ADHD and autism (ASD) pathways (Homo sapiens)

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143111537915314615315311765109, 146MitochondriaNucleusSynapticVesicleSynapticVesicleAdrenal VesicleAdrenal MedullaGABA-B-receptorNote: enzymes color coded for readability Legendexogenous cannabinoidIntestinCatecholamineSynthesisROSReactive OxygenStressFolateCycleSerotoninSynthesis(5-HT)Kynurenine Pathway (KP)MelatoninSynthesisAlex Madsen2023copyright (c) 2023CC0 1.0 Universal (CC0 1.0)Public Domain DedicationSynaptophysinSynaptobrevinComplexSynaptic Cleftcytosol (intracellular)MethionineCyclen.e.BH4SynthaseOpioid Receptorhydroxylation156Endocannabinoid System (ECS)IntercellularMetaboliteSNPsingle nucleotidepolymorphismSCN2AProteinrs6189147MN2+CNTN6rs11370701, 17, 47, 73, 74, 84...NA AldehydeTHF-polyglutamate3-MT SOSCN1Ars656133340Imidazole-4-acetate59, 113a 1-(1-hydroxyalkyl)-sn-glycerol36FMN151rs4343133ALDH259rs12843533168rs237897NOX4H2O2rs1051312147SCN4BDHMA1-O-(1,2-saturated-alkyl)-sn-glycerol36ADAM10134rs6280127q-BH2145HNMTrs799701210, 127GABRA2ACE11angiotensin I11SAM12rs148727540PCBD1145rs1087935240HCFC1 (cblX)24, 137PCBD2145L-tryptophan131, 146SLC25A32AANAT9, 69, 144, 146SCN5Ars11178997147MAOAALDHserine75TYrs60261878NMN-SOCSADPPH448serotonin146rs10521432125PTS48sepiapterin67rs192388640MG2+NMGABRB3Methylphenidate(Ritalin)7, 160rs205620246, 77rs68640THF75rs598968135, 43NOformate75MAOBL-citrulliners195090213rs146510784FADCBSGABRA3Metanephriners378514319, 157rs74060121tyraminers20710108, 68GABRA5SLC18A127, 127rs1023159rs165774GLS129SLC46A1CNTN1B6pyridoxineCPLX1PDXKglycine betaineFOLH1SHMT2taurine5-MTHFMOPGALAdoCblMeCblOPRM181deamido-NAD+132CYP2D6L-histidinol113SCN10ACNTNAP4SLC17A6rs140694640ALDH5A1DHNTP48DAG1L-cysteatemelatonin109, 146rs3622043-MTSULT1A3rs224244695, 98, 105rs229844468, 93GCATglycine75SLC25A12rs35062132rs2934966405-10MeTHF10-formyl-THF75MTRRO2−79DOPL33rs3601762, 119PNPO5, 10-MTHFPG75SCN7AHISN84-aminobutanoateNADSYN1132AHCYL1rs223622513rs237889rs590551125rs1284326851rs16976358127L-tyrosiners5949028128MTHFD2LMN-SO4nicotinate D-ribonucleotide(2−)14N-METHYL-HISTAMINE41, 100B9rs302740717, 168SLC17A8RFK151dopamineDBHAOC1SIRT3109, 146cysteine sulfinateSAH12L-dopaNM Aldehyde pyridoxine 5'-phosphaters651646 44rs2270637127S-adenosyl-L-homocysteineMHPGMOPEGrs4130047127DOPET33RS4818FLAD1Biopterinrs378202540histamine41, 113GABRA11′-OXPH448, 49SCN8ASLC19A1NOS1rs1390938127, 130, 161PNMTrs179983657, 121, 125, 133rs632382GABRA4rs658207140rs2279709127AKR1B148RS6267114BHMT60DHFR48ALDH9A1rs2270641127H4gtpGPTrs3733890106, 155HDCN-Methylhistamine41, 100imidazole-4-acetaldehyde41, 59pyridoxaminers165599GABRB1QPRT132FAAH2rs5906883 17, 168SOD2109, 146rs737865rs1801198404a-Hydroxytetrahydrobiopterinrs665180657, 70, 125CNTNAP2117rs590551257SCN2BSCN9Aq-H2BPT36, 64GABRG1SLC6A4127NAS146L-alanine5-MTFe2+rs17469621GABRG2ADGRL3GPCRsrs2268491rs1667627rs167271740rs7632287glycerolO2L-histidine113DOPAC33, 124rs265981GABRQfatty aldehydes136DHPGrs180054478, 147Alpha-dystroglycan63hemiacetals136SCN3BNOX1CNTN2TDCCNTNAP1GABRB2alkylglycerols136Xanthurenic acid131rs1051266SLC6A252GCH1GTPCH48rs594445127rs2838684023, 1232-oxoglutarateMet12rs468021, 114rs229281346, 77rs3813034127rs197927729, 31, 68, 161CBCollybistin53, 63SLC52A2FOLR1noladin ether15, 64, 159, 164rs208810221MTHFD2SLC6A3STXBP1rs3746544147QDPR145TAAR116, 154rs3785157123TYMS45SCN1Bpyridoxalrs556995rs3758653NOX3DNMT1TCN2CNTN5rs77986771, 127rs53576acetateSLC52A1rs180508729, 133AGTR1rs4633NOS3SCN4AMOCOSPAHGABRDrs6269DHFAGMO36, 64MoCoL-glutamine116, 129rs151257822rs237902rs4291133ASMT69, 146(4aS,6R)-4a-hydroxy - BH4rs25191522Derived From WP4159GABA receptor signaling5-HialDDCmoco sulfide rs674603054, 114HVAL124SOD1110NCAM1117RIT218TPH2glycerol 3-phosphateMTR12SLC52A3Derived From WP4271Vitamin B12 disordersrs4570625147Pharmacological Intervention(drug)Angiotensinogen11CNTN4MTHFRrs6318127hypotaurineNMNAT1132DOPGALSCN11ASLC25A13ALDH1L1rs237887B212, 151rs4532127SCN3Ars135225040rs4570625147GPHN53, 63OH-NOX5rs302740084rs212957531CDO1SLC17A7KYAT3ALDH1L2GKSYPFMO1REN11rs2710102127CTH6R-BH436adrenalineAKRAHCYCNTN3arachidonic acidcystathionineDOPEGSPR485-hydroxy-L-tryptophan146CNTNAP3rs7794745127rs17999715, 81, 114L-arginineTPH1GLUL4rs2254298ADHL-cysteiners444690935L-phenylalanine2′-OXPH448, 49homocysteine12MAT1AMAT2BBH4BH27,8-dihydrofolateAKR1A1AKR1C348CBR148AKR1C1B312B95, 10-MTHFPG75SHMT110-formyl-THF75MTHFD1MTHFD1LTHF75NADPrs87665742132NOS2NADPNADPHONOO-serotoninDopamineReceptorsDRD3DRD5DRD4DRD2DRD1HTR4HTR5bHTR6HTR1D96HTR1EHTR7HTR2AHTR1FHTR5aHTR2BHTR1A96HTR1B96HTR2CADRA2CADRA1AADRB3aADRA1BADRA2AADRB1ADRA2BADRA1DADRB2SerotoninReceptorsAdrenergicReceptorsserotoninNorepinephrinedopaminers1801131127, 165rs1801133127, 165rs4846049165rs180139438rs1532268rs3819331rs2518352rs121913223rs70991108NANorepinephriners16777125dopamineserotonindopamineVMAHVA33, 124COMT335-HIAANorepinephrineadrenalineClonidine50Guanfacine50Prazosin7Atomoxetine(Strattera)30SNRIEscitalopram (Lexapro)Fluoxetine (Prozac)Paroxetine (Paxil, Pexeva)Sertraline(Zoloft)L-GluL-AspL-Asprs90867046Ca2+SNAP25VAMP2SYT1STX1ACa2+GluRAMPAAMPARPSDGluNNMDANMDARmGluGRM8KCNA2KCNA1DLG3GRM6GRM5GRM3KCNA3GRIN2CDLG5DLGAP563GRM4GRIN2BDLGAP363GRIA1GRIN1GRM2GRIN2ADLGAP463KCNA4KCNA5DLG2KCNA6CNR1117GRIA2GRM7DLGAP263OXTR117MC4R117SHANK1143GRIA4F-actin153NLGN163S-SCAM153NRXN263GRIN3BABL1153HOMER2153CTNNB1GRIN3ASHANK153DLG4PSD95153SAPAP153NLGN263DLGAP163KCNA7HOMER153CBL153SRBS2163Cortactin153GRIN2DNLGN4X63NRXN363APP153SHANK320, 117GRIA3GRIP2HOMER3153DLG1NRXN163NLGN363, 85, 117PTK2B153P153HOMER1153SHANK2143GRM1GRIP1CACNG2153PSD953, 56, 63, 102CTTN153F-actin153SAPAP153SHANK153Cortactin153F-actin153F-actin153SHANK153SAPAP153Cortactin153PSD953, 56, 63, 102ABL2153SHANK153SAPAP153HOMER153PSD953, 56, 63, 102GKAP1153P153P153S-SCAM63, 153Beta-dystroglycan63Potassium(k)channelPresynapticPostsynapticMetabotropicGlutamateReceptorsNMDAReceptorsAMPARReceptorsGABRAReceptors5-MTHFFOLR2HTR3AHTR3BHTR3CHTR3DHTR3Ers154333442CACNG6CACNG7CACNG3CACNG4CACNG8CACNG5CACNG1GNAQ92PLCB92oxytocinOXTCACNA1C92angiotensin II11SOD2110SOD3110NADPHMAOIsB95-MTHF5-10MeTHFrs6198147rs629614711511511511534, 1153434343434, 115343434, 115343434, 11534115Glucocorticoid stimuliPro-inflammatorycytokines3-Hydroxykynurenine131, 142Kynurenic Acid131Picolinic Acid142IFNGKYNU3-Hydroxyanthranilic Acid14, 131, 142KAT1Quinolinic AcidQUIN2, 14, 79, 99, 131...Anthranilic Acid131, 142Kynurenine14, 131, 142NAD+132INFAKMOIDO1IDO2T23OKAT3AADATAATMTNFAQUINNitric Oxide (NO) SynthaseSynaptic CleftSynaptic CleftadrenalineNorepinephrineAdrenaline Synaptic VesicleadrenalineNeurotransmitter Catabolism (Breakdown)GABA Synaptic vesiclegamma-hydroxybutyrate L-glutamate116, 129GABAGABBR1SLC32A1succinate citrate cycleGAD2succinic semialdehydeALDH9A1ABATGAD1GABASLC6A1GABAGLS21292A-3OBUL-threonineFMO3HistamineSynthase &CatabolismCysteine Synthase &CatabolismPLPpyridoxal 5'-phosphateFADFADB2riboflavin12, 151PLPPLPPLPFMN151Lysosome26977694cblJABCD4Succinyl-CoAMMUTCblCD320R-cob(III)alamincob(II)alamin58cob(I)alamincbLAMMAAMethylmalonyl-CoAMMADHCcblFLMBRD1cbLCMMACHCcbLCMMACHCFADFMN97MMABcblBPLPPLPPLPPLPPLPPLPR-cob(III)alaminCblD-1MMADHCCblD-2MMADHCCblDMMADHCCYP3A4CYP2C19111endogenous cannabinoidsPKACBD catabolismNeuronal cell of CNS(hyppocampus, cerebellum or basal ganglia)ADCY1CNR115CYP2C911-OH-THCMAPK PhosphatidylethanolamineDAGLBcAMP NAPEPLD166ADCY7101NAPEDAGLA166Arachidonic acidTHC1''-hydroxycannabidiol1112-AG135FAAH166L-glutamate118ADORA2A89CNR2Ca2+ATPAEAAnti-inflammatory pathwaysCOOH-THC39CBD1032''-hydroxycannabidiol 1113''-hydroxycannabidiol 1114''-hydroxycannabidiol 1115''-hydroxycannabidiol 1116a-hydroxycannabidiol 1116b-hydroxycannabidiol 1117-hydroxycannabidiol 111endogeneous cannabinoid synthesisPRKACBPRKACAPRKAR1APRKAR2BPRKAR1BPRKACGPRKAR2APKA regulatory subunit type IPKAcatalytic subunitPKA regulatory subunit type IICa2+2-arachidonoylglycerolCBDKUVAN(BH4 Supplement) 7Derived From WP3869Cannabinoid receptor signalingCatabolism(Vitamin B12)pathwayPLPPLPglutamate Synaptic vesicleL-glutamate129adrenalineDextroamphetamine + Amphetamine(Adderall)viloxazine(Qelbree)30rs2550936127rs1318902140Ketamine 28, 80AEA


Description

Pathways associated with ADHD (Attention-Deficit/Hyperactivity Disorder) and Autism Spectrum Disorder (ASD). Neurodivergent conditions linked in studies to these pathways include ADHD, Autism, Dyspraxia, Dyslexia, Dyscalculia, bipolar disorder, obsessive-compulsive disorder, Sensory processing disorders, Tourette syndrome.The purpose of this project is to create a highly detailed, comprehensive map of the metabolic pathway associated with these disorders, from indicated input vitamins through synthesis to signaling across the synaptic gap, reuptake, and catabolism (breakdown) receptors. This pathway is constructed with computational analysis and machine learning in mind. Priority has been given to ensure it is parametrically accurate, detailed, and comprehensive. In cases where there's a decision between readability and parametric accuracy, parametric accuracy is given priority. This pathway is inspired by Kimberly Kitzerow and her meta-analysis research on the biomechanisms and pathways behind invisible illnesses. https://kimberly102347.com/the-chart/

Pathways included in this map: One-Carbon (1C), Metabolism Folate Cycle, Methionine Cycle, Tetrahydrobiopterin (BH4) Pathway, Neurotransmitter Synthesis, Reuptake, and Breakdown, Kynurenine Pathway (KP), Endocannabinoid System (ECS), Neuroreceptor Dynamics in the Synaptic Cleft,

ROS Reactive Oxygen Stress.

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History

View all...
CompareRevisionActionTimeUserComment
134491view05:19, 22 July 2024EgonwImproved the semantics of the references
134489view04:58, 22 July 2024EgonwRemoved template comments
134394view19:39, 21 July 2024EweitzRemove template comments
130790view09:07, 30 May 2024DeSlAll pathway models in WikiPathways are CC0, other licences are not valid.
129619view16:06, 19 May 2024Alexmadsen1
129618view15:55, 19 May 2024Alexmadsen1split Adderall into Dextroamphetamine
129599view17:29, 17 May 2024Alexmadsen1add beta blockers and connect adrenaline
129450view23:43, 22 April 2024EweitzModified title
128702view21:57, 20 February 2024EgonwFixed two datasources
128690view20:04, 19 February 2024EgonwRemoved redundant RHEA: prefix in two interaction identifiers
128491view01:18, 7 February 2024Alexmadsen1update
128483view04:10, 6 February 2024Alexmadsen1add Purine Synthesis cycle and connection and I connected in ADSL that is #22 on ASD/ADHD list.
128459view19:53, 4 February 2024Alexmadsen1updat PNMT SAD
128458view19:48, 4 February 2024Alexmadsen1add SNP
128312view19:35, 31 January 2024Khanspersupdate with latest changes from Alex Madsen
128112view19:42, 26 January 2024KhanspersReverted to version '19:33, 26 January 2024' by Khanspers
128111view19:39, 26 January 2024KhanspersLatest edits from Alex Madsen
128110view19:33, 26 January 2024KhanspersReverted to version '02:04, 6 January 2024' by Khanspers
128109view19:29, 26 January 2024KhanspersIncorporating latest changes from Alex Madsen
127881view02:04, 6 January 2024EweitzModified description
127879view23:55, 5 January 2024Alexmadsen1uodate TSC1/2 <-->AMPK <-> NOS
127878view23:13, 5 January 2024Alexmadsen1add GPT The linkage between AMPK, NOS, MECP2, PTEN, PRKCB, mTORC1, mTORC2, and their relationship to Autism Spectrum Disorder (ASD) represents a complex network of interactions critical for neuronal function and development.
127877view03:54, 5 January 2024Alexmadsen1added linkage between NOS and 5-MTH per https://doi.org/10.1159/000142363
127876view02:56, 5 January 2024Alexmadsen1added refrences for Cbl / b12 pathway and added methionine synthase interactome
127875view04:15, 4 January 2024Alexmadsen1final check in
127874view03:26, 4 January 2024Alexmadsen1add glycine > guanidinoacetate > creatine and several DOI refrences
127873view01:42, 4 January 2024Alexmadsen1
127869view03:20, 3 January 2024Alexmadsen1general cleanup
127868view03:16, 3 January 2024Alexmadsen1add mTORC1 and mTORC 2 complex and MAPK3 MAPK1
127867view01:01, 3 January 2024Alexmadsen1add PI3K/Akt/mTOR intracellular signaling pathway
127855view03:24, 2 January 2024Alexmadsen1reorganise gudimate recptors
127854view01:19, 2 January 2024Alexmadsen1
127850view18:45, 31 December 2023Alexmadsen1added DRD4 SNP and RD4 VNTR exon III-7 repeat (7R), rs916455, rs1800955
127849view02:16, 30 December 2023Alexmadsen1cleanup
127848view21:43, 28 December 2023Alexmadsen1removed incorrect linkage between DHF to THF and BH2 to BH4
127733view04:05, 30 November 2023Alexmadsen1add Risperidone
127724view04:16, 29 November 2023Alexmadsen1add SAMe to COMT Neurotransmitter Catabolism (Breakdown). Linked COMT SNP to PNMT.
127718view04:44, 28 November 2023Alexmadsen1add NDRI Bupropion (Wellbutrin), fix Guanfacine and Clonidine and other cleanup
127682view23:20, 21 November 2023EweitzModified description
127680view23:14, 21 November 2023EweitzModified title
127675view22:42, 19 November 2023Alexmadsen1clanup
127674view22:24, 19 November 2023Alexmadsen1general cleanup
127672view17:10, 18 November 2023Alexmadsen1add SAME to NA to NM with COMT
127671view05:38, 18 November 2023Alexmadsen1add SAM to SAH conversion for PNMT when convering Norepinephran to Epinephran
127665view02:51, 16 November 2023Alexmadsen1fix floating connections
127664view02:47, 16 November 2023Alexmadsen1add PEA,NMPEA,2-phenylacetaldehyde
127638view14:02, 11 November 2023EgonwFixed more reference identifiers
127637view13:33, 11 November 2023EgonwFixed a few references (removed a few duplicates) and added a missing slash is a DOI
127597view02:09, 3 November 2023Alexmadsen1clean up methods of action in synaptic gap
127596view01:46, 3 November 2023Alexmadsen1

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(4aS,6R)-4a-hydroxy - BH4MetaboliteCHEBI:15642 (ChEBI)
1''-hydroxycannabidiolMetaboliteCHEBI:133056 (ChEBI)
1-O-(1,2-saturated-alkyl)-sn-glycerolMetaboliteCHEBI:83957 (ChEBI)
10-formyl-THFMetaboliteCHEBI:15637 (ChEBI)
11-OH-THCMetaboliteHMDB0060906 (HMDB)
1′-OXPH4MetaboliteHMDB0013642 (HMDB) 1'-oxo-2'-hydroxypropyl-tetrahydropterin
2''-hydroxycannabidiol MetaboliteCHEBI:133058 (ChEBI)
2-AGMetaboliteCHEBI:52392 (ChEBI) 2-arachidonoylglycerol
2-arachidonoylglycerolMetaboliteHMDB0004666 (HMDB)
2-oxoglutarateMetaboliteCHEBI:16810 (ChEBI)
2A-3OBUMetaboliteCHEBI:78948 (ChEBI)
2′-OXPH4MetaboliteCHEBI:17248 (ChEBI) 1'-hydroxy-2'-oxopropyl-tetrahydropterin (2'-OXPH4)
3''-hydroxycannabidiol MetaboliteCHEBI:133059 (ChEBI)
3-Hydroxyanthranilic AcidMetaboliteCHEBI:15793 (ChEBI)
3-HydroxykynurenineMetaboliteCHEBI:1547 (ChEBI)
3-MT SOMetaboliteCHEBI:133708 (ChEBI)
3-MTMetaboliteCHEBI:1582 (ChEBI)
4''-hydroxycannabidiol MetaboliteCHEBI:133055 (ChEBI)
4-aminobutanoateMetaboliteCHEBI:30566 (ChEBI)
4a-HydroxytetrahydrobiopterinMetaboliteCHEBI:15642 (ChEBI)
5''-hydroxycannabidiol MetaboliteCHEBI:133062 (ChEBI)
5, 10-MTHFPGMetaboliteCHEBI:60976 (ChEBI)
5-10MeTHFMetaboliteCHEBI:20502 (ChEBI)
5-HIAAMetaboliteCHEBI:27823 (ChEBI) AKA 5-HIAA
5-HialMetaboliteCHEBI:50157 (ChEBI)
5-MTMetaboliteCHEBI:2089 (ChEBI)
5-MTHFMetaboliteCHEBI:15641 (ChEBI)
5-hydroxy-L-tryptophanMetaboliteCHEBI:58266 (ChEBI)
6R-BH4MetaboliteCHEBI:59560 (ChEBI)
6a-hydroxycannabidiol MetaboliteCHEBI:133049 (ChEBI)
6b-hydroxycannabidiol MetaboliteCHEBI:133052 (ChEBI)
7-hydroxycannabidiol MetaboliteCHEBI:133053 (ChEBI)
AADATProteinQ8N5Z0 (Uniprot-TrEMBL)
AANATProteinQ16613 (Uniprot-TrEMBL)
AATMProteinP00505 (Uniprot-TrEMBL)
ABATProteinP80404 (Uniprot-TrEMBL) 4-Aminobutyrate aminotransferase
ABL1ProteinP00519 (Uniprot-TrEMBL)
ABL2ProteinP42684 (Uniprot-TrEMBL)
ACEGeneProductP12821 (Uniprot-TrEMBL)
ADAM10ProteinO14672 (Uniprot-TrEMBL)
ADCY1GeneProductCHEBI:58165 (Uniprot-TrEMBL)
ADCY7GeneProductADCY7 (Uniprot-TrEMBL)
ADGRL3 GPCRsProteinQ9HAR2 (Uniprot-TrEMBL)
ADHProteinEC 1.1.1.1 (KEGG Genes)
ADORA2AGeneProductP29274 (Uniprot-TrEMBL)
ADRA1AProteinP35348 (Uniprot-TrEMBL)
ADRA1BGeneProductP35368 (Uniprot-TrEMBL)
ADRA1DGeneProductP25100 (Uniprot-TrEMBL)
ADRA2AGeneProduct266750 (Entrez Gene)
ADRA2BGeneProduct266751 (Entrez Gene)
ADRA2CGeneProduct266752 (Entrez Gene)
ADRB1GeneProduct557194 (Entrez Gene)
ADRB2GeneProductP07550 (Uniprot-TrEMBL)
ADRB3aGeneProduct558248 (Entrez Gene)
AEAMetaboliteCHEBI:2700 (ChEBI) anandamide
AGMOProteinQ6ZNB7 (Uniprot-TrEMBL)
AGTR1ProteinP30556 (Uniprot-TrEMBL)
AHCYL1ProteinO43865 (Uniprot-TrEMBL)
AHCYProteinP23526 (Uniprot-TrEMBL)
AKRProtein
AKR1A1ProteinP14550 (Uniprot-TrEMBL)
AKR1B1ProteinP15121 (Uniprot-TrEMBL)
AKR1C1ProteinQ04828 (Uniprot-TrEMBL)
AKR1C3ProteinP42330 (Uniprot-TrEMBL)
ALDHProtein
ALDH1L1ProteinO75891 (Uniprot-TrEMBL)
ALDH1L2ProteinQ3SY69 (Uniprot-TrEMBL)
ALDH2ProteinP05091 (Uniprot-TrEMBL)
ALDH5A1ProteinCHEBI:57706 (Uniprot-TrEMBL)
ALDH9A1ProteinP49189 (Uniprot-TrEMBL) 4-trimethylaminobutyraldehyde dehydrogenase
AOC1GeneProductP19801 (Uniprot-TrEMBL)
APPProteinP05067 (Uniprot-TrEMBL)
ASMTProteinP46597 (Uniprot-TrEMBL)
ATPMetaboliteHMDB0000538 (HMDB)
AdoCblMetaboliteCHEBI:18408 (ChEBI)
Alpha-dystroglycanProtein
AngiotensinogenMetaboliteCHEBI:2720 (ChEBI)
Anthranilic AcidMetaboliteCHEBI:16567 (ChEBI)
Anti-inflammatory pathwaysPathway
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
Atomoxetine (Strattera)MetaboliteHMDB14434 (HMDB)
B2 riboflavinMetaboliteCHEBI:17015 (ChEBI)
B2MetaboliteCHEBI:17015 (ChEBI)
B3MetaboliteCHEBI:17154 (ChEBI)
B6 pyridoxineMetaboliteCHEBI:16709 (ChEBI)
B9MetaboliteCHEBI:27470 (ChEBI)
BH2 7,8-dihydrofolateMetaboliteCHEBI:64240 (ChEBI)
BH4MetaboliteCHEBI:15372 (ChEBI)
BHMTProteinQ93088 (Uniprot-TrEMBL)
Beta-dystroglycanProtein
BiopterinMetaboliteCHEBI:15373 (ChEBI)
CACNA1CProteinQ13936 (Uniprot-TrEMBL)
CACNG1ProteinQ06432 (Uniprot-TrEMBL)
CACNG2ProteinQ9Y698 (Uniprot-TrEMBL)
CACNG3ProteinO60359 (Uniprot-TrEMBL)
CACNG4ProteinQ9UBN1 (Uniprot-TrEMBL)
CACNG5ProteinQ9UF02 (Uniprot-TrEMBL)
CACNG6ProteinQ9BXT2 (Uniprot-TrEMBL)
CACNG7ProteinP62955 (Uniprot-TrEMBL)
CACNG8ProteinQ8WXS5 (Uniprot-TrEMBL)
CB CollybistinProtein
CBDMetaboliteCHEBI:69478 (ChEBI)
CBLProteinP22681 (Uniprot-TrEMBL)
CBR1ProteinP16152 (Uniprot-TrEMBL)
CBSProteinP35520 (Uniprot-TrEMBL)
CD320ProteinQ9NPF0 (Uniprot-TrEMBL) Aka CD320 receptor
CDO1GeneProductQ16878 (Uniprot-TrEMBL)
CNR1GeneProductP21554 (Uniprot-TrEMBL) CB1
CNR2GeneProductP34972 (Uniprot-TrEMBL) CB2
CNTN1GeneProductQ9UQ52 (Uniprot-TrEMBL)
CNTN2GeneProductO94779 (Uniprot-TrEMBL)
CNTN3GeneProductQ8IWV2 (Uniprot-TrEMBL)
CNTN4GeneProductQ9P232 (Uniprot-TrEMBL)
CNTN5GeneProductQ02246 (Uniprot-TrEMBL)
CNTN6GeneProductQ12860 (Uniprot-TrEMBL)
CNTNAP1GeneProductP78357 (Uniprot-TrEMBL)
CNTNAP2GeneProductQ9UHC6 (Uniprot-TrEMBL)
CNTNAP3GeneProductQ9BZ76 (Uniprot-TrEMBL)
CNTNAP4GeneProductQ9C0A0 (Uniprot-TrEMBL)
COMTProteinP21964 (Uniprot-TrEMBL) AKA Catechol-O- metyltransferase
COOH-THCMetaboliteCHEBI:77273 (ChEBI)
CPLX1ProteinO14810 (Uniprot-TrEMBL)
CSADProteinQ9Y600 (Uniprot-TrEMBL)
CTHProteinP32929 (Uniprot-TrEMBL)
CTNNB1GeneProductENSG00000168036 (Ensembl)
CTTNProteinQ14247 (Uniprot-TrEMBL)
CYP2C19GeneProductENSG00000165841 (Ensembl)
CYP2C9GeneProductENSG00000138109 (Ensembl)
CYP2D6ProteinP10635 (Uniprot-TrEMBL)
CYP3A4GeneProductENSG00000160868 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CblD MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
CblD-1 MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
CblD-2 MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
CblMetaboliteQ3329800 (Wikidata)
ClonidineMetaboliteCHEBI:46631 (ChEBI)
CortactinGeneProductENSG00000085733 (Ensembl)
DAG1GeneProductQ14118 (Uniprot-TrEMBL)
DAGLAGeneProductENSG00000134780 (Ensembl)
DAGLBGeneProductENSG00000164535 (Ensembl)
DBHProteinP09172 (Uniprot-TrEMBL)
DDCProteinP20711 (Uniprot-TrEMBL)
DHFMetaboliteCHEBI:23743 (ChEBI)
DHFRProteinP00374 (Uniprot-TrEMBL)
DHMAMetaboliteCHEBI:27637 (ChEBI)
DHNTPMetaboliteCHEBI:18372 (ChEBI)
DHPGMetaboliteCHEBI:1387 (ChEBI)
DLG1ProteinQ12959 (Uniprot-TrEMBL)
DLG2ProteinQ15700 (Uniprot-TrEMBL)
DLG3ProteinQ92796 (Uniprot-TrEMBL)
DLG4 PSD95ProteinP78352 (Uniprot-TrEMBL)
DLG5ProteinQ8TDM6 (Uniprot-TrEMBL)
DLGAP1GeneProductO14490 (Uniprot-TrEMBL)
DLGAP2GeneProductQ9P1A6 (Uniprot-TrEMBL)
DLGAP3GeneProductO95886 (Uniprot-TrEMBL)
DLGAP4GeneProductQ9Y2H0 (Uniprot-TrEMBL)
DLGAP5GeneProductQ15398 (Uniprot-TrEMBL)
DNMT1ProteinP26358 (Uniprot-TrEMBL)
DOPACMetaboliteCHEBI:41941 (ChEBI)
DOPEGMetaboliteCHEBI:1387 (ChEBI)
DOPETMetaboliteCHEBI:68889 (ChEBI)
DOPGAL MetaboliteCHEBI:180943 (ChEBI)
DOPLMetaboliteCHEBI:27978 (ChEBI)
DRD1GeneProduct568126 (Entrez Gene)
DRD2GeneProductP14416 (Uniprot-TrEMBL)
DRD3GeneProduct282554 (Entrez Gene)
DRD4GeneProductP21917 (Uniprot-TrEMBL)
DRD5ProteinP21918 (Uniprot-TrEMBL)
Derived From WP3869 Cannabinoid receptor signalingPathwayWP3869 (WikiPathways)
Derived From WP4159 GABA receptor signalingPathwayWP4159 (WikiPathways)
Derived From WP4271 Vitamin B12 disordersPathwayWP4271 (WikiPathways)
Dextroamphetamine

+ Amphetamine

(Adderall)		MetaboliteCHEBI:2679 (ChEBI)
F-actinGeneProduct
FAAH2GeneProductQ6GMR7 (Uniprot-TrEMBL)
FAAHGeneProductENSG00000117480 (Ensembl)
FADMetaboliteCHEBI:57692 (ChEBI) cofactor
FLAD1MetaboliteQ8NFF5 (ChEBI)
FMNMetabolitecHEBI:58210 (ChEBI) cofactor
FMO1GeneProductQ01740 (Uniprot-TrEMBL)
FMO3GeneProductQ01740 (Uniprot-TrEMBL)
FOLH1GeneProductQ04609 (Uniprot-TrEMBL)
FOLR1ProteinP15328 (Uniprot-TrEMBL)
FOLR2ProteinP14207 (Uniprot-TrEMBL)
Fe2+MetaboliteCHEBI:29033 (ChEBI)
GABAMetaboliteCHEBI:59888 (ChEBI)
GABBR1ProteinQ9UBS5 (Uniprot-TrEMBL)
GABRA1ProteinP14867 (Uniprot-TrEMBL)
GABRA2ProteinP47869 (Uniprot-TrEMBL)
GABRA3ProteinP34903 (Uniprot-TrEMBL)
GABRA4ProteinP48169 (Uniprot-TrEMBL)
GABRA5ProteinP31644 (Uniprot-TrEMBL)
GABRB1ProteinP18505 (Uniprot-TrEMBL)
GABRB2ProteinP47870 (Uniprot-TrEMBL)
GABRB3ProteinP28472 (Uniprot-TrEMBL)
GABRDProteinO14764 (Uniprot-TrEMBL)
GABRG1ProteinQ8N1C3 (Uniprot-TrEMBL)
GABRG2ProteinP18507 (Uniprot-TrEMBL)
GABRQProteinQ9UN88 (Uniprot-TrEMBL)
GAD1GeneProductQ99259 (Uniprot-TrEMBL)
GAD2GeneProductQ05329 (Uniprot-TrEMBL)
GCATGeneProductO75600 (Uniprot-TrEMBL)
GCH1 GTPCHProteinP30793 (Uniprot-TrEMBL)
GKAP1GeneProductQ5VSY0 (Uniprot-TrEMBL)
GKProteinP32189 (Uniprot-TrEMBL)
GLS2ProteinQ9UI32 (Uniprot-TrEMBL)
GLSProteinO94925 (Uniprot-TrEMBL)
GLULGeneProductP15104 (Uniprot-TrEMBL)
GNAQProteinP50148 (Uniprot-TrEMBL)
GPHNProteinQ9NQX3 (Uniprot-TrEMBL)
GRIA1ProteinP42261 (Uniprot-TrEMBL)
GRIA2ProteinP42262 (Uniprot-TrEMBL)
GRIA3ProteinP42263 (Uniprot-TrEMBL)
GRIA4ProteinP48058 (Uniprot-TrEMBL)
GRIN1ProteinQ05586 (Uniprot-TrEMBL)
GRIN2AProteinQ12879 (Uniprot-TrEMBL)
GRIN2BProteinQ13224 (Uniprot-TrEMBL)
GRIN2CProteinQ14957 (Uniprot-TrEMBL)
GRIN2DProteinO15399 (Uniprot-TrEMBL)
GRIN3AProteinQ8TCU5 (Uniprot-TrEMBL)
GRIN3BProteinO60391 (Uniprot-TrEMBL)
GRIP1ProteinQ9Y3R0 (Uniprot-TrEMBL)
GRIP2ProteinQ9C0E4 (Uniprot-TrEMBL)
GRM1ProteinQ13255 (Uniprot-TrEMBL)
GRM2ProteinQ14416 (Uniprot-TrEMBL)
GRM3ProteinQ14832 (Uniprot-TrEMBL)
GRM4ProteinQ14833 (Uniprot-TrEMBL)
GRM5ProteinP41594 (Uniprot-TrEMBL)
GRM6ProteinO15303 (Uniprot-TrEMBL)
GRM7ProteinQ14831 (Uniprot-TrEMBL)
GRM8ProteinO00222 (Uniprot-TrEMBL)
GuanfacineMetaboliteHMDB15153 (HMDB)
H2O2Metabolite16240 (ChEBI)
H4gtp GPTMetaboliteCHEBI:15996 (ChEBI)
HCFC1 (cblX)GeneProductP51610 (Uniprot-TrEMBL)
HDCGeneProductP19113 (Uniprot-TrEMBL)
HISN8ProteinQ9C5U8 (Uniprot-TrEMBL)
HNMTGeneProductP50135 (Uniprot-TrEMBL)
HOMERGeneProduct
HOMER1ProteinQ86YM7 (Uniprot-TrEMBL)
HOMER2ProteinQ9NSB8 (Uniprot-TrEMBL)
HOMER3ProteinQ9NSC5 (Uniprot-TrEMBL)
HTR1AProtein100001828 (Entrez Gene)
HTR1BProtein561647 (Entrez Gene)
HTR1DProteinP28221 (Uniprot-TrEMBL)
HTR1EProteinP28566 (Uniprot-TrEMBL)
HTR1FProteinP30939 (Uniprot-TrEMBL)
HTR2AProteinP28223 (Uniprot-TrEMBL)
HTR2BProteinP41595 (Uniprot-TrEMBL)
HTR2CProtein
HTR3AProteinP40227 (Uniprot-TrEMBL)
HTR3BProteinO95264 (Uniprot-TrEMBL)
HTR3CProteinQ8WXA8 (Uniprot-TrEMBL)
HTR3DProteinQ70Z44 (Uniprot-TrEMBL)
HTR3EProteinA5X5Y0 (Uniprot-TrEMBL)
HTR4ProteinQ13639 (Uniprot-TrEMBL)
HTR5aProtein100038775 (Entrez Gene)
HTR5bProtein
HTR6ProteinP50406 (Uniprot-TrEMBL)
HTR7ProteinP34969 (Uniprot-TrEMBL)
HVAMetaboliteCHEBI:545959 (ChEBI) AKA HVA
HVALMetaboliteCHEBI:173769 (ChEBI) HVAL = Homovanillyl = alcohol(4-Hydroxy-3-methoxyphenyl)ethanol
IDO1ProteinP14902 (Uniprot-TrEMBL)
IDO2ProteinQ6ZQW0 (Uniprot-TrEMBL)
IFNGProteinP01579 (Uniprot-TrEMBL)
INFAProtein
Imidazole-4-acetateMetaboliteCHEBI:16974 (ChEBI)
KAT1ProteinQ16773 (Uniprot-TrEMBL)
KAT3ProteinQ6YP21 (Uniprot-TrEMBL)
KCNA1ProteinQ09470 (Uniprot-TrEMBL)
KCNA2ProteinP16389 (Uniprot-TrEMBL)
KCNA3ProteinP22001 (Uniprot-TrEMBL)
KCNA4ProteinP22459 (Uniprot-TrEMBL)
KCNA5ProteinP22460 (Uniprot-TrEMBL)
KCNA6ProteinP17658 (Uniprot-TrEMBL)
KCNA7ProteinQ96RP8 (Uniprot-TrEMBL)
KMOProteinO15229 (Uniprot-TrEMBL)
KUVAN (BH4 Supplement) MetaboliteCHEBI:15372 (ChEBI)
KYAT3ProteinQ6YP21 (Uniprot-TrEMBL)
KYNUProteinQ16719 (Uniprot-TrEMBL)
Ketamine MetaboliteCHEBI:6121 (ChEBI)
Kynurenic AcidMetaboliteCHEBI:58454 (ChEBI)
KynurenineMetaboliteCHEBI:57959 (ChEBI)
L-AspMetaboliteCHEBI:29991 (ChEBI)
L-GluMetaboliteCHEBI:29985 (ChEBI)
L-alanineMetabolite57972 (ChEBI)
L-arginineMetaboliteCHEBI:32682 (ChEBI)
L-citrullineMetaboliteCHEBI:57743 (ChEBI)
L-cysteateMetaboliteCHEBI:58090 (ChEBI)
L-cysteineMetaboliteCHEBI:35235 (ChEBI)
L-dopaMetaboliteCHEBI:57504 (ChEBI)
L-glutamateMetaboliteCHEBI:29985 (ChEBI)
L-glutamineMetaboliteCHEBI:58359 (ChEBI)
L-histidineMetaboliteCHEBI:57595 (ChEBI)
L-histidinolMetaboliteCHEBI:57699 (ChEBI)
L-phenylalanineMetaboliteCHEBI:58095 (ChEBI)
L-threonineMetaboliteCHEBI:57926 (ChEBI)
L-tryptophanMetaboliteCHEBI:57912 (ChEBI)
L-tyrosineMetaboliteCHEBI:58315 (ChEBI)
MAOAProteinP21397 (Uniprot-TrEMBL)
MAOBProteinP27338 (Uniprot-TrEMBL)
MAOIsMetabolite
MAPK GeneProduct2.7.11.24 (Enzyme Nomenclature)
MAT1AProteinQ00266 (Uniprot-TrEMBL)
MAT2BProteinQ9NZL9 (Uniprot-TrEMBL)
MC4RProteinP32245 (Uniprot-TrEMBL)
MG2+MetaboliteCHEBI:18420 (ChEBI)
MHPG MOPEGMetaboliteCHEBI:1576 (ChEBI)
MMAB cblBProtein60488 (Uniprot-TrEMBL) gene: MMAB
MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
MMUTProteinP22033 (Uniprot-TrEMBL) aka methylmalonyl-CoA mutase or MCM
MN-SO4MetaboliteHMDB0240719 (HMDB)
MN2+MetaboliteCHEBI:29035 (ChEBI)
MOCOSProteinQ96EN8 (Uniprot-TrEMBL)
MOPGALMetabolite27932 (ChEBI)
MTHFD1LProteinQ6UB35 (Uniprot-TrEMBL)
MTHFD1ProteinP11586 (Uniprot-TrEMBL)
MTHFD2LProteinQ9H903 (Uniprot-TrEMBL)
MTHFD2ProteinP13995 (Uniprot-TrEMBL)
MTHFRProteinP42898 (Uniprot-TrEMBL)
MTRProteinQ99707 (Uniprot-TrEMBL)
MTRRProteinQ9UBK8 (Uniprot-TrEMBL)
MeCblMetaboliteCHEBI:28115 (ChEBI)
MetMetaboliteCHEBI:64558 (ChEBI)
MetaboliteMetabolite
MetanephrineMetaboliteCHEBI:89633 (ChEBI)
Methylmalonyl-CoAMetaboliteCHEBI:16625 (ChEBI)
Methylphenidate (Ritalin)MetaboliteHMDB14566 (HMDB)
MoCoMetabolite71302 (ChEBI)
N-METHYL-HISTAMINEMetaboliteCHEBI:58600 (ChEBI)
N-MethylhistamineMetaboliteCHEBI:29009 (ChEBI)
NA NorepinephrineMetaboliteCHEBI:72587 (ChEBI)
NA AldehydeMetabolite
NAD+MetaboliteCHEBI:13389 (ChEBI)
NADPMetaboliteCHEBI:58349 (ChEBI)
NADPHMetaboliteCHEBI:57783 (ChEBI)
NADSYN1ProteinQ6IA69 (Uniprot-TrEMBL)
NAPEMetaboliteCHEBI:61232 (ChEBI)
NAPEPLDProteinNAPEPLD (Uniprot-TrEMBL)
NASMetaboliteCHEBI:17697 (ChEBI)
NCAM1ProteinP13591 (Uniprot-TrEMBL)
NLGN1ProteinQ8N2Q7 (Uniprot-TrEMBL)
NLGN2ProteinQ8NFZ4 (Uniprot-TrEMBL)
NLGN3ProteinQ9NZ94 (Uniprot-TrEMBL)
NLGN4XProteinQ8N0W4 (Uniprot-TrEMBL)
NM Aldehyde Metabolite
NMMetaboliteHMDB00819 (HMDB)
NMN-SOMetaboliteHMDB0240719 (HMDB)
NMNAT1ProteinQ9HAN9 (Uniprot-TrEMBL)
NOMetabolite16480 (ChEBI)
NOS1ProteinP29475 (Uniprot-TrEMBL)
NOS2ProteinP35228 (Uniprot-TrEMBL)
NOS3ProteinP29474 (Uniprot-TrEMBL)
NOX1ProteinQ9Y5S8 (Uniprot-TrEMBL)
NOX3ProteinQ9HBY0 (Uniprot-TrEMBL)
NOX4ProteinQ9NPH5 (Uniprot-TrEMBL)
NOX5ProteinQ96PH1 (Uniprot-TrEMBL)
NRXN1ProteinQ9ULB1 (Uniprot-TrEMBL)
NRXN2ProteinP58401 (Uniprot-TrEMBL)
NRXN3ProteinQ9HDB5 (Uniprot-TrEMBL)
NorepinephrineMetaboliteCHEBI:72587 (ChEBI)
O2MetaboliteCHEBI:5379 (ChEBI)
O2−MetaboliteCHEBI:18421 (ChEBI)
OH-MetaboliteCHEBI:16234 (ChEBI)
ONOO-MetaboliteCHEBI:25941 (ChEBI)
OPRM1ProteinP35372 (Uniprot-TrEMBL)
OXTProteinP01178 (Uniprot-TrEMBL)
OXTRProteinP30559 (Uniprot-TrEMBL)
P
PAHProteinP00439 (Uniprot-TrEMBL)
PCBD1ProteinP61457 (Uniprot-TrEMBL)
PCBD2ProteinQ9H0N5 (Uniprot-TrEMBL)
PDXKProteinO00764 (Uniprot-TrEMBL)
PLCBGeneProductP50148 (Uniprot-TrEMBL)
PLP pyridoxal 5'-phosphateMetaboliteCHEBI:597326 (ChEBI)
PLPMetaboliteCHEBI:597326 (ChEBI)
PNMTProteinP11086 (Uniprot-TrEMBL)
PNPOProteinQ9NVS9 (Uniprot-TrEMBL)
PPH4MetaboliteCHEBI:17804 (ChEBI)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PRKAR1AGeneProductENSG00000108946 (Ensembl)
PRKAR1BGeneProductENSG00000188191 (Ensembl)
PRKAR2AGeneProductENSG00000114302 (EMBL)
PRKAR2BGeneProductENSG00000005249 (Ensembl)
PSD95GeneProductP78352 (Uniprot-TrEMBL)
PTK2BProteinQ14289 (Uniprot-TrEMBL)
PTSProteinQ03393 (Uniprot-TrEMBL)
Pharmacological

Intervention

(drug)
PhosphatidylethanolamineMetaboliteHMDB0060501 (HMDB)
Picolinic AcidMetaboliteCHEBI:28747 (ChEBI)
PrazosinMetaboliteHMDB14600 (HMDB)
ProteinProtein
QDPRProteinP09417 (Uniprot-TrEMBL)
QPRTProteinQ15274 (Uniprot-TrEMBL)
QUINMetaboliteCHEBI:16675 (ChEBI)
Quinolinic Acid QUINMetaboliteCHEBI:16675 (ChEBI)
R-cob(III)alaminMetaboliteCHEBI:140785 (ChEBI)
RENProteinP00797 (Uniprot-TrEMBL)
RFKProteinQ969G6 (Uniprot-TrEMBL)
RIT2ProteinQ99578 (Uniprot-TrEMBL)
RS4818Rna
RS6267Rna
S-SCAMGeneProduct
S-adenosyl-L-homocysteineMetaboliteCHEBI:57856 (ChEBI)
SAHMetaboliteCHEBI:16680 (ChEBI)
SAM MetaboliteCHEBI:59789 (ChEBI)
SAPAPGeneProduct
SCN10AProteinQ9Y5Y9 (Uniprot-TrEMBL)
SCN11AProteinQ9UI33 (Uniprot-TrEMBL)
SCN1AProteinP35498 (Uniprot-TrEMBL)
SCN1BProteinQ07699 (Uniprot-TrEMBL)
SCN2AProteinQ99250 (Uniprot-TrEMBL)
SCN2BProteinO60939 (Uniprot-TrEMBL)
SCN3AProteinQ9NY46 (Uniprot-TrEMBL)
SCN3BProteinQ9NY72 (Uniprot-TrEMBL)
SCN4AProteinP35499 (Uniprot-TrEMBL)
SCN4BProteinQ8IWT1 (Uniprot-TrEMBL)
SCN5AProteinQ14524 (Uniprot-TrEMBL)
SCN7AProteinQ01118 (Uniprot-TrEMBL)
SCN8AProteinQ9UQD0 (Uniprot-TrEMBL)
SCN9AProteinQ15858 (Uniprot-TrEMBL)
SHANKGeneProduct
SHANK1ProteinQ9Y566 (Uniprot-TrEMBL)
SHANK2ProteinQ9UPX8 (Uniprot-TrEMBL)
SHANK3ProteinQ9BYB0 (Uniprot-TrEMBL)
SHMT1ProteinP34896 (Uniprot-TrEMBL)
SHMT2ProteinP34897 (Uniprot-TrEMBL)
SIRT3GeneProductQ9NTG7 (Uniprot-TrEMBL)
SLC17A6GeneProductQ9P2U8 (Uniprot-TrEMBL)
SLC17A7ProteinQ9P2U7 (Uniprot-TrEMBL) Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:10820226). At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity).
SLC17A8GeneProductQ8NDX2 (Uniprot-TrEMBL)
SLC18A1ProteinP54219 (Uniprot-TrEMBL)
SLC19A1ProteinP41440 (Uniprot-TrEMBL)
SLC25A12ProteinO75746 (Uniprot-TrEMBL)
SLC25A13ProteinQ9UJS0 (Uniprot-TrEMBL)
SLC25A32ProteinQ9H2D1 (Uniprot-TrEMBL)
SLC32A1ProteinQ9H598 (Uniprot-TrEMBL) Vesicular inhibitory amino acid transporter
SLC46A1ProteinQ96NT5 (Uniprot-TrEMBL)
SLC52A1GeneProductQ9NWF4 (Uniprot-TrEMBL)
SLC52A2GeneProductQ9HAB3 (Uniprot-TrEMBL)
SLC52A3GeneProductQ9NQ40 (Uniprot-TrEMBL)
SLC6A1GeneProductP30531 (Uniprot-TrEMBL)
SLC6A2ProteinP23975 (Uniprot-TrEMBL)
SLC6A3ProteinQ01959 (Uniprot-TrEMBL) Sodium-dependent dopamine transporter, DA transporter, DAT, Solute carrier family 6 member 3. AKA DAT1
SLC6A4ProteinP31645 (Uniprot-TrEMBL)
SNAP25ProteinP60880 (Uniprot-TrEMBL)
SNP

single nucleotide

polymorphism		Rna
SNRI

Escitalopram (Lexapro) Fluoxetine (Prozac) Paroxetine (Paxil, Pexeva)

Sertraline(Zoloft)		MetaboliteHMDB14600 (HMDB)
SOD1ProteinP00441 (Uniprot-TrEMBL)
SOD2ProteinP04179 (Uniprot-TrEMBL)
SOD3ProteinP08294 (Uniprot-TrEMBL)
SPRProteinP35270 (Uniprot-TrEMBL)
SRBS2ProteinO94875 (Uniprot-TrEMBL)
STX1AProteinQ16623 (Uniprot-TrEMBL)
STXBP1ProteinP61764 (Uniprot-TrEMBL)
SULT1A3ProteinP0DMM9 (Uniprot-TrEMBL)
SYPProteinP08247 (Uniprot-TrEMBL)
SYT1ProteinP21579 (Uniprot-TrEMBL)
Succinyl-CoAMetaboliteCHEBI:15380 (ChEBI)
T23OProteinP48775 (Uniprot-TrEMBL)
TAAR1ProteinQ96RJ0 (Uniprot-TrEMBL)
TCN2ProteinP20062 (Uniprot-TrEMBL)
TDC Protein
THCMetaboliteHMDB0041865 (HMDB)

  • Tetrahydrocannabinol (THC) is the primary psychoactive compound found in cannabis plants. Its effects on cannabinoid receptors CNR1 (CB1) and CNR2 (CB2) are well-documented:

    CB1 Receptor Interaction:

    THC is a partial agonist at the CB1 receptor. When it binds to the CB1 receptor, it activates the receptor to a degree, eliciting a psychoactive response which is often associated with the "high" experienced from cannabis consumption. CB2 Receptor Interaction:

    THC is also a partial agonist at the CB2 receptor, although its affinity for the CB2 receptor is less compared to the CB1 receptor. The activation of CB2 receptors by THC is associated with some of the medicinal properties of cannabis, such as its anti-inflammatory effects.

    In summary, THC acts as a partial agonist at both CB1 and CB2 receptors, stimulating these receptors to produce a variety of effects in the body, including psychoactive and potential therapeutic effects. Unlike CBD, THC does not act as an antagonist or inhibitor at these receptors, and its binding and activation of CB1 and CB2 receptors are central to its effects.
  • Type your comment here
THF-polyglutamateMetaboliteCHEBI:28624 (ChEBI)
THFMetaboliteCHEBI:26907 (ChEBI)
TNFAProteinP01375 (Uniprot-TrEMBL)
TPH1ProteinP17752 (Uniprot-TrEMBL)
TPH2ProteinQ8IWU9 (Uniprot-TrEMBL)
TYMSProteinP04818 (Uniprot-TrEMBL)
TYProteinP07101 (Uniprot-TrEMBL)
VAMP2ProteinP63027 (Uniprot-TrEMBL)
VMAMetaboliteCHEBI:27622 (ChEBI)
Xanthurenic acidMetaboliteCHEBI:10072 (ChEBI)
a 1-(1-hydroxyalkyl)-sn-glycerolMetaboliteCHEBI:73418 (ChEBI)
acetateMetaboliteCHEBI:58251 (ChEBI)
adrenalineMetaboliteCHEBI:28918 (ChEBI)
alkylglycerolsMetaboliteCHEBI:52575 (ChEBI)
angiotensin IMetaboliteCHEBI:147350 (ChEBI)
angiotensin IIMetaboliteCHEBI:58506 (ChEBI)
arachidonic acidMetaboliteCHEBI:15843 (ChEBI)
cAMP MetaboliteCHEBI:58165 (ChEBI)
cbLA MMAAProteinQ8IVH4 (Uniprot-TrEMBL) Gene: MMAA
cbLC MMACHCProteinQ9Y4U1 (Uniprot-TrEMBL) Gene is called MMAC
cblF LMBRD1ProteinQ9NUN5 (Uniprot-TrEMBL)
cblJ ABCD4ProteinO14678 (Uniprot-TrEMBL)
citrate cyclePathwayWP78 (WikiPathways)
cob(I)alaminMetaboliteCHEBI:15982 (ChEBI)
cob(II)alaminMetaboliteCHEBI:16304 (ChEBI) Should be cob(II)alamin according to literature
cystathionineMetaboliteCHEBI:58161 (ChEBI)
cysteine sulfinateMetaboliteCHEBI:61085 (ChEBI)
deamido-NAD+MetaboliteCHEBI:58437 (ChEBI)
dopamineMetaboliteCHEBI:59905 (ChEBI)
fatty aldehydesMetaboliteCHEBI:35746 (ChEBI)
formateMetaboliteCHEBI:15740 (ChEBI)
gamma-hydroxybutyrate MetaboliteQ207920 (Wikidata)
glycerol 3-phosphateMetaboliteCHEBI:57597 (ChEBI)
glycerolMetaboliteCHEBI:17754 (ChEBI)
glycine betaineMetaboliteCHEBI:17750 (ChEBI)
glycineMetaboliteCHEBI:57305 (ChEBI)
hemiacetalsMetaboliteCHEBI:5653 (ChEBI)
histamineMetaboliteCHEBI:58432 (ChEBI)
homocysteineMetaboliteCHEBI:58199 (ChEBI)
hypotaurineMetaboliteCHEBI:57853 (ChEBI)
imidazole-4-acetaldehydeMetaboliteCHEBI:27398 (ChEBI)
melatoninMetaboliteCHEBI:16796 (ChEBI)
moco sulfide Metabolite82685 (ChEBI)
nicotinate D-ribonucleotide(2−)MetaboliteCHEBI:57502 (ChEBI)
noladin etherMetaboliteCHEBI:75913 (ChEBI)
oxytocinMetaboliteCHEBI:7872 (ChEBI)
pyridoxalMetaboliteCHEBI:17310 (ChEBI)
pyridoxamineMetaboliteCHEBI:57761 (ChEBI)
pyridoxine 5'-phosphateMetaboliteCHEBI:58589 (ChEBI)
q-BH2MetaboliteCHEBI:43029 (ChEBI)
q-H2BPTMetaboliteCHEBI:43120 (ChEBI)
rs1023159Rna
rs1051266Rna
rs1051312Rna
rs10521432Rna
rs10879352Rna
rs11178997Rna
rs1137070Rna
rs121913223Rna
rs12843268Rna
rs12843533Rna
rs13189021Rna
rs1352250Rna
rs1390938Rna
rs1406946Rna
rs1465107Rna
rs1487275Rna
rs151257822GeneProduct
rs1532268Rna
rs1543334Rna
rs165599Rna
rs165774Rna
rs1667627Rna
rs1672717Rna
rs167771Rna
rs16976358Rna
rs174696Rna
rs1799836Rna
rs1799971Rna
rs1800544Rna
rs1801131Rna
rs1801133Rna
rs1801198Rna
rs1801394Rna
rs1805087Rna
rs1923886Rna
rs1950902Rna
rs1979277Rna
rs2056202Rna
rs2071010Rna
rs2088102Rna
rs2129575Rnars2129575
rs2236225Rna
rs2242446Rna
rs2254298GeneProduct
rs2268491GeneProduct
rs2270637Rna
rs2270641Rna
rs2279709Rna
rs2292813Rna
rs2298444Rna
rs237887GeneProduct
rs237889GeneProduct
rs237897GeneProduct
rs237902GeneProduct
rs2518352Rna
rs251915Rna
rs2550936Rna
rs265981Rna
rs2710102Rna
rs28386840Rna
rs2934966Rna
rs3027400Rna
rs3027407Rna
rs35062132GeneProduct
rs36017Rna
rs362204Rna
rs3733890Rnars3733890 (dbSNP)
rs3746544Rna
rs3758653Rna
rs3782025Rna
rs3785143Rna
rs3785157Rna
rs3813034Rna
rs3819331Rna
rs4130047Rna
rs4291Rna
rs4343Rna
rs4446909Rna
rs4532Rna
rs4570625Rna
rs4633Rna
rs4680Rna
rs4846049Rna
rs53576GeneProduct
rs5569Rna
rs590551Rna
rs5905512Rna
rs5906883 Rna
rs594445Rna
rs5949028Rna
rs5989681Rna
rs602618Rna
rs6189Rna
rs6198Rna
rs6269Rna
rs6280Rna
rs6296Rna
rs6318Rna
rs6323Rna
rs651646 Rna
rs6561333Rna
rs6582071Rna
rs6651806Rna
rs6746030Rna
rs686Rna
rs70991108Rna
rs737865Rna
rs740601Rna
rs7632287GeneProduct
rs7794745Rna
rs779867Rna
rs7997012Rna
rs876657421Rna
rs908670Rna
sepiapterinMetaboliteCHEBI:16095 (ChEBI)
serineMetaboliteQ82980657 (Wikidata)
serotoninMetaboliteCHEBI:350546 (ChEBI)
succinate MetaboliteQ213050 (Wikidata)
succinic semialdehydeMetaboliteCHEBI:57706 (ChEBI)
taurineMetaboliteCHEBI:507393 (ChEBI)
tyramineMetaboliteCHEBI:327995 (ChEBI)
viloxazine (Qelbree)MetaboliteCHEBI:94405 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5420"
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