival role for PML in breast cancer.''; J Clin Invest, 2012 PubMed Europe PMC Scholia
  510. Cheng X, Liu Y, Chu H, Kao HY; ''Promyelocytic leukemia protein (PML) regulates endothelial cell network formation and migration in response to tumor necrosis factor α (TNFα) and interferon α (IFNα).''; J Biol Chem, 2012 PubMed Europe PMC Scholia
  511. Martin N, Benhamed M, Nacerddine K, Demarque MD, van Lohuizen M, Dejean A, Bischof O; ''Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence.''; EMBO J, 2012 PubMed Europe PMC Scholia
  512. Lee MS, Edwards RA, Thede GL, Glover JN; ''Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  513. Kelman Z; ''PCNA: structure, functions and interactions.''; Oncogene, 1997 PubMed Europe PMC Scholia
  514. Tavtigian SV, Simard J, Rommens J, Couch F, Shattuck-Eidens D, Neuhausen S, Merajver S, Thorlacius S, Offit K, Stoppa-Lyonnet D, Belanger C, Bell R, Berry S, Bogden R, Chen Q, Davis T, Dumont M, Frye C, Hattier T, Jammulapati S, Janecki T, Jiang P, Kehrer R, Leblanc JF, Mitchell JT, McArthur-Morrison J, Nguyen K, Peng Y, Samson C, Schroeder M, Snyder SC, Steele L, Stringfellow M, Stroup C, Swedlund B, Swense J, Teng D, Thomas A, Tran T, Tranchant M, Weaver-Feldhaus J, Wong AK, Shizuya H, Eyfjord JE, Cannon-Albright L, Labrie F, Skolnick MH, Weber B, Kamb A, Goldgar DE; ''The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.''; Nat Genet, 1996 PubMed Europe PMC Scholia
  515. Kurata M, Maesako Y, Ueda C, Nishikori M, Akasaka T, Uchiyama T, Ohno H; ''Characterization of t(3;6)(q27;p21) breakpoints in B-cell non-Hodgkin's lymphoma and construction of the histone H4/BCL6 fusion gene, leading to altered expression of Bcl-6.''; Cancer Res, 2002 PubMed Europe PMC Scholia
  516. Lee Bi BI, Nguyen LH, Barsky D, Fernandes M, Wilson DM 3rd; ''Molecular interactions of human Exo1 with DNA.''; Nucleic Acids Res, 2002 PubMed Europe PMC Scholia
  517. Roots R, Holley W, Chatterjee A, Rachal E, Kraft G; ''The influence of radiation quality on the formation of DNA breaks.''; Adv Space Res, 1989 PubMed Europe PMC Scholia
  518. Nijman SM, Huang TT, Dirac AM, Brummelkamp TR, Kerkhoven RM, D'Andrea AD, Bernards R; ''The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.''; Mol Cell, 2005 PubMed Europe PMC Scholia
  519. Buisson R, Niraj J, Pauty J, Maity R, Zhao W, Coulombe Y, Sung P, Masson JY; ''Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks.''; Cell Rep, 2014 PubMed Europe PMC Scholia
  520. Bouligand J, Delemer B, Hecart AC, Meduri G, Viengchareun S, Amazit L, Trabado S, Fève B, Guiochon-Mantel A, Young J, Lombès M; ''Familial glucocorticoid receptor haploinsufficiency by non-sense mediated mRNA decay, adrenal hyperplasia and apparent mineralocorticoid excess.''; PLoS One, 2010 PubMed Europe PMC Scholia
  521. Salomoni P, Betts-Henderson J; ''The role of PML in the nervous system.''; Mol Neurobiol, 2011 PubMed Europe PMC Scholia
  522. Casper AM, Nghiem P, Arlt MF, Glover TW; ''ATR regulates fragile site stability.''; Cell, 2002 PubMed Europe PMC Scholia
  523. Sone T, Saeki Y, Toh-e A, Yokosawa H; ''Sem1p is a novel subunit of the 26 S proteasome from Saccharomyces cerevisiae.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  524. Varon R, Vissinga C, Platzer M, Cerosaletti KM, Chrzanowska KH, Saar K, Beckmann G, Seemanová E, Cooper PR, Nowak NJ, Stumm M, Weemaes CM, Gatti RA, Wilson RK, Digweed M, Rosenthal A, Sperling K, Concannon P, Reis A; ''Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome.''; Cell, 1998 PubMed Europe PMC Scholia
  525. Unsal-Kaçmaz K, Sancar A; ''Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities.''; Mol Cell Biol, 2004 PubMed Europe PMC Scholia
  526. Bennett RA, Wilson DM 3rd, Wong D, Demple B; ''Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.''; Proc Natl Acad Sci U S A, 1997 PubMed Europe PMC Scholia
  527. Neganova I, Vilella F, Atkinson SP, Lloret M, Passos JF, von Zglinicki T, O'Connor JE, Burks D, Jones R, Armstrong L, Lako M; ''An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.''; Stem Cells, 2011 PubMed Europe PMC Scholia
  528. Caestecker KW, Van de Walle GR; ''The role of BRCA1 in DNA double-strand repair: past and present.''; Exp Cell Res, 2013 PubMed Europe PMC Scholia
  529. Lancaster JM, Wooster R, Mangion J, Phelan CM, Cochran C, Gumbs C, Seal S, Barfoot R, Collins N, Bignell G, Patel S, Hamoudi R, Larsson C, Wiseman RW, Berchuck A, Iglehart JD, Marks JR, Ashworth A, Stratton MR, Futreal PA; ''BRCA2 mutations in primary breast and ovarian cancers.''; Nat Genet, 1996 PubMed Europe PMC Scholia
  530. Sigurdsson S, Van Komen S, Petukhova G, Sung P; ''Homologous DNA pairing by human recombination factors Rad51 and Rad54.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  531. Gong Z, Chen J; ''E3 ligase RFWD3 participates in replication checkpoint control.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  532. Zhao S, Weng YC, Yuan SS, Lin YT, Hsu HC, Lin SC, Gerbino E, Song MH, Zdzienicka MZ, Gatti RA, Shay JW, Ziv Y, Shiloh Y, Lee EY; ''Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products.''; Nature, 2000 PubMed Europe PMC Scholia
  533. Jang YJ, Ma S, Terada Y, Erikson RL; ''Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  534. Reini K, Uitto L, Perera D, Moens PB, Freire R, Syväoja JE; ''TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis.''; Chromosoma, 2004 PubMed Europe PMC Scholia
  535. Haracska L, Unk I, Johnson RE, Phillips BB, Hurwitz J, Prakash L, Prakash S; ''Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA.''; Mol Cell Biol, 2002 PubMed Europe PMC Scholia
  536. Rendtlew Danielsen JM, Larsen DH, Schou KB, Freire R, Falck J, Bartek J, Lukas J; ''HCLK2 is required for activity of the DNA damage response kinase ATR.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  537. Feng L, Wang J, Chen J; ''The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  538. Flores O, Wang Z, Knudsen KE, Burnstein KL; ''Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition.''; Endocrinology, 2010 PubMed Europe PMC Scholia
  539. Hang H, Lieberman HB; ''Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression.''; Genomics, 2000 PubMed Europe PMC Scholia
  540. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W, et al.; ''A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.''; Science, 1994 PubMed Europe PMC Scholia
  541. Vignard J, Mirey G, Salles B; ''''; , PubMed Europe PMC Scholia
  542. Sy SM, Huen MS, Chen J; ''PALB2 is an integral component of the BRCA complex required for homologous recombination repair.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia
  543. Firsanov DV, Solovjeva LV, Svetlova MP; ''H2AX phosphorylation at the sites of DNA double-strand breaks in cultivated mammalian cells and tissues.''; Clin Epigenetics, 2011 PubMed Europe PMC Scholia
  544. Guo A, Salomoni P, Luo J, Shih A, Zhong S, Gu W, Pandolfi PP; ''The function of PML in p53-dependent apoptosis.''; Nat Cell Biol, 2000 PubMed Europe PMC Scholia
  545. Huang X, Luan B, Wu J, Shi Y; ''An atomic structure of the human 26S proteasome.''; Nat Struct Mol Biol, 2016 PubMed Europe PMC Scholia
  546. Dray E, Etchin J, Wiese C, Saro D, Williams GJ, Hammel M, Yu X, Galkin VE, Liu D, Tsai MS, Sy SM, Schild D, Egelman E, Chen J, Sung P; ''Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.''; Nat Struct Mol Biol, 2010 PubMed Europe PMC Scholia
  547. Pollok S, Grosse F; ''Cdc45 degradation during differentiation and apoptosis.''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC Scholia
  548. Strebhardt K; ''Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy.''; Nat Rev Drug Discov, 2010 PubMed Europe PMC Scholia
  549. Wei SJ, Williams JG, Dang H, Darden TA, Betz BL, Humble MM, Chang FM, Trempus CS, Johnson K, Cannon RE, Tennant RW; ''Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation.''; J Mol Biol, 2008 PubMed Europe PMC Scholia
  550. Wu Y, Sommers JA, Suhasini AN, Leonard T, Deakyne JS, Mazin AV, Shin-Ya K, Kitao H, Brosh RM Jr; ''Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes.''; Blood, 2010 PubMed Europe PMC Scholia
  551. Aboussekhra A, Biggerstaff M, Shivji MK, Vilpo JA, Moncollin V, Podust VN, Protić M, Hübscher U, Egly JM, Wood RD; ''Mammalian DNA nucleotide excision repair reconstituted with purified protein components.''; Cell, 1995 PubMed Europe PMC Scholia
  552. Auclair Y, Rouget R, Drobetsky EA; ''ATR kinase as master regulator of nucleotide excision repair during S phase of the cell cycle.''; Cell Cycle, 2009 PubMed Europe PMC Scholia
  553. Hoeller D, Hecker CM, Wagner S, Rogov V, Dötsch V, Dikic I; ''E3-independent monoubiquitination of ubiquitin-binding proteins.''; Mol Cell, 2007 PubMed Europe PMC Scholia
  554. St Onge RP, Besley BD, Park M, Casselman R, Davey S; ''DNA damage-dependent and -independent phosphorylation of the hRad9 checkpoint protein.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  555. Wang W, Lindsey-Boltz LA, Sancar A, Bambara RA; ''Mechanism of stimulation of human DNA ligase I by the Rad9-rad1-Hus1 checkpoint complex.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  556. Wang SC, Nakajima Y, Yu YL, Xia W, Chen CT, Yang CC, McIntush EW, Li LY, Hawke DH, Kobayashi R, Hung MC; ''Tyrosine phosphorylation controls PCNA function through protein stability.''; Nat Cell Biol, 2006 PubMed Europe PMC Scholia
  557. Travali S, Ku DH, Rizzo MG, Ottavio L, Baserga R, Calabretta B; ''Structure of the human gene for the proliferating cell nuclear antigen.''; J Biol Chem, 1989 PubMed Europe PMC Scholia
  558. Dellaire G, Ching RW, Ahmed K, Jalali F, Tse KC, Bristow RG, Bazett-Jones DP; ''Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR.''; J Cell Biol, 2006 PubMed Europe PMC Scholia
  559. Ma CA, Wang HY, Temmerman S, Zhao Y, Wu L, Hornung RL, Wara D, Jain A; ''Dendritic cells from humans with hypomorphic mutations in IKBKG/NEMO have impaired mitogen-activated protein kinase activity.''; Hum Mutat, 2011 PubMed Europe PMC Scholia
  560. Brown NR, Lowe ED, Petri E, Skamnaki V, Antrobus R, Johnson LN; ''Cyclin B and cyclin A confer different substrate recognition properties on CDK2.''; Cell Cycle, 2007 PubMed Europe PMC Scholia
  561. Tremblay CS, Huang FF, Habi O, Huard CC, Godin C, Lévesque G, Carreau M; ''HES1 is a novel interactor of the Fanconi anemia core complex.''; Blood, 2008 PubMed Europe PMC Scholia
  562. Carracedo A, Ito K, Pandolfi PP; ''The nuclear bodies inside out: PML conquers the cytoplasm.''; Curr Opin Cell Biol, 2011 PubMed Europe PMC Scholia
  563. Taniguchi T, Garcia-Higuera I, Andreassen PR, Gregory RC, Grompe M, D'Andrea AD; ''S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51.''; Blood, 2002 PubMed Europe PMC Scholia
  564. Pan YR, Lee EY; ''UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity.''; Cell Cycle, 2009 PubMed Europe PMC Scholia
  565. Ward IM, Minn K, Chen J; ''UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  566. Chen MS, Ryan CE, Piwnica-Worms H; ''Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding.''; Mol Cell Biol, 2003 PubMed Europe PMC Scholia
  567. Kawai T, Nishikomori R, Izawa K, Murata Y, Tanaka N, Sakai H, Saito M, Yasumi T, Takaoka Y, Nakahata T, Mizukami T, Nunoi H, Kiyohara Y, Yoden A, Murata T, Sasaki S, Ito E, Akutagawa H, Imai C, Okada S, Kobayashi M, Heike T; ''Frequent somatic mosaicism of NEMO in T cells of patients with X-linked anhidrotic ectodermal dysplasia with immunodeficiency.''; Blood, 2012 PubMed Europe PMC Scholia
  568. Zheng L, Zhou M, Chai Q, Parrish J, Xue D, Patrick SM, Turchi JJ, Yannone SM, Chen D, Shen B; ''Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks.''; EMBO Rep, 2005 PubMed Europe PMC Scholia
  569. El-Shemerly M, Hess D, Pyakurel AK, Moselhy S, Ferrari S; ''ATR-dependent pathways control hEXO1 stability in response to stalled forks.''; Nucleic Acids Res, 2008 PubMed Europe PMC Scholia
  570. Geoffroy MC, Chelbi-Alix MK; ''Role of promyelocytic leukemia protein in host antiviral defense.''; J Interferon Cytokine Res, 2011 PubMed Europe PMC Scholia
  571. Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR; ''Diversity and specialization of mammalian SWI/SNF complexes.''; Genes Dev, 1996 PubMed Europe PMC Scholia
  572. Raymond AC, Rideout MC, Staker B, Hjerrild K, Burgin AB Jr; ''Analysis of human tyrosyl-DNA phosphodiesterase I catalytic residues.''; J Mol Biol, 2004 PubMed Europe PMC Scholia
  573. Yavuzer U, Smith GC, Bliss T, Werner D, Jackson SP; ''DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D.''; Genes Dev, 1998 PubMed Europe PMC Scholia
  574. Ball HL, Cortez D; ''ATRIP oligomerization is required for ATR-dependent checkpoint signaling.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  575. Zhang Y, Zhou J, Lim CU; ''The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control.''; Cell Res, 2006 PubMed Europe PMC Scholia
  576. Mascle X, Albagli O, Lemercier C; ''Point mutations in BCL6 DNA-binding domain reveal distinct roles for the six zinc fingers.''; Biochem Biophys Res Commun, 2003 PubMed Europe PMC Scholia
  577. Chen MJ, Lin YT, Lieberman HB, Chen G, Lee EY; ''ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  578. Tuteja N, Tuteja R, Ochem A, Taneja P, Huang NW, Simoncsits A, Susic S, Rahman K, Marusic L, Chen J; ''Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen.''; EMBO J, 1994 PubMed Europe PMC Scholia
  579. Savitsky K, Sfez S, Tagle DA, Ziv Y, Sartiel A, Collins FS, Shiloh Y, Rotman G; ''The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species.''; Hum Mol Genet, 1995 PubMed Europe PMC Scholia
  580. Van der Schans GP, Paterson MC, Cross WG; ''DNA strand break and rejoining in cultured human fibroblasts exposed to fast neutrons or gamma rays.''; Int J Radiat Biol Relat Stud Phys Chem Med, 1983 PubMed Europe PMC Scholia
  581. Gerhardt J, Guler GD, Fanning E; ''Human DNA helicase B interacts with the replication initiation protein Cdc45 and facilitates Cdc45 binding onto chromatin.''; Exp Cell Res, 2015 PubMed Europe PMC Scholia
  582. Honda R, Tanaka H, Yasuda H; ''Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53.''; FEBS Lett, 1997 PubMed Europe PMC Scholia
  583. Ishiai M, Kitao H, Smogorzewska A, Tomida J, Kinomura A, Uchida E, Saberi A, Kinoshita E, Kinoshita-Kikuta E, Koike T, Tashiro S, Elledge SJ, Takata M; ''FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway.''; Nat Struct Mol Biol, 2008 PubMed Europe PMC Scholia
  584. Willis DM, Loewy AP, Charlton-Kachigian N, Shao JS, Ornitz DM, Towler DA; ''Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  585. Mordes DA, Glick GG, Zhao R, Cortez D; ''TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.''; Genes Dev, 2008 PubMed Europe PMC Scholia
  586. Saville MK, Sparks A, Xirodimas DP, Wardrop J, Stevenson LF, Bourdon JC, Woods YL, Lane DP; ''Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  587. Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH, Brody LC; ''BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage.''; Nat Genet, 2002 PubMed Europe PMC Scholia
  588. Myers JS, Cortez D; ''Rapid activation of ATR by ionizing radiation requires ATM and Mre11.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  589. Cliby WA, Roberts CJ, Cimprich KA, Stringer CM, Lamb JR, Schreiber SL, Friend SH; ''Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.''; EMBO J, 1998 PubMed Europe PMC Scholia
  590. Chung JH, Bunz F; ''Cdk2 is required for p53-independent G2/M checkpoint control.''; PLoS Genet, 2010 PubMed Europe PMC Scholia
  591. de Winter JP, van der Weel L, de Groot J, Stone S, Waisfisz Q, Arwert F, Scheper RJ, Kruyt FA, Hoatlin ME, Joenje H; ''The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG.''; Hum Mol Genet, 2000 PubMed Europe PMC Scholia
  592. Fernandez-Capetillo O, Celeste A, Nussenzweig A; ''Focusing on foci: H2AX and the recruitment of DNA-damage response factors.''; Cell Cycle, 2003 PubMed Europe PMC Scholia
  593. Sar F, Lindsey-Boltz LA, Subramanian D, Croteau DL, Hutsell SQ, Griffith JD, Sancar A; ''Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  594. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998 PubMed Europe PMC Scholia
  595. Yang S, Kuo C, Bisi JE, Kim MK; ''PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2.''; Nat Cell Biol, 2002 PubMed Europe PMC Scholia
  596. Jacobs DM, Lipton AS, Isern NG, Daughdrill GW, Lowry DF, Gomes X, Wold MS; ''Human replication protein A: global fold of the N-terminal RPA-70 domain reveals a basic cleft and flexible C-terminal linker.''; J Biomol NMR, 1999 PubMed Europe PMC Scholia
  597. Liu P, Barkley LR, Day T, Bi X, Slater DM, Alexandrow MG, Nasheuer HP, Vaziri C; ''The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  598. Roos-Mattjus P, Hopkins KM, Oestreich AJ, Vroman BT, Johnson KL, Naylor S, Lieberman HB, Karnitz LM; ''Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  599. Bachmann C, Nguyen H, Rosenbusch J, Pham L, Rabe T, Patwa M, Sokpor G, Seong RH, Ashery-Padan R, Mansouri A, Stoykova A, Staiger JF, Tuoc T; ''mSWI/SNF (BAF) Complexes Are Indispensable for the Neurogenesis and Development of Embryonic Olfactory Epithelium.''; PLoS Genet, 2016 PubMed Europe PMC Scholia
  600. Timofeev O, Cizmecioglu O, Settele F, Kempf T, Hoffmann I; ''Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  601. Lou Z, Minter-Dykhouse K, Wu X, Chen J; ''MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.''; Nature, 2003 PubMed Europe PMC Scholia
  602. Gilmore-Hebert M, Ramabhadran R, Stern DF; ''Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.''; Mol Cancer Res, 2010 PubMed Europe PMC Scholia
  603. Brown KD, Ziv Y, Sadanandan SN, Chessa L, Collins FS, Shiloh Y, Tagle DA; ''The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage.''; Proc Natl Acad Sci USA, 1997 PubMed Europe PMC Scholia
  604. Guo R, Chen J, Zhu F, Biswas AK, Berton TR, Mitchell DL, Johnson DG; ''E2F1 localizes to sites of UV-induced DNA damage to enhance nucleotide excision repair.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  605. Sy SM, Huen MS, Zhu Y, Chen J; ''PALB2 regulates recombinational repair through chromatin association and oligomerization.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  606. Bomgarden RD, Yean D, Yee MC, Cimprich KA; ''A novel protein activity mediates DNA binding of an ATR-ATRIP complex.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  607. Cimprich KA, Cortez D; ''ATR: an essential regulator of genome integrity.''; Nat Rev Mol Cell Biol, 2008 PubMed Europe PMC Scholia
  608. Akhter S, Legerski RJ; ''SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint.''; Biochem Biophys Res Commun, 2008 PubMed Europe PMC Scholia
  609. Stiff T, Walker SA, Cerosaletti K, Goodarzi AA, Petermann E, Concannon P, O'Driscoll M, Jeggo PA; ''ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling.''; EMBO J, 2006 PubMed Europe PMC Scholia
  610. Escribano-Díaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, Tká� J, Cook MA, Rosebrock AP, Munro M, Canny MD, Xu D, Durocher D; ''A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.''; Mol Cell, 2013 PubMed Europe PMC Scholia
  611. Müller B, Blackburn J, Feijoo C, Zhao X, Smythe C; ''DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication.''; J Cell Biol, 2007 PubMed Europe PMC Scholia
  612. Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ; ''MDC1 is a mediator of the mammalian DNA damage checkpoint.''; Nature, 2003 PubMed Europe PMC Scholia
  613. Niu H, Ye BH, Dalla-Favera R; ''Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor.''; Genes Dev, 1998 PubMed Europe PMC Scholia
  614. Kaygun H, Marzluff WF; ''Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1.''; Nat Struct Mol Biol, 2005 PubMed Europe PMC Scholia
  615. Zhang S, Chea J, Meng X, Zhou Y, Lee EY, Lee MY; ''PCNA is ubiquitinated by RNF8.''; Cell Cycle, 2008 PubMed Europe PMC Scholia
  616. Huertas P, Jackson SP; ''Human CtIP mediates cell cycle control of DNA end resection and double strand break repair.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  617. Yuan J, Adamski R, Chen J; ''Focus on histone variant H2AX: to be or not to be.''; FEBS Lett, 2010 PubMed Europe PMC Scholia
  618. Yan Q, Xu R, Zhu L, Cheng X, Wang Z, Manis J, Shipp MA; ''BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8.''; Mol Cell Biol, 2013 PubMed Europe PMC Scholia
  619. Matthess Y, Raab M, Sanhaji M, Lavrik IN, Strebhardt K; ''Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity.''; Mol Cell Biol, 2010 PubMed Europe PMC Scholia
  620. Ward IM, Minn K, Jorda KG, Chen J; ''Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  621. Kamitani T, Kito K, Nguyen HP, Wada H, Fukuda-Kamitani T, Yeh ET; ''Identification of three major sentrinization sites in PML.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  622. Lo Ten Foe JR, Rooimans MA, Bosnoyan-Collins L, Alon N, Wijker M, Parker L, Lightfoot J, Carreau M, Callen DF, Savoia A, Cheng NC, van Berkel CG, Strunk MH, Gille JJ, Pals G, Kruyt FA, Pronk JC, Arwert F, Buchwald M, Joenje H; ''Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA.''; Nat Genet, 1996 PubMed Europe PMC Scholia
  623. Mordes DA, Cortez D; ''Activation of ATR and related PIKKs.''; Cell Cycle, 2008 PubMed Europe PMC Scholia
  624. Kannouche PL, Wing J, Lehmann AR; ''Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  625. Kassube SA, Jinek M, Fang J, Tsutakawa S, Nogales E; ''Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5.''; Nat Struct Mol Biol, 2013 PubMed Europe PMC Scholia
  626. Wolff S, Afzal V, Wiencke JK, Olivieri G, Michaeli A; ''Human lymphocytes exposed to low doses of ionizing radiations become refractory to high doses of radiation as well as to chemical mutagens that induce double-strand breaks in DNA.''; Int J Radiat Biol Relat Stud Phys Chem Med, 1988 PubMed Europe PMC Scholia
  627. Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ; ''Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.''; Science, 2007 PubMed Europe PMC Scholia
  628. Schmidt U, Wollmann Y, Franke C, Grosse F, Saluz HP, Hänel F; ''Characterization of the interaction between the human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein.''; Biochem J, 2008 PubMed Europe PMC Scholia
  629. Kadyrov FA, Dzantiev L, Constantin N, Modrich P; ''Endonucleolytic function of MutLalpha in human mismatch repair.''; Cell, 2006 PubMed Europe PMC Scholia
  630. Yu X, Baer R; ''Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  631. Feki A, Jefford CE, Berardi P, Wu JY, Cartier L, Krause KH, Irminger-Finger I; ''BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase.''; Oncogene, 2005 PubMed Europe PMC Scholia
  632. Trenz K, Errico A, Costanzo V; ''Plx1 is required for chromosomal DNA replication under stressful conditions.''; EMBO J, 2008 PubMed Europe PMC Scholia
  633. Pomerening JR, Ubersax JA, Ferrell JE Jr; ''Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF.''; Mol Biol Cell, 2008 PubMed Europe PMC Scholia
  634. Johnson N, Shapiro GI; ''Cyclin-dependent kinases (cdks) and the DNA damage response: rationale for cdk inhibitor-chemotherapy combinations as an anticancer strategy for solid tumors.''; Expert Opin Ther Targets, 2010 PubMed Europe PMC Scholia
  635. Nieduszynski CA, Murray J, Carrington M; ''Whole-genome analysis of animal A- and B-type cyclins.''; Genome Biol, 2002 PubMed Europe PMC Scholia
  636. Cantor S, Drapkin R, Zhang F, Lin Y, Han J, Pamidi S, Livingston DM; ''The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations.''; Proc Natl Acad Sci U S A, 2004 PubMed Europe PMC Scholia
  637. Singleton MR, Wentzell LM, Liu Y, West SC, Wigley DB; ''Structure of the single-strand annealing domain of human RAD52 protein.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC Scholia
  638. Yu X, Fu S, Lai M, Baer R, Chen J; ''BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP.''; Genes Dev, 2006 PubMed Europe PMC Scholia
  639. Sivasubramaniam S, Sun X, Pan YR, Wang S, Lee EY; ''Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.''; Genes Dev, 2008 PubMed Europe PMC Scholia
  640. Huang X, Tran T, Zhang L, Hatcher R, Zhang P; ''DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint.''; Proc Natl Acad Sci U S A, 2005 PubMed Europe PMC Scholia
  641. Khanna KK, Keating KE, Kozlov S, Scott S, Gatei M, Hobson K, Taya Y, Gabrielli B, Chan D, Lees-Miller SP, Lavin MF; ''ATM associates with and phosphorylates p53: mapping the region of interaction.''; Nat Genet, 1998 PubMed Europe PMC Scholia
  642. Chiang SC, Carroll J, El-Khamisy SF; ''TDP1 serine 81 promotes interaction with DNA ligase IIIalpha and facilitates cell survival following DNA damage.''; Cell Cycle, 2010 PubMed Europe PMC Scholia
  643. Zou L, Liu D, Elledge SJ; ''Replication protein A-mediated recruitment and activation of Rad17 complexes.''; Proc Natl Acad Sci U S A, 2003 PubMed Europe PMC Scholia
  644. Temmerman ST, Ma CA, Borges L, Kubin M, Liu S, Derry JM, Jain A; ''Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination.''; Blood, 2006 PubMed Europe PMC Scholia
  645. Ahn J, Urist M, Prives C; ''The Chk2 protein kinase.''; DNA Repair (Amst), 2004 PubMed Europe PMC Scholia
  646. Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJ; ''Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.''; Genes Dev, 2000 PubMed Europe PMC Scholia
  647. Jowsey P, Morrice NA, Hastie CJ, McLauchlan H, Toth R, Rouse J; ''Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR.''; DNA Repair(Amst), 2007 PubMed Europe PMC Scholia
  648. Tréand C, du Chéné I, Brès V, Kiernan R, Benarous R, Benkirane M, Emiliani S; ''Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter.''; EMBO J, 2006 PubMed Europe PMC Scholia
  649. Myers JS, Zhao R, Xu X, Ham AJ, Cortez D; ''Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage.''; Cancer Res, 2007 PubMed Europe PMC Scholia
  650. Zhao LY, Liu J, Sidhu GS, Niu Y, Liu Y, Wang R, Liao D; ''Negative regulation of p53 functions by Daxx and the involvement of MDM2.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  651. Stokes MP, Rush J, Macneill J, Ren JM, Sprott K, Nardone J, Yang V, Beausoleil SA, Gygi SP, Livingstone M, Zhang H, Polakiewicz RD, Comb MJ; ''Profiling of UV-induced ATM/ATR signaling pathways.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  652. Garg R, Callens S, Lim DS, Canman CE, Kastan MB, Xu B; ''Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation.''; Mol Cancer Res, 2004 PubMed Europe PMC Scholia
  653. Bahassi EM, Ovesen JL, Riesenberg AL, Bernstein WZ, Hasty PE, Stambrook PJ; ''The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage.''; Oncogene, 2008 PubMed Europe PMC Scholia
  654. Komatsu K, Wharton W, Hang H, Wu C, Singh S, Lieberman HB, Pledger WJ, Wang HG; ''PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition.''; Oncogene, 2000 PubMed Europe PMC Scholia
  655. Lo YC, Lin SC, Rospigliosi CC, Conze DB, Wu CJ, Ashwell JD, Eliezer D, Wu H; ''Structural basis for recognition of diubiquitins by NEMO.''; Mol Cell, 2009 PubMed Europe PMC Scholia
  656. Guo Z, Zheng L, Xu H, Dai H, Zhou M, Pascua MR, Chen QM, Shen B; ''Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding.''; Nat Chem Biol, 2010 PubMed Europe PMC Scholia
  657. Smirnova E, Toueille M, Markkanen E, Hübscher U; ''The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery.''; Biochem J, 2005 PubMed Europe PMC Scholia
  658. Bansbach CE, Bétous R, Lovejoy CA, Glick GG, Cortez D; ''The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks.''; Genes Dev, 2009 PubMed Europe PMC Scholia
  659. Perry JJ, Yannone SM, Holden LG, Hitomi C, Asaithamby A, Han S, Cooper PK, Chen DJ, Tainer JA; ''WRN exonuclease structure and molecular mechanism imply an editingrole in DNA end processing.''; Nat Struct Mol Biol, 2006 PubMed Europe PMC Scholia
  660. Varon R, Reis A, Henze G, von Einsiedel HG, Sperling K, Seeger K; ''Mutations in the Nijmegen Breakage Syndrome gene (NBS1) in childhood acute lymphoblastic leukemia (ALL).''; Cancer Res, 2001 PubMed Europe PMC Scholia
  661. Hayashi S, Yamaguchi M; ''Kinase-independent activity of Cdc2/cyclin A prevents the S phase in the Drosophila cell cycle.''; Genes Cells, 1999 PubMed Europe PMC Scholia
  662. Post S, Weng YC, Cimprich K, Chen LB, Xu Y, Lee EY; ''Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage.''; Proc Natl Acad Sci U S A, 2001 PubMed Europe PMC Scholia
  663. Temime-Smaali N, Guittat L, Wenner T, Bayart E, Douarre C, Gomez D, Giraud-Panis MJ, Londono-Vallejo A, Gilson E, Amor-Guéret M, Riou JF; ''Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres.''; EMBO J, 2008 PubMed Europe PMC Scholia
  664. Ramamoorthy M, May A, Tadokoro T, Popuri V, Seidman MM, Croteau DL, Bohr VA; ''The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair.''; Carcinogenesis, 2013 PubMed Europe PMC Scholia
  665. Spengler ML, Guo LW, Brattain MG; ''Phosphorylation mediates Sp1 coupled activities of proteolytic processing, desumoylation and degradation.''; Cell Cycle, 2008 PubMed Europe PMC Scholia
  666. Hejna J, Philip S, Ott J, Faulkner C, Moses R; ''The hSNM1 protein is a DNA 5'-exonuclease.''; Nucleic Acids Res, 2007 PubMed Europe PMC Scholia
  667. Feng L, Huang J, Chen J; ''MERIT40 facilitates BRCA1 localization and DNA damage repair.''; Genes Dev, 2009 PubMed Europe PMC Scholia
  668. Kitao H, Yuan ZM; ''Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  669. Tadokoro T, Ramamoorthy M, Popuri V, May A, Tian J, Sykora P, Rybanska I, Wilson DM 3rd, Croteau DL, Bohr VA; ''Human RECQL5 participates in the removal of endogenous DNA damage.''; Mol Biol Cell, 2012 PubMed Europe PMC Scholia
  670. Kim KJ, Park MC, Choi SJ, Oh YS, Choi EC, Cho HJ, Kim MH, Kim SH, Kim DW, Kim S, Kang BS; ''Determination of three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with ATM.''; J Biol Chem, 2008 PubMed Europe PMC Scholia
  671. Akhter S, Richie CT, Deng JM, Brey E, Zhang X, Patrick C Jr, Behringer RR, Legerski RJ; ''Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress.''; Mol Cell Biol, 2004 PubMed Europe PMC Scholia
  672. Ding C, Li Y, Kim BJ, Malovannaya A, Jung SY, Wang Y, Qin J; ''Quantitative analysis of cohesin complex stoichiometry and SMC3 modification-dependent protein interactions.''; J Proteome Res, 2011 PubMed Europe PMC Scholia
  673. Lee J, Kumagai A, Dunphy WG; ''The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  674. Zietlow L, Smith LA, Bessho M, Bessho T; ''Evidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-links.''; Biochemistry, 2009 PubMed Europe PMC Scholia
  675. Fujiwara T, Saito A, Suzuki M, Shinomiya H, Suzuki T, Takahashi E, Tanigami A, Ichiyama A, Chung CH, Nakamura Y, Tanaka K; ''Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease.''; Genomics, 1998 PubMed Europe PMC Scholia
  676. Zhao H, Piwnica-Worms H; ''ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1.''; Mol Cell Biol, 2001 PubMed Europe PMC Scholia
  677. Noll A, Ruppenthal SL, Montenarh M; ''The mitotic phosphatase cdc25C at the Golgi apparatus.''; Biochem Biophys Res Commun, 2006 PubMed Europe PMC Scholia
  678. Kumar PP, Bischof O, Purbey PK, Notani D, Urlaub H, Dejean A, Galande S; ''Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus.''; Nat Cell Biol, 2007 PubMed Europe PMC Scholia
  679. Pampin M, Simonin Y, Blondel B, Percherancier Y, Chelbi-Alix MK; ''Cross talk between PML and p53 during poliovirus infection: implications for antiviral defense.''; J Virol, 2006 PubMed Europe PMC Scholia
  680. Goldberg M, Stucki M, Falck J, D'Amours D, Rahman D, Pappin D, Bartek J, Jackson SP; ''MDC1 is required for the intra-S-phase DNA damage checkpoint.''; Nature, 2003 PubMed Europe PMC Scholia
  681. Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, Zhou BB, Bartek J, Lukas J; ''Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.''; Cancer Cell, 2003 PubMed Europe PMC Scholia
  682. Thacker J, Ganesh AN; ''DNA-break repair, radioresistance of DNA synthesis, and camptothecin sensitivity in the radiation-sensitive irs mutants: comparisons to ataxia-telangiectasia cells.''; Mutat Res, 1990 PubMed Europe PMC Scholia
  683. Wang B, Elledge SJ; ''Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  684. Sharma S, Sommers JA, Driscoll HC, Uzdilla L, Wilson TM, Brosh RM Jr; ''The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  685. Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM; ''Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.''; Cell, 1995 PubMed Europe PMC Scholia
  686. Shen B, Nolan JP, Sklar LA, Park MS; ''Essential amino acids for substrate binding and catalysis of human flap endonuclease 1.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  687. Yin J, Sobeck A, Xu C, Meetei AR, Hoatlin M, Li L, Wang W; ''BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity.''; EMBO J, 2005 PubMed Europe PMC Scholia
  688. Yang XH, Zou L; ''Checkpoint and coordinated cellular responses to DNA damage.''; Results Probl Cell Differ, 2006 PubMed Europe PMC Scholia
  689. Maldonado-Codina G, Glover DM; ''Cyclins A and B associate with chromatin and the polar regions of spindles, respectively, and do not undergo complete degradation at anaphase in syncytial Drosophila embryos.''; J Cell Biol, 1992 PubMed Europe PMC Scholia
  690. Li L, Peterson CA, Kanter-Smoler G, Wei YF, Ramagli LS, Sunnerhagen P, Siciliano MJ, Legerski RJ; ''hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation.''; Oncogene, 1999 PubMed Europe PMC Scholia
  691. Wu L, Bachrati CZ, Ou J, Xu C, Yin J, Chang M, Wang W, Li L, Brown GW, Hickson ID; ''BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  692. Ou YH, Chung PH, Sun TP, Shieh SY; ''p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.''; Mol Biol Cell, 2005 PubMed Europe PMC Scholia
  693. Fu Z, Malureanu L, Huang J, Wang W, Li H, van Deursen JM, Tindall DJ, Chen J; ''Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression.''; Nat Cell Biol, 2008 PubMed Europe PMC Scholia
  694. Lehner CF, O'Farrell PH; ''The roles of Drosophila cyclins A and B in mitotic control.''; Cell, 1990 PubMed Europe PMC Scholia
  695. Lovly CM, Yan L, Ryan CE, Takada S, Piwnica-Worms H; ''Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379.''; Mol Cell Biol, 2008 PubMed Europe PMC Scholia
  696. Yuan J, Chen J; ''N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  697. White DE, Negorev D, Peng H, Ivanov AV, Maul GG, Rauscher FJ 3rd; ''KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions.''; Cancer Res, 2006 PubMed Europe PMC Scholia
  698. Buchko GW, Daughdrill GW, de Lorimier R, Rao B K, Isern NG, Lingbeck JM, Taylor JS, Wold MS, Gochin M, Spicer LD, Lowry DF, Kennedy MA; ''Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies.''; Biochemistry, 1999 PubMed Europe PMC Scholia
  699. Tanaka H, Mendonca MS, Bradshaw PS, Hoelz DJ, Malkas LH, Meyn MS, Gilley D; ''DNA damage-induced phosphorylation of the human telomere-associated protein TRF2.''; Proc Natl Acad Sci U S A, 2005 PubMed Europe PMC Scholia
  700. Foray N, Marot D, Gabriel A, Randrianarison V, Carr AM, Perricaudet M, Ashworth A, Jeggo P; ''A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.''; EMBO J, 2003 PubMed Europe PMC Scholia
  701. Clerici M, Mourão A, Gutsche I, Gehring NH, Hentze MW, Kulozik A, Kadlec J, Sattler M, Cusack S; ''Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2.''; EMBO J, 2009 PubMed Europe PMC Scholia
  702. Otsuki T, Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu JM; ''Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNFcomplex.''; Hum Mol Genet, 2001 PubMed Europe PMC Scholia
  703. Tsao CC, Geisen C, Abraham RT; ''Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling.''; EMBO J, 2004 PubMed Europe PMC Scholia
  704. David Y, Ziv T, Admon A, Navon A; ''The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  705. Ziółkowska-Suchanek I, Mosor M, Wierzbicka M, Rydzanicz M, Baranowska M, Nowak J; ''The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers.''; Mol Cancer, 2013 PubMed Europe PMC Scholia
  706. Dou H, Huang C, Singh M, Carpenter PB, Yeh ET; ''Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex.''; Mol Cell, 2010 PubMed Europe PMC Scholia
  707. Tan Y, Raychaudhuri P, Costa RH; ''Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes.''; Mol Cell Biol, 2007 PubMed Europe PMC Scholia
  708. Bauerschmidt C, Woodcock M, Stevens DL, Hill MA, Rothkamm K, Helleday T; ''Cohesin phosphorylation and mobility of SMC1 at ionizing radiation-induced DNA double-strand breaks in human cells.''; Exp Cell Res, 2011 PubMed Europe PMC Scholia
  709. Xia B, Sheng Q, Nakanishi K, Ohashi A, Wu J, Christ N, Liu X, Jasin M, Couch FJ, Livingston DM; ''Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.''; Mol Cell, 2006 PubMed Europe PMC Scholia
  710. Fujimoto H, Onishi N, Kato N, Takekawa M, Xu XZ, Kosugi A, Kondo T, Imamura M, Oishi I, Yoda A, Minami Y; ''Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase.''; Cell Death Differ, 2006 PubMed Europe PMC Scholia
  711. de Jager M, van Noort J, van Gent DC, Dekker C, Kanaar R, Wyman C; ''Human Rad50/Mre11 is a flexible complex that can tether DNA ends.''; Mol Cell, 2001 PubMed Europe PMC Scholia
  712. Hung JJ, Wang YT, Chang WC; ''Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription.''; Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  713. Jackson AP, Eastwood H, Bell SM, Adu J, Toomes C, Carr IM, Roberts E, Hampshire DJ, Crow YJ, Mighell AJ, Karbani G, Jafri H, Rashid Y, Mueller RF, Markham AF, Woods CG; ''Identification of microcephalin, a protein implicated in determining the size of the human brain.''; Am J Hum Genet, 2002 PubMed Europe PMC Scholia
  714. Arimoto K, Funami K, Saeki Y, Tanaka K, Okawa K, Takeuchi O, Akira S, Murakami Y, Shimotohno K; ''Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  715. Andreassen PR, D'Andrea AD, Taniguchi T; ''ATR couples FANCD2 monoubiquitination to the DNA-damage response.''; Genes Dev, 2004 PubMed Europe PMC Scholia
  716. Debec A, Montmory C; ''Cyclin B is associated with centrosomes in Drosophila mitotic cells.''; Biol Cell, 1992 PubMed Europe PMC Scholia
  717. Sangrithi MN, Bernal JA, Madine M, Philpott A, Lee J, Dunphy WG, Venkitaraman AR; ''Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.''; Cell, 2005 PubMed Europe PMC Scholia
  718. Blackwell LJ, Martik D, Bjornson KP, Bjornson ES, Modrich P; ''Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  719. Roberts SA, Strande N, Burkhalter MD, Strom C, Havener JM, Hasty P, Ramsden DA; ''Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends.''; Nature, 2010 PubMed Europe PMC Scholia
  720. Franks TM, Singh G, Lykke-Andersen J; ''Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay.''; Cell, 2010 PubMed Europe PMC Scholia
  721. Cortez D, Guntuku S, Qin J, Elledge SJ; ''ATR and ATRIP: partners in checkpoint signaling.''; Science, 2001 PubMed Europe PMC Scholia
  722. Cimprich KA, Shin TB, Keith CT, Schreiber SL; ''cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC Scholia
  723. Su TT, Jaklevic B; ''DNA damage leads to a Cyclin A-dependent delay in metaphase-anaphase transition in the Drosophila gastrula.''; Curr Biol, 2001 PubMed Europe PMC Scholia
  724. Whitehouse A, Taylor GR, Deeble J, Phillips SE, Meredith DM, Markham AF; ''A carboxy terminal domain of the hMSH-2 gene product is sufficient for binding specific mismatched oligonucleotides.''; Biochem Biophys Res Commun, 1996 PubMed Europe PMC Scholia
  725. Seki M, Yanagisawa J, Kohda T, Sonoyama T, Ui M, Enomoto T; ''Purification of two DNA-dependent adenosinetriphosphatases having DNA helicase activity from HeLa cells and comparison of the properties of the two enzymes.''; J Biochem, 1994 PubMed Europe PMC Scholia
  726. Rosen EM; ''BRCA1 in the DNA damage response and at telomeres.''; Front Genet, 2013 PubMed Europe PMC Scholia
  727. Lee DH, Pan Y, Kanner S, Sung P, Borowiec JA, Chowdhury D; ''A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination.''; Nat Struct Mol Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
120667view00:23, 23 December 2021EweitzStandardize font, weight, case
119294view11:20, 23 June 2021FinterlyRemoved empty Biopax and corresponding BiopaxRefs
108188view10:55, 29 November 2019FehrhartOntology Term : 'cancer' added !
101923view16:07, 17 November 2018EgonwRemoved whitespace in PubMed identifiers.
101837view16:45, 12 November 2018EgonwReplaced old Uniprot data sources with the new ones.
94684view21:53, 4 October 2017KhanspersModified description
94104view09:28, 21 August 2017DeSlChanged appearence of 2 nodes (changed to text labels, since these cannot be annotated).
94103view09:03, 21 August 2017DeSlChanged layout of legend.
93700view17:20, 10 August 2017AmanzoOntology Term : 'G2/M checkpoint pathway' added !
93699view17:19, 10 August 2017AmanzoOntology Term : 'G1/S DNA damage checkpoint pathway' added !
93698view17:18, 10 August 2017AmanzoOntology Term : 'altered double-strand DNA repair pathway' added !
93697view17:16, 10 August 2017AmanzoOntology Term : 'altered single-strand DNA repair pathway' added !
93696view16:58, 10 August 2017AmanzoOntology Term : 'skin cancer' added !
93695view16:58, 10 August 2017AmanzoOntology Term : 'Seckel syndrome' added !
93694view16:57, 10 August 2017AmanzoOntology Term : 'ATM and Rad3-related (ATR) signaling pathway' added !
93693view16:43, 10 August 2017AmanzoModified description
93692view16:41, 10 August 2017AmanzoModified description
92863view15:31, 10 July 2017AmanzoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATMGeneProductENSG00000149311 (Ensembl)
ATRIPProteinQ8WXE1 (Uniprot-TrEMBL)
ATRProteinQ13535 (Uniprot-TrEMBL) From Pathway: SPIKE 00003
BARD1ProteinQ99728 (Uniprot-TrEMBL)
BCL6ProteinP41182 (Uniprot-TrEMBL)
BLMProtein
BRCA1ProteinP38398 (Uniprot-TrEMBL)
BRCA2ProteinP51587 (Uniprot-TrEMBL)
BRCC3ProteinP46736 (Uniprot-TrEMBL)
BRIP1ProteinQ9BX63 (Uniprot-TrEMBL)
CDC25CProteinP30307 (Uniprot-TrEMBL)
CDC45ProteinO75419 (Uniprot-TrEMBL)
CEP164ProteinQ9UPV0 (Uniprot-TrEMBL)
CHK1ProteinO14757 (Uniprot-TrEMBL)
CHK2ProteinO96017 (Uniprot-TrEMBL)
CLK2ProteinP49760 (Uniprot-TrEMBL)
CLSPNProteinQ9HAW4 (Uniprot-TrEMBL)
Cdc2ProteinP06493 (Uniprot-TrEMBL)
Cdk2ProteinP24941 (Uniprot-TrEMBL)
Cell cycle checkpoint activationPathwayWP1775 (WikiPathways)
Cellular response to DNA damagePathway
CycAProteinP14785 (Uniprot-TrEMBL)
CycBProteinP20439 (Uniprot-TrEMBL)
DCLRE1AProteinQ6PJP8 (Uniprot-TrEMBL)
DNA Polymerase delta tetramerProtein
DNA repairPathwayWP707 (WikiPathways)
Damage processingPathway
E2F1ProteinQ01094 (Uniprot-TrEMBL)
EEF1E1ProteinO43324 (Uniprot-TrEMBL)
EXO1ProteinQ9UQ84 (Uniprot-TrEMBL)
FAM175AProteinQ6UWZ7 (Uniprot-TrEMBL)
FANCAProteinO15360 (Uniprot-TrEMBL)
FANCD2ProteinQ9BXW9 (Uniprot-TrEMBL)
FANCIProteinQ9NVI1 (Uniprot-TrEMBL)
FEN1ProteinP39748 (Uniprot-TrEMBL)
FOXM1ProteinQ08050 (Uniprot-TrEMBL)
G1/S boundary activationPathway
G2/M-phase checkpointPathwayR-HSA-69481 (Reactome)
Gamma H2AXProteinP16104 (Uniprot-TrEMBL)
H2AXProteinP16104 (Uniprot-TrEMBL)
HERC2ProteinO95714 (Uniprot-TrEMBL)
HUS1ProteinO60921 (Uniprot-TrEMBL)
IKPKBProteinQ9Y6K9 (Uniprot-TrEMBL)
Intra-S-phase

checkpoint mediated arrest of cell cycle

progression
PathwayR-HSA-5693571 (Reactome)
M-phase progressionPathwayhsa04110 (KEGG Pathway)
MCM2ProteinP49736 (Uniprot-TrEMBL)
MCPH1ProteinQ8NEM0 (Uniprot-TrEMBL)
MDC1ProteinQ14676 (Uniprot-TrEMBL)
MDM2ProteinQ00987 (Uniprot-TrEMBL)
MRE11AProteinP49959 (Uniprot-TrEMBL)
MSH2ProteinP43246 (Uniprot-TrEMBL)
MUTL-ALPHA MLH1ProteinP40692 (Uniprot-TrEMBL)
NBNProteinO60934 (Uniprot-TrEMBL)
PALB2ProteinQ86YC2 (Uniprot-TrEMBL)
PARP1ProteinP09874 (Uniprot-TrEMBL)
PCNAProteinP12004 (Uniprot-TrEMBL)
PLK1ProteinP53350 (Uniprot-TrEMBL)
PMLProteinP29590 (Uniprot-TrEMBL)
POLBProteinP06746 (Uniprot-TrEMBL)
POLNProteinQ7Z5Q5 (Uniprot-TrEMBL)
PPM1DProteinO15297 (Uniprot-TrEMBL)
PRKDCProteinP78527 (Uniprot-TrEMBL)
RAD17ProteinO75943 (Uniprot-TrEMBL)
RAD1ProteinO60671 (Uniprot-TrEMBL)
RAD50ProteinQ92878 (Uniprot-TrEMBL)
RAD51ProteinQ06609 (Uniprot-TrEMBL)
RAD52ProteinP43351 (Uniprot-TrEMBL)
RAD9ProteinQ99638 (Uniprot-TrEMBL)
RBBP8ProteinQ99708 (Uniprot-TrEMBL)
RECQL4ProteinO94761 (Uniprot-TrEMBL)
RECQL5ProteinO94762 (Uniprot-TrEMBL)
RECQLProteinP46063 (Uniprot-TrEMBL)
RFWD3ProteinQ6PCD5 (Uniprot-TrEMBL)
RMI1ProteinQ9H9A7 (Uniprot-TrEMBL)
RNF8Protein
RPA1Protein
RPA1ProteinP27694 (Uniprot-TrEMBL)
RPA2ProteinP15927 (Uniprot-TrEMBL)
SHFM1ProteinP60896 (Uniprot-TrEMBL)
SMARCAL1ProteinQ9NZC9 (Uniprot-TrEMBL)
SMARCC2ProteinQ8TAQ2 (Uniprot-TrEMBL)
SMC1AProteinQ14683 (Uniprot-TrEMBL)
SP1ProteinP08047 (Uniprot-TrEMBL)
TDP1ProteinQ9NUW8 (Uniprot-TrEMBL)
TOP3AProteinQ13472 (Uniprot-TrEMBL)
TOPBP1ProteinQ92547 (Uniprot-TrEMBL)
TP53BP1ProteinQ12888 (Uniprot-TrEMBL)
TP53ProteinP04637 (Uniprot-TrEMBL)
TRIM28ProteinQ13263 (Uniprot-TrEMBL)
UB2D3ProteinP61077 (Uniprot-TrEMBL)
UIMC1ProteinQ96RL1 (Uniprot-TrEMBL)
UPF1ProteinQ92900 (Uniprot-TrEMBL)
USP1ProteinO94782 (Uniprot-TrEMBL)
WRNProteinQ14191 (Uniprot-TrEMBL)
XPAProteinP23025 (Uniprot-TrEMBL)
XRCC5ProteinP13010 (Uniprot-TrEMBL)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
ATMTP53mim-stimulation00006 (SPIKE)
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