Pro-survival signaling of neuroprotectin D1 (Homo sapiens)

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Revision as of 12:34, 11 February 2022 by LucHooglugt (Talk | contribs)

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Luc Hooglugt, Eric Weitz, Denise Slenter, Jesper

Description

Uncompensated oxidative stress triggers Neuroprotectin D1 to inhibit caspase activity via the intrinsic mitochondrial pathway and via the stimulation of BIRC3 leading to pro-survival stimuli.

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Ontology Terms

Pathway Ontology : bone disease pathway

Disease : Adams-Oliver syndrome bone disease cleidocranial dysplasia Pallister-Hall syndrome polydactyly brachydactyly brachydactyly type A1 campomelic dysplasia acrocapitofemoral dysplasia syndactyly type 1 Robinow syndrome autosomal dominant Robinow syndrome 1 osteogenesis imperfecta spondylocostal dysostosis 1 split hand-foot malformation 6

Cell Type : osteoblast osteocyte chondrocyte

Bibliography

Asatryan A, Bazan NG; ''Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection.''; J Biol Chem, 2017 PubMed Europe PMC Scholia

History

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Revision	Action	Time	User	Comment
138239	view	03:20, 26 March 2025	Eweitz	Refine legend
138238	view	03:19, 26 March 2025	Eweitz	Align nodes
138237	view	03:17, 26 March 2025	Eweitz	Economize layout
138236	view	03:16, 26 March 2025	Eweitz	Fix cell type label: endothelial -> epithelial
138235	view	02:58, 26 March 2025	Eweitz	Standardize case, refine color
138234	view	02:55, 26 March 2025	Eweitz	Economize layout
138233	view	02:45, 26 March 2025	Eweitz	Economize layout
138232	view	02:40, 26 March 2025	Eweitz	Use gene symbols, stack nodes
138231	view	02:25, 26 March 2025	Eweitz	Tailor node height
138230	view	02:23, 26 March 2025	Eweitz	Tailor node width
122168	view	14:32, 14 March 2022	LucHooglugt	Updated identifiers
122166	view	14:21, 14 March 2022	LucHooglugt	Line type updated
122062	view	13:56, 9 March 2022	LucHooglugt	Legend added
122058	view	13:35, 9 March 2022	LucHooglugt	Legend added
122039	view	10:56, 9 March 2022	LucHooglugt	Ontology Term : 'neurodegenerative pathway' added !
122038	view	10:53, 9 March 2022	LucHooglugt	Ontology Term : 'Alzheimer's disease' added !
122037	view	10:53, 9 March 2022	LucHooglugt	Ontology Term : 'Parkinson's disease' added !
121922	view	13:05, 8 March 2022	LucHooglugt	Modified description
121920	view	12:49, 8 March 2022	LucHooglugt	Ontology Term : 'retinal pigment epithelial cell' added !
121918	view	12:37, 8 March 2022	LucHooglugt	Updated DataNodes
121873	view	22:40, 7 March 2022	DeSl	Updated pathway layout
121675	view	14:32, 24 February 2022	LucHooglugt	Layout changes
121631	view	14:47, 22 February 2022	Jesper	Aligned a dew data nodes
121225	view	15:18, 12 February 2022	Eweitz	Modified description
121224	view	15:17, 12 February 2022	Eweitz	Modified title
121202	view	13:16, 11 February 2022	LucHooglugt	Literature added
121200	view	12:34, 11 February 2022	LucHooglugt	Modified description
121199	view	12:29, 11 February 2022	LucHooglugt	Modified title
121198	view	12:20, 11 February 2022	LucHooglugt	New pathway

External references

DataNodes

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Name	Type	Database reference
BAX	Protein	Q07812 (Uniprot-TrEMBL)
BIRC3	GeneProduct	Q13489 (Uniprot-TrEMBL)
Bcl-xL	Protein	Q07817-1 (Uniprot-TrEMBL)
Bcl-xL	Protein	Q07817-1 (Uniprot-TrEMBL)
Caspase-3	Protein	P42574 (Uniprot-TrEMBL)
Caspase-7	Protein	P55210 (Uniprot-TrEMBL)
Caspase-8	Protein	Q14790 (Uniprot-TrEMBL)
Caspase-9	Protein	P55211 (Uniprot-TrEMBL)
Cytochrome c	Protein	P99999 (Uniprot-TrEMBL)
FADD	Protein	Q13158 (Uniprot-TrEMBL)
NPD1	Metabolite	CHEBI:138655 (ChEBI)
PP2A	Protein	P62714 (Uniprot-TrEMBL)
Procaspase-8	Protein
RIP1	Protein	Q13546 (Uniprot-TrEMBL)
RIP3	Protein	Q9Y572 (Uniprot-TrEMBL)
TNF alpha	Protein	P01375 (Uniprot-TrEMBL)
TNFR1	Protein	P19438 (Uniprot-TrEMBL)
TRADD	Protein	Q15628 (Uniprot-TrEMBL)
TRAF2	Protein	Q12933 (Uniprot-TrEMBL)