Omega-3 / omega-6 fatty acid synthesis (Homo sapiens)

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1From the dietFADS2ACSL1FADS2GlycerophospholipidsArachidonic acidPLA2G5PLA2G6PLA2G4APLA2G4BLinoleic acidCoA(18:2(9Z,12Z))CoA(18:3(6Z,9Z,12Z))CoA(20:2(11Z,14Z))CoA(20:3(8Z,11Z,14Z))Arachidonoyl-CoAgamma-Linolenic acidCoA(22:4)CoA(24:4)20:2(11Z,14Z)Bishomo-gamma-linolenic acidCoA(22:5(4Z,7Z,10Z,13Z,16Z))alpha-Linolenic acidCoA(18:3(9Z,12Z,15Z))CoA(18:4(6Z,9Z,12Z,15Z))CoA(20:4(8Z,11Z,14Z,17Z))CoA(20:5)CoA(22:5(7Z,10Z,13Z,16Z,19Z))CoA(22:6)CoA(24:5(9Z,12Z,15Z,18Z,21Z))CoA(24:6)DHA24:6(6Z,9Z,12Z,15Z,18Z,21Z)24:5(9Z,12Z,15Z,18Z,21Z)22:5(7Z,10Z,13Z,16Z,19Z)20:5(5Z,8Z,11Z,14Z,17Z)20:4(8Z,11Z,14Z,17Z)Stearidonic acid22:5(4Z,7Z,10Z,13Z,16Z)22:4(7Z,10Z,13Z,16Z)24:4(9Z,12Z,15Z,18Z)CoA(22:2(13Z,16Z))22:2(13Z,16Z)CoA(20:3(11Z,14Z,17Z))20:3(11Z,14Z,17Z)CoA(24:5(6Z,9Z,12Z,15Z,18Z))24:5(6Z,9Z,12Z,15Z,18Z)ACSL3ACSL4ELOVL2ELOVL5FADS1ACOX1ACOX3FADS1ACOT1ACOT2FADS2ELOVL2ELOVL5ACSL1ACSL3ACSL4FADS2From the dietPLA2G5PLA2G6PLA2G4APLA2G4BACOX1ACOX3ELOVL2ELOVL5ACOT1ACOT2


Description

This pathway is inspired by the Lipidmaps>Omega-3 and omega-6 fatty acids) [1]. Omega-3 and omega-6 FAs (Fatty acids) are important fats obtained from diet, and are both polyunsaturated (indicating many double bonds in the lipid tail).The position of the double bond is given in the name of the lipid, for example 22:2(13Z,16Z) means a tail length of 22 carbons, with 2 double bond. One double bond is at the 13 Carbon, the second on the 16th.This number is counted from the tail end of the lipid chain (indicating that the example lipid is a 22 - 16 = omega-6 FA).

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway [WP4350_106336.gpml] with a 94.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''A mouse macrophage lipidome.''; J Biol Chem, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124738view08:47, 8 December 2022DeSlUpdated link to LIPID MAPS PWs.
124737view08:35, 8 December 2022DeSlRemoved version info
123512view09:13, 29 July 2022Conroy lipidsaded ID for ACOT1 (corrected name to upper case, fixed ID for FA 20:2
120315view15:17, 26 November 2021DeSlOntology Term : 'fatty acid omega degradation pathway' added !
120314view15:17, 26 November 2021DeSlOntology Term : 'PW:0001253' removed !
120313view15:16, 26 November 2021DeSlOntology Term : 'unsaturated fatty acid biosynthetic pathway' added !
120312view15:15, 26 November 2021DeSlOntology Term : 'PW:0001137' removed !
120311view15:15, 26 November 2021DeSlOntology Term : 'fatty acid metabolic pathway' added !
120310view15:14, 26 November 2021DeSlOntology Term : 'amino acid metabolic pathway' added !
120309view15:14, 26 November 2021DeSlOntology Term : 'PW:0000058' removed !
120308view15:14, 26 November 2021DeSlOntology Term : 'fatty acid elongation pathway' added !
120307view15:13, 26 November 2021DeSlOntology Term : 'PW:0001136' removed !
118840view09:19, 2 June 2021EweitzModified title
117811view14:45, 22 May 2021EweitzModified title
114096view13:14, 22 December 2020EgonwTyped a metabolite DataNode
107600view15:18, 23 October 2019DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
20:2(11Z,14Z)MetaboliteLMFA01031043 (LIPID MAPS) aka 11,14-eicosadienoic acid
20:3(11Z,14Z,17Z)MetaboliteLMFA01030378 (LIPID MAPS) AKA 11,14,17-eicosatrienoic acid
20:4(8Z,11Z,14Z,17Z)MetaboliteLMFA01030818 (LIPID MAPS)
20:5(5Z,8Z,11Z,14Z,17Z)MetaboliteLMFA01030759 (LIPID MAPS)
22:2(13Z,16Z)MetaboliteLMFA01030405 (LIPID MAPS) aka 13,16-docodadienoic acid
22:4(7Z,10Z,13Z,16Z)MetaboliteLMFA01030178 (LIPID MAPS)
22:5(4Z,7Z,10Z,13Z,16Z)MetaboliteLMFA04000064 (LIPID MAPS)
22:5(7Z,10Z,13Z,16Z,19Z)MetaboliteLMFA04000044 (LIPID MAPS)
24:4(9Z,12Z,15Z,18Z)MetaboliteLMFA01030819 (LIPID MAPS)
24:5(6Z,9Z,12Z,15Z,18Z)MetaboliteLMFA01030820 (LIPID MAPS)
24:5(9Z,12Z,15Z,18Z,21Z)MetaboliteLMFA01030821 (LIPID MAPS)
24:6(6Z,9Z,12Z,15Z,18Z,21Z)MetaboliteLMFA01030822 (LIPID MAPS)
ACOT1GeneProductQ86TX2 (Uniprot-TrEMBL) No homologues found for original id L:26897
ACOT2GeneProductENSG00000119673 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:171210
ACOX1GeneProductENSG00000161533 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430
ACOX3GeneProductENSG00000087008 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911
ACSL1GeneProductENSG00000151726 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14081
ACSL3GeneProductENSG00000123983 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74205
ACSL4GeneProductENSG00000068366 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50790
Arachidonic acidMetaboliteLMFA01030001 (LIPID MAPS)
Arachidonoyl-CoAMetaboliteLMFA07050288 (LIPID MAPS) aka CoA(20:4)
Bishomo-gamma-linolenic acidMetaboliteLMFA01030158 (LIPID MAPS)
CoA(18:2(9Z,12Z))MetaboliteLMFA07050343 (LIPID MAPS)
CoA(18:3(6Z,9Z,12Z))MetaboliteLMFA07050322 (LIPID MAPS)
CoA(18:3(9Z,12Z,15Z))MetaboliteLMFA07050286 (LIPID MAPS)
CoA(18:4(6Z,9Z,12Z,15Z))MetaboliteLMFA07050123 (LIPID MAPS)
CoA(20:2(11Z,14Z))MetaboliteLMFA07050036 (LIPID MAPS)
CoA(20:3(11Z,14Z,17Z))MetaboliteLMFA07050044 (LIPID MAPS)
CoA(20:3(8Z,11Z,14Z))MetaboliteLMFA07050278 (LIPID MAPS)
CoA(20:4(8Z,11Z,14Z,17Z))MetaboliteLMFA07050134 (LIPID MAPS)
CoA(20:5)MetaboliteLMFA07050122 (LIPID MAPS)
CoA(22:2(13Z,16Z))MetaboliteLMFA07050037 (LIPID MAPS)
CoA(22:4)MetaboliteLMFA07050129 (LIPID MAPS)
CoA(22:5(4Z,7Z,10Z,13Z,16Z))MetaboliteLMFA07050043 (LIPID MAPS)
CoA(22:5(7Z,10Z,13Z,16Z,19Z))MetaboliteLMFA07050131 (LIPID MAPS)
CoA(22:6)MetaboliteLMFA07050121 (LIPID MAPS)
CoA(24:4)MetaboliteLMFA07050139 (LIPID MAPS)
CoA(24:5(6Z,9Z,12Z,15Z,18Z))MetaboliteLMFA07050042 (LIPID MAPS)
CoA(24:5(9Z,12Z,15Z,18Z,21Z))MetaboliteLMFA07050141 (LIPID MAPS)
CoA(24:6)MetaboliteLMFA07050127 (LIPID MAPS)
DHAMetaboliteLMFA01030185 (LIPID MAPS)
ELOVL2GeneProductENSG00000197977 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54326
ELOVL5GeneProductENSG00000012660 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68801
FADS1GeneProductENSG00000149485 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:76267
FADS2GeneProductENSG00000134824 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473
GlycerophospholipidsMetaboliteCHEBI:37739 (ChEBI)
Linoleic acidMetaboliteLMFA01030120 (LIPID MAPS)
PLA2G4AProteinENSG00000116711 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18783
PLA2G4BProteinENSG00000243708 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:211429
PLA2G5ProteinENSG00000127472 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18784
PLA2G6ProteinENSG00000184381 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53357
Stearidonic acidMetaboliteLMFA01030357 (LIPID MAPS) aka 5,8,11,14,17-eicosapentaenoic acid
alpha-Linolenic acidMetaboliteLMFA01030152 (LIPID MAPS)
gamma-Linolenic acidMetaboliteLMFA01030141 (LIPID MAPS)

Annotated Interactions

No annotated interactions
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