Pro-survival signaling of neuroprotectin D1 (Homo sapiens)

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1ApoptosisSer-62NecroptosisPhosphorylatesReleasesRetinal Pigment Endothelial CellApoptososomeUncompensatedoxidative stressInternalizationTNF alphaBAXRIP3FADDTRADDCaspase-3Cytochrome cBAXTRAF2NPD1Bcl-xLCaspase-7Bcl-xLBIRC3Caspase-9TNFR1Bcl-xL Procaspase-8PP2ACaspase-8RIP1PTNFR1TRAF2TRADDTNF alphaRIP1TRADDTRAF2RIP1RIP3P


Description

Uncompensated oxidative stress triggers neuroprotectin D1 to inhibit caspase activity via the intrinsic mitochondrial pathway and via the stimulation of BIRC3 leading to pro-survival stimuli.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Asatryan A, Bazan NG; ''Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection.''; J Biol Chem, 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
122168view14:32, 14 March 2022LucHooglugtUpdated identifiers
122166view14:21, 14 March 2022LucHooglugtLine type updated
122062view13:56, 9 March 2022LucHooglugtLegend added
122058view13:35, 9 March 2022LucHooglugtLegend added
122039view10:56, 9 March 2022LucHooglugtOntology Term : 'neurodegenerative pathway' added !
122038view10:53, 9 March 2022LucHooglugtOntology Term : 'Alzheimer's disease' added !
122037view10:53, 9 March 2022LucHooglugtOntology Term : 'Parkinson's disease' added !
121922view13:05, 8 March 2022LucHooglugtModified description
121920view12:49, 8 March 2022LucHooglugtOntology Term : 'retinal pigment epithelial cell' added !
121918view12:37, 8 March 2022LucHooglugtUpdated DataNodes
121873view22:40, 7 March 2022DeSlUpdated pathway layout
121675view14:32, 24 February 2022LucHooglugtLayout changes
121631view14:47, 22 February 2022JesperAligned a dew data nodes
121225view15:18, 12 February 2022EweitzModified description
121224view15:17, 12 February 2022EweitzModified title
121202view13:16, 11 February 2022LucHooglugtLiterature added
121200view12:34, 11 February 2022LucHooglugtModified description
121199view12:29, 11 February 2022LucHooglugtModified title
121198view12:20, 11 February 2022LucHooglugtNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ApoptosisPathwayWP254 (WikiPathways)
BAXProteinQ07812 (Uniprot-TrEMBL)
BIRC3ProteinQ13489 (Uniprot-TrEMBL)
Bcl-xL ProteinQ07817-1 (Uniprot-TrEMBL)
Bcl-xLProteinQ07817-1 (Uniprot-TrEMBL)
Caspase-3ProteinP42574 (Uniprot-TrEMBL)
Caspase-7ProteinP55210 (Uniprot-TrEMBL)
Caspase-8ProteinQ14790 (Uniprot-TrEMBL)
Caspase-9ProteinP55211 (Uniprot-TrEMBL)
Cytochrome cProteinP99999 (Uniprot-TrEMBL)
FADDProteinQ13158 (Uniprot-TrEMBL)
NPD1MetaboliteCHEBI:138655 (ChEBI)
NecroptosisPathway
PP2AProteinP62714 (Uniprot-TrEMBL)
Procaspase-8Protein
RIP1ProteinQ13546 (Uniprot-TrEMBL)
RIP3ProteinQ9Y572 (Uniprot-TrEMBL)
TNF alphaProteinP01375 (Uniprot-TrEMBL)
TNFR1ProteinP19438 (Uniprot-TrEMBL)
TRADDProteinQ15628 (Uniprot-TrEMBL)
TRAF2ProteinQ12933 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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