Metabolic pathways of fibroblasts (Homo sapiens)

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2, 2845ConversionLegendPDCGlycolysisFibroblastCell proliferation,survival, migrationMitochondrion6XDermatan sulfateUGDHXFGFR1Keratan sulfateFatty acidHyaluronic acidChondroitin sulfateXXHeparan sulfateUDP-GlcA35CD36 3P5CRGlycineGLUT11ProlineGLSP5CNucleotide BiosynthesisGLDH24G6PI8SHMT14P3H4LPAR1LOX7BMP133CollagenFGFR4UGP219SerineADAMTS233PHGDHRhoAP5CSPSPPLCP3H3Hsp479PSALDH16GlutamateHK15G6PPentose Phosphate PathwayFatty acid β-oxidationTCA cycleGLS25Acetyl-CoAPyruvateGlutamineαKGGlucose3PGF6PLactic acid22Golgi ApparatusGlutamineSLC1A525L-glutamateGlutamineGlucoseEndoplasmic ReticulumSerine biosynthesis29Glutaminolysis34ROCK ActivationMCT130Lactic acidG1PUDP-glucosePGM123 Signaling by FGFR1 Signaling by FGFR4ProcollagenTropocollagenPreprocollagenBMP113PLOD1Lysyl hydroxylase17P4HA3P4HA1P4HA2Prolyl hydroxylase17LPAR1 Signaling31SLC1A525ExocytosisPI3K-Akt SignalingIP3 and DAG SignalingGSAL32Proline biosynthesis18Fatty acidCollagen synthesis 11Glycosaminoglycan synthesis 20XStimulation/ActivationCatalysisTranscription/TranslationIndirect conversion MetaboliteProtein/gene productPathwayChannel protein/TransporterReceptor


Description

Fibroblasts are known to contribute to tissue and organ connectivity by producing and secreting extracellular matrix (ECM) proteins. Although several diseases, such as fibrosis and malignancies, have been linked to changes in fibroblast metabolism, the resting metabolic conditions that exist in healthy cells generally go unreported. However, because fibroblasts are known to display heterogeneity, the metabolic processes of different tissues may vary. We aimed to identify and map out the general metabolic pathways that are present in fibroblasts. However, there is a lack of data on fibroblasts' metabolic activities, and further research is required to understand the complete metabolic pathways of fibroblasts

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Bibliography

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  1. Rabinowitz JD, Mutlu GM; ''A metabolic strategy to reverse fibrosis?''; Nat Metab, 2019 PubMed Europe PMC Scholia
  2. Jarett Casale, Jonathan S. Crane; ''Biochemistry, Glycosaminoglycans ''; StatPearls [Internet], 2022 PubMed Europe PMC Scholia
  3. Egger S, Chaikuad A, Kavanagh KL, Oppermann U, Nidetzky B; ''Structure and mechanism of human UDP-glucose 6-dehydrogenase.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  4. Timothy D. Hewitson, Edward R. Smith; ''A Metabolic Reprogramming of Glycolysis and Glutamine Metabolism Is a Requisite for Renal Fibrogenesis—Why and How? ''; Sec. Renal Physiology and Pathophysiology , 2021 PubMed Europe PMC Scholia
  5. Wang S, Liang Y, Dai C; ''Metabolic Regulation of Fibroblast Activation and Proliferation during Organ Fibrosis.''; Kidney Dis (Basel), 2022 PubMed Europe PMC Scholia
  6. Young-Mi Kim, Eun-Cheol Kim, Youngho Kim; ''The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin ''; Molecular Biology Reports, 2011 PubMed Europe PMC Scholia
  7. Para R, Romero F, George G, Summer R; ''Metabolic Reprogramming as a Driver of Fibroblast Activation in Pulmonary Fibrosis.''; Am J Med Sci, 2019 PubMed Europe PMC Scholia
  8. Tim Cundy, Michael Dray, John Delahunt, Jannie Dahl Hald, Bente Langdahl, Chumei Li, Marta Szybowska, Shehla Mohammed, Emma L Duncan, Aideen M McInerney-Leo, Patricia G Wheeler, Paul Roschger, Klaus Klaushofer, Jyoti Rai, MaryAnn Weis, David Eyre, Ulrike Schwarze, Peter H Byers; ''Mutations That Alter the Carboxy-Terminal-Propeptide Cleavage Site of the Chains of Type I Procollagen Are Associated With a Unique Osteogenesis Imperfecta Phenotype ''; Journal of Bone and Mineral Research, 2018 PubMed Europe PMC Scholia
  9. N.V.Bhagavan, Chung-EunHa; ''Chapter 14 - Carbohydrate Metabolism II: Gluconeogenesis, Glycogen Synthesis and Breakdown, and Alternative Pathways ''; Essentials of Medical Biochemistry (Second Edition), 2015 PubMed Europe PMC Scholia
  10. Oyinlade O, Wei S, Lal B, Laterra J, Zhu H, Goodwin CR, Wang S, Ma D, Wan J, Xia S; ''Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration.''; Oncogene, 2018 PubMed Europe PMC Scholia
  11. Cappelletti P, Tallarita E, Rabattoni V, Campomenosi P, Sacchi S, Pollegioni L; ''Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line.''; PLoS One, 2018 PubMed Europe PMC Scholia
  12. Zhan D, Yalcin F, Ma D, Fu Y, Wei S, Lal B, Li Y, Dzaye O, Laterra J, Ying M, Lopez-Bertoni H, Xia S; ''Targeting UDP-α-d-glucose 6-dehydrogenase alters the CNS tumor immune microenvironment and inhibits glioblastoma growth.''; Genes Dis, 2022 PubMed Europe PMC Scholia
  13. Timothy D. Hewitson, Edward R. Smith; ''A Metabolic Reprogramming of Glycolysis and Glutamine Metabolism Is a Requisite for Renal Fibrogenesis—Why and How? ''; Frontiers in Physiology , 2021 PubMed Europe PMC Scholia
  14. J. Chiang; ''Liver Physiology: Metabolism and Detoxification''; https://www.sciencedirect.com/science/article/pii/B9780123864567042027, 2014 PubMed Europe PMC Scholia
  15. Hiroshi Nonaka, Yuki Nakanishi, Satoshi Kuno, Tomoki Ota, Kentaro Mochidome, Yutaro Saito, Fuminori Sugihara, Yoichi Takakusagi, Ichio Aoki, Satoru Nagatoishi, Kouhei Tsumoto, Shinsuke Sando; ''Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction ''; Nature Communications, 2019 PubMed Europe PMC Scholia
  16. Rachel Para, Freddy Romero, Gautam George, Ross Summer; ''Metabolic Reprogramming as a Driver of Fibroblast Activation in PulmonaryFibrosis ''; American Journal of the Medical Sciences, 2019 PubMed Europe PMC Scholia
  17. Timothy D. Hewitson, Edward R. Smith; ''A Metabolic Reprogramming of Glycolysis and Glutamine Metabolism Is a Requisite for Renal Fibrogenesis—Why and How?''; Frontiers in Physiology, 2021 PubMed Europe PMC Scholia
  18. Ishida Y, Nagata K; ''Hsp47 as a collagen-specific molecular chaperone.''; Methods Enzymol, 2011 PubMed Europe PMC Scholia
  19. Ivano Amelio, Francesca Cutruzzolá, Alexey Antonov, Massimiliano Agostini, Gerry Melino; ''Serine and glycine metabolism in cancer''; Trends in Biochemical Sciences, 2014 PubMed Europe PMC Scholia
  20. Sze, J.H., Brownlie, J.C., Love, C.A.; ''Biotechnological production of hyaluronic acid: a mini review''; Biotech, 2016 PubMed Europe PMC Scholia
  21. J.Chiang; ''Liver Physiology: Metabolism and Detoxification ''; Pathobiology of Human Disease, 2014 PubMed Europe PMC Scholia
  22. ''''; , DOI Scholia
  23. Mojzikova R, Koralkova P, Holub D, Saxova Z, Pospisilova D, Prochazkova D, Dzubak P, Horvathova M, Divoky V; ''Two novel mutations (p.(Ser160Pro) and p.(Arg472Cys)) causing glucose-6-phosphate isomerase deficiency are associated with erythroid dysplasia and inappropriately suppressed hepcidin.''; Blood Cells Mol Dis, 2018 PubMed Europe PMC Scholia
  24. J. Tarrant; ''Emerging Translatable Safety Biomarkers ''; Comprehensive Medicinal Chemistry III, 2017 PubMed Europe PMC Scholia
  25. Thoden JB, Holden HM; ''The molecular architecture of glucose-1-phosphate uridylyltransferase.''; Protein Sci, 2007 PubMed Europe PMC Scholia
  26. Karen E.Burke; ''Prevention and Treatment of Aging Skin with Topical Antioxidants''; Skin Aging Handbook , 2009 PubMed Europe PMC Scholia
  27. Galić S, Schneider HP, Bröer A, Deitmer JW, Bröer S; ''The loop between helix 4 and helix 5 in the monocarboxylate transporter MCT1 is important for substrate selection and protein stability.''; Biochem J, 2003 PubMed Europe PMC Scholia
  28. Yoo HC, Yu YC, Sung Y, Han JM; ''Glutamine reliance in cell metabolism.''; Exp Mol Med, 2020 PubMed Europe PMC Scholia
  29. Xu LZ, Weber IT, Harrison RW, Gidh-Jain M, Pilkis SJ; ''Sugar specificity of human beta-cell glucokinase: correlation of molecular models with kinetic measurements.''; Biochemistry, 1995 PubMed Europe PMC Scholia
  30. Olutobi Oyinlade, Shuang Wei, Bachchu Lal, John Laterra, Heng Zhu, C. Rory Goodwin, Shuyan Wang, Ding Ma, Jun Wan, Shuli Xia; ''Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration''; Oncogene, 2018 PubMed Europe PMC Scholia
  31. Andrew Beenken, Moosa Mohammadi; ''The FGF family: biology, pathophysiology and therapy ''; Nature Reviews Drug Discovery, 2009 PubMed Europe PMC Scholia
  32. Geraldo LHM, Spohr TCLS, Amaral RFD, Fonseca ACCD, Garcia C, Mendes FA, Freitas C, dosSantos MF, Lima FRS; ''Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies.''; Signal Transduct Target Ther, 2021 PubMed Europe PMC Scholia
  33. Li M, Wu Y, Ye L; ''The Role of Amino Acids in Endothelial Biology and Function.''; Cells, 2022 PubMed Europe PMC Scholia
  34. Read JA, Winter VJ, Eszes CM, Sessions RB, Brady RL; ''Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase.''; Proteins, 2001 PubMed Europe PMC Scholia
  35. Backe PH, Laerdahl JK, Kittelsen LS, Dalhus B, Mørkrid L, Bjørås M; ''Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily.''; Sci Rep, 2020 PubMed Europe PMC Scholia
  36. Efrat Kessler; ''Procollagen C-Endopeptidase''; Handbook of Proteolytic Enzymes, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125794view11:24, 10 March 2023DeSlChanged DataNodes in legend to textLabels
125756view10:33, 9 March 2023DeSlChanged MIMconversion to Arrow for Fatty Acid to PW node interaction
125744view08:43, 9 March 2023DeSlRemoved empty comment beneath description
125743view08:41, 9 March 2023DeSlConverted MIM-conversion arrow for FA Beta ox to Acetyl-CoA to arrow; converted interactions in legend to graphical lines, converted pathway ndoes to current standard color.
125567view22:42, 27 February 2023AlexanderPicoSetting all missing PublicationXref IDs to NA
125541view21:07, 26 February 2023AndraOntology Term : 'classic metabolic pathway' added !
125540view21:06, 26 February 2023AndraOntology Term : 'pulmonary fibrosis' added !
125535view08:04, 26 February 2023EgonwUpdated the UniProt data sources
125530view06:16, 26 February 2023EgonwMarked a data node with a ChEBI identifier as "Metabolite"
125250view17:39, 30 January 2023Mariamierzejewskalayout
125249view17:38, 30 January 2023Mariamierzejewskalayout
125248view17:37, 30 January 2023Mariamierzejewskalayout
125247view17:35, 30 January 2023Mariamierzejewskalayout
125245view17:17, 30 January 2023JgumbaragyteModified description
125244view16:34, 30 January 2023JgumbaragyteModified description
125239view15:48, 30 January 2023Mariamierzejewskalayout
125238view15:47, 30 January 2023Mariamierzejewskalayout adjustment
125237view15:44, 30 January 2023Mariamierzejewskalayout adjustment
125236view15:43, 30 January 2023Mariamierzejewskalayout adjustment
125235view15:42, 30 January 2023Mariamierzejewskalayout update
125234view15:41, 30 January 2023Mariamierzejewskavisual adjustment
125233view15:40, 30 January 2023Mariamierzejewskalayout change
125232view15:35, 30 January 2023JgumbaragyteAdjustment
125229view13:25, 30 January 2023MatejKrivulkaGLUT1 relocation
125224view11:20, 30 January 2023Alippifedtitle change
125223view11:11, 30 January 2023Mariamierzejewskatitle adjustment
125222view11:00, 30 January 2023JgumbaragyteGlycosaminoglycan synthesis pathway expanded
125221view10:40, 30 January 2023AliHbdladaptation of the legend
125215view20:50, 29 January 2023AliHbdlconversion arrow changed to activation in the signaling pathways
125214view20:48, 29 January 2023AliHbdlAdding source to fgfr signaling
125213view20:43, 29 January 2023AliHbdlAddition of legend and modification of glycosamidoglycan synthesis
125212view19:41, 29 January 2023AliHbdlMore citations, modification of the collagen and proline pathways
125211view16:56, 29 January 2023AliHbdlAddition of citations and gene names
125206view16:02, 29 January 2023AliHbdlCorrection of references

Addition of comments with gene name

Correction of the glycosaminoglycan synthesis pathway and adaptation of the signalling pathways
125203view13:20, 29 January 2023AliHbdlFix citation 10
125196view14:02, 28 January 2023JgumbaragyteLPAR1 signaling modified
125193view12:04, 28 January 2023JgumbaragyteLiterature added
125168view11:56, 26 January 2023AliHbdlAddition of litterature
125162view16:23, 25 January 2023AliHbdlAddition of proteins for collagen synthesis
125134view17:27, 24 January 2023JgumbaragytePI3K-Akt signaling pathway expanded
125133view17:05, 24 January 2023JgumbaragyteFGFR signaling pathways added
125128view16:13, 24 January 2023JgumbaragyteChanged arrows to show activation; expanded LPAR1 pathway; expanded and fixed glycosaminoglycan synthesis pathway
125099view00:39, 23 January 2023EweitzModified title
125095view13:39, 22 January 2023AliHbdladdition of the lactate transporter
125093view07:03, 22 January 2023JgumbaragyteLPAR1 signaling added
125086view14:45, 20 January 2023AliHbdlAddition of proteins + fixing colors
125085view14:15, 20 January 2023AliHbdlcorrection colors
125084view14:14, 20 January 2023AliHbdlAddition of serine biosynthesis and graphic changes
125073view13:57, 19 January 2023AliHbdladdition of catalysts
125071view13:33, 19 January 2023AliHbdlphysical changes

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Signaling by FGFR1 PathwayR-HSA-5654736 (Reactome)
Signaling by FGFR4PathwayR-HSA-5654743 (Reactome)
3PGMetaboliteHMDB00807 (HMDB)
ADAMTS2GeneProductO95450 (Uniprot-SwissProt) Full name: A disintegrin and metalloproteinase with thrombospondin motifs 2 Gene: ADAMTS2
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
BMP1ProteinP13497 (Uniprot-SwissProt) Full name: Bone morphogenetic protein 1 Gene: BMP1
CD36 GeneProductP16671 (Uniprot-SwissProt) Full name: Platelet glycoprotein 4

Gene: CD36

Chondroitin sulfateMetaboliteCHEBI:37397 (ChEBI)
CollagenGeneProductCHEBI:3815 (ChEBI)
Dermatan sulfateMetaboliteHMDB00632 (HMDB)
F6PMetaboliteCHEBI:15946 (ChEBI)
FGFR1GeneProductP11362 (Uniprot-SwissProt) Full name: Fibroblast growth factor receptor 1 Gene: FGFR1
FGFR4GeneProductP22455 (Uniprot-SwissProt) Full name: Fibroblast growth factor receptor 4 Gene: FGFR4
Fatty acid β-oxidationPathwayWP143 (WikiPathways)
Fatty acidMetaboliteCHEBI:35366 (ChEBI)
G1PMetaboliteCHEBI:29042 (ChEBI)
G6PMetaboliteHMDB01401 (HMDB)
G6PIGeneProductP06744 (Uniprot-SwissProt) Full name: Glucose-6-phosphate isomerase Gene: GPI
GLDHProteinP00367 (Uniprot-SwissProt) Full name: Glutamate dehydrogenase 1 Gene: GLUD1
GLSProteinO94925 (Uniprot-SwissProt) Full name: Glutaminase kidney isoform, mitochondrial Gene: GLS
GLUT1ProteinP11166 (Uniprot-SwissProt) Full name: Solute carrier family 2, facilitated glucose transporter member 1 Gene: SLC2A1
GSALMetaboliteQ2823261 (Wikidata)
GlucoseMetaboliteHMDB00122 (HMDB)
GlutamateMetaboliteCHEBI:29985 (ChEBI)
GlutamineMetaboliteCHEBI:18050 (ChEBI)
GlycineMetabolite15428 (ChEBI)
HKProteinP35557 (Uniprot-SwissProt) Full name: Hexokinase-4 Gene: GCK
Heparan sulfateMetaboliteHMDB00693 (HMDB)
Hsp47GeneProductP50454 (Uniprot-SwissProt) Full name: Serpin H1 Gene: SERPINH1
Hyaluronic acidMetaboliteHMDB02061 (HMDB)
IP3 and DAG SignalingPathwayWP2688 (WikiPathways)
Keratan sulfateMetaboliteCHEBI:60924 (ChEBI)
L-glutamateMetaboliteCHEBI:29985 (ChEBI)
LDHGeneProductP00338 (Uniprot-SwissProt) Full name: L-lactate dehydrogenase A chain Gene: LDHA
LOXGeneProductQ9Y4K0 (Uniprot-SwissProt) Full name: Lysyl oxidase homolog 2 Gene: LOXL2
LPAR1GeneProductENSG00000198121 (Ensembl)
Lactic acidMetaboliteHMDB00190 (HMDB)
MCT1ProteinP53985 (Uniprot-SwissProt) Full name: Monocarboxylate transporter 1 Gene: SLC16A1
Nucleotide BiosynthesisPathwayWP404 (WikiPathways)
P3H3GeneProductQ8IVL6 (Uniprot-SwissProt) Full name: Prolyl 3-hydroxylase 3 Gene: P3H3
P3H4GeneProductQ92791 (Uniprot-SwissProt) Full name: Endoplasmic reticulum protein SC65 Gene: P3H4
P4HA1GeneProductP13674 (Uniprot-SwissProt) Full name: Prolyl 4-hydroxylase subunit alpha-1 Gene: P4HA1
P4HA2GeneProductO15460 (Uniprot-SwissProt) Full name: Prolyl 4-hydroxylase subunit alpha-2 Gene: P4HA2
P4HA3GeneProductQ7Z4N8 (Uniprot-SwissProt) Full name: Prolyl 4-hydroxylase subunit alpha-3 Gene: P4HA3
P5CMetaboliteCHEBI:15893 (ChEBI)
P5CRProteinP32322 (Uniprot-SwissProt) Full name: Pyrroline-5-carboxylate reductase 1, mitochondrial Gene: PYCR1
P5CSProteinP54886 (Uniprot-SwissProt) Full name: Delta-1-pyrroline-5-carboxylate synthase Gene: ALDH18A1
PGM1ProteinP36871 (Uniprot-SwissProt) Full name: Phosphoglucomutase-1 Gene: PGM1
PHGDHProteinO43175 (Uniprot-SwissProt) Full name: D-3-phosphoglycerate dehydrogenase Gene: PHGDH
PI3K-Akt SignalingPathwayWP4172 (WikiPathways)
PLCProteinP19174 (Uniprot-SwissProt) Full name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Gene: PLCG1
PLOD1GeneProductQ02809 (Uniprot-SwissProt) Full name: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Gene: PLOD1
PSAProteinQ9Y617 (Uniprot-SwissProt) Full name: Phosphoserine aminotransferase Gene: PSAT1
PSPProteinP78330 (Uniprot-SwissProt) Full name: Phosphoserine phosphatase Gene: PSPH
Pentose Phosphate PathwayPathwayWP134 (WikiPathways)
PreprocollagenMetabolite
ProcollagenMetabolite
ProlineMetaboliteCHEBI:17203 (ChEBI)
PyruvateMetaboliteHMDB00243 (HMDB)
ROCK ActivationPathwayWP3365 (WikiPathways)
RhoAProteinP61586 (Uniprot-SwissProt) Full name: Transforming protein RhoA/Ras homolog family member A Gene: RHOA
SHMTProteinO62585 (Uniprot-SwissProt) Full name: Serine hydroxymethyltransferase, cytosolic Gene: SHMT1
SLC1A5GeneProductQ15758 (Uniprot-SwissProt) Full name: Neutral amino acid transporter B(0) Gene: SLC1A5
SerineMetaboliteCHEBI:17822 (ChEBI)
TCA cyclePathwayWP78 (WikiPathways)
TropocollagenMetabolite
UDP-GlcAMetaboliteCHEBI:17200 (ChEBI)
UDP-glucoseMetaboliteCHEBI:18066 (ChEBI)
UGDHProteinO60701 (Uniprot-SwissProt)
UGP2ProteinQ16851 (Uniprot-SwissProt) Full name: UTP--glucose-1-phosphate uridylyltransferase Gene: UGP2
XGeneProduct
XPathwayWP3365 (WikiPathways)
αKGMetaboliteHMDB00208 (HMDB)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5312"
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