Metabolic pathways of fibroblasts (Homo sapiens)

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15, 2666Cell proliferation,survival, migrationFibroblastTranscription & TranslationGlycolysisPDCMitochondrionGLS2GlycineBMP1P5CSP3H4P3H3P5CGAGsUDP-glucuronic acidPSAG6PINucleotide BiosynthesisPLCProlineFGFR1LPAR1HSP47RhoAP5CRGLUT1PHGDHADAMTS2GLDHLOXL2UGP2UGDHASCT2SHMTPSPCollagenFGFR4Serine191122203516122, 273LDH7GlutamateHK4G6PPentose Phosphate PathwayFatty Acid MetabolismTCA cycleGLS28Acetyl-CoAPyruvateGlutamineαKGGlucose3PGF6PLactic acid18Golgi ApparatusGlutamineSLC1A528GlutamateGlutamineGlucoseEndoplasmic ReticulumSerine biosynthesisGlutaminolysis2321PI3K-Akt Signaling PathwayROCK ActivationIP3 and DAG Signaling PathwayMCT110Lactic acidG1PUDP-glucosePGM1FGFR1 Signaling13FGFR4 SignalingProcollagenTropocollagenHydroxyproline14PreprocollagenBMP1PLOD18Lysyl hydroxylase19P4HA3P4HA1P4HA2Prolyl hydroxylase19


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Metabolic pathways of fibroblasts: basis

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Bibliography

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  7. Para R, Romero F, George G, Summer R; ''Metabolic Reprogramming as a Driver of Fibroblast Activation in Pulmonary Fibrosis.''; Am J Med Sci, 2019 PubMed Europe PMC Scholia
  8. Tim Cundy, Michael Dray, John Delahunt, Jannie Dahl Hald, Bente Langdahl, Chumei Li, Marta Szybowska, Shehla Mohammed, Emma L Duncan, Aideen M McInerney-Leo, Patricia G Wheeler, Paul Roschger, Klaus Klaushofer, Jyoti Rai, MaryAnn Weis, David Eyre, Ulrike Schwarze, Peter H Byers; ''Mutations That Alter the Carboxy-Terminal-Propeptide Cleavage Site of the Chains of Type I Procollagen Are Associated With a Unique Osteogenesis Imperfecta Phenotype ''; Journal of Bone and Mineral Research, 2018 PubMed Europe PMC Scholia
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  11. Cappelletti P, Tallarita E, Rabattoni V, Campomenosi P, Sacchi S, Pollegioni L; ''Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line.''; PLoS One, 2018 PubMed Europe PMC Scholia
  12. Zhan D, Yalcin F, Ma D, Fu Y, Wei S, Lal B, Li Y, Dzaye O, Laterra J, Ying M, Lopez-Bertoni H, Xia S; ''Targeting UDP-α-d-glucose 6-dehydrogenase alters the CNS tumor immune microenvironment and inhibits glioblastoma growth.''; Genes Dis, 2022 PubMed Europe PMC Scholia
  13. Timothy D. Hewitson, Edward R. Smith; ''A Metabolic Reprogramming of Glycolysis and Glutamine Metabolism Is a Requisite for Renal Fibrogenesis—Why and How? ''; Frontiers in Physiology , 2021 PubMed Europe PMC Scholia
  14. J. Chiang; ''Liver Physiology: Metabolism and Detoxification''; https://www.sciencedirect.com/science/article/pii/B9780123864567042027, 2014 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
125794view11:24, 10 March 2023DeSlChanged DataNodes in legend to textLabels
125756view10:33, 9 March 2023DeSlChanged MIMconversion to Arrow for Fatty Acid to PW node interaction
125744view08:43, 9 March 2023DeSlRemoved empty comment beneath description
125743view08:41, 9 March 2023DeSlConverted MIM-conversion arrow for FA Beta ox to Acetyl-CoA to arrow; converted interactions in legend to graphical lines, converted pathway ndoes to current standard color.
125567view22:42, 27 February 2023AlexanderPicoSetting all missing PublicationXref IDs to NA
125541view21:07, 26 February 2023AndraOntology Term : 'classic metabolic pathway' added !
125540view21:06, 26 February 2023AndraOntology Term : 'pulmonary fibrosis' added !
125535view08:04, 26 February 2023EgonwUpdated the UniProt data sources
125530view06:16, 26 February 2023EgonwMarked a data node with a ChEBI identifier as "Metabolite"
125250view17:39, 30 January 2023Mariamierzejewskalayout
125249view17:38, 30 January 2023Mariamierzejewskalayout
125248view17:37, 30 January 2023Mariamierzejewskalayout
125247view17:35, 30 January 2023Mariamierzejewskalayout
125245view17:17, 30 January 2023JgumbaragyteModified description
125244view16:34, 30 January 2023JgumbaragyteModified description
125239view15:48, 30 January 2023Mariamierzejewskalayout
125238view15:47, 30 January 2023Mariamierzejewskalayout adjustment
125237view15:44, 30 January 2023Mariamierzejewskalayout adjustment
125236view15:43, 30 January 2023Mariamierzejewskalayout adjustment
125235view15:42, 30 January 2023Mariamierzejewskalayout update
125234view15:41, 30 January 2023Mariamierzejewskavisual adjustment
125233view15:40, 30 January 2023Mariamierzejewskalayout change
125232view15:35, 30 January 2023JgumbaragyteAdjustment
125229view13:25, 30 January 2023MatejKrivulkaGLUT1 relocation
125224view11:20, 30 January 2023Alippifedtitle change
125223view11:11, 30 January 2023Mariamierzejewskatitle adjustment
125222view11:00, 30 January 2023JgumbaragyteGlycosaminoglycan synthesis pathway expanded
125221view10:40, 30 January 2023AliHbdladaptation of the legend
125215view20:50, 29 January 2023AliHbdlconversion arrow changed to activation in the signaling pathways
125214view20:48, 29 January 2023AliHbdlAdding source to fgfr signaling
125213view20:43, 29 January 2023AliHbdlAddition of legend and modification of glycosamidoglycan synthesis
125212view19:41, 29 January 2023AliHbdlMore citations, modification of the collagen and proline pathways
125211view16:56, 29 January 2023AliHbdlAddition of citations and gene names
125206view16:02, 29 January 2023AliHbdlCorrection of references

Addition of comments with gene name

Correction of the glycosaminoglycan synthesis pathway and adaptation of the signalling pathways
125203view13:20, 29 January 2023AliHbdlFix citation 10
125196view14:02, 28 January 2023JgumbaragyteLPAR1 signaling modified
125193view12:04, 28 January 2023JgumbaragyteLiterature added
125168view11:56, 26 January 2023AliHbdlAddition of litterature
125162view16:23, 25 January 2023AliHbdlAddition of proteins for collagen synthesis
125134view17:27, 24 January 2023JgumbaragytePI3K-Akt signaling pathway expanded
125133view17:05, 24 January 2023JgumbaragyteFGFR signaling pathways added
125128view16:13, 24 January 2023JgumbaragyteChanged arrows to show activation; expanded LPAR1 pathway; expanded and fixed glycosaminoglycan synthesis pathway
125099view00:39, 23 January 2023EweitzModified title
125095view13:39, 22 January 2023AliHbdladdition of the lactate transporter
125093view07:03, 22 January 2023JgumbaragyteLPAR1 signaling added
125086view14:45, 20 January 2023AliHbdlAddition of proteins + fixing colors
125085view14:15, 20 January 2023AliHbdlcorrection colors
125084view14:14, 20 January 2023AliHbdlAddition of serine biosynthesis and graphic changes
125073view13:57, 19 January 2023AliHbdladdition of catalysts
125071view13:33, 19 January 2023AliHbdlphysical changes

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3PGMetaboliteHMDB00807 (HMDB)
ADAMTS2GeneProductO95450 (Uniprot-SwissProt)
ASCT2GeneProductQ15758 (Uniprot-SwissProt)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
BMP1GeneProductP13497 (Uniprot-SwissProt)
CollagenGeneProductCHEBI:3815 (ChEBI) Hewitson, Timothy D., and Edward R. Smith. “A Metabolic Reprogramming of Glycolysis and Glutamine Metabolism Is a Requisite for Renal Fibrogenesis—Why and How?” Frontiers in Physiology, vol. 12, 2021, https://doi.org/10.3389/fphys.2021.645857.
F6PMetaboliteCHEBI:15946 (ChEBI)
FGFR1 SignalingPathwayR-HSA-5654736.4 (Reactome)
FGFR1GeneProductP11362 (Uniprot-SwissProt)
FGFR4 SignalingPathwayR-HSA-5654743.2 (Reactome)
FGFR4GeneProductP22455 (Uniprot-SwissProt)
Fatty Acid MetabolismPathwayWP143 (WikiPathways)
G1PMetaboliteCHEBI:29042 (ChEBI)
G6PMetaboliteHMDB01401 (HMDB)
G6PIGeneProductP06744 (Uniprot-SwissProt) Full name: Glucose-6-phosphate isomerase Gene: GPI
GAGsMetaboliteCHEBI:18085 (ChEBI) Full name: Glycosaminoglycans
GLDHProteinP00367 (Uniprot-SwissProt) Full name: Glutamate dehydrogenase 1 Gene: GLUD1
GLS2ProteinENSG00000135423 (Ensembl Human) Gene: GLS
GLSProteinO94925 (Uniprot-SwissProt) Full name: Glutaminase kidney isoform, mitochondrial Gene: GLS
GLUT1ProteinP11166 (Uniprot-SwissProt) Full name: Solute carrier family 2, facilitated glucose transporter member 1 Gene: SLC2A1
GlucoseMetaboliteHMDB00122 (HMDB)
GlutamateMetaboliteCHEBI:29985 (ChEBI)
GlutamineMetaboliteCHEBI:18050 (ChEBI)
GlycineMetabolite15428 (ChEBI)
HKProteinP35557 (Uniprot-SwissProt) Full name: Hexokinase-4 Gene: GCK
HSP47GeneProductP50454 (Uniprot-SwissProt)
HydroxyprolineMetaboliteCHEBI:18240 (ChEBI)
IP3 and DAG Signaling PathwayPathwayWP2688 (WikiPathways)
LDHGeneProductP00338 (Uniprot-SwissProt) Full name: L-lactate dehydrogenase A chain Gene: LDHA
LOXL2GeneProductQ9Y4K0 (Uniprot-SwissProt)
LPAR1GeneProductENSG00000198121 (Ensembl)
Lactic acidMetaboliteHMDB00190 (HMDB)
MCT1ProteinP53985 (Uniprot-SwissProt) Full name: Monocarboxylate transporter 1 Gene: SLC16A1
Nucleotide BiosynthesisPathwayWP404 (WikiPathways)
P3H3GeneProductQ8IVL6 (Uniprot-SwissProt)
P3H4GeneProductQ92791 (Uniprot-SwissProt)
P4HA1GeneProductP13674 (Uniprot-SwissProt)
P4HA2GeneProductO15460 (Uniprot-SwissProt)
P4HA3GeneProductQ7Z4N8 (Uniprot-SwissProt)
P5CMetaboliteCHEBI:15893 (ChEBI)
P5CRProteinP32322 (Uniprot-SwissProt) Gene: PYCR1
P5CSProteinP54886 (Uniprot-SwissProt) Gene: ALDH18A1
PGM1ProteinP36871 (Uniprot-SwissProt) Full name: Phosphoglucomutase-1 Gene: PGM1
PHGDHProteinO43175 (Uniprot-SwissProt) Full name: D-3-phosphoglycerate dehydrogenase Gene: PHGDH
PI3K-Akt Signaling PathwayPathwayWP4172 (WikiPathways)
PLCProteinP19174 (Uniprot-SwissProt) Full name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Gene: PLCG1
PLOD1GeneProductQ02809 (Uniprot-SwissProt)
PSAProteinQ9Y617 (Uniprot-SwissProt) Full name: Phosphoserine aminotransferase Gene: PSAT1
PSPProteinP78330 (Uniprot-SwissProt) Full name: Phosphoserine phosphatase Gene: PSPH
Pentose Phosphate PathwayPathwayWP134 (WikiPathways)
PreprocollagenMetabolite
ProcollagenMetabolite
ProlineMetaboliteCHEBI:26271 (ChEBI)
PyruvateMetaboliteHMDB00243 (HMDB)
ROCK ActivationPathwayWP3365 (WikiPathways)
RhoAGeneProductENSG00000067560 (Ensembl)
SHMTProteinO62585 (Uniprot-SwissProt) Full name: Serine hydroxymethyltransferase, cytosolic Gene: SHMT1
SLC1A5GeneProductQ15758 (Uniprot-SwissProt) Full name: Neutral amino acid transporter B(0) Gene: SLC1A5
SerineMetaboliteCHEBI:17822 (ChEBI)
TCA cyclePathwayWP78 (WikiPathways)
TropocollagenMetabolite
UDP-glucoseMetaboliteCHEBI:18066 (ChEBI)
UDP-glucuronic acidMetabolite17473 (PubChem-compound)
UGDHProteinO60701 (Uniprot-SwissProt) Full name: UDP-glucose 6-dehydrogenase Gene: UGDH
UGP2ProteinQ16851 (Uniprot-SwissProt) Full name: UTP--glucose-1-phosphate uridylyltransferase Gene: UGP2
αKGMetaboliteHMDB00208 (HMDB)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5312"
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