Arsenic liver toxicity pathway (Homo sapiens)

From WikiPathways

Revision as of 13:16, 26 April 2022 by ZDLech (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
TNF-alpha signaling pathwayCell cycleKE1487:Binding, Thiol/seleno-proteins involved in protection against oxidative stressKE1395: Liver CancerKE1969: Increase, Oxidative StressDNA damage responseKE1940: Up-regulation of Reactive Oxygen SpeciesArsenicKE1194: Increase, DNA damageKE716: Increase, cell proliferation (hepatocytes)Phase II - Conjugation of compounds KE1894: Chronic low grade systemic inflammationOxidative damage responseNRF2 pathway


Description

This is an adverse outcome pathway of arsenic toxicity on liver including key processes leading to arsenic induced liver cancer.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Angrish MM, Allard P, McCullough SD, Druwe IL, Helbling Chadwick L, Hines E, Chorley BN; ''Epigenetic Applications in Adverse Outcome Pathways and Environmental Risk Evaluation.''; Environ Health Perspect, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129377view09:48, 27 March 2024MkutmonOntology Term : 'disease pathway' added !
128630view03:16, 17 February 2024EweitzEconomize layout, standardize case
128617view00:05, 17 February 2024EweitzOntology Term : 'hepatocyte' added !
128616view00:05, 17 February 2024EweitzOntology Term : 'liver cancer' added !
128615view00:04, 17 February 2024EweitzModified title
128606view20:25, 15 February 2024Marvin M2Added reference
122969view12:43, 5 June 2022ZDLech
122896view12:00, 30 May 2022ZDLechChanged ID for pathway: Arsenic carcinogenesis - reactive oxygen species
122862view17:14, 25 May 2022ZDLechAdded Key Event 155
122694view13:23, 3 May 2022ZDLechPathway change under KE1487
122660view15:03, 27 April 2022ZDLechRemoved arsenic node add added arrows to the interactions
122656view13:16, 26 April 2022ZDLechNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Arsenic
Cell cyclePathwayWP179 (WikiPathways)
DNA damage responsePathwayWP707 (WikiPathways)
KE1194: Increase, DNA damage1194 (AOP-Wiki KE)
KE1395: Liver Cancer1395 (AOP-Wiki KE)
KE1487:Binding, Thiol/seleno-proteins involved in protection against oxidative stress1487 (AOP-Wiki KE)
KE1894: Chronic low grade systemic inflammation1894 (AOP-Wiki KE)
KE1940: Up-regulation of Reactive Oxygen Species1940 (AOP-Wiki KE)
KE1969: Increase, Oxidative Stress1969 (AOP-Wiki KE)
KE716: Increase, cell proliferation (hepatocytes)716 (AOP-Wiki KE)
NRF2 pathwayPathwayWP2884 (WikiPathways)
Oxidative damage responsePathwayWP3941 (WikiPathways)
Phase II - Conjugation of compounds PathwayWP4111 (WikiPathways)
TNF-alpha signaling pathwayPathwayWP231 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5228"
Personal tools