Phospholipid biosynthesis (Saccharomyces cerevisiae)

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1NucleusCytoplasmCDP-ethanolamine(1−)CDP-DAGGIT1PSDAGPSD2CDP-cholineGPELPP1PAH1ALE1DPP1CLCHO1GPCATCPT1LPEPAPILPCcholine-PPEG3PNTE1PCDHAPGPCSCT1CDS1CholineLPAPSD1PGHNM1GPT2LPCCholineALE1LPEDAGGPC


Description

This phospholipid biosynthesis shows a schematic outline of the major pathways for phospholipid biosynthesis in yeast, including the phosphatidylcholine/phosphatidyl- ethanolamine (PC/PE) reacylation pathways and the glycerophosphocholine acyltransferase (GPCAT) and glycerophosphoethanolamine acyltransferase (GPEAT) activities described in the present paper. CL, cardiolipin; DAG, diacylglycerol; DHAP, dihydroxyacetone phos- phate; G3P, glycerol-3-phosphate; GPC, glycerophosphocholine; GPE, glycerophosphoethanolamine; LPA, lysophosphatidic acid; LPC, lysophosphatidylcholine; LPE, lysophosphatidylethanolamine; PA, phosphatidic acid; PG, phosphatidylglycerol; PI, phosphatidylinositol; PS, phosphatidylserine.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kjell Stålberg, Andrea C Neal, Hans Ronne, Ulf Ståhl; ''Identification of a novel GPCAT activity and a new pathway for phosphatidylcholine biosynthesis in S. cerevisiae''; Elsevier, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
122220view09:19, 16 March 2022DeSlUpdated ID for GPCAT to Ensembl for consistency
122219view09:16, 16 March 2022DeSlConverted PC visualization to match DataNode type.
122218view09:15, 16 March 2022DeSlSmall layout changes; converted MIM-catalysis to MIM-conversion for CDP-choline interaction.
122198view14:42, 15 March 2022Linda24012000i changed the ID of G3P, i grouped DHAP and G3P, I changed LPA into a metabolite
122194view14:15, 15 March 2022Linda24012000Modified description
122192view14:14, 15 March 2022Linda24012000Modified description
122164view14:03, 14 March 2022Linda24012000Ontology Term : 'glycerophospholipid metabolic pathway' added !
122163view14:00, 14 March 2022Linda24012000Ontology Term : 'lipid metabolic pathway' added !
122162view13:59, 14 March 2022Linda24012000Ontology Term : 'classic metabolic pathway' added !
122161view13:57, 14 March 2022Linda24012000Connected arrows properly, added ID for GPC and added localization details
122026view10:30, 9 March 2022Linda24012000i added all the arrows to molecules
122011view09:43, 9 March 2022Linda24012000reference added
121653view11:44, 23 February 2022Linda24012000New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ALE1GeneProductYOR175C (Ensembl)
CDP-DAGMetaboliteCHEBI:17962 (ChEBI)
CDP-cholineMetaboliteCHEBI:58779 (ChEBI)
CDP-ethanolamine(1−)Metabolite57876 (ChEBI)
CDS1GeneProductYBR029C (Ensembl)
CHO1GeneProductYER026C (Ensembl)
CLMetaboliteCHEBI:28494 (ChEBI)
CPT1GeneProductYNL130C (Ensembl)
CholineMetaboliteCHEBI:15354 (ChEBI)
DAGMetaboliteCHEBI:75475 (ChEBI)
DHAPMetaboliteCHEBI:16108 (ChEBI)
DPP1GeneProductYDR284C (Ensembl)
G3PMetaboliteQ82325564 (Wikidata)
GIT1GeneProductYCR098C (Ensembl)
GPCMetabolite16870 (ChEBI) GPC is the abbreviation for glycerophosphocholine. This is an alternative name for choline alfoscerate
GPCATGeneProductP48236 (Uniprot-TrEMBL)
GPEMetaboliteCHEBI:36314 (ChEBI)
GPT2GeneProductYKR067W (Ensembl)
HNM1GeneProductYGL077C (Ensembl)
LPAMetaboliteCHEBI:132742 (ChEBI)
LPCMetaboliteCHEBI:132742 (ChEBI)
LPEMetaboliteCHEBI:131690 (ChEBI)
LPP1GeneProductYDR503C (Ensembl)
NTE1GeneProductYML059C (Ensembl)
PAMetaboliteCHEBI:132564 (ChEBI)
PAH1GeneProductYMR165C (Ensembl)
PCMetaboliteCHEBI:64423 (ChEBI)
PE Metabolite16038 (ChEBI)
PGMetaboliteCHEBI:73879 (ChEBI)
PIMetaboliteCHEBI:16749 (ChEBI)
PSMetaboliteCHEBI:72036 (ChEBI)
PSD1GeneProductYNL169C (Ensembl)
PSD2GeneProductYGR170W (Ensembl)
SCT1GeneProductYBL011W (Ensembl)
choline-PMetaboliteCHEBI:34635 (ChEBI)

Annotated Interactions

No annotated interactions

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