Urotensin-II-mediated signaling (Homo sapiens)

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ROSPrimary Kupffer cells Human coronary artery endothelial cells LigandRAW264.7 macrophages NADPHDownregulatedGNAQ mediated activationGene regulationLiver injury and acute liver failure DissociationKidneyMyocardial damage in atherosclerotic ratsPhosphorylationCell proliferationReactive oxygen species (ROS)ReceptorInhibitionHMOX1BCL2SOD2NCF2CYBBNCF4NCF1BAXCYBACATCASP3PCNANPPACASP9CAMKIIAT286PLCAKT1S473PT308CYBAIFN-γ HSPA2MAPK3T202Y204MMP9IL1β Atherosclerosis and fibrosisNCF1CYBBCOL1A1THP1-Monocytes and macrophagesCREBS133UTRCOL3A1LTB4AGTR1CBPIL-6ACTA2PRKACAPCCNE1ABCA1CDK1ALOX5MMP9TNFTFPRKACANCF1IL-6ICAM1p300TNF-alphaCOL4A1MMP2IFNBUrotensin-IICOL2A1NOX4TRPC4MAPK1T185Y187VCAM1CDK2ProteinPTGFB1FN1A1FM2DDIT3NCF4ESPL1UpregulatedIL1BJAK2PT1007STAT3PT705STAT3MAPK8Y185PMAPK9T183PMAPK14PNFKB1PNFKB1APERK and IL-1ß pathway activation FibroblastsTGFB1SMAD3SMAD2Proliferation,neuropathy development, vascular fibrosis and collagen synthesisTGFB1Urotensin-IIUTRMAPK1Y204PMAPK3PT202RELARELAS536PNFKB1APS32IRF3Translocation from CP to NUTranslocation from CP to NUDissociationNFKB1RHOAMAPK8Y185PMAPK9T183PInflammationCardiac hypertrophyNPPBNPPAMAPK1Y204PMAPK3PT202MAPK14T180PY182Urotensin-IIUTREGFRPY1068ROSPTPN11HypertrophyCHUKS176PIKBKBS180PGSK3BS9PGSK3AS21PNFKB1RELAHDAC5HDAC5PS493NFKB1ANFKB1AKT1PS473ATP2A2CAMKIIAPT286PLNPT17Ca2+Inhibits dephosphorylation activity of PTPN11Hemodynamic effectsPIP2PI3KCAPPIP3PTENPTENPCTNNB1FN1COL1A1COL3A1Cardiac hypertrophyUrotensin-IIUTRMAPK1Y204PMAPK3T202PMAPK8PY185MAPK9T183PAKT1PS473PI3KCAPCYBBFSCN1ROSNCF1NADPH++H+O2Cell invasion and migrationCY to PMNFKB1PNFKB1APDissociationNFKB1CancerUrotensin-IIUTRCREBCa2+IP3Endoplasmic reticulam stressEpithelial-mesenchymal transitionCOL4A1FN1Aristoiochic acid nephropathyProliferationExtracellular matric protein accumulationTranslocation from CP to NUGANQTranslocation from CP to NUTranslocation from nucleus(NU) to cytoplasm (CP)RELACardiac hypertrophyMyocardial fibrosis and hypertrophyInhibition of PTEN leads to activation of AKT1/GSK3BIRF3IL1β TNF-alphaPromote the release of inflammatory cytokinsDissociationKidney diseaseMAPK14T180PY182TRPC4 channel-mediated store-operated Ca2+ entry (SOCE) and sequential activation of CaMKIIPRKACAProduction against ischemic reperfusion injuryTranslocation from CP to NUTranslocation from NU to CPTranslocation from cytoplasm (CP) to nucleus (NU)ROS mediated activationTranslocation from cytoplasm (CP) to plasma membrane (PM)ActivationFigure legend


Description

Schematic representation of Urotensin-II-mediated signaling pathway

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Bibliography

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  1. Bianca Rd, Mitidieri E, Fusco F, D'Aiuto E, Grieco P, Novellino E, Imbimbo C, Mirone V, Cirino G, Sorrentino R; ''Endogenous urotensin II selectively modulates erectile function through eNOS.''; PLoS One, 2012 PubMed Europe PMC Scholia
  2. Segain JP, Rolli-Derkinderen M, Gervois N, Raingeard de la Blétière D, Loirand G, Pacaud P; ''Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes.''; J Immunol, 2007 PubMed Europe PMC Scholia
  3. Gong H, Chen Z, Zhang X, Li Y, Zhang J, Chen Y, Ding Y, Zhang G, Yang C, Zhu Y, Zou Y; ''Urotensin II Protects Cardiomyocytes from Apoptosis Induced by Oxidative Stress through the CSE/H2S Pathway.''; Int J Mol Sci, 2015 PubMed Europe PMC Scholia
  4. Liang DY, Liu LM, Ye CG, Zhao L, Yu FP, Gao DY, Wang YY, Yang ZW; ''Inhibition of UII/UTR system relieves acute inflammation of liver through preventing activation of NF-κB pathway in ALF mice.''; PLoS One, 2014 PubMed Europe PMC Scholia
  5. Zhou CH, Wan YY, Chu XH, Song Z, Xing SH, Wu YQ, Yin XX; ''Urotensin II contributes to the formation of lung adenocarcinoma inflammatory microenvironment through the NF-κB pathway in tumor-bearing nude mice.''; Oncol Lett, 2012 PubMed Europe PMC Scholia
  6. Trebicka J, Leifeld L, Hennenberg M, Biecker E, Eckhardt A, Fischer N, Pröbsting AS, Clemens C, Lammert F, Sauerbruch T, Heller J; ''Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats.''; Hepatology, 2008 PubMed Europe PMC Scholia
  7. Diebold I, Petry A, Burger M, Hess J, Görlach A; ''NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2 expression by urotensin-II.''; Mol Biol Cell, 2011 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129675view00:45, 22 May 2024EweitzModified title
126484view16:57, 8 May 2023Khanspersremove labels as identifiers from xrefs
126369view17:47, 25 April 2023EgonwNot a mim-conversion
126326view20:57, 21 April 2023KhanspersOntology Term : 'signaling pathway' added !
126325view20:21, 21 April 2023Khanspersxrefs
126315view23:46, 20 April 2023Khanspersxrefs
126314view23:10, 20 April 2023Khanspersmore xrefs
126313view21:08, 20 April 2023Khanspersmore xrefs
126287view05:24, 20 April 2023Khanspersmore xrefs
126260view22:29, 18 April 2023Khanspersadded xrefs to first box
126259view22:06, 18 April 2023Khanspersconnected interactions, converted to graphical line where appropriate
122561view08:39, 16 April 2022EgonwRemove gene symbols which are not valid identifiers in the stated data sources
120968view06:29, 4 February 2022Keshav
120925view19:20, 31 January 2022EgonwFixed the data sources for UniProt identifiers
120900view08:22, 29 January 2022KeshavModified title
120899view08:20, 29 January 2022KeshavNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
A1FM2GeneProductA1FM2
ABCA1GeneProductABCA1 (Entrez Gene)
ACTA2GeneProductACTA2
AGTR1GeneProductAGTR1 (Entrez Gene)
AKT1ProteinAKT1 (Uniprot-SwissProt)
ALOX5GeneProductALOX5 (Entrez Gene)
ATP2A2ProteinATP2A2 (Uniprot-SwissProt)
BAXGeneProductBAX
BCL2GeneProductBCL2
CAMKIIAGeneProductCAMKIIA (NCBI Protein)
CAMKIIAProteinCAMKIIA (Uniprot-SwissProt)
CASP3GeneProductCASP3
CASP9GeneProductCASP9
CATGeneProductCAT
CBPGeneProductCBP
CCNE1GeneProductCCNE1
CDK1GeneProductCDK1
CDK2GeneProductCDK2
CHUKProteinCHUK (Uniprot-SwissProt)
COL1A1GeneProductCOL1A1 (Ensembl)
COL1A1GeneProductCOL1A1 (Entrez Gene)
COL2A1GeneProductCOL2A1 (Ensembl)
COL3A1GeneProductCOL3A1 (Ensembl)
COL3A1GeneProductCOL3A1 (Entrez Gene)
COL4A1GeneProductCOL4A1
CREBGeneProductCREB
CTNNB1GeneProductCTNNB1 (Entrez Gene)
CYBAGeneProductCYBA
CYBAGeneProductCYBA (Ensembl)
CYBBGeneProductCYBB
DDIT3GeneProductDDIT3
EGFRProteinEGFR (Uniprot-SwissProt)
ESPL1GeneProductESPL1
FN1GeneProductFN1
FN1GeneProductFN1 (Entrez Gene)
FSCN1GeneProductFSCN1 (Entrez Gene)
GANQProteinGANQ
GSK3AProteinGSK3A (Uniprot-SwissProt)
GSK3BProteinGSK3B (Uniprot-SwissProt)
HDAC5GeneProductHDAC5 (Entrez Gene)
HDAC5ProteinHDAC5 (Uniprot-SwissProt)
HMOX1GeneProductHMOX1
HSPA2GeneProductHSPA2
ICAM1GeneProductICAM1
IFN-γ GeneProductIFN-γ
IFNBGeneProductIFNB (Entrez Gene)
IKBKBProteinIKBKB (Uniprot-SwissProt)
IL-6GeneProductIL-6
IL1BGeneProductIL1B (Entrez Gene)
IL1β GeneProductIL1β
IRF3GeneProductIRF3 (Ensembl)
JAK2ProteinJAK2 (Uniprot-SwissProt)
LTB4GeneProductLTB4 (Entrez Gene)
MAPK14ProteinMAPK14 (Uniprot-SwissProt)
MAPK1ProteinMAPK1 (Uniprot-SwissProt)
MAPK3ProteinMAPK3 (Uniprot-SwissProt)
MAPK8ProteinMAPK8 (Uniprot-SwissProt)
MAPK9ProteinMAPK9 (Uniprot-SwissProt)
MMP2GeneProductMMP2
MMP9GeneProductMMP9
MMP9GeneProductMMP9 (Entrez Gene)
NCF1GeneProductNCF1
NCF1GeneProductNCF1 (Ensembl)
NCF2GeneProductNCF2
NCF4GeneProductNCF4
NFKB1AProteinNFKB1A (Uniprot-SwissProt)
NFKB1ProteinNFKB1 (Uniprot-SwissProt)
NOX4GeneProductNOX4 (BioCyc)
NPPAGeneProductNPPA
NPPAGeneProductNPPA (Entrez Gene)
NPPBGeneProductNPPB (Entrez Gene)
PCNAGeneProductPCNA
PI3KCAProteinPI3KCA (Uniprot-SwissProt)
PIP2ProteinPIP2 (Uniprot-SwissProt)
PIP3ProteinPIP3 (Uniprot-SwissProt)
PLCGeneProductPLC
PLNProteinPLN (Uniprot-SwissProt)
PRKACAGeneProductPRKACA
PRKACAProteinPRKACA (Entrez Gene)
PTENProteinPTEN (Uniprot-SwissProt)
PTPN11ProteinPTPN11 (Uniprot-SwissProt)
ProteinGeneProductProtein
RELAGeneProductRELA (Entrez Gene)
RELAProteinRELA (Uniprot-SwissProt)
RHOAProteinRHOA (Uniprot-SwissProt)
SMAD2GeneProductSMAD2 (Entrez Gene)
SMAD3GeneProductSMAD3 (Entrez Gene)
SOD2GeneProductSOD2
STAT3ProteinSTAT3 (Uniprot-SwissProt)
TFGeneProductTF
TGFB1GeneProductTGFB1
TGFB1GeneProductTGFB1 (Entrez Gene)
TNF-alphaGeneProductTNF-alpha
TNFGeneProductTNF (NCBI Protein)
TRPC4GeneProductTRPC4
UTRProteinUTR (Uniprot-SwissProt)
Urotensin-IIProteinU-II (Uniprot-SwissProt)
VCAM1GeneProductVCAM1
p300GeneProductp300

Annotated Interactions

No annotated interactions

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