Bacterial ceramide synthesis (Caulobacter vibrioides)

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Revision as of 10:08, 16 March 2023 by DeSl (Talk | contribs)
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N-acyl-sphinganineL-Serine3-ketosphinganinePalmitic acidLong-chain FA-CoA LigasePalmitoyl-CoAN-acyl-3-oxosphinganineAcyl-CoASPT1bCerSCerR1CoA1CoA


Description

This pathway depicts the bacterial ceramide synthesis; bacteria are known to produces various groups of sphingolipids. This lipid class holds several physiological functions. In the human microbiome, commensal and pathogenic bacteria use sphingolipids to mimic the inflammatory system of the host. Several key eukaryotic ceramide synthesis enzymes have no bacterial homologue, which creates a challenge in understanding their biosynthetic pathway(s).

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Ontology Terms

 

Bibliography

  1. Stankeviciute G, Tang P, Ashley B, Chamberlain JD, Hansen MEB, Coleman A, D'Emilia R, Fu L, Mohan EC, Nguyen H, Guan Z, Campopiano DJ, Klein EA; ''Convergent evolution of bacterial ceramide synthesis.''; Nat Chem Biol, 2022 PubMed Europe PMC Scholia
  2. Peter J. Harrison, Teresa M. Dunn, Dominic J. Campopiano; ''Sphingolipid biosynthesis in man and microbes''; Nat. Prod. Rep., 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125877view10:52, 16 March 2023DeSlOntology Term : 'sphingolipid biosynthetic pathway' added !
125876view10:51, 16 March 2023DeSlAdded info on modeling species vs described species.
125875view10:44, 16 March 2023DeSlAnnotated interactions with Rhea IDs
125873view10:16, 16 March 2023DeSlAdded another lit. ref and more details to description
125872view10:08, 16 March 2023DeSlAdded more details to description
123973view10:31, 9 September 2022EweitzOntology Term : 'lipid metabolic pathway' added !
123409view21:25, 23 July 2022AlexanderPicouniform datanode widths and heights
123383view17:22, 21 July 2022EgonwSome layout cleanup.
123377view07:43, 19 July 2022EgonwCaulobacter vibrioides is now supported
123375view07:05, 19 July 2022Conroy lipidsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3-ketosphinganineMetaboliteLMSP01020002 (LIPID MAPS)
Acyl-CoAMetaboliteLMFA07050000 (LIPID MAPS)
CerRGeneProductA0A0H3C8X7 (Uniprot-TrEMBL)
CoAMetabolite15346 (ChEBI)
L-SerineMetabolite17115 (ChEBI)
Long-chain FA-CoA LigaseGeneProductA0A0H3C6D9 (Uniprot-TrEMBL)
N-acyl-3-oxosphinganineMetaboliteLMSP02080000 (LIPID MAPS)
N-acyl-sphinganineMetaboliteLMSP02020000 (LIPID MAPS)
Palmitic acidMetaboliteLMFA01010001 (LIPID MAPS)
Palmitoyl-CoAMetaboliteLMFA07050360 (LIPID MAPS)
SPTGeneProductA0A0H3C7E9 (Uniprot-TrEMBL)
bCerSGeneProductA0A0H3C8X0 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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