Resolvin E1 and resolvin D1 signaling decrease inflammation (Homo sapiens)

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NucleusThr308Epithetial integritySecretionRvD1FPR2MTORC2G protein-coupled receptor kinaseNFkBTNF-α signalingLTB4RAdenylate cyclaseAKT1phosphatidylinositol 3-kinase RvE1CMKLR1ERKPDK1LTB4PPTNF-α signalingAcinar Cell1AKT1PPSer473Ser473Thr308Polymorphonuclear Neutrophils1NucleusMigrationApoptosis


Description

Resolvin

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Quality Tags

Ontology Terms

 

Bibliography

  1. Makoto Arita, Taisuke Ohira, Yee-Ping Sun, Siva Elangovan, Nan Chiang, Charles N Serhan; ''Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation''; Pubmed, 2007 PubMed Europe PMC Scholia
  2. David Keinan, Noel J Leigh, Joel W Nelson, Laura De Oleo, Olga J Baker; ''Understanding resolvin signaling pathways to improve oral health''; Pubmed, 2013 PubMed Europe PMC Scholia
  3. David Keinan, Noel J. Leigh, Joel W. Nelson, Laura De Oleo, Olga J. Baker.; ''Understanding Resolvin Signaling Pathways to Improve Oral Health''; Pubmed, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129560view14:42, 13 May 2024EweitzIndividualize nodes where appropriate
129559view13:23, 13 May 2024EweitzFix typos, economize layout
129558view13:08, 13 May 2024EweitzUse standard components for cell and nucleus, economize layout in neutrophil
129550view13:40, 12 May 2024EweitzModified description
129549view13:39, 12 May 2024EweitzOntology Term : 'acinar cell' added !
129548view13:38, 12 May 2024EweitzModified title
125329view22:22, 31 January 2023LarsgwAdd PMID to reference
122556view02:15, 16 April 2022EweitzModified title
122383view12:28, 26 March 2022EgonwNot a mim-conversion
122382view11:41, 26 March 2022EgonwModified title
122036view10:53, 9 March 2022ElisaSantarsieroadded new datanode for mTORC2
122030view10:46, 9 March 2022ElisaSantarsierochanged phosphatidylinositol 3-kinases into the corrresponding complex
122029view10:44, 9 March 2022ElisaSantarsieroERK changed
122025view10:26, 9 March 2022ElisaSantarsierochanged ERK into MAPK
121916view12:02, 8 March 2022ElisaSantarsieroChanged G-protein coupled receptor kinase (metabolite) into GRK1 (protein)
121913view11:41, 8 March 2022ElisaSantarsierofixed a typing mistake
121911view10:57, 8 March 2022ElisaSantarsieroChanged adenylate cyclase ID.
121910view10:43, 8 March 2022ElisaSantarsieroAdenylate cyclase conversion of ATP to cAMP changed.
121909view10:32, 8 March 2022ElisaSantarsieroModified description
121905view10:20, 8 March 2022ElisaSantarsieroModified title
121903view10:17, 8 March 2022ElisaSantarsieroOntology Term : 'lipid signaling pathway' added !
121902view10:16, 8 March 2022ElisaSantarsieroOntology Term : 'mature neutrophil' added !
121900view10:05, 8 March 2022ElisaSantarsieroModified description
121806view14:19, 6 March 2022EgonwI don't think this is a chemical conversion
121782view11:41, 5 March 2022EgonwNot a conversion.
121773view16:19, 3 March 2022DeSldisconnected reactions to phosphatidylinositol 3-kinase, type is wrong.
121770view12:44, 3 March 2022DeSlConverted colour of ERK to show metabolite
121769view12:41, 3 March 2022DeSlCondensed PW
121768view12:40, 3 March 2022DeSlConnected unconnected line hidden behind MTORC2
121767view12:39, 3 March 2022DeSldisconnected cAMP catalysis
121766view12:35, 3 March 2022DeSlMade PW nodes clickable, small layout changes
121765view12:34, 3 March 2022DeSlConverted MIM-catalysis from metabolites to proteins to arrows
121764view12:34, 3 March 2022DeSlConverted arrows in legend to graphical Lines, small layout change
121556view11:07, 21 February 2022ElisaSantarsieroFixed the role of ATP in adenylate cyclase's catalysis of cAMP.
121555view11:04, 21 February 2022ElisaSantarsieroAdded label of G protein alpha subunit. Added another reference used to understand the role of adenylate cyclase and the function of ATP in it.
121532view09:06, 21 February 2022ElisaSantarsieroAdded RvE2 details
121487view11:43, 18 February 2022ElisaSantarsieroupdate LTB4 connection with LTB4R
121349view09:06, 16 February 2022ElisaSantarsieroNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
Adenylate cyclaseProteinA0A0A0MSC1 (Uniprot-TrEMBL)
CMKLR1GeneProductENSG00000174600 (Ensembl)
ERKMetaboliteQ27077219 (Wikidata)
FPR2GeneProductENSG00000171049 (Ensembl)
G protein-coupled receptor kinaseMetaboliteQ4355943 (Wikidata)
LTB4MetaboliteCHEBI:15647 (ChEBI)
LTB4RGeneProductENSG00000213903 (Ensembl)
MTORC2ComplexMTOR (HGNC)
NFkBPathwayWP4562 (WikiPathways)
PDK1GeneProductENSG00000152256 (Ensembl)
RvD1MetaboliteCHEBI:81564 (ChEBI)
RvE1MetaboliteCHEBI:81559 (ChEBI)
TNF-α signalingPathwayWP231 (WikiPathways)
phosphatidylinositol 3-kinase MetaboliteCHEBI:50914 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5191"
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