Metabolic pathways of fibroblasts (Homo sapiens)

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9, 1476151717Cell proliferation,survival, migrationFibroblastGlycolysisMitochondrionLOXL2P5CSUGP2CollagenHSP47PSAT1FGFR1RhoAPSPHADAMTS2SerineGlycineSHMTProlineGLS2ASCT2Nucleotide BiosynthesisGPIPHGDHBMP1P5CGLUT1PIP2LPAR1FGFR4P3H3P5CRP3H431631025LDHGlutamateHKG6PPentose Phosphate PathwayFatty Acid MetabolismTCA cycleGLSAcetyl-CoAPyruvateGlutamineαKGGlucose3PGF6PLactic acid15Glycosaminoglycan SynthesisGolgi ApparatusGlutamineASCT2GlutamateGlutamineGlucoseEndoplasmic ReticulumSerine biosynthesisGlutaminolysis811PI3K-Akt Signaling PathwayROCK ActivationIP3 and DAG Signaling PathwayMCT1Lactic acidG1PUDP-glucosePLCIP3DAGsPGM1PGM3FGFR1 Signaling PathwayFGFR4 Signaling PathwayPIP2PIP3ProcollagenTropocollagenHydroxyprolinePreprocollagen1BMP112PLOD1Lysyl hydroxylase4P4HA3P4HA1P4HA2Prolyl hydroxylase4


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Metabolic pathways of fibroblasts: basis

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Bibliography

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  1. Rabinowitz JD, Mutlu GM; ''A metabolic strategy to reverse fibrosis?''; Nat Metab, 2019 PubMed Europe PMC Scholia
  2. Jarett Casale, Jonathan S. Crane; ''Biochemistry, Glycosaminoglycans ''; StatPearls [Internet], 2022 PubMed Europe PMC Scholia
  3. Egger S, Chaikuad A, Kavanagh KL, Oppermann U, Nidetzky B; ''Structure and mechanism of human UDP-glucose 6-dehydrogenase.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  4. Timothy D. Hewitson, Edward R. Smith; ''A Metabolic Reprogramming of Glycolysis and Glutamine Metabolism Is a Requisite for Renal Fibrogenesis—Why and How? ''; Sec. Renal Physiology and Pathophysiology , 2021 PubMed Europe PMC Scholia
  5. Wang S, Liang Y, Dai C; ''Metabolic Regulation of Fibroblast Activation and Proliferation during Organ Fibrosis.''; Kidney Dis (Basel), 2022 PubMed Europe PMC Scholia
  6. Young-Mi Kim, Eun-Cheol Kim, Youngho Kim; ''The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin ''; Molecular Biology Reports, 2011 PubMed Europe PMC Scholia
  7. Para R, Romero F, George G, Summer R; ''Metabolic Reprogramming as a Driver of Fibroblast Activation in Pulmonary Fibrosis.''; Am J Med Sci, 2019 PubMed Europe PMC Scholia
  8. Tim Cundy, Michael Dray, John Delahunt, Jannie Dahl Hald, Bente Langdahl, Chumei Li, Marta Szybowska, Shehla Mohammed, Emma L Duncan, Aideen M McInerney-Leo, Patricia G Wheeler, Paul Roschger, Klaus Klaushofer, Jyoti Rai, MaryAnn Weis, David Eyre, Ulrike Schwarze, Peter H Byers; ''Mutations That Alter the Carboxy-Terminal-Propeptide Cleavage Site of the Chains of Type I Procollagen Are Associated With a Unique Osteogenesis Imperfecta Phenotype ''; Journal of Bone and Mineral Research, 2018 PubMed Europe PMC Scholia
  9. N.V.Bhagavan, Chung-EunHa; ''Chapter 14 - Carbohydrate Metabolism II: Gluconeogenesis, Glycogen Synthesis and Breakdown, and Alternative Pathways ''; Essentials of Medical Biochemistry (Second Edition), 2015 PubMed Europe PMC Scholia
  10. Oyinlade O, Wei S, Lal B, Laterra J, Zhu H, Goodwin CR, Wang S, Ma D, Wan J, Xia S; ''Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration.''; Oncogene, 2018 PubMed Europe PMC Scholia
  11. Cappelletti P, Tallarita E, Rabattoni V, Campomenosi P, Sacchi S, Pollegioni L; ''Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line.''; PLoS One, 2018 PubMed Europe PMC Scholia
  12. Zhan D, Yalcin F, Ma D, Fu Y, Wei S, Lal B, Li Y, Dzaye O, Laterra J, Ying M, Lopez-Bertoni H, Xia S; ''Targeting UDP-α-d-glucose 6-dehydrogenase alters the CNS tumor immune microenvironment and inhibits glioblastoma growth.''; Genes Dis, 2022 PubMed Europe PMC Scholia
  13. Timothy D. Hewitson, Edward R. Smith; ''A Metabolic Reprogramming of Glycolysis and Glutamine Metabolism Is a Requisite for Renal Fibrogenesis—Why and How? ''; Frontiers in Physiology , 2021 PubMed Europe PMC Scholia
  14. J. Chiang; ''Liver Physiology: Metabolism and Detoxification''; https://www.sciencedirect.com/science/article/pii/B9780123864567042027, 2014 PubMed Europe PMC Scholia
  15. Hiroshi Nonaka, Yuki Nakanishi, Satoshi Kuno, Tomoki Ota, Kentaro Mochidome, Yutaro Saito, Fuminori Sugihara, Yoichi Takakusagi, Ichio Aoki, Satoru Nagatoishi, Kouhei Tsumoto, Shinsuke Sando; ''Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction ''; Nature Communications, 2019 PubMed Europe PMC Scholia
  16. Rachel Para, Freddy Romero, Gautam George, Ross Summer; ''Metabolic Reprogramming as a Driver of Fibroblast Activation in PulmonaryFibrosis ''; American Journal of the Medical Sciences, 2019 PubMed Europe PMC Scholia
  17. Timothy D. Hewitson, Edward R. Smith; ''A Metabolic Reprogramming of Glycolysis and Glutamine Metabolism Is a Requisite for Renal Fibrogenesis—Why and How?''; Frontiers in Physiology, 2021 PubMed Europe PMC Scholia
  18. Ishida Y, Nagata K; ''Hsp47 as a collagen-specific molecular chaperone.''; Methods Enzymol, 2011 PubMed Europe PMC Scholia
  19. Ivano Amelio, Francesca Cutruzzolá, Alexey Antonov, Massimiliano Agostini, Gerry Melino; ''Serine and glycine metabolism in cancer''; Trends in Biochemical Sciences, 2014 PubMed Europe PMC Scholia
  20. Sze, J.H., Brownlie, J.C., Love, C.A.; ''Biotechnological production of hyaluronic acid: a mini review''; Biotech, 2016 PubMed Europe PMC Scholia
  21. J.Chiang; ''Liver Physiology: Metabolism and Detoxification ''; Pathobiology of Human Disease, 2014 PubMed Europe PMC Scholia
  22. ''''; , DOI Scholia
  23. Mojzikova R, Koralkova P, Holub D, Saxova Z, Pospisilova D, Prochazkova D, Dzubak P, Horvathova M, Divoky V; ''Two novel mutations (p.(Ser160Pro) and p.(Arg472Cys)) causing glucose-6-phosphate isomerase deficiency are associated with erythroid dysplasia and inappropriately suppressed hepcidin.''; Blood Cells Mol Dis, 2018 PubMed Europe PMC Scholia
  24. J. Tarrant; ''Emerging Translatable Safety Biomarkers ''; Comprehensive Medicinal Chemistry III, 2017 PubMed Europe PMC Scholia
  25. Thoden JB, Holden HM; ''The molecular architecture of glucose-1-phosphate uridylyltransferase.''; Protein Sci, 2007 PubMed Europe PMC Scholia
  26. Karen E.Burke; ''Prevention and Treatment of Aging Skin with Topical Antioxidants''; Skin Aging Handbook , 2009 PubMed Europe PMC Scholia
  27. Galić S, Schneider HP, Bröer A, Deitmer JW, Bröer S; ''The loop between helix 4 and helix 5 in the monocarboxylate transporter MCT1 is important for substrate selection and protein stability.''; Biochem J, 2003 PubMed Europe PMC Scholia
  28. Yoo HC, Yu YC, Sung Y, Han JM; ''Glutamine reliance in cell metabolism.''; Exp Mol Med, 2020 PubMed Europe PMC Scholia
  29. Xu LZ, Weber IT, Harrison RW, Gidh-Jain M, Pilkis SJ; ''Sugar specificity of human beta-cell glucokinase: correlation of molecular models with kinetic measurements.''; Biochemistry, 1995 PubMed Europe PMC Scholia
  30. Olutobi Oyinlade, Shuang Wei, Bachchu Lal, John Laterra, Heng Zhu, C. Rory Goodwin, Shuyan Wang, Ding Ma, Jun Wan, Shuli Xia; ''Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration''; Oncogene, 2018 PubMed Europe PMC Scholia
  31. Andrew Beenken, Moosa Mohammadi; ''The FGF family: biology, pathophysiology and therapy ''; Nature Reviews Drug Discovery, 2009 PubMed Europe PMC Scholia
  32. Geraldo LHM, Spohr TCLS, Amaral RFD, Fonseca ACCD, Garcia C, Mendes FA, Freitas C, dosSantos MF, Lima FRS; ''Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies.''; Signal Transduct Target Ther, 2021 PubMed Europe PMC Scholia
  33. Li M, Wu Y, Ye L; ''The Role of Amino Acids in Endothelial Biology and Function.''; Cells, 2022 PubMed Europe PMC Scholia
  34. Read JA, Winter VJ, Eszes CM, Sessions RB, Brady RL; ''Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase.''; Proteins, 2001 PubMed Europe PMC Scholia
  35. Backe PH, Laerdahl JK, Kittelsen LS, Dalhus B, Mørkrid L, Bjørås M; ''Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily.''; Sci Rep, 2020 PubMed Europe PMC Scholia
  36. Efrat Kessler; ''Procollagen C-Endopeptidase''; Handbook of Proteolytic Enzymes, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125794view11:24, 10 March 2023DeSlChanged DataNodes in legend to textLabels
125756view10:33, 9 March 2023DeSlChanged MIMconversion to Arrow for Fatty Acid to PW node interaction
125744view08:43, 9 March 2023DeSlRemoved empty comment beneath description
125743view08:41, 9 March 2023DeSlConverted MIM-conversion arrow for FA Beta ox to Acetyl-CoA to arrow; converted interactions in legend to graphical lines, converted pathway ndoes to current standard color.
125567view22:42, 27 February 2023AlexanderPicoSetting all missing PublicationXref IDs to NA
125541view21:07, 26 February 2023AndraOntology Term : 'classic metabolic pathway' added !
125540view21:06, 26 February 2023AndraOntology Term : 'pulmonary fibrosis' added !
125535view08:04, 26 February 2023EgonwUpdated the UniProt data sources
125530view06:16, 26 February 2023EgonwMarked a data node with a ChEBI identifier as "Metabolite"
125250view17:39, 30 January 2023Mariamierzejewskalayout
125249view17:38, 30 January 2023Mariamierzejewskalayout
125248view17:37, 30 January 2023Mariamierzejewskalayout
125247view17:35, 30 January 2023Mariamierzejewskalayout
125245view17:17, 30 January 2023JgumbaragyteModified description
125244view16:34, 30 January 2023JgumbaragyteModified description
125239view15:48, 30 January 2023Mariamierzejewskalayout
125238view15:47, 30 January 2023Mariamierzejewskalayout adjustment
125237view15:44, 30 January 2023Mariamierzejewskalayout adjustment
125236view15:43, 30 January 2023Mariamierzejewskalayout adjustment
125235view15:42, 30 January 2023Mariamierzejewskalayout update
125234view15:41, 30 January 2023Mariamierzejewskavisual adjustment
125233view15:40, 30 January 2023Mariamierzejewskalayout change
125232view15:35, 30 January 2023JgumbaragyteAdjustment
125229view13:25, 30 January 2023MatejKrivulkaGLUT1 relocation
125224view11:20, 30 January 2023Alippifedtitle change
125223view11:11, 30 January 2023Mariamierzejewskatitle adjustment
125222view11:00, 30 January 2023JgumbaragyteGlycosaminoglycan synthesis pathway expanded
125221view10:40, 30 January 2023AliHbdladaptation of the legend
125215view20:50, 29 January 2023AliHbdlconversion arrow changed to activation in the signaling pathways
125214view20:48, 29 January 2023AliHbdlAdding source to fgfr signaling
125213view20:43, 29 January 2023AliHbdlAddition of legend and modification of glycosamidoglycan synthesis
125212view19:41, 29 January 2023AliHbdlMore citations, modification of the collagen and proline pathways
125211view16:56, 29 January 2023AliHbdlAddition of citations and gene names
125206view16:02, 29 January 2023AliHbdlCorrection of references

Addition of comments with gene name

Correction of the glycosaminoglycan synthesis pathway and adaptation of the signalling pathways
125203view13:20, 29 January 2023AliHbdlFix citation 10
125196view14:02, 28 January 2023JgumbaragyteLPAR1 signaling modified
125193view12:04, 28 January 2023JgumbaragyteLiterature added
125168view11:56, 26 January 2023AliHbdlAddition of litterature
125162view16:23, 25 January 2023AliHbdlAddition of proteins for collagen synthesis
125134view17:27, 24 January 2023JgumbaragytePI3K-Akt signaling pathway expanded
125133view17:05, 24 January 2023JgumbaragyteFGFR signaling pathways added
125128view16:13, 24 January 2023JgumbaragyteChanged arrows to show activation; expanded LPAR1 pathway; expanded and fixed glycosaminoglycan synthesis pathway
125099view00:39, 23 January 2023EweitzModified title
125095view13:39, 22 January 2023AliHbdladdition of the lactate transporter
125093view07:03, 22 January 2023JgumbaragyteLPAR1 signaling added
125086view14:45, 20 January 2023AliHbdlAddition of proteins + fixing colors
125085view14:15, 20 January 2023AliHbdlcorrection colors
125084view14:14, 20 January 2023AliHbdlAddition of serine biosynthesis and graphic changes
125073view13:57, 19 January 2023AliHbdladdition of catalysts
125071view13:33, 19 January 2023AliHbdlphysical changes

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3PGMetaboliteHMDB00807 (HMDB)
ADAMTS2GeneProductO95450 (Uniprot-SwissProt)
ASCT2GeneProductQ15758 (Uniprot-SwissProt)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
BMP1GeneProductP13497 (Uniprot-SwissProt)
CollagenGeneProductCHEBI:3815 (ChEBI) Hewitson, Timothy D., and Edward R. Smith. “A Metabolic Reprogramming of Glycolysis and Glutamine Metabolism Is a Requisite for Renal Fibrogenesis—Why and How?” Frontiers in Physiology, vol. 12, 2021, https://doi.org/10.3389/fphys.2021.645857.
DAGsMetaboliteCHEBI:18035 (ChEBI)
F6PMetaboliteCHEBI:15946 (ChEBI)
FGFR1 Signaling PathwayPathwayR-HSA-5654736.4 (Reactome)
FGFR1GeneProductP11362 (Uniprot-SwissProt)
FGFR4 Signaling PathwayPathwayR-HSA-5654743.2 (Reactome)
FGFR4GeneProductP22455 (Uniprot-SwissProt)
Fatty Acid MetabolismPathwayWP143 (WikiPathways)
G1PMetaboliteCHEBI:29042 (ChEBI)
G6PMetaboliteHMDB01401 (HMDB)
GLS2ProteinENSG00000135423 (Ensembl Human) Gene: GLS
GLSGeneProductENSG00000115419 (Ensembl)
GLUT1ProteinP11166 (Uniprot-SwissProt) Gene: SLC2A4 Longo N, Bell GI, Shuster RC, Griffin LD, Langley SD, Elsas LJ. Human fibroblasts express the insulin-responsive glucose transporter (GLUT4). Trans Assoc Am Physicians. 1990;103:202-13. PMID: 2132532.
GPIGeneProductENSG00000105220 (Ensembl Human)
GlucoseMetaboliteHMDB00122 (HMDB)
GlutamateMetaboliteCHEBI:29985 (ChEBI)
GlutamineMetaboliteCHEBI:18050 (ChEBI)
GlycineMetabolite15428 (ChEBI)
Glycosaminoglycan SynthesisPathwayWP2743 (WikiPathways)
HKGeneProduct3098 (Entrez Gene)
HSP47GeneProductP50454 (Uniprot-SwissProt)
HydroxyprolineMetaboliteCHEBI:18240 (ChEBI)
IP3 and DAG Signaling PathwayPathwayWP2688 (WikiPathways)
IP3MetaboliteCHEBI:16595 (ChEBI)
LDHGeneProductENSG00000134333 (Ensembl)
LOXL2GeneProductQ9Y4K0 (Uniprot-SwissProt)
LPAR1GeneProductENSG00000198121 (Ensembl)
Lactic acidMetaboliteHMDB00190 (HMDB)
MCT1ProteinENSG00000155380 (Ensembl Human) Gene: SLC16A1
Nucleotide BiosynthesisPathwayWP404 (WikiPathways)
P3H3GeneProductQ8IVL6 (Uniprot-SwissProt)
P3H4GeneProductQ92791 (Uniprot-SwissProt)
P4HA1GeneProductP13674 (Uniprot-SwissProt)
P4HA2GeneProductO15460 (Uniprot-SwissProt)
P4HA3GeneProductQ7Z4N8 (Uniprot-SwissProt)
P5CMetaboliteCHEBI:15893 (ChEBI)
P5CRProteinP32322 (Uniprot-SwissProt) Gene: PYCR1
P5CSProteinP54886 (Uniprot-SwissProt) Gene: ALDH18A1
PGM1ProteinP36871 (Uniprot-SwissProt)
PGM3ProteinO95394 (Uniprot-SwissProt)
PHGDHGeneProductENSG00000092621 (Ensembl Human)
PI3K-Akt Signaling PathwayPathwayWP4172 (WikiPathways)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PLCProteinP19174 (Uniprot-TrEMBL)
PLOD1GeneProductQ02809 (Uniprot-SwissProt)
PSAT1GeneProductENSG00000135069 (Ensembl Human)
PSPHGeneProductENSG00000146733 (Ensembl Human)
Pentose Phosphate PathwayPathwayWP134 (WikiPathways)
PreprocollagenMetabolite
ProcollagenMetabolite
ProlineMetaboliteCHEBI:26271 (ChEBI)
PyruvateMetaboliteHMDB00243 (HMDB)
ROCK ActivationPathwayWP3365 (WikiPathways)
RhoAGeneProductENSG00000067560 (Ensembl)
SHMTProteinO62585 (Uniprot-SwissProt) Gene: SHMT-1; SHMT-2 National Center for Biotechnology Information (2023). PubChem Pathway Summary for PathwayBlob SMP0000004, Glycine and Serine Metabolism, Source: PathBank. Retrieved January 19, 2023 from https://pubchem.ncbi.nlm.nih.gov/pathway/PathBank:SMP0000004.
SerineMetaboliteCHEBI:17822 (ChEBI)
TCA cyclePathwayWP78 (WikiPathways)
TropocollagenMetabolite
UDP-glucoseMetaboliteCHEBI:18066 (ChEBI)
UGP2GeneProductQ16851 (Uniprot-SwissProt)
αKGMetaboliteHMDB00208 (HMDB)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5312"
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