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Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:10820226).
At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity).
Tetrahydrocannabinol (THC) is the primary psychoactive compound found in cannabis plants. Its effects on cannabinoid receptors CNR1 (CB1) and CNR2 (CB2) are well-documented:
CB1 Receptor Interaction:
THC is a partial agonist at the CB1 receptor. When it binds to the CB1 receptor, it activates the receptor to a degree, eliciting a psychoactive response which is often associated with the "high" experienced from cannabis consumption.
CB2 Receptor Interaction:
THC is also a partial agonist at the CB2 receptor, although its affinity for the CB2 receptor is less compared to the CB1 receptor. The activation of CB2 receptors by THC is associated with some of the medicinal properties of cannabis, such as its anti-inflammatory effects.
In summary, THC acts as a partial agonist at both CB1 and CB2 receptors, stimulating these receptors to produce a variety of effects in the body, including psychoactive and potential therapeutic effects. Unlike CBD, THC does not act as an antagonist or inhibitor at these receptors, and its binding and activation of CB1 and CB2 receptors are central to its effects.
Neurodivergent conditions linked in studies to these pathways include: ADHD, Autism, Dyspraxia, Dyslexia, Dyscalculia, bipolar disorder, obsessive-compulsive disorder, Sensory processing disorders, Tourette syndrome.
Pathways included in this map:
One-Carbon (1C) Metabolism Folate Cycle Methionine Cycle Tetrahydrobiopterin (BH4) Pathway Neurotransmitter Synthesis, Reuptake, and Breakdown
Kynurenine Pathway (KP)
Endocannabinoid System (ECS)
Neuroreceptor Dynamics in the Synaptic Cleft
ROS Reactive Oxygen Stress
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View approved pathways at the new wikipathways.org.Quality Tags
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Intervention
(drug)Escitalopram (Lexapro) Fluoxetine (Prozac) Paroxetine (Paxil, Pexeva)
Sertraline(Zoloft)Tetrahydrocannabinol (THC) is the primary psychoactive compound found in cannabis plants. Its effects on cannabinoid receptors CNR1 (CB1) and CNR2 (CB2) are well-documented:
CB1 Receptor Interaction:
THC is a partial agonist at the CB1 receptor. When it binds to the CB1 receptor, it activates the receptor to a degree, eliciting a psychoactive response which is often associated with the "high" experienced from cannabis consumption. CB2 Receptor Interaction:
THC is also a partial agonist at the CB2 receptor, although its affinity for the CB2 receptor is less compared to the CB1 receptor. The activation of CB2 receptors by THC is associated with some of the medicinal properties of cannabis, such as its anti-inflammatory effects.
In summary, THC acts as a partial agonist at both CB1 and CB2 receptors, stimulating these receptors to produce a variety of effects in the body, including psychoactive and potential therapeutic effects. Unlike CBD, THC does not act as an antagonist or inhibitor at these receptors, and its binding and activation of CB1 and CB2 receptors are central to its effects.Annotated Interactions
No annotated interactions