Cysteine biosynthesis from homoserine (Saccharomyces cerevisiae)

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H2OH2OH2SO-Acetyl-L-homoserineNH3homoserineL-serinecystathionine2-oxobutanoateL-cysteineCoenzyme Ahomocysteineacetyl-CoAMET17acetateCYS3MET2CYS4


Description

O-Acetyl-L-homoserine sulfhydrylase participates in an alternative pathway of L-homocysteine synthesis. Cysteine can then be produced by the reverse transsulfuration pathway, which involves the conversion of homocysteine to cysteine with the help of a cystathionine intermediate. This process takes place in two steps: First, cystathionine-synthase (Cys4p) catalyzes a -displacement reaction, whereby the thiol group of homocysteine replaces the hydroxyl group of serine, resulting in the formation of cystathionine. Second, cystathionine-lyase (Cys3p) catalyzes an ,-elimination reaction, which hydrolyzes cystathionine to generate cysteine, -ketobutyrate, and ammonia.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
125521view09:24, 25 February 2023EgonwMade a few more labels data nodes
125513view02:15, 24 February 2023AlexanderPicoadded description
117279view10:46, 20 May 2021EweitzModified title
107015view13:47, 17 September 2019MaintBotHMDB identifier normalization
92816view19:32, 8 July 2017AlexanderPicoRemoved old genmapp tags and unused attributes
92815view19:32, 8 July 2017AlexanderPicoReverted to version '07:15, 19 July 2016' by AlexanderPico
92793view15:28, 6 July 2017DeSlQuick edit to datanode annotation or property
87209view14:15, 19 July 2016SusanOntology Term : 'cysteine metabolic pathway' added !
77328view18:55, 19 August 2014Mkutmonconnected lines
69833view15:05, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69622view20:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
41856view04:51, 2 March 2011MaintBotRemoved redundant pathway information and comments
21217view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Cysteine Biosynthesis from Homoserine]] moved to [[Pathway:WP256]]: Moved to stable identifier
12680view07:57, 17 May 2008MaintBotautomated metabolite conversion
8678view14:06, 7 January 2008MaintBotAdded to category $category
8676view14:06, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-oxobutanoateMetaboliteHMDB0000005 (HMDB)
CYS3GeneProductS000000010 (SGD)
CYS4GeneProductS000003387 (SGD)
Coenzyme AMetabolite64885-97-8 (CAS)
L-cysteineMetabolite52-90-4 (CAS)
L-serineMetabolite56-45-1 (CAS)
MET17GeneProductS000004294 (SGD)
MET2GeneProductS000005221 (SGD)
NH3MetaboliteHMDB0000051 (HMDB)
acetateMetabolite64-19-7 (CAS)
acetyl-CoAMetabolite72-89-9 (CAS)
cystathionineMetabolite56-88-2 (CAS)
homocysteineMetabolite6027-13-0 (CAS)
homoserineMetabolite672-15-1 (CAS)

Annotated Interactions

No annotated interactions

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