Vitamin K metabolism and activation of dependent proteins (Homo sapiens)
From WikiPathways
Description
Vitamin K activates coagulation factors
Quality Tags
Ontology Terms
Pathway Ontology : classic metabolic pathway vitamin K antagonist drug pathway vitamin K metabolic pathway hemostasis pathway lipid metabolic pathway ferroptosis pathway vitamin K cycle pathway vitamin and vitamin metabolites signaling pathway
Disease : vitamin K deficiency bleeding
Cell Type : hepatocyte
Bibliography
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- Dmitry A Ravcheev, Ines Thiele; ''Genomic Analysis of the Human Gut Microbiome Suggests Novel Enzymes Involved in Quinone Biosynthesis''; Front Microbiol., 2016 PubMed Europe PMC Scholia
- Villa JKD, Diaz MAN, Pizziolo VR, Martino HSD; ''Effect of vitamin K in bone metabolism and vascular calcification: A review of mechanisms of action and evidences.''; Crit Rev Food Sci Nutr, 2017 PubMed Europe PMC Scholia
- Eikan Mishima, Junya Ito, Zijun Wu, Toshitaka Nakamura, Adam Wahida, Sebastian Doll, Wulf Tonnus, Palina Nepachalovich, Elke Eggenhofer, Maceler Aldrovandi, Bernhard Henkelmann, Ken-Ichi Yamada, Jonas Wanninger, Omkar Zilka, Emiko Sato, Regina Feederle, Daniela Hass, Adriano Maida, André Santos Dias Mourão, Andreas Linkermann, Edward K Geissler, Kiyotaka Nakagawa, Takaaki Abe, Maria Fedorova, Bettina Proneth, Derek A Pratt, Marcus Conrad; ''A non-canonical vitamin K cycle is a potent ferroptosis suppressor''; Nature, 2022 PubMed Europe PMC Scholia
- Han Yan, Yi Chen, Hong Zhu, Wei-Hua Huang, Xin-He Cai, Dan Li, Ya-Juan Lv, Si-Zhao, Hong-Hao Zhou, Fan-Yan Luo, Wei Zhang, Xi Li; ''The Relationship Among Intestinal Bacteria, Vitamin K and Response of Vitamin K Antagonist: A Review of Evidence and Potential Mechanism''; Front Med (Lausanne), 2022 PubMed Europe PMC Scholia
- Gallieni M, Fusaro M; ''Vitamin K and cardiovascular calcification in CKD: is patient supplementation on the horizon?''; Kidney Int, 2014 PubMed Europe PMC Scholia
- Nathan P Ward, Gina M DeNicola; ''Long-sought mediator of vitamin K recycling discovered''; Nature, 2022 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
GGCX | GeneProduct | ENSG00000115486 (Ensembl) | |
NAD(P)H dehydrogenase [quinone] 1 | GeneProduct | P15559 (Uniprot-TrEMBL) | |
NADP+ | Metabolite | CHEBI:18009 (ChEBI) | |
NADPH | Metabolite | HMDB00221 (HMDB) | |
VKORC1 | GeneProduct | ENSG00000167397 (Ensembl) | |
Vitamin K epoxide | Metabolite | CHEBI:28371 (ChEBI) | |
Vitamin K hydroquinone | Metabolite | CHEBI:28433 (ChEBI) | |
Vitamin K reductase | GeneProduct | ||
Vitamin K1 | Metabolite | HMDB03555 (HMDB) | |
Warfarin | Metabolite | HMDB01935 (HMDB) | |
disulfides | Metabolite | CHEBI:48343 (ChEBI) | |
dithiols | Metabolite | CHEBI:23853 (ChEBI) | |
gamma-carboxyglutamate | Metabolite | CHEBI:61938 (ChEBI) | |
glutamate | Metabolite | CHEBI:14321 (ChEBI) | |
vitamin K2 | Metabolite | CHEBI:16374 (ChEBI) |
Annotated Interactions
No annotated interactions