Pro-survival signaling of neuroprotectin D1 (Homo sapiens)

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Revision as of 12:37, 8 March 2022 by LucHooglugt (Talk | contribs)
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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none ApoptosisRetinal Pigment Endothelial CellNecroptosisApoptososomeReleasesPhosphorylatesSer-62Uncompensatedoxidative stressInternalizationPP2ABcl-xLBIRC3Caspase-9Cytochrome cPBcl-xLCaspase-8BAXNPD1BAXBcl-xLProcaspase-8RIP3TNFR1TRAF2TRADDTNF alphaRIP1FADDTRADDTRAF2RIP1PRIP3TNFR1TRAF2TRADDTNF alphaRIP1Caspase-3Caspase-7Name: Pro-survival signaling of neuroprotectin D1Organism: Homo sapiens


Description

Uncompensated oxidative stress triggers neuroprotectin D1 to inhibit caspase activity via the intrinsic mitochondrial pathway and via the stimulation of BIRC3 leading to pro-survival stimuli.

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Quality Tags

Image:Wplogo_31.pngCommunity: Lipids and LIPID MAPS
Image:Curated.pngReview changes for Approved

Ontology Terms

Bibliography

  1. Asatryan A, Bazan NG; ''Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection.''; J Biol Chem, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
138239
Approved
view03:20, 26 March 2025EweitzRefine legend
138238view03:19, 26 March 2025EweitzAlign nodes
138237view03:17, 26 March 2025EweitzEconomize layout
138236view03:16, 26 March 2025EweitzFix cell type label: endothelial -> epithelial
138235view02:58, 26 March 2025EweitzStandardize case, refine color
138234view02:55, 26 March 2025EweitzEconomize layout
138233view02:45, 26 March 2025EweitzEconomize layout
138232view02:40, 26 March 2025EweitzUse gene symbols, stack nodes
138231view02:25, 26 March 2025EweitzTailor node height
138230view02:23, 26 March 2025EweitzTailor node width
122168
Lipids
view14:32, 14 March 2022LucHooglugtUpdated identifiers
122166view14:21, 14 March 2022LucHooglugtLine type updated
122062view13:56, 9 March 2022LucHooglugtLegend added
122058view13:35, 9 March 2022LucHooglugtLegend added
122039view10:56, 9 March 2022LucHooglugtOntology Term : 'neurodegenerative pathway' added !
122038view10:53, 9 March 2022LucHooglugtOntology Term : 'Alzheimer's disease' added !
122037view10:53, 9 March 2022LucHooglugtOntology Term : 'Parkinson's disease' added !
121922view13:05, 8 March 2022LucHooglugtModified description
121920view12:49, 8 March 2022LucHooglugtOntology Term : 'retinal pigment epithelial cell' added !
121918view12:37, 8 March 2022LucHooglugtUpdated DataNodes
121873view22:40, 7 March 2022DeSlUpdated pathway layout
121675view14:32, 24 February 2022LucHooglugtLayout changes
121631view14:47, 22 February 2022JesperAligned a dew data nodes
121225view15:18, 12 February 2022EweitzModified description
121224view15:17, 12 February 2022EweitzModified title
121202view13:16, 11 February 2022LucHooglugtLiterature added
121200view12:34, 11 February 2022LucHooglugtModified description
121199view12:29, 11 February 2022LucHooglugtModified title
121198view12:20, 11 February 2022LucHooglugtNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ApoptosisPathwayWP254 (WikiPathways)
BAXProteinQ07812 (Uniprot-TrEMBL)
BIRC3ProteinQ13489 (Uniprot-TrEMBL)
Bcl-xL ProteinQ07817-1 (Uniprot-TrEMBL)
Bcl-xLProteinQ07817-1 (Uniprot-TrEMBL)
Caspase-3ProteinP42574 (Uniprot-TrEMBL)
Caspase-7ProteinP55210 (Uniprot-TrEMBL)
Caspase-8ProteinQ14790 (Uniprot-TrEMBL)
Caspase-9ProteinP55211 (Uniprot-TrEMBL)
Cytochrome cProteinP99999 (Uniprot-TrEMBL)
FADDProteinQ13158 (Uniprot-TrEMBL)
NPD1MetaboliteCHEBI:138655 (ChEBI)
NecroptosisPathway
PP2AProteinP62714 (Uniprot-TrEMBL)
Procaspase-8Protein
RIP1ProteinQ13546 (Uniprot-TrEMBL)
RIP3ProteinQ9Y572 (Uniprot-TrEMBL)
TNF alphaProteinP01375 (Uniprot-TrEMBL)
TNFR1ProteinP19438 (Uniprot-TrEMBL)
TRADDProteinQ15628 (Uniprot-TrEMBL)
TRAF2ProteinQ12933 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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