T-cell activation SARS-CoV-2 (Homo sapiens)

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Endoplasmatic Reticulum479, 4013, 23, 25263, 31203, 3178, 18, 2823, 25-27263, 3123, 254623, 2523, 25, 29, 3223, 255, 24, 45392, 41463846461413, 23, 2512221423, 25, 2712, 17, 374, 101, 12, 33, 34, 441446NucleusLysosomeAntigen presenting cell (APC)Naive T-cellCa2+HLA-DRASARS-CoV-2 SpikeHLA-DRAHLA-DRB1HLA-DRB1TRATRBCD247CD247CD3ECD3DCD3ECD3GLATCD80CD4LCKZAP70CD28PIK3R1PDPK1AKT1mTORGSK3BTSC2NFATC1PLCG1PPP33CGRB2SOS1RASGRP1HRASRAF1MAP2K1MAPK346ITPR1PRKCQNFKB1RHEBmTORTSC1NFATC1ICOSCARD11BCL10MALT1CHUK26IKBKBIKBKGNFKBIAProliferationCell GrowthGlucose MetabolismPTPRCFYNRELANFKB1RELAJUNFOSJUNFOSSARS-CoVSpike proteinFOXO330CTLA4TYK2JAK2IL12RB2STAT416IL23R16STAT4STAT4STAT4STAT4IFNAR1IL12AIL23AIL12BIL12RB1IL12RB1TYK2JAK2IL12BIFNAR2CCND1Cell Cycle Control6, 11, 35, 42, 43IL236CDKN2A CCND1TP53 CDKN1AIRF2BPLMYD8815IFNGTNFIL18R1IL12RB2LCP2GRAP2PIP2NFAT213, 23, 25PIP214PIK3CDPTENIFNGIL4IL17ACCL19CCL28IL12BIL12ATLATNFIFNGIL23AIFNB1MLST8DeptorRaptorCD8619, 21BAX19, 21BCL2L1 IL12BIL12AIL2DEPTORMLST8RICTORCa2+IP3DAGPIP3MAP2K2MAPK1


Description

T-cell activation SARS-CoV-2 (Work in Progress)

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Bibliography

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History

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CompareRevisionActionTimeUserComment
135185view03:58, 7 August 2024EweitzClear cache to fix board dimensions
135184view03:57, 7 August 2024EweitzEconomize layout
135183view03:11, 7 August 2024EweitzAnchor interaction
135182view03:10, 7 August 2024EweitzEconomize layout
135181view03:03, 7 August 2024EweitzEconomize layout
135180view02:58, 7 August 2024EweitzTailor node heights
135179view02:38, 7 August 2024EweitzStandardize font name, economize layout
135178view02:32, 7 August 2024EweitzEconomize layout
129246view02:40, 16 March 2024EweitzOntology Term : 'naive T cell' added !
129245view02:39, 16 March 2024EweitzOntology Term : 'professional antigen presenting cell' added !
125315view21:43, 31 January 2023LarsgwAdd PMID to reference
124943view15:41, 3 January 2023EgonwAdded a reference for the CARD11-BLC10-MALT1 complex
124801view21:24, 11 December 2022AlexanderPicoOntology Term : 'T cell' added !
124800view21:24, 11 December 2022AlexanderPicoOntology Term : 'COVID-19' added !
124799view21:22, 11 December 2022AlexanderPicofixed citations
119538view21:24, 13 July 2021Mkutmonfix unconnected line
119489view14:24, 2 July 2021ClclassChanged NFAT2 to NFATC1
119483view08:34, 2 July 2021EgonwNot a mim-conversion and correct ID for Ca2+
119480view11:39, 1 July 2021Clclassenlarged data nodes
119479view10:56, 1 July 2021Clclassenlarged data nodes
119478view10:52, 1 July 2021ClclassEnlarged data nodes, changed gene annotations
119476view20:09, 30 June 2021MkutmonOntology Term : 'T cell' added !
119475view20:09, 30 June 2021MkutmonOntology Term : 'COVID-19' added !
119471view06:27, 30 June 2021EgonwNot mim-conversions
119180view14:10, 20 June 2021ClclassAdded literature annotations
119179view12:58, 20 June 2021Clclassadded transcription targets
119178view10:16, 20 June 2021Clclassadded literatur annotations
119177view10:05, 20 June 2021ClclassAdded CD86
119176view10:04, 20 June 2021ClclassAdded data nodes
119175view08:50, 20 June 2021ClclassAdded annotations
119165view12:39, 19 June 2021ClclassAdded data nodes
119158view12:37, 18 June 2021ClclassAdded transcriptional targets and identifiers
119095view08:35, 17 June 2021FinterlyAdded PubMed IDs
119065view08:59, 14 June 2021ClclassAdded literature annotations
119051view12:24, 12 June 2021ClclassAdded literature reference
119050view11:55, 12 June 2021ClclassAdded data nodes
119049view09:57, 12 June 2021ClclassAdded Uniprot identifiers
119048view09:54, 12 June 2021ClclassAdded Uniprot identifiers
119047view09:19, 12 June 2021ClclassAdded Uniprot identifiers
119046view09:01, 12 June 2021ClclassAdded Uniprot identifiers
119032view10:21, 11 June 2021ClclassDeleted a pathway
119031view10:01, 11 June 2021ClclassAdded new pathways and annotations
118982view13:28, 6 June 2021ClclassAdded Data nodes and Literature references
118643view13:22, 31 May 2021ClclassAdded Literature Annotations
118614view07:15, 31 May 2021ClclassAdded Literature Annotations
118556view11:47, 28 May 2021ClclassAdded Literature Annotations
118123view18:24, 24 May 2021ClclassAdded Literature Annotations
118122view18:11, 24 May 2021ClclassAdded Literature Annotations
117102view11:45, 17 May 2021ClclassAdded literature annotations
116776view09:49, 14 May 2021EweitzModified title

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1ProteinP31749 (Uniprot-TrEMBL)
BAXProteinQ07812 (Uniprot-TrEMBL)
BCL10ProteinO95999 (Uniprot-TrEMBL)
BCL2L1 ProteinQ07817 (Uniprot-TrEMBL)
CARD11ProteinQ9BXL7 (Uniprot-TrEMBL)
CCL19ProteinQ99731 (Uniprot-TrEMBL)
CCL28ProteinQ9NRJ3 (Uniprot-TrEMBL)
CCND1ProteinP24385 (Uniprot-TrEMBL)
CD247ProteinP20963 (Uniprot-TrEMBL)
CD28ProteinP10747 (Uniprot-TrEMBL)
CD3DProteinP04234 (Uniprot-TrEMBL)
CD3EProteinP07766 (Uniprot-TrEMBL)
CD3GProteinP09693 (Uniprot-TrEMBL)
CD4ProteinP01730 (Uniprot-TrEMBL)
CD80ProteinP33681 (Uniprot-TrEMBL)
CD86ProteinP42081 (Uniprot-TrEMBL)
CDKN1AProteinP38936 (Uniprot-TrEMBL)
CDKN2A ProteinP42771 (Uniprot-TrEMBL)
CHUKProteinO15111 (Uniprot-TrEMBL)
CTLA4ProteinP16410 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI compound)
DAGMetabolite84974 (ChEBI)
DEPTORProteinQ8TB45 (Uniprot-TrEMBL)
DeptorProteinQ8TB45 (Uniprot-TrEMBL)
FOSProteinP01100 (Uniprot-TrEMBL)
FOXO3ProteinO43524 (Uniprot-TrEMBL)
FYNProteinP06241 (Uniprot-TrEMBL)
GRAP2ProteinO75791 (Uniprot-TrEMBL)
GRB2ProteinP62993 (Uniprot-TrEMBL)
GSK3BProteinP49841 (Uniprot-TrEMBL)
HLA-DRAProteinP01903 (Uniprot-TrEMBL)
HLA-DRB1ProteinP01911 (Uniprot-TrEMBL)
HLA-DRB1ProteinP79483 (Uniprot-TrEMBL)
HRASProteinP01112 (Uniprot-TrEMBL)
ICOSProteinQ9Y6W8 (Uniprot-TrEMBL)
IFNAR1ProteinP17181 (Uniprot-TrEMBL)
IFNAR2ProteinP48551 (Uniprot-TrEMBL)
IFNB1ProteinP01574 (Uniprot-TrEMBL)
IFNGProteinP01579 (Uniprot-TrEMBL)
IKBKBProteinO14920 (Uniprot-TrEMBL)
IKBKGProteinQ9Y6K9 (Uniprot-TrEMBL)
IL12AProteinP29459 (Uniprot-TrEMBL)
IL12BProteinP29460 (Uniprot-TrEMBL)
IL12RB1ProteinP42701 (Uniprot-TrEMBL)
IL12RB2ProteinQ99665 (Uniprot-TrEMBL)
IL17AProteinQ16552 (Uniprot-TrEMBL)
IL18R1ProteinQ13478 (Uniprot-TrEMBL)
IL23AProteinQ9NPF7 (Uniprot-TrEMBL)
IL23RProteinQ5VWK5 (Uniprot-TrEMBL)
IL2ProteinP60568 (Uniprot-TrEMBL)
IL4ProteinP05112 (Uniprot-TrEMBL)
IP3Metabolite139109 (ChEBI)
IRF2BPLProteinQ9H1B7 (Uniprot-TrEMBL)
ITPR1ProteinQ14643 (Uniprot-TrEMBL)
JAK2ProteinO60674 (Uniprot-TrEMBL)
JUNProteinP05412 (Uniprot-TrEMBL)
LATProteinO43561 (Uniprot-TrEMBL)
LCKProteinP06239 (Uniprot-TrEMBL)
LCP2ProteinQ13094 (Uniprot-TrEMBL)
MALT1ProteinQ9UDY8 (Uniprot-TrEMBL)
MAP2K1ProteinQ02750 (Uniprot-TrEMBL)
MAP2K2ProteinP36507 (Uniprot-TrEMBL)
MAPK1ProteinP28482 (Uniprot-TrEMBL)
MAPK3ProteinP27361 (Uniprot-TrEMBL)
MLST8ProteinQ9BVC4 (Uniprot-TrEMBL)
MYD88ProteinQ99836 (Uniprot-TrEMBL)
NFAT2ProteinO95644 (Uniprot-TrEMBL)
NFATC1ProteinO95644 (Uniprot-TrEMBL)
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NFKBIAProteinP25963 (Uniprot-TrEMBL)
PDPK1ProteinO15530 (Uniprot-TrEMBL)
PIK3CDProteinO00329 (Uniprot-TrEMBL)
PIK3R1ProteinP27986 (Uniprot-TrEMBL)
PIP2Metabolite145877 (ChEBI)
PIP3Metabolite84238 (ChEBI)
PLCG1ProteinP19174 (Uniprot-TrEMBL)
PPP33CProteinP48454 (Uniprot-TrEMBL)
PRKCQProteinQ04759 (Uniprot-TrEMBL)
PTENProteinP60484 (Uniprot-TrEMBL)
PTPRCProteinP08575 (Uniprot-TrEMBL)
RAF1ProteinP04049 (Uniprot-TrEMBL)
RASGRP1ProteinO95267 (Uniprot-TrEMBL)
RELAProteinQ04206 (Uniprot-TrEMBL)
RHEBProteinQ15382 (Uniprot-TrEMBL)
RICTORProteinQ6R327 (Uniprot-TrEMBL)
RaptorProteinQ8N122 (Uniprot-TrEMBL)
SARS-CoV-2 SpikeProteinP0DTC2 (Uniprot-TrEMBL)
SOS1ProteinQ07889 (Uniprot-TrEMBL)
STAT4ProteinQ14765 (Uniprot-TrEMBL)
TLAProteinP01374 (Uniprot-TrEMBL)
TNFProteinP01375 (Uniprot-TrEMBL)
TP53 ProteinP04637 (Uniprot-TrEMBL)
TRAProteinP0DTU3 (Uniprot-TrEMBL)
TRBProteinP0DTU4 (Uniprot-TrEMBL)
TSC1ProteinQ92574 (Uniprot-TrEMBL)
TSC2ProteinP49815 (Uniprot-TrEMBL)
TYK2ProteinP29597 (Uniprot-TrEMBL)
ZAP70ProteinP43403 (Uniprot-TrEMBL)
mTORProteinP42345 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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