Phosphoinositides metabolism (Homo sapiens)

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Epithetial integritySecretion1NucleusG α subunitLTB4 would normally bind to its receptor LTB4R and consequently activate AKT1 and NFkB pathway.However, when RvE1 is present, it binds to the receptoor, therefore inhibitimng the binding of LTB4 and inhibiting the NFkB pathway as well.Thr308ADCY1PDK1ATPRvD1LTB4TNF-α signalingMTORC2GRK1MAPK1NFkBRvE1LTB4RFPR2AKT12PPTNF-α signalingAcinar Cell3AKT1PPSer473Ser473Thr308Polymorphonuclear NeutrophilsNucleusMigrationApoptosisRvE2 also has a very similar function as RvE1, however the latter was found to be a stronger activator of the receptor CMKLR1.CMKLR1cAMPPIK3CGPI-3 kinase IPIK3CBPIK3CAPIK3CD


Description

Signaling pathway of Resolvin for resolution of inflammation in Polymorphonuclear Neutrophils and Acinar Cells.

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Bibliography

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  1. Laporte J, Hu LJ, Kretz C, Mandel JL, Kioschis P, Coy JF, Klauck SM, Poustka A, Dahl N; ''A gene mutated in X-linked myotubular myopathy definesa new putative tyrosine phosphatase family conserved in yeast.''; Nat Genet, 1996 PubMed Europe PMC Scholia
  2. Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW; ''''; , PubMed Europe PMC Scholia
  3. Rameh LE, Tolias KF, Duckworth BC, Cantley LC; ''A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.''; Nature, 1997 PubMed Europe PMC Scholia
  4. Rohrschneider LR, Fuller JF, Wolf I, Liu Y, Lucas DM; ''Structure, function, and biology of SHIP proteins.''; Genes Dev, 2000 PubMed Europe PMC Scholia
  5. Li S, Tiab L, Jiao X, Munier FL, Zografos L, Frueh BE, Sergeev Y, Smith J, Rubin B, Meallet MA, Forster RK, Hejtmancik JF, Schorderet DF; ''Mutations in PIP5K3 are associated with François-Neetens mouchetée fleck corneal dystrophy.''; Am J Hum Genet, 2005 PubMed Europe PMC Scholia
  6. Bolino A, Muglia M, Conforti FL, LeGuern E, Salih MA, Georgiou DM, Christodoulou K, Hausmanowa-Petrusewicz I, Mandich P, Schenone A, Gambardella A, Bono F, Quattrone A, Devoto M, Monaco AP; ''Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2.''; Nat Genet, 2000 PubMed Europe PMC Scholia
  7. Rusten TE, Stenmark H; ''Analyzing phosphoinositides and their interacting proteins.''; Nat Methods, 2006 PubMed Europe PMC Scholia
  8. Malek M, Kielkowska A, Chessa T, Anderson KE, Barneda D, Pir P, Nakanishi H, Eguchi S, Koizumi A, Sasaki J, Juvin V, Kiselev VY, Niewczas I, Gray A, Valayer A, Spensberger D, Imbert M, Felisbino S, Habuchi T, Beinke S, Cosulich S, Le Novère N, Sasaki T, Clark J, Hawkins PT, Stephens LR; ''PTEN Regulates PI(3,4)P2Signaling Downstream of Class I PI3K.''; Mol Cell, 2017 PubMed Europe PMC Scholia
  9. Poli A, Zaurito AE, Abdul-Hamid S, Fiume R, Faenza I, Divecha N; ''Phosphatidylinositol 5 Phosphate (PI5P): From Behind the Scenes to the Front (Nuclear) Stage.''; Int J Mol Sci, 2019 PubMed Europe PMC Scholia
  10. Backer JM; ''The regulation and function of Class III PI3Ks:novel roles for Vps34.''; Biochem J, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134602view01:23, 23 July 2024EweitzImprove contrast for readability
134601view01:22, 23 July 2024EweitzCopyedit, standardize case
134600view01:17, 23 July 2024EweitzModified description
122106view23:55, 10 March 2022DeSlReverted to version '06:26, 2 October 2020' by DeSl
122027view10:35, 9 March 2022ElisaSantarsieroFixed ADCY1 catalysis of ATP into cAMP and changed phosphatidylinositol 3-kinase into the corresponding complex.
112223view06:26, 2 October 2020EgonwRemoved the prefixes. We don't have support for that yet.
112200view14:27, 1 October 2020DeSlOntology Term : 'centronuclear myopathy' added !
112199view14:27, 1 October 2020DeSlOntology Term : 'Fleck corneal dystrophy' added !
112198view14:26, 1 October 2020DeSlOntology Term : 'Charcot-Marie-Tooth disease type 4B1' added !
112197view14:23, 1 October 2020DeSlAdded 3 rare (metabolic) diseases.
112196view14:15, 1 October 2020DeSlAdded effector functions for each metabolite.
112195view14:12, 1 October 2020DeSlAdded localization for metabolites as comment.
112180view09:24, 1 October 2020DeSlOntology Term : 'oculocerebrorenal syndrome' added !
112179view09:23, 1 October 2020DeSlAdded IDs for proteins under Phospholipase C
112177view09:17, 1 October 2020DeSlConnected last unconnected lines.
112176view09:15, 1 October 2020DeSlUpdated description
112175view09:14, 1 October 2020DeSlAdded last details
112174view08:52, 1 October 2020DeSlAdded PI-3 kinase III class.
112169view10:20, 30 September 2020DeSlAdded PI-3 kinase I + II.
112168view10:06, 30 September 2020DeSlAdded MTMRs section
112167view08:26, 30 September 2020DeSlUpdated IDs+interactions for PtdIns + PtdIns(3)P; reverted colour scheme to normal.
112150view12:38, 29 September 2020DeSlAdded ref for SHIP further reading material.
112149view12:37, 29 September 2020DeSlUpdated interaction for PIP5 kinase and SHIP.
112148view12:28, 29 September 2020DeSlUpdated IDs for PtdIns(3,4)P2.
112147view12:19, 29 September 2020DeSlUpdated description with refs.
112146view12:15, 29 September 2020DeSlUpdated description.
112145view12:11, 29 September 2020DeSlNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADCY1ProteinENSG00000164742 (Uniprot-TrEMBL)
AKT1GeneProductENSG00000142208 (Ensembl)
ATPMetaboliteCHEBI:30616 (ChEBI)
CMKLR1GeneProductENSG00000174600 (Ensembl)
FPR2GeneProductENSG00000171049 (Ensembl)
GRK1ProteinQ15835 (Uniprot-TrEMBL)
LTB4MetaboliteCHEBI:15647 (ChEBI)
LTB4RGeneProductENSG00000213903 (Ensembl)
MAPK1ProteinP28482 (Uniprot-TrEMBL)
MTORC2GeneProductMTOR (HGNC)
NFkBPathwayWP4562 (WikiPathways)
PDK1GeneProductENSG00000152256 (Ensembl)
PI-3 kinase IProtein2.7.1.137 (Enzyme Nomenclature)
PIK3CAProteinP42336 (Uniprot-TrEMBL)
PIK3CBProteinP42338 (Uniprot-TrEMBL)
PIK3CDProteinO00329 (Uniprot-TrEMBL)
PIK3CGProteinP48736 (Uniprot-TrEMBL)
RvD1MetaboliteCHEBI:81564 (ChEBI)
RvE1MetaboliteCHEBI:81559 (ChEBI)
TNF-α signalingPathwayWP231 (WikiPathways)
cAMPMetaboliteCHEBI:17489 (ChEBI)

Annotated Interactions

No annotated interactions

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