This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [1] and extended with the top left side of Figure 1 from Dennis and Norris (2015 [2]).
Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[3], lipooxygenases(LOX)[4], or cytochrome P450 monooxygenases (CYP)[5].
This pathway visualises the first route, via COX, where additonal colours have been used to visualise which conversions are being performed by the same enzymes.
Green and orange boxes represent receptors, where the orange colour depicts peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.
Comments
HomologyMapper
This pathway was inferred from Mus musculus pathway [WP4347_106328.gpml] with a 87.0% conversion rate.
The current version of this pathway has been developed together with lipidomics community, including LIPID MAPS and part of the Lipids Portal (tagged
by Andra Waagmeester).
Dennis EA, Norris PC; ''Eicosanoid storm in infection and inflammation.''; Nat Rev Immunol, 2015 PubMedEurope PMCScholia
Dennis EA, Norris PC; ''Eicosanoid storm in infection and inflammation.''; Nat Rev Immunol, 2015 PubMedEurope PMCScholia
Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''A mouse macrophage lipidome.''; J Biol Chem, 2010 PubMedEurope PMCScholia
Moreno JJ; ''New aspects of the role of hydroxyeicosatetraenoicacids in cell growth and cancer development.''; Biochem Pharmacol, 2009 PubMedEurope PMCScholia
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