Pro-survival signaling of neuroprotectin D1 (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none ApoptosisPathwayNecroptosisRetinal Pigment Endothelial CellApoptososomeLegendReleasesCleavageProteinConversionPhosphorylatesSer-62ModificationUncompensatedoxidative stressMetaboliteStimulationInhibitionBindingInternalizationPP2ABcl-xLBIRC3Caspase-9NeuroprotectionPathwayCytochrome cPBcl-xLCaspase-8BAXNPD1BAXBcl-xLProcaspase-8RIP3TNFR1TRAF2TRADDTNF alphaRIP1FADDTRADDTRAF2RIP1PRIP3TNFR1TRAF2TRADDTNF alphaRIP1Caspase-3Caspase-7Name: Pro-survival signaling of neuroprotectin D1Organism: Homo sapiens


Description

Uncompensated oxidative stress triggers neuroprotectin D1 to inhibit caspase activity via the intrinsic mitochondrial pathway and via the stimulation of BIRC3 leading to pro-survival stimuli. By inhibiting the formation of the Bax/Bcl-xL complex in the mitochondrial membrane, NPD1 decreases the release of Cytochrome c leading to a lower pro-apoptotic activity. Furthermore, NPD1 inhibits the internalization of death-inducing signaling complex (DISC) which is involved in the initiation of apoptosis, thereby promoting survival of the cell. The neuroprotective effect of NPD1 therefore contributes to the management of diseases like Alzheimer's disease, stroke, age-related macular degeneration, traumatic brain injury, Parkinson's disease and other neurodegenerations.

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Quality Tags

Image:Wplogo_31.pngCommunity: Lipids and LIPID MAPS
Image:Curated.pngReview changes for Approved

Ontology Terms

 

Bibliography

  1. Asatryan A, Bazan NG; ''Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection.''; J Biol Chem, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
122168
Lipids
Approved
view14:32, 14 March 2022LucHooglugtUpdated identifiers
122166view14:21, 14 March 2022LucHooglugtLine type updated
122062view13:56, 9 March 2022LucHooglugtLegend added
122058view13:35, 9 March 2022LucHooglugtLegend added
122039view10:56, 9 March 2022LucHooglugtOntology Term : 'neurodegenerative pathway' added !
122038view10:53, 9 March 2022LucHooglugtOntology Term : 'Alzheimer's disease' added !
122037view10:53, 9 March 2022LucHooglugtOntology Term : 'Parkinson's disease' added !
121922view13:05, 8 March 2022LucHooglugtModified description
121920view12:49, 8 March 2022LucHooglugtOntology Term : 'retinal pigment epithelial cell' added !
121918view12:37, 8 March 2022LucHooglugtUpdated DataNodes
121873view22:40, 7 March 2022DeSlUpdated pathway layout
121675view14:32, 24 February 2022LucHooglugtLayout changes
121631view14:47, 22 February 2022JesperAligned a dew data nodes
121225view15:18, 12 February 2022EweitzModified description
121224view15:17, 12 February 2022EweitzModified title
121202view13:16, 11 February 2022LucHooglugtLiterature added
121200view12:34, 11 February 2022LucHooglugtModified description
121199view12:29, 11 February 2022LucHooglugtModified title
121198view12:20, 11 February 2022LucHooglugtNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ApoptosisPathwayWP254 (WikiPathways)
BAXProteinQ07812 (Uniprot-TrEMBL)
BIRC3ProteinQ13489 (Uniprot-TrEMBL)
Bcl-xL ProteinQ07817-1 (Uniprot-TrEMBL)
Bcl-xLProteinQ07817-1 (Uniprot-TrEMBL)
Caspase-3ProteinP42574 (Uniprot-TrEMBL)
Caspase-7ProteinP55210 (Uniprot-TrEMBL)
Caspase-8ProteinQ14790 (Uniprot-TrEMBL)
Caspase-9ProteinP55211 (Uniprot-TrEMBL)
Cytochrome cProteinP99999 (Uniprot-TrEMBL)
FADDProteinQ13158 (Uniprot-TrEMBL)
NPD1MetaboliteCHEBI:138655 (ChEBI)
NecroptosisPathway
Neuroprotection PathwayPathwayWP4008 (WikiPathways)
PP2AProteinP62714 (Uniprot-TrEMBL)
Procaspase-8Pathway
RIP1ProteinQ13546 (Uniprot-TrEMBL)
RIP3ProteinQ9Y572 (Uniprot-TrEMBL)
TNF alphaProteinP01375 (Uniprot-TrEMBL)
TNFR1ProteinP19438 (Uniprot-TrEMBL)
TRADDProteinQ15628 (Uniprot-TrEMBL)
TRAF2ProteinQ12933 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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