Roles of ceramides in development of insulin resistance (Homo sapiens)

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TRAF12336666165Insulin promoter+ROSGLUT4 translocationER StressInflammationSkeletal muscle cell7CPT1ARPS6KB1TNF-alphaIL-1BMAPK8TNFRIL-6CD36/FATGLUT4ERN1PP2IRS-1pSPalmitatepY8SMIRS-2ceramideINSRPP2APKCzetaTNF-alphaCCL2AKT1PPI3K-Palmitoyl-CoA+MAFACD36/FAT1glucoseOleic acidInsulinFatty acid oxidationEIF2AK2OAnSMase23PDX11Sphingolipid pathwayAMPKP4++6


Description

Insulin resistance in Homo Sapiens

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Ontology Terms

 

Bibliography

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  1. Salvadó L, Palomer X, Barroso E, Vázquez-Carrera M; ''Targeting endoplasmic reticulum stress in insulin resistance.''; Trends Endocrinol Metab, 2015 PubMed Europe PMC Scholia
  2. Sindhu S, Leung YH, Arefanian H, Madiraju SRM, Al-Mulla F, Ahmad R, Prentki M; ''Neutral sphingomyelinase-2 and cardiometabolic diseases.''; Obes Rev, 2021 PubMed Europe PMC Scholia
  3. Bar-Tana J, Rose G, Brandes R, Shapiro B; ''Palmitoyl-coenzyme A synthetase. Mechanism of reaction.''; Biochem J, 1973 PubMed Europe PMC Scholia
  4. Bellini L, Campana M, Mahfouz R, Carlier A, Véret J, Magnan C, Hajduch E, Le Stunff H; ''Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes.''; Expert Opin Ther Targets, 2015 PubMed Europe PMC Scholia
  5. Pinter K, Grignani RT, Watkins H, Redwood C; ''Localisation of AMPK γ subunits in cardiac and skeletal muscles.''; J Muscle Res Cell Motil, 2013 PubMed Europe PMC Scholia
  6. Kaneto H, Katakami N, Matsuhisa M, Matsuoka TA; ''Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis.''; Mediators Inflamm, 2010 PubMed Europe PMC Scholia
  7. Palomer X, Pizarro-Delgado J, Barroso E, Vázquez-Carrera M; ''Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus.''; Trends Endocrinol Metab, 2018 PubMed Europe PMC Scholia
  8. Lim JH, Gerhart-Hines Z, Dominy JE, Lee Y, Kim S, Tabata M, Xiang YK, Puigserver P; ''Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex.''; J Biol Chem, 2013 PubMed Europe PMC Scholia
  9. Al-Rashed F, Ahmad Z, Thomas R, Melhem M, Snider AJ, Obeid LM, Al-Mulla F, Hannun YA, Ahmad R; ''Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α.''; Sci Rep, 2020 PubMed Europe PMC Scholia
  10. Miljkovic I, Yerges LM, Li H, Gordon CL, Goodpaster BH, Kuller LH, Nestlerode CS, Bunker CH, Patrick AL, Wheeler VW, Zmuda JM; ''Association of the CPT1B gene with skeletal muscle fat infiltration in Afro-Caribbean men.''; Obesity (Silver Spring), 2009 PubMed Europe PMC Scholia
  11. Kirwan JP; ''Plasma ceramides target skeletal muscle in type 2 diabetes.''; Diabetes, 2013 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134495view05:29, 22 July 2024EgonwRemoved a template comment
134377view15:38, 21 July 2024EweitzRemove template comments
124851view21:48, 14 December 2022EweitzModified description
124850view21:42, 14 December 2022EweitzModified title
124468view08:58, 30 October 2022EgonwTyped two translocations
124467view08:55, 30 October 2022EgonwRemoved an empty node
122326view09:01, 18 March 2022GiangNguyen126Update connection false format
122325view03:52, 18 March 2022GiangNguyen126Edit malformed references
122324view03:48, 18 March 2022GiangNguyen126Edit malformed references
122217view08:32, 16 March 2022DeSlChanged IDs for PI3K and Insulin to reviewed UniProt IDs, updated some DataNode colours to their repsective type.
122216view08:25, 16 March 2022DeSlSmall layout changes, updated legend to include non DataNodes
122214view05:05, 16 March 2022GiangNguyen126Update legend
122213view05:00, 16 March 2022GiangNguyen126Fixing connections
122191view14:05, 15 March 2022GiangNguyen126Update the interactions
122190view13:58, 15 March 2022GiangNguyen126Modified title
122189view13:55, 15 March 2022GiangNguyen126Modified description
121946view15:56, 8 March 2022GiangNguyen126Ontology Term : 'diabetes mellitus' added !
121945view15:55, 8 March 2022GiangNguyen126Ontology Term : 'obesity' added !
121944view15:54, 8 March 2022GiangNguyen126Ontology Term : 'type 2 diabetes mellitus pathway' added !
121943view15:54, 8 March 2022GiangNguyen126Ontology Term : 'atherosclerosis' added !
121942view15:48, 8 March 2022GiangNguyen126Ontology Term : 'cell of skeletal muscle' added !
121941view15:47, 8 March 2022GiangNguyen126Ontology Term : 'insulin signaling pathway' added !
121912view11:04, 8 March 2022GiangNguyen126Update Legend, color of the arrow, and incorporate feedback
121834view12:02, 7 March 2022DeSlChanged up/down regulation arrows to graphical lines, connected last unconnected line
121740view08:45, 1 March 2022GiangNguyen126Update connections, literature references
121663view07:46, 24 February 2022GiangNguyen126Update interactions
121630view14:20, 22 February 2022LucHooglugtConnected interactions
121380view08:03, 17 February 2022GiangNguyen126
121379view06:51, 17 February 2022GiangNguyen126Add in Oleic acid pathway; Add in mitochondria
121226view15:18, 12 February 2022EweitzModified description
121222view15:17, 12 February 2022EweitzModified title
121195view09:23, 11 February 2022GiangNguyen126Ceramide causes ER stress
121193view05:06, 11 February 2022GiangNguyen126Ceramide inhibits insulin promoter, update literature sources
121192view03:46, 11 February 2022GiangNguyen126Add in cell and cytokines
121172view13:37, 10 February 2022GiangNguyen126New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AMPKProteinQ9UGI9 (Uniprot-TrEMBL)
CCL2GeneProductENSG00000108691 (Ensembl)
CD36/FATProteinP16671 (Uniprot-TrEMBL)
CPT1AProteinP50416 (Uniprot-TrEMBL)
EIF2AK2GeneProductENSG00000055332 (Ensembl)
  • Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
  • Type your comment here
ERN1ProteinO75460 (Uniprot-TrEMBL)
GLUT4ProteinP14672 (Uniprot-TrEMBL)
IL-1BProteinP01584 (Uniprot-TrEMBL)
IL-6ProteinB4DNV3 (Uniprot-TrEMBL)
INSRProteinP06213 (Uniprot-TrEMBL)
IRS-1ProteinP35568 (Uniprot-TrEMBL)
IRS-2ProteinQ9Y4H2 (Uniprot-TrEMBL)
InsulinProteinA6XGL2 (Uniprot-TrEMBL)
MAFAProteinQ8NHW3 (Uniprot-TrEMBL)
MAPK8GeneProductENSG00000107643 (Ensembl)
OAMetaboliteHMDB00207 (HMDB)
Oleic acidMetaboliteHMDB00207 (HMDB)
PDX1GeneProductP52945 (Uniprot-TrEMBL)
PI3KProteinE5RGI8 (Uniprot-TrEMBL) PI3K subunit alpha
PKCzetaProteinQ05513 (Uniprot-TrEMBL)
  • Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
  • Type your comment here
PP2AProteinP67775 (Uniprot-TrEMBL)
  • Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
  • Type your comment here
PalmitateMetaboliteCHEBI:15756 (ChEBI)
Palmitoyl-CoAMetaboliteCHEBI:15525 (ChEBI)
RPS6KB1ProteinP23443 (Uniprot-TrEMBL)
SM
Sphingolipid pathwayPathwayWP1422 (WikiPathways)
TNF-alphaProteinP01375 (Uniprot-TrEMBL)
TNFRProtein
TRAF1ProteinQ13077 (Uniprot-TrEMBL)
ceramideMetaboliteCHEBI:52639 (ChEBI)
glucoseMetaboliteCHEBI:17234 (ChEBI)
nSMase2ProteinO60906 (Uniprot-TrEMBL)
  • Sphingomyelin phosphodiesterase 2
  • Type your comment here

Annotated Interactions

No annotated interactions

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