Non-genomic actions of 1,25-dihydroxyvitamin D3 (Homo sapiens)

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1Cell deathTranscription of:Transcription of anti-viral genes?TLR2/4/8ligandsStressPlasma membranePLCB1AKT3PLCG2CaMK2BRXRGPRKCQPRKCGAKT2PIK3CBIFI27LETS1OAS1TLR4AASTAT1PRKCHCaMK2DIFNR gammaPIK3C2BVSEDAGPIK3CAPIK3R2OAS3PIK3R3IKK2CaMK2AISG15RXRBPLCB2CYP27B1PLCB3TLR2PRKCBPLCE1PRKCEPIK3C2GPLCD325DPIK3CDPLA2G1BPLCB4VDRCaveolin-1MED1RSAD2PIK3R4PMASP3AKT11,25DPIK3C2APRKCDRXRASTAT2JAK1PLCD4PRKCAPIK3C3IFI44LPIK3CGPIK3R1PLCD1PLCG1CaMK2GPIK3R5CD40LGOAS2TLR825DVDRnCD40INF gammaINF alphaIFNR alphaCYP27B1VDRTYK2STAT2STAT1AA1,25DVDRm/nVDRVDRnSP1VDRcJUNVDR transcriptionKRASHRASNRASMAPK3MAPK1MAPK7MAPK8MAPK9PKC zetaVDRnNFKB1RELBNFKB2NFKB1RELBNFKB2MAPK8MAPK9TNFR1TNFMAPK11MAPK14MAPK13MAPK12MAPK11MAPK14MAPK13MAPK12Gene transcriptionCYP24A1CAMPDEFB4ANOD2VDRCCL2CXCL8IL-6Gene transcriptionNucleusIon channels


Description

The pathway summarizes the knowlegde on the non-genomic actions of the hormonally active form of vitamin D, 1,25 dihydroxyvitamin D3. It is based the pathway figure published by Hii and Ferrante (Nutrients, 2016).

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hii CS, Ferrante A; ''The Non-Genomic Actions of Vitamin D.''; Nutrients, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134957view09:37, 30 July 2024EgonwRemoved an identifier without datasource
134806view03:04, 27 July 2024EweitzFix colliding graphics for nucleus and cell membranes
134804view03:02, 27 July 2024EweitzModified title
134803view03:02, 27 July 2024EweitzModified description
122900view11:55, 31 May 2022DeSlOntology Term : 'signaling pathway' added !
122899view11:51, 31 May 2022DeSlAdded missing IDs for IFNR alpha and gamma
122898view11:41, 31 May 2022DeSlConverted metabolite DataNodes to blue blocks, annotated DAG.
107169view14:25, 17 September 2019MaintBotChEBI identifier normalization
98497view08:39, 13 September 2018SusanModified description
98496view08:26, 13 September 2018SusanModified description
98495view08:23, 13 September 2018SusanOntology Term : 'vitamin D signaling pathway' added !
98494view08:20, 13 September 2018SusanNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,25DMetaboliteHMDB0001903 (HMDB)
25DMetaboliteHMDB0003550 (HMDB)
AAMetaboliteHMDB0001043 (HMDB)
AKT1GeneProductENSG00000142208 (GenBank)
AKT2GeneProductENSG00000105221 (GenBank)
AKT3GeneProductENSG00000117020 (GenBank)
CAMPGeneProductENSG00000164047 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CD40GeneProductENSG00000101017 (Ensembl)
CD40LGGeneProductENSG00000102245 (Ensembl)
CXCL8GeneProductENSG00000169429 (Ensembl)
CYP24A1GeneProductENSG00000019186 (Ensembl)
CYP27B1GeneProductENSG00000111012 (Ensembl)
CaMK2AGeneProductENSG00000070808 (Ensembl)
CaMK2BGeneProductENSG00000058404 (Ensembl)
CaMK2DGeneProductENSG00000145349 (Ensembl)
CaMK2GGeneProductENSG00000148660 (Ensembl)
Caveolin-1ProteinQ03135 (Uniprot-TrEMBL)
DAGMetaboliteLMGL0201 (LIPID MAPS)
DEFB4AGeneProductENSG00000171711 (Ensembl)
ETS1GeneProductENSG00000134954 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
IFI27LGeneProductENSG00000119632 (Ensembl)
IFI44LGeneProductENSG00000137959 (Ensembl)
IFNR alphaGeneProduct
IFNR gammaGeneProduct
IKK2GeneProductENSG00000104365 (Ensembl)
IL-6GeneProductENSG00000136244 (Ensembl)
INF alphaProteinP01563 (Uniprot-TrEMBL)
INF gammaProteinP01579 (Uniprot-TrEMBL)
ISG15GeneProductENSG00000187608 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK7GeneProductENSG00000166484 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MED1GeneProductENSG00000125686 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB2GeneProductENSG00000077150 (Ensembl)
NOD2GeneProductENSG00000167207 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
OAS1GeneProductENSG00000089127  (Ensembl)
OAS2GeneProductENSG00000111335 (Ensembl)
OAS3GeneProductENSG00000111331  (Ensembl)
PIK3C2AGeneProductENSG00000011405 (GenBank)
PIK3C2BGeneProductENSG00000133056 (GenBank)
PIK3C2GGeneProductENSG00000139144  (GenBank)
PIK3C3GeneProductENSG00000078142  (GenBank)
PIK3CAGeneProductENSG00000121879 (GenBank)
PIK3CBGeneProductENSG00000051382 (GenBank)
PIK3CDGeneProductENSG00000171608 (GenBank)
PIK3CGGeneProductENSG00000105851 (GenBank)
PIK3R1GeneProductENSG00000145675 (GenBank)
PIK3R2GeneProductENSG00000105647 (GenBank)
PIK3R3GeneProductENSG00000117461 (GenBank)
PIK3R4GeneProductENSG00000196455 (GenBank)
PIK3R5GeneProductENSG00000141506 (GenBank)
PKC zetaGeneProductENSG00000067606 (Ensembl)
PLA2G1BGeneProductENSG00000170890 (GenBank)
PLCB1GeneProductENSG00000182621 (Ensembl)
PLCB2GeneProductENSG00000137841 (Ensembl)
PLCB3GeneProductENSG00000149782 (Ensembl)
PLCB4GeneProductENSG00000101333 (Ensembl)
PLCD1GeneProductENSG00000187091 (Ensembl)
PLCD3GeneProductENSG00000187091 (Ensembl)
PLCD4GeneProductENSG00000187091 (Ensembl)
PLCE1GeneProductENSG00000138193 (Ensembl)
PLCG1GeneProductENSG00000187091 (Ensembl)
PLCG2GeneProductENSG00000197943 (Ensembl)
PMAMetaboliteCHEBI:37537 (ChEBI)
PRKCAGeneProductENSG00000154229 (Ensembl)
PRKCBGeneProductENSG00000166501 (Ensembl)
PRKCDGeneProductENSG00000163932 (Ensembl)
PRKCEGeneProductENSG00000171132 (Ensembl)
PRKCGGeneProductENSG00000126583 (Ensembl)
PRKCHGeneProductENSG00000027075 (Ensembl)
PRKCQGeneProductENSG00000065675 (Ensembl)
RELBGeneProductENSG00000104856 (Ensembl)
RSAD2GeneProductENSG00000134321 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
RXRBGeneProductENSG00000204231 (Ensembl)
RXRGGeneProductENSG00000143171 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
SP3GeneProductENSG00000172845 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT2GeneProductENSG00000170581 (Ensembl)
TLR2GeneProductENSG00000137462 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TLR8GeneProductENSG00000101916 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TNFR1GeneProductENSG00000067182 (Ensembl)
TYK2GeneProductENSG00000105397 (Ensembl)
VDRGeneProductENSG00000111424 (Ensembl)
VDRm/nGeneProductENSG00000111424 (Ensembl)
VDRnGeneProductENSG00000111424 (Ensembl)
VSEGeneProductVSE
cJUNGeneProductENSG00000177606 (Ensembl)

Annotated Interactions

No annotated interactions

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