Urotensin-II-mediated signaling (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none ROSPrimary Kupffer cellsHuman coronary artery endothelial cellsLigandRAW264.7 macrophagesNADPHDownregulatedGNAQ mediated activationGene regulationLiver injury and acute liver failureDissociationKidneyMyocardial damage in atherosclerotic ratsPhosphorylationCell proliferationReactive oxygen species (ROS)ReceptorInhibitionCYBANCF4NCF1NCF2CYBBNPPASOD2CATHMOX1BCL2CASP9BAXCASP3PCNAT286CAMKIIAPLCPT308S473AKT1CYBAIFN-γHSPA2Y204T202MAPK3Y187T185MAPK1MMP9IL1βAtherosclerosis and fibrosisNCF1CYBBCYBBCOL1A1THP1-Monocytes and macrophagesS133CREBUTRCOL3A1LTB4AGTR1CBPp300IL-6ACTA2PPRKACACCNE1ABCA1CDK1ALOX5MMP9TNFTFPRKACANCF1IL-6ICAM1TNF-alphaCOL4A1MMP2IFNBUrotensin-IICOL2A1NOX4TRPC4VCAM1CDK2PProteinTGFB1FN1A1FM2DDIT3NCF4ESPL1UpregulatedIL1BT1007PJAK2T705PSTAT3STAT3PY185MAPK8T183PMAPK9PMAPK14PNFKB1PNFKB1AERK and IL-1ß pathway activationFibroblastsTGFB1SMAD3SMAD2Proliferation,neuropathy development, vascular fibrosis and collagen synthesisTGFB1Urotensin-IIUTRY187T185MAPK1Y204T202MAPK3RELAS536PRELAS32PNFKB1AIRF3Translocation from CP to NUTranslocation from CP to NUDissociationNFKB1RHOAY185PMAPK8PT183MAPK9InflammationCardiac hypertrophyNPPBNPPAT185Y187MAPK1PY204T202MAPK3PT180Y182MAPK14Urotensin-IIUTRY1068PEGFRPTPN11ROSHypertrophyPS176CHUKS180PIKBKBS9PGSK3BPS21GSK3ANFKB1RELAHDAC5S493PHDAC5NFKB1ANFKB1PS473AKT1ATP2A2T286PCAMKIIAPT17PLNCa2+Inhibits dephosphorylation activity of PTPN11Hemodynamic effectsPIP2PPI3KCAPIP3PTENPPTENCTNNB1FN1COL1A1COL3A1Cardiac hypertrophyUrotensin-IIUTRY187T185MAPK1T202Y204MAPK3Y185PMAPK8PT183MAPK9S473PAKT1PPI3KCAFSCN1ROSNCF1NADPH++H+O2Cell invasion and migrationCY to PMPNFKB1PNFKB1ADissociationNFKB1CancerUrotensin-IIUTRCREBCa2+IP3Endoplasmic reticulam stressEpithelial-mesenchymal transitionCOL4A1FN1Aristoiochic acid nephropathyProliferationExtracellular matric protein accumulationTranslocation from CP to NUGANQTranslocation from CP to NUTranslocation from nucleus(NU) to cytoplasm (CP)RELACardiac hypertrophyMyocardial fibrosis and hypertrophyInhibition of PTEN leads to activation of AKT1/GSK3BIRF3IL1βTNF-alphaPromote the release of inflammatory cytokinsDissociationKidney diseaseT180Y182PMAPK14TRPC4 channel-mediated store-operated Ca2+ entry (SOCE) and sequential activation of CaMKIIPRKACAProduction against ischemic reperfusion injuryTranslocation from CP to NUTranslocation from NU to CPTranslocation from cytoplasm (CP) to nucleus (NU)ROS mediated activationTranslocation from cytoplasm (CP) to plasma membrane (PM)ActivationFigure legendName: Urotensin-II-mediated signaling pathwayLast Modified: 01292022Organism: Homo sapiens


Description

Schematic representation of Urotensin-II-mediated signaling pathway

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Ontology Terms

 

Bibliography

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  1. Gong H, Chen Z, Zhang X, Li Y, Zhang J, Chen Y, Ding Y, Zhang G, Yang C, Zhu Y, Zou Y; ''Urotensin II Protects Cardiomyocytes from Apoptosis Induced by Oxidative Stress through the CSE/H2S Pathway.''; Int J Mol Sci, 2015 PubMed Europe PMC Scholia
  2. Liang DY, Liu LM, Ye CG, Zhao L, Yu FP, Gao DY, Wang YY, Yang ZW; ''Inhibition of UII/UTR system relieves acute inflammation of liver through preventing activation of NF-κB pathway in ALF mice.''; PLoS One, 2014 PubMed Europe PMC Scholia
  3. Bianca Rd, Mitidieri E, Fusco F, D'Aiuto E, Grieco P, Novellino E, Imbimbo C, Mirone V, Cirino G, Sorrentino R; ''Endogenous urotensin II selectively modulates erectile function through eNOS.''; PLoS One, 2012 PubMed Europe PMC Scholia
  4. Trebicka J, Leifeld L, Hennenberg M, Biecker E, Eckhardt A, Fischer N, Pröbsting AS, Clemens C, Lammert F, Sauerbruch T, Heller J; ''Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats.''; Hepatology, 2008 PubMed Europe PMC Scholia
  5. Zhou CH, Wan YY, Chu XH, Song Z, Xing SH, Wu YQ, Yin XX; ''Urotensin II contributes to the formation of lung adenocarcinoma inflammatory microenvironment through the NF-κB pathway in tumor-bearing nude mice.''; Oncol Lett, 2012 PubMed Europe PMC Scholia
  6. Diebold I, Petry A, Burger M, Hess J, Görlach A; ''NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2 expression by urotensin-II.''; Mol Biol Cell, 2011 PubMed Europe PMC Scholia
  7. Segain JP, Rolli-Derkinderen M, Gervois N, Raingeard de la Blétière D, Loirand G, Pacaud P; ''Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes.''; J Immunol, 2007 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
137394view23:25, 1 March 2025EweitzRemove obsolete metadata fields
137393view23:24, 1 March 2025EweitzEconomize layout
129675view00:45, 22 May 2024EweitzModified title
126484view16:57, 8 May 2023Khanspersremove labels as identifiers from xrefs
126369view17:47, 25 April 2023EgonwNot a mim-conversion
126326view20:57, 21 April 2023KhanspersOntology Term : 'signaling pathway' added !
126325view20:21, 21 April 2023Khanspersxrefs
126315view23:46, 20 April 2023Khanspersxrefs
126314view23:10, 20 April 2023Khanspersmore xrefs
126313view21:08, 20 April 2023Khanspersmore xrefs
126287view05:24, 20 April 2023Khanspersmore xrefs
126260view22:29, 18 April 2023Khanspersadded xrefs to first box
126259view22:06, 18 April 2023Khanspersconnected interactions, converted to graphical line where appropriate
122561view08:39, 16 April 2022EgonwRemove gene symbols which are not valid identifiers in the stated data sources
120968view06:29, 4 February 2022Keshav
120925view19:20, 31 January 2022EgonwFixed the data sources for UniProt identifiers
120900view08:22, 29 January 2022KeshavModified title
120899view08:20, 29 January 2022KeshavNew pathway

External references

DataNodes

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Name  ↓Type  ↓Database reference  ↓Comment  ↓
A1FM2GeneProductA1FM2
ABCA1GeneProduct19 (Entrez Gene)
ACTA2GeneProductACTA2
AGTR1GeneProduct185 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
AKT1Protein
ALOX5GeneProduct240 (Entrez Gene)
ATP2A2Protein
BAXGeneProduct581 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
CAMKIIAGeneProduct
CAMKIIAProtein
CASP3GeneProduct836 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CATGeneProductCAT
CBPGeneProductCBP
CCNE1GeneProductCCNE1
CDK1GeneProductCDK1
CDK2GeneProductCDK2
CHUKGeneProduct1147 (Entrez Gene)
COL1A1GeneProduct1277 (Entrez Gene)
COL2A1GeneProduct1280 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
COL4A1GeneProductCOL4A1
CREBGeneProductCREB
CTNNB1GeneProduct1499 (Entrez Gene)
CYBAGeneProduct1535 (Entrez Gene)
CYBAGeneProductCYBA
CYBBGeneProductCYBB
DDIT3GeneProductDDIT3
EGFRGeneProduct1956 (Entrez Gene)
ESPL1GeneProductESPL1
FN1GeneProduct2335 (Entrez Gene)
FN1GeneProductFN1
FSCN1GeneProduct
GANQProteinGANQ
GSK3AGeneProduct2931 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
HDAC5GeneProduct10014 (Entrez Gene)
HMOX1GeneProduct3162 (Entrez Gene)
HSPA2GeneProductHSPA2
ICAM1GeneProductICAM1
IFN-γ GeneProductIFN-γ
IFNBGeneProduct
IKBKBGeneProduct3551 (Entrez Gene)
IL-6GeneProductIL-6
IL1BGeneProduct3553 (Entrez Gene)
IL1β GeneProductIL1β
IRF3GeneProduct
JAK2GeneProduct3717 (Entrez Gene)
LTB4GeneProduct
MAPK14GeneProduct1432 (Entrez Gene)
MAPK14Protein
MAPK1Protein5594 (Entrez Gene)
MAPK1Protein
MAPK3Protein5595 (Entrez Gene)
MAPK3Protein
MAPK8GeneProduct5599 (Entrez Gene)
MAPK8Protein
MAPK9GeneProduct5601 (Entrez Gene)
MAPK9Protein
MMP2GeneProductMMP2
MMP9GeneProduct
MMP9GeneProductMMP9
NCF1GeneProduct653361 (Entrez Gene)
NCF1GeneProductNCF1
NCF2GeneProductNCF2
NCF4GeneProductNCF4
NFKB1AProteinNFKB1A (HGNC)
NFKB1AProtein
NFKB1Protein
NOX4GeneProduct50507 (Entrez Gene)
NPPAGeneProduct4878 (Entrez Gene)
NPPAGeneProductNPPA
NPPBGeneProduct4879 (Entrez Gene)
PCNAGeneProductPCNA
PI3KCAProtein
PIP2Protein
PIP3Protein
PLCGeneProductPLC
PLNGeneProduct5350 (Entrez Gene)
PRKACAGeneProduct5566 (Entrez Gene)
PRKACAProtein
PTENProtein5728 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
ProteinGeneProduct
RELAGeneProduct5970 (Entrez Gene)
RELAGeneProduct
RELAProtein
RHOAProtein
SMAD2GeneProductSMAD2 (HGNC)
SMAD3GeneProduct4088 (Entrez Gene)
SOD2GeneProductSOD2
STAT3Protein6774 (Entrez Gene)
TFGeneProductTF
TGFB1GeneProduct7040 (Entrez Gene)
TGFB1GeneProductTGFB1
TNF-alphaGeneProductTNF-alpha
TNFGeneProduct
TRPC4GeneProductTRPC4
UTRProtein2837 (Entrez Gene)
UTRProtein
Urotensin-IIProteinO95399 (Uniprot-TrEMBL)
Urotensin-IIProtein
VCAM1GeneProduct
p300GeneProductp300

Annotated Interactions

No annotated interactions

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