Acetogenesis (Acetobacterium woodii)

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1Co(I) corrinoid Fe-S proteinRnfDADPdihydrogenRnfC5,10-MethylenetetrahydrofolatemethylRnfAcarbon dioxideHydD5-MethyltetrahydrofolateRnfC2HSCoAHydA1HycB2formateTetrahydrofolateHycB3HycB1AtpEacetateRnfEcarbon monooxide10-FormyltetrahydrofolateRnfGhydrogenphosphateMetVRnfBhydron5,10-MethenyltetrahydrofolateATPcarbon dioxideFdhF1MetFAcsAacetyl-CoAFhs1HydA2HydBHydCATPADPhydrogenphosphateFdhF2HycB3HydA2MetFRnfGRnfDRnfARnfBRnfEhydrondihydrogenNADHNAD(1-)Oxidised ferredoxinReduced ferredoxinAtpBAtpHAtpFAtpDAtpCAtpGAtpAFolDFchAAcsEdihydrogenAcsDAcsCCo(III) corrinoid Fe-S proteinAcsDAcsCAcsB1Ptaacetyl-phosphateAckA


Description

Acetogenesis from H2 and CO2 in Acetobacterium woodii, based on Figure 3 from Diender et al (2015) [PMID:26635746]. This pathway model shows both proposed theoretical pathways of CO conversion to acetate, as well as the acetogenic metabolism driven by CO co-fermented with formate. Two large complexes are involved in this process (top right corner): 1. the RnF complex (sodium ion transport outside of the cell membrane) 2. the ATPase complex (sodium ion translocation to inner cell membrane).

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Ontology Terms

 

Bibliography

  1. Diender M, Stams AJ, Sousa DZ; ''Pathways and Bioenergetics of Anaerobic Carbon Monoxide Fermentation.''; Front Microbiol, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
120854view14:18, 20 January 2022DeSlOntology Term : 'carbon fixation pathway' added !
120853view14:16, 20 January 2022DeSlAdded ref, updated description
113882view02:17, 6 December 2020KhanspersOntology Term : 'classic metabolic pathway' added !
113587view12:24, 3 November 2020LarsgwClarify pathway branches
113580view01:11, 3 November 2020LarsgwAdd enzymes, update acetyl-CoA->acetate reaction
113458view11:53, 2 November 2020Larsgw
113056view14:43, 1 November 2020LarsgwAdd ATP synthase
113055view12:58, 1 November 2020LarsgwAdd some protein complexes
113054view23:43, 31 October 2020LarsgwAdd main pathway metabolites
113052view17:21, 31 October 2020LarsgwNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
10-FormyltetrahydrofolateMetaboliteCHEBI:15637 (ChEBI)
5,10-MethenyltetrahydrofolateMetaboliteCHEBI:15638 (ChEBI)
5,10-MethylenetetrahydrofolateMetaboliteCHEBI:1989 (ChEBI)
5-MethyltetrahydrofolateMetaboliteCHEBI:15641 (ChEBI)
ADPMetaboliteCHEBI:456216 (ChEBI)
ATPMetaboliteCHEBI:30616 (ChEBI)
AckAProteinH6LBE7 (Uniprot-TrEMBL) acetate kinase
AcsAProteinH6LD21 (Uniprot-TrEMBL) CO dehydrogenase
AcsB1ProteinH6LD23 (Uniprot-TrEMBL) Acetyl-CoA synthase
AcsCProteinH6LD19 (Uniprot-TrEMBL) Large subunit
AcsDProteinH6LD18 (Uniprot-TrEMBL) Small subunit
AcsEProteinH6LD20 (Uniprot-TrEMBL) Methyl-transferase
AtpAProteinP50000 (Uniprot-TrEMBL) Subunit alpha
AtpBProteinQ9RMB6 (Uniprot-TrEMBL) Subunit a
AtpCProteinP50009 (Uniprot-TrEMBL) Subunit epsilon
AtpDProteinP50002 (Uniprot-TrEMBL) Subunit beta
AtpEProteinQ9RMB5 (Uniprot-TrEMBL) Subunit c
AtpFProteinQ9RMB4 (Uniprot-TrEMBL) Subunit b
AtpGProteinP50005 (Uniprot-TrEMBL) Subunit gamma
AtpHProteinQ9RMB3 (Uniprot-TrEMBL) Subunit delta
FchAProteinH6LBX5 (Uniprot-TrEMBL) Methenyl-THF cyclohydrolase
FdhF1ProteinH6LB59 (Uniprot-TrEMBL)
FdhF2ProteinH6LB61 (Uniprot-TrEMBL)
Fhs1ProteinH6LBX4 (Uniprot-TrEMBL) Formate--tetrahydrofolate ligase
FolDProteinH6LBX6 (Uniprot-TrEMBL)
HSCoAMetaboliteCHEBI:15346 (ChEBI)
HycB1ProteinH6LB60 (Uniprot-TrEMBL)
HycB2ProteinH6LB62 (Uniprot-TrEMBL)
HycB3ProteinH6LB64 (Uniprot-TrEMBL)
HydA1ProteinH6LFG3 (Uniprot-TrEMBL)
HydA2ProteinH6LB65 (Uniprot-TrEMBL)
HydBProteinH6LFG4 (Uniprot-TrEMBL)
HydCProteinH6LFG7 (Uniprot-TrEMBL)
HydDProteinH6LFG5 (Uniprot-TrEMBL)
MetFProteinH6LBX9 (Uniprot-TrEMBL)
MetVProteinH6LBX8 (Uniprot-TrEMBL)
NAD(1-)MetaboliteCHEBI:57540 (ChEBI)
NADHMetaboliteCHEBI:16908 (ChEBI)
Oxidised ferredoxinMetaboliteCHEBI:17908 (ChEBI)
PtaProteinH6LJY6 (Uniprot-TrEMBL)
Reduced ferredoxinMetaboliteCHEBI:17513 (ChEBI)
RnfAProteinH6LC28 (Uniprot-TrEMBL)
RnfBProteinH6LC27 (Uniprot-TrEMBL)
RnfC2ProteinH6LBX7 (Uniprot-TrEMBL)
RnfCProteinH6LC32 (Uniprot-TrEMBL)
RnfDProteinH6LC31 (Uniprot-TrEMBL)
RnfEProteinH6LC29 (Uniprot-TrEMBL)
RnfGProteinH6LC30 (Uniprot-TrEMBL)
TetrahydrofolateMetaboliteCHEBI:20506 (ChEBI)
acetateMetaboliteCHEBI:30089 (ChEBI)
acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
acetyl-phosphateMetaboliteCHEBI:15350 (ChEBI)
carbon dioxideMetaboliteCHEBI:16526 (ChEBI)
carbon monooxideMetaboliteCHEBI:17245 (ChEBI)
dihydrogenMetaboliteCHEBI:18276 (ChEBI)
formateMetaboliteCHEBI:15740 (ChEBI)
hydrogenphosphateMetaboliteCHEBI:43474 (ChEBI)
hydronMetaboliteCHEBI:15378 (ChEBI)
methylMetaboliteCHEBI:32875 (ChEBI)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
acetyl-CoAacetyl-phosphatemim-conversion19521 (Rhea)
acetyl-phosphateacetatemim-conversion11352 (Rhea)
carbon dioxidecarbon monooxidemim-conversion21040 (Rhea)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5019"
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