Meiotic recombination genes (Saccharomyces cerevisiae)

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**Late Exchange Genespathway convergencesDouble Strand BreakEarly Synapsis GenesEarly Exchange GenesSynapsis GenesEarly Exchange GenesRAD57HOP1MER2SPO11MEK1RAD57REC102RED1RAD51MRE11REC104RAD55MEI4REC114RAD50RAD50XRS2HOP1RAD51RAD52RED1RAD52


Description

Meiotic double strand breaks are initiated by Spo11, a conserved topoisomerase-derived protein, together with its partner subunits. After the breaks are formed, Spo11 remains covalently attached to the 5 prime strands at both ends of the DNA. It is released through an endonucleolytic cleavage reaction, which is facilitated by MRX (Mre11, Rad50, and Xrs2) and Sae2. This reaction liberates Spo11, which is attached to a short oligonucleotide. The 5 prime strands are further processed by exonucleases, such as Exo1 in yeast, leading to the production of long single-stranded tails. These tails are coated with RPA, an ssDNA-binding protein, before being replaced by recombinases Rad51 and Dmc1. The recombinases form a nucleoprotein filament and search for sequence similarity, which is primarily located on the homologous chromosome. This process leads to the production of D-loop structures.

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History

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CompareRevisionActionTimeUserComment
125517view03:01, 24 February 2023AlexanderPicoModified description
125512view02:07, 24 February 2023AlexanderPicoadded description
117286view10:57, 20 May 2021EweitzModified title
87533view02:04, 25 July 2016AlexanderPicoOntology Term : 'cell cycle pathway, meiotic' added !
87532view02:03, 25 July 2016AlexanderPicoOntology Term : 'regulatory pathway' added !
69605view20:32, 8 July 2013MaintBotUpdated to 2013 gpml schema
41837view04:50, 2 March 2011MaintBotRemoved redundant pathway information and comments
21471view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Genes of Meiotic Recombination]] moved to [[Pathway:WP377]]: Moved to stable identifier
20392view19:56, 3 November 2008AlexanderPico
8723view14:07, 7 January 2008MaintBotAdded to category $category
8721view14:07, 7 January 2008MaintBotUploaded new pathway

External references

DataNodes

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NameTypeDatabase referenceComment
HOP1GeneProductS000001334 (SGD)
MEI4GeneProductS000001954 (SGD)
MEK1GeneProductS000005878 (SGD)
MER2GeneProductS000003782 (SGD)
MRE11GeneProductS000004837 (SGD)
RAD50GeneProductS000005194 (SGD)
RAD51GeneProductS000000897 (SGD)
RAD52GeneProductS000004494 (SGD)
RAD55GeneProductS000002483 (SGD)
RAD57GeneProductS000002411 (SGD)
REC102GeneProductS000004321 (SGD)
REC104GeneProductS000001200 (SGD)
REC114GeneProductS000004740 (SGD)
RED1GeneProductS000004253 (SGD)
SPO11GeneProductS000001014 (SGD)
XRS2GeneProductS000002777 (SGD)

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