Chronic hyperglycemia impairment of neuron function (Homo sapiens)

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1ProteinKinasesSensitizationHyperexcitationO2- radicalcytokinesRAGEETCTKRDNAGlut-1Na+O2- radicalGlut-3glucoseglucoseglucoseROSProteinSynthesis


Description

First 20% drawn. No identifiers yet. Work in progress.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Perrone A, Giovino A, Benny J, Martinelli F; ''Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects.''; Oxid Med Cell Longev, 2020 PubMed Europe PMC Scholia
  2. Rajchgot T, Thomas SC, Wang JC, Ahmadi M, Balood M, Crosson T, Dias JP, Couture R, Claing A, Talbot S; ''Neurons and Microglia; A Sickly-Sweet Duo in Diabetic Pain Neuropathy.''; Front Neurosci, 2019 PubMed Europe PMC Scholia
  3. King RH; ''The role of glycation in the pathogenesis of diabetic polyneuropathy.''; Mol Pathol, 2001 PubMed Europe PMC Scholia
  4. Turner DP; ''Advanced glycation end-products: a biological consequence of lifestyle contributing to cancer disparity.''; Cancer Res, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128337view02:37, 2 February 2024EweitzModified description
128336view12:56, 1 February 2024EweitzBold "Excessive glucose" and "Growth cone", like original diagram
128335view12:47, 1 February 2024EweitzIncrease height of sugar nodes
128334view12:45, 1 February 2024EweitzBold sugar nodes on primary axis, like original diagram
128333view12:43, 1 February 2024EweitzAdd missing nodes: aldose reductase and NO
128332view02:14, 1 February 2024EweitzEconomize layout
128331view02:01, 1 February 2024EweitzEconomize layout
128330view01:44, 1 February 2024EweitzEconomize layout horizontally
128329view01:35, 1 February 2024EweitzPolish graphics
128328view01:30, 1 February 2024EweitzEconomize layout
128327view01:07, 1 February 2024EweitzColor blood vessel, label neuron, refine growth cone color
128326view00:54, 1 February 2024EweitzUse line thickness 2 instead of 3 (site shows much thicker than PathVisio)
128325view00:52, 1 February 2024EweitzRefine graphics per source: color growth cone, thicken some lines
128324view00:36, 1 February 2024EweitzIdentify pathway
128322view00:27, 1 February 2024EweitzClarify glucose reaction, refine microangiopathy to disease node
128321view23:59, 31 January 2024EweitzOntology Term : 'brain small vessel disease' added !
128319view23:12, 31 January 2024EweitzConvert legended-but-unidentified pointers to text
128318view23:02, 31 January 2024EweitzDenote legend
128317view22:55, 31 January 2024EweitzEconomize layout
128316view22:49, 31 January 2024EweitzGroup abstracted genes, refine text placement for readability
128315view22:45, 31 January 2024EweitzStandardize case
126558view09:40, 2 June 2023DdiglesAdded rhea ID
126557view09:19, 2 June 2023DdiglesAdded sorbitol dehydrogenase
124551view12:16, 8 November 2022EweitzModified description
124085view20:17, 16 September 2022EgonwMore pathways clickable
124074view06:10, 16 September 2022EgonwMade a pathway clickable
124034view14:49, 14 September 2022DeSlOntology Term : 'diabetic neuropathy' added !
124033view14:48, 14 September 2022DeSlAddedmissing IDs for glucose nodes, TRPV1 and TRPA1
124032view14:44, 14 September 2022DeSlAdded InterPro ID for NMDA
124031view14:42, 14 September 2022DeSlAdded more details on NMDA; not possible to add EC code
124030view14:38, 14 September 2022DeSlAdded ID for PKC
124029view14:37, 14 September 2022DeSlAdded some more details on NRS
124028view14:24, 14 September 2022DeSlAdded details on iNOS
124027view14:21, 14 September 2022DeSlAdded ETC ID for OXPHOS system PW
124026view14:19, 14 September 2022DeSlAdded note for BDNFR, added PW ID for DNA
124025view14:14, 14 September 2022DeSlAdded sodium-potassium pump annotation
124013view06:01, 13 September 2022EgonwAnother ROS
124012view06:00, 13 September 2022EgonwFinal clean up: removed a few incorrect annotations; grouped PKC and SNAP proteins
124011view05:56, 13 September 2022EgonwMoved the PKC proteins together
124010view05:20, 13 September 2022EgonwA few more identifiers
124009view05:09, 13 September 2022EgonwTwo more identifiers: cytokines, and C3 (which was correct afterall)
124008view05:05, 13 September 2022EgonwAdded an AGE/RAGE interaction reference
124007view04:57, 13 September 2022EgonwAGE := advanced glycation end-product
124006view04:50, 13 September 2022EgonwMissing info: protein typing; missing data source
124005view04:44, 13 September 2022EgonwSmall updates: BDNF identifier, link to related pathway, and remove wrong C3
124003view16:03, 12 September 2022EgonwThree more identifiers
124002view15:58, 12 September 2022EgonwModified description
124001view13:33, 11 September 2022EgonwLast bits of missing content. Much bio annotation missing, including references for the interactions
123999view09:08, 11 September 2022EgonwSome further work, annotations, MMPs together.
123998view07:02, 11 September 2022EgonwOntology Term : 'neuron' added !

External references

DataNodes

View all...
NameTypeDatabase referenceComment
DNAGeneProduct
ETCProtein
Glut-1Protein
Glut-3Protein
Na+Metabolite
O2- radicalMetabolite
Protein KinasesProtein
Protein SynthesisPathway
RAGEProtein
ROSMetabolite
Sensitization HyperexcitationPathway
TKRProteinAlso known as TKTL1
cytokines
glucoseMetabolite

Annotated Interactions

No annotated interactions

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