Metabolic pathways of fibroblasts (Homo sapiens)

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23, 292812ConversionLegendPDCGlycolysisFibroblastCell proliferation,survival, migrationMitochondrion6UDP-GlcAUGDHFGFR1Fatty acidXHeparan sulfateHyaluronic acidXKeratan sulfateXXDermatan sulfateChondroitin sulfate27CD36 3P5CRGlycineGLUT133ProlineGLSP5CNucleotide BiosynthesisGLDH31G6PI19SHMT18P3H4LPAR1LOX35BMP115CollagenFGFR4UGP224SerineADAMTS215PHGDHRhoAP5CSPSPPLCP3H3Hsp4710PSALDH16GlutamateHK9G6PPentose Phosphate PathwayFatty acid β-oxidationTCA cycleGLS17Acetyl-CoAPyruvateGlutamineαKGGlucose3PGF6PLactic acid13Golgi ApparatusGlutamineSLC1A517L-glutamateGlutamineGlucoseEndoplasmic ReticulumSerine biosynthesis8Glutaminolysis22ROCK ActivationMCT121Lactic acidG1PUDP-glucosePGM15 Signaling by FGFR1 Signaling by FGFR4ProcollagenTropocollagenPreprocollagenBMP111PLOD1Lysyl hydroxylase34P4HA3P4HA1P4HA2Prolyl hydroxylase34LPAR1 Signaling32SLC1A517ExocytosisPI3K-Akt SignalingIP3 and DAG SignalingGSALProline biosynthesis202Fatty acidCollagen synthesis 25Glycosaminoglycan synthesis 36XStimulation/ActivationCatalysisTranscription/TranslationIndirect conversion MetaboliteProtein/gene productPathwayChannel protein/TransporterReceptor


Description

Fibroblasts are known to contribute to tissue and organ connectivity by producing and secreting extracellular matrix (ECM) proteins. Although several diseases, such as fibrosis and cancer, have been linked to changes in fibroblast metabolism, the resting metabolic conditions that are present in healthy cells generally go unreported. Because fibroblasts are known to display heterogeneity, the metabolic processes of different tissues may vary. The aim was to identify and map out the general metabolic pathways present in fibroblasts. The pathways for collagen, serine, and proline, as well as glycosaminoglycan synthesis, are nearly complete. Nonetheless, dashed arrows indicate missing process steps that should be identified and included. There is a lack of data on fibroblasts' metabolic activities, and further research is required to understand the complete metabolic pathways of fibroblasts.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
125794view11:24, 10 March 2023DeSlChanged DataNodes in legend to textLabels
125756view10:33, 9 March 2023DeSlChanged MIMconversion to Arrow for Fatty Acid to PW node interaction
125744view08:43, 9 March 2023DeSlRemoved empty comment beneath description
125743view08:41, 9 March 2023DeSlConverted MIM-conversion arrow for FA Beta ox to Acetyl-CoA to arrow; converted interactions in legend to graphical lines, converted pathway ndoes to current standard color.
125567view22:42, 27 February 2023AlexanderPicoSetting all missing PublicationXref IDs to NA
125541view21:07, 26 February 2023AndraOntology Term : 'classic metabolic pathway' added !
125540view21:06, 26 February 2023AndraOntology Term : 'pulmonary fibrosis' added !
125535view08:04, 26 February 2023EgonwUpdated the UniProt data sources
125530view06:16, 26 February 2023EgonwMarked a data node with a ChEBI identifier as "Metabolite"
125250view17:39, 30 January 2023Mariamierzejewskalayout
125249view17:38, 30 January 2023Mariamierzejewskalayout
125248view17:37, 30 January 2023Mariamierzejewskalayout
125247view17:35, 30 January 2023Mariamierzejewskalayout
125245view17:17, 30 January 2023JgumbaragyteModified description
125244view16:34, 30 January 2023JgumbaragyteModified description
125239view15:48, 30 January 2023Mariamierzejewskalayout
125238view15:47, 30 January 2023Mariamierzejewskalayout adjustment
125237view15:44, 30 January 2023Mariamierzejewskalayout adjustment
125236view15:43, 30 January 2023Mariamierzejewskalayout adjustment
125235view15:42, 30 January 2023Mariamierzejewskalayout update
125234view15:41, 30 January 2023Mariamierzejewskavisual adjustment
125233view15:40, 30 January 2023Mariamierzejewskalayout change
125232view15:35, 30 January 2023JgumbaragyteAdjustment
125229view13:25, 30 January 2023MatejKrivulkaGLUT1 relocation
125224view11:20, 30 January 2023Alippifedtitle change
125223view11:11, 30 January 2023Mariamierzejewskatitle adjustment
125222view11:00, 30 January 2023JgumbaragyteGlycosaminoglycan synthesis pathway expanded
125221view10:40, 30 January 2023AliHbdladaptation of the legend
125215view20:50, 29 January 2023AliHbdlconversion arrow changed to activation in the signaling pathways
125214view20:48, 29 January 2023AliHbdlAdding source to fgfr signaling
125213view20:43, 29 January 2023AliHbdlAddition of legend and modification of glycosamidoglycan synthesis
125212view19:41, 29 January 2023AliHbdlMore citations, modification of the collagen and proline pathways
125211view16:56, 29 January 2023AliHbdlAddition of citations and gene names
125206view16:02, 29 January 2023AliHbdlCorrection of references

Addition of comments with gene name

Correction of the glycosaminoglycan synthesis pathway and adaptation of the signalling pathways
125203view13:20, 29 January 2023AliHbdlFix citation 10
125196view14:02, 28 January 2023JgumbaragyteLPAR1 signaling modified
125193view12:04, 28 January 2023JgumbaragyteLiterature added
125168view11:56, 26 January 2023AliHbdlAddition of litterature
125162view16:23, 25 January 2023AliHbdlAddition of proteins for collagen synthesis
125134view17:27, 24 January 2023JgumbaragytePI3K-Akt signaling pathway expanded
125133view17:05, 24 January 2023JgumbaragyteFGFR signaling pathways added
125128view16:13, 24 January 2023JgumbaragyteChanged arrows to show activation; expanded LPAR1 pathway; expanded and fixed glycosaminoglycan synthesis pathway
125099view00:39, 23 January 2023EweitzModified title
125095view13:39, 22 January 2023AliHbdladdition of the lactate transporter
125093view07:03, 22 January 2023JgumbaragyteLPAR1 signaling added
125086view14:45, 20 January 2023AliHbdlAddition of proteins + fixing colors
125085view14:15, 20 January 2023AliHbdlcorrection colors
125084view14:14, 20 January 2023AliHbdlAddition of serine biosynthesis and graphic changes
125073view13:57, 19 January 2023AliHbdladdition of catalysts
125071view13:33, 19 January 2023AliHbdlphysical changes

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Signaling by FGFR1 PathwayR-HSA-5654736 (Reactome)
Signaling by FGFR4PathwayR-HSA-5654743 (Reactome)
3PGMetaboliteHMDB00807 (HMDB)
ADAMTS2GeneProductO95450 (Uniprot-TrEMBL) Full name: A disintegrin and metalloproteinase with thrombospondin motifs 2 Gene: ADAMTS2
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
BMP1ProteinP13497 (Uniprot-TrEMBL) Full name: Bone morphogenetic protein 1 Gene: BMP1
CD36 GeneProductP16671 (Uniprot-TrEMBL) Full name: Platelet glycoprotein 4

Gene: CD36

Chondroitin sulfateMetaboliteCHEBI:37397 (ChEBI)
CollagenMetaboliteCHEBI:3815 (ChEBI)
Dermatan sulfateMetaboliteHMDB00632 (HMDB)
F6PMetaboliteCHEBI:15946 (ChEBI)
FGFR1GeneProductP11362 (Uniprot-TrEMBL) Full name: Fibroblast growth factor receptor 1 Gene: FGFR1
FGFR4GeneProductP22455 (Uniprot-TrEMBL) Full name: Fibroblast growth factor receptor 4 Gene: FGFR4
Fatty acid β-oxidationPathwayWP143 (WikiPathways)
Fatty acidMetaboliteCHEBI:35366 (ChEBI)
G1PMetaboliteCHEBI:29042 (ChEBI)
G6PMetaboliteHMDB01401 (HMDB)
G6PIGeneProductP06744 (Uniprot-TrEMBL) Full name: Glucose-6-phosphate isomerase Gene: GPI
GLDHProteinP00367 (Uniprot-TrEMBL) Full name: Glutamate dehydrogenase 1 Gene: GLUD1
GLSProteinO94925 (Uniprot-TrEMBL) Full name: Glutaminase kidney isoform, mitochondrial Gene: GLS
GLUT1ProteinP11166 (Uniprot-TrEMBL) Full name: Solute carrier family 2, facilitated glucose transporter member 1 Gene: SLC2A1
GSALMetaboliteQ2823261 (Wikidata)
GlucoseMetaboliteHMDB00122 (HMDB)
GlutamateMetaboliteCHEBI:29985 (ChEBI)
GlutamineMetaboliteCHEBI:18050 (ChEBI)
GlycineMetabolite15428 (ChEBI)
HKProteinP35557 (Uniprot-TrEMBL) Full name: Hexokinase-4 Gene: GCK
Heparan sulfateMetaboliteHMDB00693 (HMDB)
Hsp47GeneProductP50454 (Uniprot-TrEMBL) Full name: Serpin H1 Gene: SERPINH1
Hyaluronic acidMetaboliteHMDB02061 (HMDB)
IP3 and DAG SignalingPathwayWP2688 (WikiPathways)
Keratan sulfateMetaboliteCHEBI:60924 (ChEBI)
L-glutamateMetaboliteCHEBI:29985 (ChEBI)
LDHGeneProductP00338 (Uniprot-TrEMBL) Full name: L-lactate dehydrogenase A chain Gene: LDHA
LOXGeneProductQ9Y4K0 (Uniprot-TrEMBL) Full name: Lysyl oxidase homolog 2 Gene: LOXL2
LPAR1GeneProductENSG00000198121 (Ensembl)
Lactic acidMetaboliteHMDB00190 (HMDB)
MCT1ProteinP53985 (Uniprot-TrEMBL) Full name: Monocarboxylate transporter 1 Gene: SLC16A1
Nucleotide BiosynthesisPathwayWP404 (WikiPathways)
P3H3GeneProductQ8IVL6 (Uniprot-TrEMBL) Full name: Prolyl 3-hydroxylase 3 Gene: P3H3
P3H4GeneProductQ92791 (Uniprot-TrEMBL) Full name: Endoplasmic reticulum protein SC65 Gene: P3H4
P4HA1GeneProductP13674 (Uniprot-TrEMBL) Full name: Prolyl 4-hydroxylase subunit alpha-1 Gene: P4HA1
P4HA2GeneProductO15460 (Uniprot-TrEMBL) Full name: Prolyl 4-hydroxylase subunit alpha-2 Gene: P4HA2
P4HA3GeneProductQ7Z4N8 (Uniprot-TrEMBL) Full name: Prolyl 4-hydroxylase subunit alpha-3 Gene: P4HA3
P5CMetaboliteCHEBI:15893 (ChEBI)
P5CRProteinP32322 (Uniprot-TrEMBL) Full name: Pyrroline-5-carboxylate reductase 1, mitochondrial Gene: PYCR1
P5CSProteinP54886 (Uniprot-TrEMBL) Full name: Delta-1-pyrroline-5-carboxylate synthase Gene: ALDH18A1
PGM1ProteinP36871 (Uniprot-TrEMBL) Full name: Phosphoglucomutase-1 Gene: PGM1
PHGDHProteinO43175 (Uniprot-TrEMBL) Full name: D-3-phosphoglycerate dehydrogenase Gene: PHGDH
PI3K-Akt SignalingPathwayWP4172 (WikiPathways)
PLCProteinP19174 (Uniprot-TrEMBL) Full name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Gene: PLCG1
PLOD1GeneProductQ02809 (Uniprot-TrEMBL) Full name: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Gene: PLOD1
PSAProteinQ9Y617 (Uniprot-TrEMBL) Full name: Phosphoserine aminotransferase Gene: PSAT1
PSPProteinP78330 (Uniprot-TrEMBL) Full name: Phosphoserine phosphatase Gene: PSPH
Pentose Phosphate PathwayPathwayWP134 (WikiPathways)
PreprocollagenMetabolite
ProcollagenMetabolite
ProlineMetaboliteCHEBI:17203 (ChEBI)
PyruvateMetaboliteHMDB00243 (HMDB)
ROCK ActivationPathwayWP3365 (WikiPathways)
RhoAProteinP61586 (Uniprot-TrEMBL) Full name: Transforming protein RhoA/Ras homolog family member A Gene: RHOA
SHMTProteinO62585 (Uniprot-TrEMBL) Full name: Serine hydroxymethyltransferase, cytosolic Gene: SHMT1
SLC1A5GeneProductQ15758 (Uniprot-TrEMBL) Full name: Neutral amino acid transporter B(0) Gene: SLC1A5
SerineMetaboliteCHEBI:17822 (ChEBI)
TCA cyclePathwayWP78 (WikiPathways)
TropocollagenMetabolite
UDP-GlcAMetaboliteCHEBI:17200 (ChEBI)
UDP-glucoseMetaboliteCHEBI:18066 (ChEBI)
UGDHProteinO60701 (Uniprot-TrEMBL)
UGP2ProteinQ16851 (Uniprot-TrEMBL) Full name: UTP--glucose-1-phosphate uridylyltransferase Gene: UGP2
XGeneProduct
XPathwayWP3365 (WikiPathways)
αKGMetaboliteHMDB00208 (HMDB)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5312"
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