Immune infiltration in pancreatic cancer (Homo sapiens)

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1PDACM1 macrophageTh17CD8+ T cellTregMDSCCAFVasculatureTh1NeutrophilIL12IL17IL10TNFaCarbon monoxideCXCL1IL5IL6IL2IL13CXCL8TGFβnitric oxideIL13IL23GM-CSFIL8VEGFMMPIL4IFN-γM2 macrophagenitric oxideTGFβTh2TNFαM2 macrophageVEGFIL4IL6IL10TGFβ


Description

Immune infiltration in pancreatic cancer. The pathway model is based on a review by Liu et al, 2019 (https://doi.org/10.1186/s12943-019-1117-9).

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Ontology Terms

 

Bibliography

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  1. ''''; , PubMed Europe PMC Scholia
  2. Ren B, Cui M, Yang G, Wang H, Feng M, You L, Zhao Y; ''Tumor microenvironment participates in metastasis of pancreatic cancer.''; Mol Cancer, 2018 PubMed Europe PMC Scholia
  3. Ma X, Wu D, Zhou S, Wan F, Liu H, Xu X, Zhao Y, Tang M; ''The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway.''; Oncol Rep, 2016 PubMed Europe PMC Scholia
  4. Masucci MT, Minopoli M, Carriero MV; ''Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy.''; Front Oncol, 2019 PubMed Europe PMC Scholia
  5. Goulart MR, Stasinos K, Fincham REA, Delvecchio FR, Kocher HM; ''T cells in pancreatic cancer stroma.''; World J Gastroenterol, 2021 PubMed Europe PMC Scholia
  6. Liu B, Jia Y, Ma J, Wu S, Jiang H, Cao Y, Sun X, Yin X, Yan S, Shang M, Mao A; ''Tumor-associated macrophage-derived CCL20 enhances the growth and metastasis of pancreatic cancer.''; Acta Biochim Biophys Sin (Shanghai), 2016 PubMed Europe PMC Scholia
  7. Cui R, Yue W, Lattime EC, Stein MN, Xu Q, Tan XL; ''Targeting tumor-associated macrophages to combat pancreatic cancer.''; Oncotarget, 2016 PubMed Europe PMC Scholia
  8. Sideras K, Braat H, Kwekkeboom J, van Eijck CH, Peppelenbosch MP, Sleijfer S, Bruno M; ''Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies.''; Cancer Treat Rev, 2014 PubMed Europe PMC Scholia
  9. Fan JQ, Wang MF, Chen HL, Shang D, Das JK, Song J; ''Current advances and outlooks in immunotherapy for pancreatic ductal adenocarcinoma.''; Mol Cancer, 2020 PubMed Europe PMC Scholia
  10. Liu X, Xu J, Zhang B, Liu J, Liang C, Meng Q, Hua J, Yu X, Shi S; ''The reciprocal regulation between host tissue and immunecells in pancreatic ductal adenocarcinoma: new insights and therapeutic implications.''; Mol Cancer, 2019 PubMed Europe PMC Scholia
  11. Zhang R, Liu Q, Peng J, Wang M, Li T, Liu J, Cui M, Zhang X, Gao X, Liao Q, Zhao Y; ''CXCL5 overexpression predicts a poor prognosis in pancreatic ductal adenocarcinoma and is correlated with immune cell infiltration.''; J Cancer, 2020 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
136849view12:59, 24 February 2025EweitzRefine label placement
136848view12:59, 24 February 2025EweitzFix truncated label
136847view12:57, 24 February 2025EweitzEconomize layout
136846view12:55, 24 February 2025EweitzEconomize layout
136845view12:54, 24 February 2025EweitzEconomize layout
136844view12:53, 24 February 2025EweitzEconomize layout
136843view12:52, 24 February 2025EweitzEconomize layout
136842view12:50, 24 February 2025EweitzEconomize layout
136841view12:49, 24 February 2025EweitzEconomize layout
136840view12:46, 24 February 2025EweitzEconomize layout
136834view23:30, 23 February 2025EweitzEconomize layout
136833view23:21, 23 February 2025EweitzTailor node height
128268view00:27, 30 January 2024EweitzOntology Term : 'pancreatic stellate cell' added !
128267view00:26, 30 January 2024EweitzOntology Term : 'fibroblast' added !
128266view00:26, 30 January 2024EweitzOntology Term : 'myeloid suppressor cell' added !
128265view00:25, 30 January 2024EweitzOntology Term : 'T-helper 2 cell' added !
128264view00:25, 30 January 2024EweitzOntology Term : 'T-helper 1 cell' added !
128263view00:25, 30 January 2024EweitzOntology Term : 'T-helper 17 cell' added !
128262view00:24, 30 January 2024EweitzOntology Term : 'neutrophil' added !
128261view00:24, 30 January 2024EweitzOntology Term : 'regulatory T cell' added !
128260view00:24, 30 January 2024EweitzOntology Term : 'macrophage' added !
125922view11:07, 20 March 2023IsabelWassinkOntology Term : 'disease pathway' added !
125921view09:24, 20 March 2023IsabelWassinkminor changes in layout
125902view13:07, 17 March 2023IsabelWassinkminor layout changes
125081view12:47, 20 January 2023IsabelWassinkOntology Term : 'immune response pathway' added !
124818view08:36, 12 December 2022IsabelWassinkremoved vasculature data node
124598view13:54, 14 November 2022IsabelWassinkModified description
124557view14:28, 8 November 2022DdiglesCXCL5 identifier reload (is causing test failures)
124469view09:10, 30 October 2022DdiglesRemoved "(Ensembl)" in identifier of CCL5
124457view14:51, 28 October 2022IsabelWassinkUpdated pathway
124383view13:07, 21 October 2022IsabelWassinkREG4 data node added
124344view11:38, 18 October 2022IsabelWassinkPathway extended
124341view14:10, 17 October 2022IsabelWassinkModified description
124320view12:19, 13 October 2022IsabelWassinkPathway extended with new data node with reference
124300view13:48, 11 October 2022IsabelWassinkUpdated the layout
124298view11:55, 11 October 2022IsabelWassinkInteraction between macrophages and MDSC added
124282view09:40, 7 October 2022IsabelWassinkNew interaction with reference between Th1 and CD8+ T cell
124281view08:19, 7 October 2022IsabelWassinkMMP9 data node and reference added
124262view10:05, 6 October 2022IsabelWassinkNames changed to official gene names and arrows to show secretion changed
124240view14:41, 4 October 2022IsabelWassinkUpdated the TNFA identifier
124215view12:20, 30 September 2022IsabelWassinkData nodes added
124211view14:35, 29 September 2022IsabelWassinkShape of metabolite data nodes changed to rounded rectangles
124210view13:39, 29 September 2022IsabelWassinkUpdated secreted factors to groups instead of individual nodes and linked the groups to cells in the pathway
124201view14:49, 27 September 2022IsabelWassinkModified description
124199view11:57, 27 September 2022IsabelWassinkPDAC cell color changed for clarity
124198view11:15, 27 September 2022IsabelWassinkModified description
124197view11:05, 27 September 2022IsabelWassinkData node annotations updated
124194view13:30, 26 September 2022Mkutmonmaking groups instead of individual nodes
124064view10:44, 15 September 2022IsabelWassinkOntology Term : 'pancreatic cancer pathway' added !
124063view10:44, 15 September 2022IsabelWassinkOntology Term : 'pancreatic cancer' added !

External references

DataNodes

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NameTypeDatabase referenceComment
CXCL1GeneProductENSG00000163739 (Ensembl)
CXCL8GeneProductENSG00000169429 (Ensembl)
Carbon monoxideMetaboliteHMDB01361 (HMDB)
GM-CSFGeneProduct
IFN-γGeneProduct
IL10GeneProductENSG00000136634 (Ensembl)
IL12GeneProduct
IL13GeneProductENSG00000169194 (Ensembl)
IL17GeneProduct
IL23GeneProduct
IL2GeneProductENSG00000109471 (Ensembl)
IL4GeneProductENSG00000113520 (Ensembl)
IL5GeneProductENSG00000113525 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IL8MetaboliteCHEBI:138181 (ChEBI)
MMPMetaboliteCHEBI:340824 (ChEBI)
TGFβGeneProduct
TNFaGeneProduct
TNFαGeneProduct
VEGFGeneProduct
nitric oxideMetaboliteCHEBI:16480 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5285"