Isoglobo series sphingolipids (Homo sapiens)

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1, 222222Enzyme is thought not to be active in humans?α1–3GalT417Galalpha1-3(GalNAcbeta1-4Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-CeriGB4HSO3-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-CerCytolipin Rβ3GalNAcTNeuAcalpha2-3Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-CeriGB5β3GalT-VGalalpha1-3Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-CerForssman-like iGb4iGB3HSO3-3Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-CerNeuAcα2-IGB5LacCerFucalpha1-2Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-CerGlycosphingolipidmetabolismGalbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-CerGalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(GlcNAcbeta1-6)Galbeta1-4Glcbeta-CerGalNAcbeta1-3Galalpha1-3(Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-CerGalalpha1-3(Fucalpha1-2)Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer3428NeuAcalpha1-3Galbeta1-4GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-CerGalalpha1-3(NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-CerFucalpha1-3GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-CerGalbeta1-4GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-CerGalbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer420422421NeuAcalpha1-3Galbeta1-4GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-CerNeuAcalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer423NeuAcalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-CerGalbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer416399419418Galalpha1-3(Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer432GalNAcbeta1-3Galalpha1-3(GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer431GalNAcbeta1-3Galalpha1-3Galalpha1-3Galbeta1-4Glcbeta-CerGalbeta1-4GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-CerFucalpha1-3GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-CerGlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer Galalpha1-3Galalpha1-3Galbeta1-4Glcbeta-CerGalalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-CerFucalpha1-2Galalpha1-3Galbeta1-4Glcbeta-Cer Galalpha1-3Galalpha1-3Galbeta1-4Glcbeta-CerGalalpha1-3(Fucalpha1-2)Galbeta1-4Glcbeta-CerGalalpha1-3(GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer433435


Description

Isoglobo pathway in its entirety from SphinGOMAP.

Solid conversion arrows are documented according to Sphingomap. Dotted conversions are hypothetical, either not occurring or undocumented (Sphingomap details all possible permutations of a pathway to the final glycolipid).

Numbers represent the sphingomap IDs, to be converted. Metabolites coloured red are not yet in LIPIDMAPS

Metabolites with a dotted box are hypothetical. These may or may not exist on the pathway to the final product as several different routes could occur.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Ronak Y Patel, Petety V Balaji; ''Fold-recognition and comparative modeling of human beta3GalT I, II, IV, V and VI and beta3GalNAcT I: prediction of residues conferring acceptor substrate specificity''; J Mol Graph Model ., 2007 PubMed Europe PMC Scholia
  2. Alfred H. Merrill, Jr.; ''Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics''; Chem Rev., 2011 PubMed Europe PMC Scholia
  3. Merril AH Jr; ''SphinGOMAP--a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids.''; Glycobiology, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134475view00:54, 22 July 2024EweitzOntology Term : 'lipid metabolic pathway' added !
134389view19:20, 21 July 2024EweitzRemove template comments
127501view13:04, 13 October 2023Conroy lipidsmore names and ECO
127500view11:08, 13 October 2023Conroy lipidsupdate names, add ECO comment
127499view19:21, 12 October 2023Conroy lipidsupdate names, add ECO terms to presumptive species
125791view11:09, 10 March 2023DeSlAdded linkout to sphinGOMAP in description
125790view11:07, 10 March 2023DeSlAdded another enzyme
125789view10:57, 10 March 2023DeSlAdded some enzymes for reactions based on PMID: 21942574
125788view10:14, 10 March 2023DeSlFixed typo in description
125550view21:35, 26 February 2023AndraOntology Term : 'sphingolipid metabolic pathway' added !
125104view06:38, 23 January 2023EgonwWe need a bigger box
125103view06:37, 23 January 2023EgonwMade a pathway clickable
125007view11:53, 12 January 2023Conroy lipidsModified description
125006view11:51, 12 January 2023Conroy lipidsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Galalpha1-3Galalpha 1-3Galbeta1-4Glcbeta-CerMetaboliteLMSP0506AT00 (LIPID MAPS)
  • S_id 372
  • ECO:0008028
Galalpha1-3Galalpha 1-3Galbeta1-4Glcbeta-CerMetaboliteLMSP0506BD00 (LIPID MAPS)
  • S-id 384
  • ECO:0008028
399MetaboliteLMSP0601GX00 (LIPID MAPS) S_id 399
416MetaboliteLMSP0506AH00 (LIPID MAPS) S_ID 416
418MetaboliteLMSP0601GO00 (LIPID MAPS) S_id 418
419MetaboliteLMSP0601GP00 (LIPID MAPS) S_id 419
420MetaboliteLMSP0601GQ00 (LIPID MAPS) S_id 420
421MetaboliteLMSP0506AI00 (LIPID MAPS) S_id 421
422MetaboliteLMSP0506AJ00 (LIPID MAPS) S_id 422
423MetaboliteLMSP0601GR00 (LIPID MAPS) S_id 423
Cytolipin RMetaboliteLMSP0506AR00 (LIPID MAPS) s_id 353
Forssman-like iGb4MetaboliteLMSP0506AD00 (LIPID MAPS) S_id 398
Fucalpha1-2Galalpha 1-3Galbeta1-4Glcbeta-CerMetaboliteLMSP0506AA00 (LIPID MAPS) Sphingolipid ID 411
Fucalpha1-2Galbeta1-3

GalNAcbeta1-3Galalpha1-3

Galbeta1-4Glcbeta-Cer		MetaboliteLMSP0506BB00 (LIPID MAPS)
  • S_id 382
  • ECO:0008028
Fucalpha1-3GlcNAcbeta1-3

Galalpha1-3(GalNAcbeta1-4)

Galbeta1-4Glcbeta-Cer		MetaboliteLMSP0506BI00 (LIPID MAPS)
  • S_id 395
  • ECO:0008028
Fucalpha1-3GlcNAcbeta1-3

Galalpha1-3Galbeta1-4

Glcbeta-Cer		MetaboliteLMSP0506AV00 (LIPID MAPS)
  • s_id 374
  • ECO:0008028
GalNAcalpha1-3GalNAcbeta1-3

Galalpha1-3(GlcNAcbeta1-6)

Galbeta1-4Glcbeta-Cer		MetaboliteLMSP0506AL00 (LIPID MAPS)
  • S_id 426
  • ECO:0008028
GalNAcbeta1-3Galalpha1-3

(Galbeta1-4GlcNAcbeta1-6)

Galbeta1-4Glcbeta-Cer		MetaboliteLMSP0506AK00 (LIPID MAPS)
  • S_id 424
  • ECO:0008028
GalNAcbeta1-3Galalpha1-3

(GlcNAcbeta1-6)Galbeta1-4

Glcbeta-Cer		MetaboliteLMSP0506AO00 (LIPID MAPS)
  • S_id 430
  • ECO:0008028
GalNAcbeta1-3Galalpha1-3

Galalpha1-3Galbeta1-4

Glcbeta-Cer		MetaboliteLMSP0506BE00 (LIPID MAPS) S_id 385
Galalpha1-3(Fucalpha1-2)

Galbeta1-3GalNAcbeta1-3

Galalpha1-3Galbeta1-4Glcbeta-Cer		MetaboliteLMSP0506BC00 (LIPID MAPS) S_id 383
Galalpha1-3(Fucalpha1-2) Galbeta1-4Glcbeta-CerMetaboliteLMSP0506AZ00 (LIPID MAPS) s_id 380
Galalpha1-3(GalNAcbeta1-4

Galbeta1-4GlcNAcbeta1-6)

Galbeta1-4Glcbeta-Cer		MetaboliteLMSP0506AM00 (LIPID MAPS)
  • S_id 427
  • ECO:0008028
Galalpha1-3(GalNAcbeta1-4) Galbeta1-4Glcbeta-CerMetaboliteLMSP0506BF00 (LIPID MAPS)
  • S_id 392
  • ECO:0008028
Galalpha1-3(Galbeta1-4

GlcNAcbeta1-6)Galbeta1-4

Glcbeta-Cer		MetaboliteLMSP0506AN00 (LIPID MAPS)
  • S_id 429
  • ECO:0008028
Galalpha1-3(GlcNAcbeta1-6) Galbeta1-4Glcbeta-CerMetaboliteLMSP0506AP00 (LIPID MAPS) ECO:0008028
Galalpha1-3(NeuAcalpha2-3

Galbeta1-4GlcNAcbeta1-6)

Galbeta1-4Glcbeta-Cer		MetaboliteLMSP0601GS00 (LIPID MAPS) ECO:0008028
Galalpha1-3Galbeta1-3

GalNAcbeta1-3Galalpha1-3

Galbeta1-4Glcbeta-Cer		MetaboliteLMSP0506BA00 (LIPID MAPS)
  • S_id 381
  • ECO:0008028
Galbeta1-3GalNAcbeta1-3

Galalpha1-3Galbeta1-4

Glcbeta-Cer		MetaboliteLMSP0506AY00 (LIPID MAPS) S_id 378
Galbeta1-4(Fucalpha1-3)

GlcNAcbeta1-3Galalpha1-3

(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer		MetaboliteLMSP0506BJ00 (LIPID MAPS)
  • S_id 396
  • ECO:0008028
Galbeta1-4(Fucalpha1-3)

GlcNAcbeta1-3Galalpha1-3

Galbeta1-4Glcbeta-Cer		MetaboliteLMSP0506AW00 (LIPID MAPS)
  • S_id 375
  • ECO:0008028
Galbeta1-4GlcNAcbeta1-3

Galalpha1-3(GalNAcbeta1-4)

Galbeta1-4Glcbeta-Cer		MetaboliteLMSP0506BH00 (LIPID MAPS)
  • S_id 394
  • ECO:0008028
Galbeta1-4GlcNAcbeta1-3

Galalpha1-3Galbeta1-4

Glcbeta-Cer		MetaboliteLMSP0506AU00 (LIPID MAPS)
  • S_id 373
  • ECO:0008028
GlcNAcbeta1-3Galalpha1-3

(GalNAcbeta1-4)Galbeta1-4 Glcbeta-Cer

MetaboliteLMSP0506BG00 (LIPID MAPS)
  • S-id 393
  • ECO:0008028
Glycosphingolipid metabolismPathwayWP5292 (WikiPathways)
HSO3-3GalNAcbeta1-3

Galalpha1-3Galbeta1-4

Glcbeta-Cer		MetaboliteLMSP0602AP00 (LIPID MAPS) S_id 400
HSO3-3Galbeta1-3GalNAcbeta1-3 Galalpha1-3Galbeta1-4Glcbeta-CerMetaboliteLMSP0602AO00 (LIPID MAPS) S_id 415
LacCerMetaboliteCHEBI:17950 (ChEBI)
NeuAcalpha1-3Galbeta1-4

GlcNAcbeta1-3Galalpha1-3

(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer		MetaboliteLMSP0601GV00 (LIPID MAPS)
  • S_id 376
  • ECO:0008028
NeuAcalpha1-3Galbeta1-4

GlcNAcbeta1-3Galalpha1-3

Galbeta1-4Glcbeta-Cer		MetaboliteLMSP0601GW00 (LIPID MAPS)
  • S_id 397
  • ECO:0008028
NeuAcalpha2-3Galbeta1-3

GalNAcbeta1-3Galalpha1-3

Galbeta1-4Glcbeta-Cer		MetaboliteLMSP0601GK00 (LIPID MAPS) S_id 379
NeuAcalpha2-3Galbeta1-4

(Fucalpha1-3)GlcNAcbeta1-3 Galalpha1-3(GalNAcbeta1-4)

Galbeta1-4Glcbeta-Cer		MetaboliteLMSP0601GI00 (LIPID MAPS)
  • S_id 371
  • Type your comment here
NeuAcalpha2-3Galbeta1-4

(Fucalpha1-3)GlcNAcbeta1-3

Galalpha1-3Galbeta1-4Glcbeta-Cer		MetaboliteLMSP0601GH00 (LIPID MAPS)
  • s_id
  • ECO:0008028
NeuAcα2-IGB5MetaboliteLMSP0601GL00 (LIPID MAPS)
  • s_id 401
  • NeuAcα2-6Galβ1-3GalNAcβ1-3Galα1-3Galβ1-4Glcβ-Cer
iGB3MetaboliteLMSP0506AQ00 (LIPID MAPS)
  • s_id 11
  • Galα1–4Galβ1–4Glcβ1Cer
iGB4MetaboliteLMSP0506AX00 (LIPID MAPS) s_id 377
iGB5MetaboliteLMSP0506AS00 (LIPID MAPS)
  • S_id=354
  • Galβ1-3GalNAcβ1-3Galα1-3Galβ1-4Glcβ-Cer
α1–3GalTProtein
  • iGb3 synthase
  • "Enzyme is not thought to be active in humans, [...], the human iGb3 synthase gene contains several mutations that render its product nonfunctional,([PMID:18630988]) and this has been supported by in vitro assays.(PMID:20206917])". Source: PMID 21942574
β3GalNAcTProteinAKA 3-N-acetylgalactosaminyltransferase [PMID:17212986]
β3GalT-VProteinQ9Y2C3 (Uniprot-TrEMBL)
  • AKA β3-Galactosyltransferase (β3GalT) , B3GALT5
  • Annotation based on Book chapter, DOI: 10.1007/978-4-431-67877-9_6
417Metabolite
428Metabolite
431Metabolite
432Metabolite
433Metabolite
435Metabolite

Annotated Interactions

No annotated interactions

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