Female steroid hormones in cardiomyocyte energy metabolism (Homo sapiens)

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Adrenal GlandSarcoplasmic reticulumCortisolTamoxifenOXPHOSPKBApob-lipoproteinCyclic GMPFructose 1, 6-biphosphateATP ProductionIncreased risk of carcinogenesisTCA CycleATP ExportPI3KFatty Acid SynthesisFatty Acid UptakeLKB1Triglyceride Formation andStorage in Lipid Droplets21118611939463ERaTroponinGlucocoticoid receptorCortisol17OH-progesterone21-hydrolase11B-HSD1MitochondrionNucleusAMPK10K+CoAMTP2cTNLPGC-1α7FoxO1KATP channelGLUT4ppara1HADHBRyR2GATA4PI3K/AktEstrogen response elementeNOS4MYH6Inhibition of TNF-aCa2+MAPK10TFcAMPPPARα1MCAD1Inhibition of IL-6ATP citrate synthase 1HADHB2GLUT4ROSNOS34AMPK-stimulated GLUT-44RAF/KSR family kinases10acadm1EstrogenERRa5ERRaERbPeroxisomeERK1/2Elk-1MEF2ProgesteronePGRCardiomyocyteSuperoxide radicalSOD2Hydrogen peroxideH20O2Catalase11-deoxycortisolInhibition of IL1-BGLUT1Glucocoticoid response elementsEstrogen7ERaEstrogenEstrogenGLUT46ERaERab-oxidation of long-chain fatty acids1


Description

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Montaigne D, Butruille L, Staels B; ''PPAR control of metabolism and cardiovascular functions.''; Nat Rev Cardiol, 2021 PubMed Europe PMC Scholia
  2. Hsieh YC, Yang S, Choudhry MA, Yu HP, Rue LW 3rd, Bland KI, Chaudry IH; ''PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide onheart function after trauma-hemorrhage.''; Am J Physiol Heart Circ Physiol, 2005 PubMed Europe PMC Scholia
  3. Wang T, McDonald C, Petrenko NB, Leblanc M, Giguere V, Evans RM, Patel VV, Pei L; ''Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and function.''; Mol Cell Biol, 2015 PubMed Europe PMC Scholia
  4. Shao D, Tian R; ''Glucose Transporters in Cardiac Metabolism and Hypertrophy.''; Compr Physiol, 2015 PubMed Europe PMC Scholia
  5. Lee S, Bao H, Ishikawa Z, Wang W, Lim HY; ''Cardiomyocyte Regulation of Systemic Lipid Metabolism by the Apolipoprotein B-Containing Lipoproteins in Drosophila.''; PLoS Genet, 2017 PubMed Europe PMC Scholia
  6. Yuan J, Dong X, Yap J, Hu J; ''The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy.''; J Hematol Oncol, 2020 PubMed Europe PMC Scholia
  7. Barros RP, Machado UF, Warner M, Gustafsson JA; ''Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  8. Giguère V; ''Transcriptional control of energy homeostasis by the estrogen-related receptors.''; Endocr Rev, 2008 PubMed Europe PMC Scholia
  9. Daval M, Foufelle F, Ferré P; ''Functions of AMP-activated protein kinase in adipose tissue.''; J Physiol, 2006 PubMed Europe PMC Scholia
  10. Zhou Z, Zhou J, Du Y; ''Estrogen receptor alpha interacts with mitochondrial protein HADHB and affects beta-oxidation activity.''; Mol Cell Proteomics, 2012 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134651view09:12, 24 July 2024EgonwAdded more data node types
134650view09:08, 24 July 2024EgonwAdded a missing node type
134538view17:59, 22 July 2024EgonwAdded the Ensembl SOD2 id and the ChEBI id for superoxide radical
134473view00:48, 22 July 2024EweitzModified description
134472view00:48, 22 July 2024EweitzOntology Term : 'cardiac muscle cell' added !
125826view19:02, 12 March 2023EgonwMade a data node with a ChEBI identifier a Metabolite (was Complex)
125620view19:45, 5 March 2023AlexanderPicoModified description
125582view07:36, 1 March 2023EgonwNot a mim-conversion
125578view05:34, 1 March 2023EgonwAdded missing @Type and typo fix in gene identifier
125551view21:40, 26 February 2023AndraOntology Term : 'classic metabolic pathway' added !
125534view06:22, 26 February 2023EgonwUpdated the Ensembl data source
125532view06:20, 26 February 2023EgonwMarked a data node with an Ensembl identifier as "GeneProduct"
125531view06:18, 26 February 2023EgonwMarked a data node with a ChEBI identifier as "Metabolite"
125529view17:57, 25 February 2023EgonwUpdated the UniProt data sources
125527view17:53, 25 February 2023EgonwMade a few pathways clickable
125263view12:28, 31 January 2023LianatyrrelleNOS pathway added
125252view19:07, 30 January 2023LianatyrrellAdded Element Type
125251view17:44, 30 January 2023Mehaa
125243view16:18, 30 January 2023Natalie.vlinked keywords to existing pathways
125231view14:35, 30 January 2023LianatyrrellReferences
125230view14:11, 30 January 2023LianatyrrellAltered ERa pathways
125181view11:46, 27 January 2023Natalie.v
125180view11:43, 27 January 2023Natalie.vadded all identifiers and references for ERRa pathwa
125179view11:33, 27 January 2023Natalie.vadded some references
125174view14:11, 26 January 2023Mehaa
125172view14:06, 26 January 2023Mehaa
125170view13:18, 26 January 2023Natalie.vadded parts to ERRa and made the map cleaner
125169view13:00, 26 January 2023Natalie.v
125161view15:06, 25 January 2023Natalie.vtest
125159view14:43, 25 January 2023Natalie.vModified title
125152view13:35, 25 January 2023Mehaa
125147view13:05, 25 January 2023Mehaa
125146view12:51, 25 January 2023Mehaa
125145view11:43, 25 January 2023Mehaa
125144view11:40, 25 January 2023Mehaa
125143view11:39, 25 January 2023Mehaa
125142view11:37, 25 January 2023Mehaa
125139view21:36, 24 January 2023Mehaa
125138view21:29, 24 January 2023Mehaa
125137view21:25, 24 January 2023Mehaa
125136view20:05, 24 January 2023MehaaTitle changed
125135view20:03, 24 January 2023MehaaNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11-deoxycortisolR-HSA-194002 (Reactome)
11B-HSD1R-HSA-194002 (Reactome)
17OH-progesteroneR-HSA-194002 (Reactome)
21-hydrolaseR-HSA-194002 (Reactome)
AMPK-stimulated GLUT-4Protein
AMPKPathway2.7.11.31 (Enzyme Nomenclature)
ATP ExportPathwayWP1902 (WikiPathways)
ATP ProductionPathwayWP1902 (WikiPathways)
ATP citrate synthase ProteinP53396 (Uniprot-SwissProt)
Apob-lipoproteinProteinENSG00000084674 (Ensembl)
Ca2+9606 (NCI Pathway Interaction Database)
CatalaseP04040 (Pathway Commons)
CoAProteinCoenzyme A
CortisolR-HSA-194002 (Reactome)
Cyclic GMPComplex16356 (ChEBI)
ERK1/2PathwayWP382 (WikiPathways)
ERRaProteinP11474 (Uniprot-SwissProt)
ERaProteinP03372 (Uniprot-SwissProt)
ERbProteinP11474 (Uniprot-SwissProt)
Elk-1GeneProductUP000005640 (Uniprot-SwissProt)
Estrogen response elementGeneProduct
EstrogenMetaboliteCHEBI:50114 (ChEBI)
Fatty Acid SynthesisPathwayWP357 (WikiPathways)
Fatty Acid UptakePathwayWP357 (WikiPathways)
FoxO1GeneProductUP000005640 (Uniprot-SwissProt)
Fructose 1, 6-biphosphateProtein
GATA4GeneProductENSG00000181856 (Ensembl Human)
GLUT1GeneProductENSG00000181856 (Ensembl Human)
GLUT4GeneProduct
GLUT4GeneProductENSG00000181856 (Ensembl)
Glucocoticoid receptorP04150 (Pathway Commons)
Glucocoticoid response elements P04150 (Pathway Commons)
H20Metabolite
HADHBGeneProductENSG00000138029 (Ensembl)
Hydrogen peroxideMetabolite
Increased risk of carcinogenesis
Inhibition of IL-6P05231 (Pathway Commons)
Inhibition of IL1-BP01584 (Pathway Commons)
Inhibition of TNF-aGeneProductUP000005640 (Uniprot-SwissProt)
K+
KATP channelPathwayQ15842 (Pathway Commons)
LKB1ProteinENSG00000118046 (Ensembl)
MAPKPathwayENSG00000100030 (Ensembl)
MCADProteinP11310 (Uniprot-SwissProt)
MEF2GeneProductUP0000005640 (Uniprot-SwissProt)
MTPMetaboliteENGS00000138823 (Ensembl)
MYH6GeneProductUP000005640 (Uniprot-SwissProt)
NOS3ProteinENSG00000164867 (Ensembl)
O2Metabolite
OXPHOSPathwayWP623 (WikiPathways)
PGC-1αProteinQ86YN6 (Uniprot-SwissProt)
PGRProteinP11474 (Uniprot-SwissProt)
PI3KProtein
PI3K/AktPathwayWP4448 (WikiPathways)
PKBProteinENSG00000105221 (Ensembl)
PPARαProteinQ07869 (Uniprot-SwissProt)
ProgesteroneProteinP11474 (Uniprot-SwissProt)
RAF/KSR family kinasesProtein
ROSGeneProductUP000002494 (Uniprot-SwissProt)
RyR2ProteinENST000006099119.1 (Ensembl Human)
SOD29606 (NCBI Taxonomy Database)
Superoxide radical Metabolite
TCA CyclePathwayWP78 (WikiPathways)
TFProteinTranscription Factors
TamoxifenComplex41774 (ChEBI)
Triglyceride Formation and Storage in Lipid DropletsPathwayWP4131 (WikiPathways)
TroponinUP000005640 (Uniprot-SwissProt)
acadm GeneProductENSG00000117054 (Ensembl Human)
b-oxidation of long-chain fatty acidsPathwayWP5123 (WikiPathways)
cAMPMetabolite17489 (ChEBI)
cTNLGeneProducthsa:1514 (KEGG Genes)
eNOSProtein
ppara GeneProductENSG00000186951 (Ensembl Human)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5318"
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