Omega-6-fatty acids in senescence (Homo sapiens)

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79, 103110, 12221, 111, 136412312743, 90, 1441373, 13331, 14921, 48, 136, 15018220, 66, 1453970, 848520, 30, 35, 76, 134...752213323493, 15973, 92, 1183738, 65, 103, 1507093, 1603139, 148236, 71, 14823, 93120, 15141, 108, 1532, 543425, 50, 104, 108, 1501432, 9093, 16014138531, 7462146141373517, 82, 932, 542, 6, 11639, 8914117, 82, 9339160143101, 1591101370, 71, 739786212, 6, 1165, 4127, 52, 14743, 14471, 939743, 143145541271433343, 90, 14427011, 50, 108, 15373, 92, 133223, 931, 75133286229341431325421, 24, 79, 118, 13654232175, 98, 14370132, 5443, 143, 14413, 34, 63, 67, 78...3769371, 73, 133341001396237173, 92, 11843, 144752143, 90, 143, 14423, 120, 15412343, 14415718, 7343, 1441815012613131343, 14471, 12043, 143, 1442, 6, 11621, 89, 10175, 98143143, 1444175862, 5493243, 90, 1445293, 1183931, 142398221429914343, 143, 144343, 143, 14425, 4171732, 54933, 121285411931, 149543671, 127754, 9723, 9362, 1215, 41963722, 34, 6314218712, 6, 11643, 143, 144393, 11824, 118, 12750, 108, 130, 153PDietary Lipids4S,5-epoxy-17S-hydroxy-HDHAPGD1Peroxidase*Irradiation-induced senescenceUnknownNon-enzymatic degradationΔ12-PGJ25S,6S,18R-TriHEPE*Hydrolase*DH-PGJ2DehydraseReductionPeroxidase*18-oxo-RvE1PGF1a10,11,dihydro-12-oxo-RvE1β and ω oxidation*HPGD 15S-hydroxy-5S-HpEPE*PTGS2TxA1*PGA25S,12S,18R-TriHEPE*ALOX15Enzymatic Epoxidation9,15-dideoxy-Δ9,12,14-PGD2*Docosahexaenoic acid (DHA) (22:6,w3)TxB1AKR1B1Hydrolase*RvE1AKR1C3Arachidonic Acid (20:4,w6)13,14-dihydro-15-keto-PGA2RvD515-keto-PGE16-keto-PGF1a15-keto-PGF2a5S,6S-epoxy-18S-HEPECMKLR1Non-enzymatic hydrolysis4,13-diketo-7,9-dihydroxy-2,3-dinor prostanoic acid*20-hydroxy-RvE17S,17S-diHpDPALGE2IP3PG-9KRPGDSPGDS11-dehydro-Thromboxane B2ALOX5EETs20-carboxy-RvE1*w-hydroxylase*RvD6PTGS2ALOX5RvD5(n-3 DPA)*17R-HDHANon-enzymatic dehydrationTXAS19-OH-PGE1PGC IsomeraseDH-PGF1a*4S,5-epoxy-17R-HDHAβ-oxidation*ALOX5Cell Cycle ArrestSenescenceDH-15d-Δ12,14-PGD2Ca2+AKR1C3Non-enzymatic dehydration17S-HpDHAΔ13-reductaseLTA4HALOX1517S-HDHA9alpha,11alpha-PGF2aDH-PGD2*15-deoxy-Δ12,14-PGJ2RvE3Hydrolysis*GqPTGER1Excretion via urinecAMPAlbumin-mediated degradationPPARγReduction18S-HpEPE*15-keto-PGI2Dihomo-15d-PGJ2Excretion via urineBeta-oxidationPGB1DH-PGF2a13,14-dihydro-15-keto-PGD2 9-hydroxyprostaglandin dehydrogenase*11-deoxy-13,14-dihydro-15-keto-11,16-cyclo-PGE2*P450β-oxidationProstaglandin [e]5(S)-HETE4S-hydroperoxy-17S-HDHA5S,12R,18R-TriHEPE*PGE 19-hydroxylaseUnknown8-iso-13,14-dihydro-15-keto-PGE2*15-hydroxy PG dehydrogenase*prostaglandin Δreductase*β-oxidase*PGC1AT-RvD4H-PGDS17R-HpDHA17S-HpDPA10,11-dihydro-RvE1DehydrationLinoleic acid (LA) (18:2,w6)15-ketoprostaglandin reductaseRvD413,14-dihydro-PGE2*RvD3Unknown9α, 11β-dihydroxy-15-oxo-2,3,18,19-tetranorprost-5-ene-1,20-dioic acid*PTGESΔ9-Elongase*IP315S-HEPEMitochondrial dysfunction-associated senescenceOncogene-induced senescence(RAS)Irradiation-induced senescence11,15-dioxo-9α-hydroxy-, 2,3,4,5-tetranorprostan-1,20-dioic acid*Ca2+Adrenic acid (22:4,w6)13,14-dihydro-PGF2aLGD25S,6R,18R-TriHEPE*9a, 11a-dihydroxy-11-keto-2,3,4,5-tetranorprostane-1,16-dioic acid*UnknownPTGDRPeroxidasePGESPGES6-keto-PGE1DH-PGH2*15R-HpEPESLCO2A1ExcretionALOX5Mitochondrial dysfunction-associated senescenceOncogene-induced senescenceUnknownABCC47S,8-epoxy-17S-HDHARvE4Radiation-induced senescence7S,8R-epoxy-17S-HDPA*Docosapentaenoic acid (DPA) (22:5,w3)9-deoxy-Δ12-PGD2*MAPK cascade18S-RvE2Reduction*Spontaneous hydrolysisDH-TxB*UnknownAT-RvD3L-PGDS11a-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoic acid2,3 dinor-6-keto-PGF1a*Non-enzymatic5α,7α-dihydroxy-11-keto tetranor-prostane-1,16-dioic acid*ElongaseRvE2Hydrolysis (Unknown Hydrolase)PGA Isomerase15S-HpEPEp53GiALOX15BEnzymatic dehydrogenationPGE1PGH1Dehydration*Δ12-PGD2PGH2Senescence phenotypeUnknownp53S37Osbond acid (22:5,w6)5S,6S-epoxy-18R-HEPEEnzymatic β and w oxidation*LTA4HPGE 19-hydroxylaseDihomo-y-linolenic acid (DGLA) (20:3,w6)PGI27S,8-epoxy-17R-HDHAPGD2PGG2Dinor-4-keto-7,9,13-trihydroxy-prosta-11,12-enoic acid*PGE215-keto-13,14-dihydro-PGE1CYP4F818R-HpEPEGPR32PGFS18S-RvE1PGG1RASPGJ2DH-PGE25S-hydroxyperoxy-18R-HEPEEicosadienoic acid (20:2,w6)ALOX156-trans-LTB412-oxo-RvE1Carbonyl reductase*15-keto-PGD2CYP8A119-hydroxy-RvE15S-hydroxyperoxy-18S-HEPEDH-TxA2*FPR2 Non-enzymatic,albumin-mediated degradationPGI1*15-keto-13,14-dihydro-PGE1elongationdelta6 desaturationbeta-oxidation9alpha,11beta-PGF2Gsy-linolenic acid (GLA) (18:3,w6)TBXAS119-OH-PGH2*RvD2(n-3 DPA)*7S-hydroperoxy-17S-HDHANeurofuranesTxA5-series leukotrienesHETEs15-keto-13,14-dihydro-PGF2aGqALOX5PGA1Δ6-trans-12-epi-leukotriene B413,14-dihydro-15-keto-PGE2PRAK/MAPKAPK51173413411756563356934, 9733, 106375613610, 19, 23, 47, 159939389, 9321, 26, 89, 93, 95...21, 89, 93, 101, 146...21, 95, 101, 159114, 13621, 48, 62, 72, 96...19, 102, 111, 16010, 44, 102, 112, 127...PTGES2PTGES3AKR1B146, 53, 127, 16046, 127, 16022, 34, 63PTGDR2 3319-OH-PGE215-keto-PGE2PTGER24, 97PTGER34, 97PTGER44, 97PGC2PGB2PTGFR TxBTBXA2RGsPTGIRcAMPMembrane phospholipids9416Cytosolic phospholipase A2Cytosolic phospholipase A2p38 MAPKNon-enzymatic dehydration11-hydroxy-9,15-dioxo-prost-5-en-1,20-dioic acid*937α-hydroxy-5,11-diketo-tetranorprosta-1,16-dioc acid*83β-oxidase*34Dinor-4,13-diketo-7,9-dihydroxy-prostanoic acid*Dinor-4,13-diketo-7,9-dihydroxy-prostan-1,18-dioic acid*Unknown2,3-dinor 6-keto pentanor*19-OH-6-keto-PGF1aβ-oxidation*6,15-Diketo-13,14-dihydro-PGF1a*6,15-Diketo-13,14-dihydro-2,3-dinor PGF1a*β-oxidation*Unknown2,3-dinor-11β-PGF2*33UnknownUnknown38, 65, 10379, 10310310338, 79, 10310350, 103, 10450, 77, 103, 104, 10825, 87, 103, 1562,3-Dinor-Thromboxane B211-OH-dehydrogenaseUnknownUnknownUnknownUnknownPPTGS1PTGS2108, 153100, 113, 12511, 108, 15391, 104PGH3ELOVL5TXASPGDSPGI3Eicosatetraenoic acid (ETA) (20:4,w3)PGE3PGF3aPGD3PGESProstaglandin F synthaseStearidonic acid (SDA) (18:4,w3)Phospholipase (cPLA2α)PGISTxA3a-Linolenic acid (ALA) (18:3,w3)Eicosapentaenoic acid (EPA) (20:5,w3)PGG3Eicosatrienoic acid (20:3,w3)FADS2FADS1Dietary Lipids100, 113, 12579, 113, 12579, 113, 12579, 113, 125113, 12579, 113, 12591, 104, 108, 15391, 104, 108, 15315-deoxy-Δ12,14-PGD291, 104, 108, 153PTGS1PTGS2FADS2Δ9-Elongase*ELOVL210010051, 10051515123, 515151515151, 100515151FADS2ELOVL5FADS2FADS1ELOVL5Excretion via urineExcretion via urineExcretion via urineExcretion via urineΔ13-reductaseUnknownΔ13-reductaseExcretion via urine6,15-diketo PGF1aUnknown14, 60, 8660, 1553, 16DPEP116GGT1DPEP2LTC4SGGT5LTA4H55, 60, 128, 15514, 60, 155714, 60, 155863, 14, 60, 1557777ALOX5LTB45-HPETELTD4LTA4LTE4LTC4SASPFLAPHPGD HPGD HPGD Prostaglandin [c]Prostaglandin [e]Prostaglandin [c]Prostaglandin [e]Prostaglandin [c]DH-PGI2Non-enzymatic8661, 8661, 86, 13261, 86132613, 16, 86CysLT1R132SIRT1132p53ROSp53Pp21RbRbP61, 863, 16LipoxinsEoxinsProtectinsResolvinsMaresinsALOX12ALOX15PAI-158, 13258, 132Senescencep53Ac6120-OH-LTB4Oncogene-induced senescenceDNA damage-induced senescenceOxidative stress-induced senescenceReplicative senescenceIrradiation-induced senescence56Replicative senescenceRadiation-induced senescenceMtochondrial dysfunction-associated senescenceOncogene-induced senescenceSASP56IsofuranesDH-PGG2*Irradiation-induced senescenceIrradiation-induced senescence5656Irradiation-induced SenescenceOncogene-induced senescence (RAS)56333Irradiation-induced Senescence563333Radiation-induced senescenceOncogene-induced senescence(RAS)14s-HpDHA5613S,14S-epoxy-maresinMaresin 1Maresin 2MCTR1MCTR2MCTR3LGR6 receptorRORalphaSEHALOX15ALOX12epoxide hydrolysisGSTM4s/LTC4sGGTDPEP1Irradiation-induced senescence56Oncogene-induced senescence(RAS)356Mitochondrial dysfunction-associated senescenceOncogene-induced senescence(RAS)356Mitochondrial dysfunction-associated senescenceOncogene-induced senescence(RAS)356333333, 16Oncogene-induced senescence(RAS)3563327, 52, 14727, 52, 14727, 52, 14727, 52, 14727, 52, 14727, 52, 14727, 52, 147PeroxidasePTGS2RvD1(n-3 DPA)*43, 57, 90, 143, 1448, 10943, 57, 908, 1098, 10943, 57, 90, 143, 1448, 10943, 57, 90HPGD17-oxo-RvD1RvD2AT-RvD28-oxo-RvD1RvD1AT-RvD116-oxo-RvD27-oxo-RvD259, 1315959, 13159, 13159, 1315959, 131RvT2UnknownRvT4PTGS27,8-epoxy-13R-HDPA*7-hydroperoxy-13R-HpDPA*13R-HpDPA*RvT3UnknownRvT1ELOVL2FADS2ALOX15Hydrolase*ALOX516S,17S-epoxyprotectins10S,17S-dihydroxy-DHA15Δ-trans PD110epi-S15Δ-trans PD116R/S,17S-dihydroxy-DHA10R/S,17S-dihydroxy-DHA10S,17S-11E,13Z,15E-diHpDHAPDXProtectin D1Protectin D281, 908114081, 908181GPx-481h15-LOX1ALOX15ALOX5Non-enzymatic HydrolysisNon-enzymatic HydrolysisEnzymatic HydrolysisLipoxinsMaresinsDNA damage-induced senescenceOncogene-induced senescence56Mitochondrial dysfunction-associated senescenceOncogene-induced senescence(RAS)56Mitochondrial dysfunction-associated senescenceOncogene-induced senescence(RAS)Irradiation-induced senescence56Replicative senescenceOncogene-induced senescence(RAS)5656Paracrine senescence5615, 6815, 68, 12915, 68, 12915, 68, 88, 12949, 12912968, 88, 12968, 129157124, 151, 157, 16015, 68, 88, 12915, 68, 88, 1299, 107, 12949, 1299, 12968, 88, 12968, 88, 129151, 15712915-keto-8-iso-PGF2a2,3-dinor-5,6-dihydro-8-IsoPGF2a2,3-dinor-8-IsoPGF2a15-E2-IsoK15-keto-13,14-dihydro-8-iso-PGF2a15-TxB2-IsoP15-D2-IsoKalpha-tetranor-15-keto-13,14-dihydro-8-iso-PGF2a15-TxA2-IsoP15-H2-IsoP15-G2-IsoP15-F2-IsoP15-D2-IsoP15-J2-IsoP15-15d-J2-IsoP12915-E2-IsoP15-A2-IsoP68, 12949, 129964, 12968, 12915, 68, 12968, 12968, 12949, 129915, 68, 12912-E2-IsoK12-D2-IsoK12-H2-IsoP12-G2-IsoP12-F2-IsoP12-D2-IsoP12-J2-IsoP12-15d-J2-IsoP12-E2-IsoP12912-A2-IsoP12-Dioxolane-IsoP12-TxA2-IsoP12-TxB2-IsoP49, 12964, 12915, 68, 12968, 12968, 12915, 68, 12949, 1299968, 12968, 1298-Dioxolane-IsoP8-D2-IsoK8-E2-IsoK8-H2-IsoP8-G2-IsoP8-F2-IsoP8-D2-IsoP8-J2-IsoP8-15d-J2-IsoP1298-E2-IsoP8-A2-IsoP8-TxA2-IsoP8-TxA2-IsoP68, 12949, 129949, 12915, 68, 12968, 12968968, 1295-D2-IsoK15, 68, 1295-E2-IsoK5-TxA2-IsoP5-H2-IsoP5-G2-IsoP5-F2-IsoP5-D2-IsoP5-J2-IsoP5-15d-J2-IsoP5-E2-IsoP1295-A2-IsoP5-TxB2-IsoPFree radical-catalyzed peroxidationFree radical-catalyzed peroxidationExcretion via urineHPGD Δ13-reductaseβ-oxidation1381381381387-dihomo-F2-IsoP14-dihomo-F2-IsoP10-dihomo-F2-IsoP17-dihomo-F2-IsoP12, 15, 1381212121212, 15, 1381212, 15, 138121212121212, 15, 138121212, 15, 13812, 15, 13818-F3-IsoP12-F3-IsoP8-F3-IsoP16111-F3-IsoP5-F3-IsoP15-F3-IsoP5-H3-IsoP5-G3-IsoP8-G3-IsoP8-H3-IsoP11-H3-IsoP11-G3-IsoP12-H3-IsoP12-G3-IsoP15-H3-IsoP15-G3-IsoP18-H3-IsoP18-G3-IsoP11580, 105, 115, 13811511511511511511511511591, 11511580, 115, 13811580, 115, 13811511511511511511511511511511580, 115, 13811511511511511580, 115, 13891, 11511511511511580, 115, 13880, 115, 13880, 115, 1387-G4-NeuroP*4-E4-NeuroP4-F4-NeuroP4-D4-NeuroP11-F4-NeuroP14-F4-NeuroP7-F4-NeuroP17-F4-NeuroP10-F4-NeuroP13-F4-NeuroP20-F4-NeuroP4-G4-NeuroP*4-H4-NeuroP*7-H4-NeuroP*7-E4-NeuroP7-D4-NeuroP10-E4-NeuroP10-D4-NeuroP10-H4-NeuroP10-G4-NeuroP*11-E4-NeuroP11-D4-NeuroP11-H4-NeuroP11-G4-NeuroP*13-E4-NeuroP13-D4-NeuroP13-H4-NeuroP*13-G4-NeuroP*14-E4-NeuroP14-D4-NeuroP14-H4-NeuroP14-G4-NeuroP*17-D4-NeuroP17-E4-NeuroP17-H4-NeuroP*17-G4-NeuroP*20-D4-NeuroP20-E4-NeuroP20-H4-NeuroP*20-G4-NeuroP*Leukotriene 3-series


Description

Oxylipins, notably prostaglandins, are synthetized by senescent cells and then accumulate, promoting the senescent-associated secretory phenotype (Wiley et al., 2021). The prostaglandins are classified into three main groups, depending on the starting point of their biosynthesis. The serie-1-prostaglandins are derived from its precursor dihomo-γ-linolenic acid (DGLA). The serie-2-prostaglandins and serie-3-prostaglandins are derived from arachidonic acid (AA) and eicosapentae-noic acid (EPA), respectively (Noverr et al., 2003)

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  178. Reinertsen AF, Primdahl KG, Shay AE, Serhan CN, Hansen TV, Aursnes M; ''Stereoselective Synthesis and Structural Confirmation of the Specialized Pro-Resolving Mediator Resolvin E4.''; J Org Chem, 2021 PubMed Europe PMC Scholia
  179. Nourooz-Zadeh J, Cooper MB, Ziegler D, Betteridge DJ; ''Urinary 8-epi-PGF2alpha and its endogenous beta-oxidation products (2,3-dinor and 2,3-dinor-5,6-dihydro) as biomarkers of total body oxidative stress.''; Biochem Biophys Res Commun, 2005 PubMed Europe PMC Scholia
  180. Deng B, Wang CW, Arnardottir HH, Li Y, Cheng CY, Dalli J, Serhan CN; ''Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages.''; PLoS One, 2014 PubMed Europe PMC Scholia
  181. Kramer RM, Roberts EF, Um SL, Börsch-Haubold AG, Watson SP, Fisher MJ, Jakubowski JA; ''p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  182. Yung-Sheng Huang, Wen-Cheng Huang, Chi-Wei LI, Lu-Te Chuang; ''''; , PubMed Europe PMC Scholia
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  184. K Watanabe, Y Iguchi, S Iguchi, Y Arai, O Hayaishi, L J Roberts; ''Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase.''; National Library of Medicine, 1986 PubMed Europe PMC Scholia
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  187. Granström E, Fitzpatrick FA, Kindahl H; ''Radioimmunologic determination of 15-keto-13,14-dihydro-PGE2: a method for its stable degradation product, 11-deoxy-15-keto-13,14-dihydro-11 beta, 16 xi-cyclo-PGE2.''; Methods Enzymol, 1982 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134415view22:53, 21 July 2024EweitzModified description
134273view07:05, 19 July 2024EgonwRemoved template comments
129383view18:52, 29 March 2024Nikita KrstevskaAddition of missing Ensembl identifiers
129101view14:29, 11 March 2024Nikita KrstevskaAddition of isoforms NAT1 and NAT2 in LTE4 -> N-acetyl LTE4 reaction
128985view14:11, 27 February 2024Nikita KrstevskaUpdating a comment on the LTB4 -> 20-OXO-LTB4 reaction.
128703view22:00, 20 February 2024EgonwCorrected the EC format
128691view20:08, 19 February 2024EgonwRemoved redundant RHEA: prefixes in 27 interaction identifiers
128662view16:10, 18 February 2024Nikita KrstevskaModification of text labels of the gene products 'PGA isomerase' and 'PGC isomerase'
128639view17:52, 17 February 2024Nikita KrstevskaAddition of missing gene product identifiers
128612view12:30, 16 February 2024Nikita KrstevskaAddition of missing gene IDs
128601view19:39, 15 February 2024Nikita KrstevskaAddition of missing gene product annotations
128579view11:07, 14 February 2024Nikita KrstevskaModification of glutathione cofactor
128559view18:33, 12 February 2024Nikita KrstevskaAnnotation of missing gene product IDs
128502view13:49, 10 February 2024Nikita KrstevskaPositive feedback loop of dihomo-15d-PGJ2
128091view16:57, 25 January 2024JuliaUMRHEA IDs for PGs
128089view13:47, 25 January 2024DeSlOntology Term : 'fatty acid omega degradation pathway' added !
128087view13:45, 25 January 2024DeSlOntology Term : 'lipid metabolic pathway' added !
127870view13:10, 3 January 2024AndreapascaudModified title
127831view12:52, 22 December 2023JuliaUMCorrection of reaction + IDs
127820view12:44, 19 December 2023JuliaUMHX and TRX were added
127803view14:02, 16 December 2023EgonwCorrected the format of a few EC identifiers
127802view13:58, 16 December 2023EgonwMade multiple pathways clickable
127800view13:46, 16 December 2023EgonwIP3 is not a complex itself
127793view15:14, 14 December 2023JuliaUMNew reaction + IDs
127792view18:00, 13 December 2023JuliaUMNew LX and LT reactions
127791view13:02, 13 December 2023JuliaUMNew LT reactions + new IDs
127789view16:56, 12 December 2023JuliaUMFinish of the map splitting + rearrangement + eoxins were added
127778view15:51, 6 December 2023JuliaUMsmall changes in reactions
127777view09:08, 6 December 2023JuliaUMSmall changes in PG reaction
127703view17:23, 23 November 2023JuliaUMNew references + minor corrections in the LT pathway
127702view08:36, 23 November 2023JuliaUMSmall changes in the reactions
127677view17:29, 20 November 2023JuliaUMNew IDs + minimized duplicated nodes
127676view12:36, 20 November 2023JuliaUMAddition of a legend
127670view15:11, 16 November 2023JuliaUMNew Maresins & protectins (DPA)
127669view13:05, 16 November 2023JuliaUMDeletion/Addition of PG reactions + references
127668view12:27, 16 November 2023Mra1221Modified title
127663view08:47, 15 November 2023JuliaUMMore references for isoprostanes + change to hypothetical reaction in comments
127656view07:58, 14 November 2023JuliaUMNew IDs + references for Isoprostanes
127632view14:46, 10 November 2023JuliaUMNew Isoprostanes + IDs
127631view09:47, 10 November 2023JuliaUMNew Isoprostanes + IDs
127627view17:11, 9 November 2023JuliaUMMore consistency in senescence links + isoprostanes
127626view13:58, 9 November 2023JuliaUMMore consistency in senescence links
127615view19:25, 7 November 2023JuliaUMNew IDs + some changes in resolvin T
127604view08:23, 7 November 2023JuliaUMOntology Term : 'cellular senescence pathway' added !
127591view07:17, 29 October 2023EgonwNot a mim-conversion
127589view08:52, 27 October 2023AndreapascaudAddition of CHEBI IDs to the metabolites
127588view17:55, 26 October 2023JuliaUMSmall changes on DH-PG reactions + new IDs for enzymes
127587view11:40, 26 October 2023EgonwFixed a few EC numbers (syntax)
127584view10:09, 25 October 2023AndreapascaudUpdate Protectins
127583view09:49, 25 October 2023AndreapascaudUpdate

External references

DataNodes

View all...
NameTypeDatabase referenceComment

Oncogene-induced senescence(RAS)

10,11,dihydro-12-oxo-RvE1MetaboliteCHEBI:165276 (ChEBI)
10,11-dihydro-RvE1MetaboliteCHEBI:165277 (ChEBI)
10-D4-NeuroPMetaboliteLMFA04010186 (LIPID MAPS)
10-E4-NeuroPMetaboliteLMFA04010314 (LIPID MAPS)
10-F4-NeuroPMetaboliteLMFA04010005 (LIPID MAPS)
10-G4-NeuroP*Metabolite
10-H4-NeuroPMetaboliteCHEBI:185511 (ChEBI)
10-dihomo-F2-IsoPMetaboliteLMFA03110315 (LIPID MAPS)
10R/S,17S-dihydroxy-DHAMetabolite
10S,17S-11E,13Z,15E-diHpDHAMetabolite
10S,17S-dihydroxy-DHAMetaboliteCHEBI:138653 (ChEBI)
10epi-S15Δ-trans PD1Metabolite
11,15-dioxo-9α-hydroxy-, 2,3,4,5-tetranorprostan-1,20-dioic acid*Metabolite
11-D4-NeuroPMetaboliteLMFA04010202 (LIPID MAPS)
11-E4-NeuroPMetaboliteLMFA04010330 (LIPID MAPS)
11-F3-IsoPMetabolite
11-F4-NeuroPMetaboliteLMFA04010006 (LIPID MAPS)
11-G3-IsoPMetabolite
11-G4-NeuroP*Metabolite
11-H3-IsoPMetabolite
11-H4-NeuroPMetaboliteCHEBI:187424 (ChEBI)
11-OH-dehydrogenaseGeneProduct1.2.1.3 (Enzyme Nomenclature)
11-dehydro-Thromboxane B2MetaboliteCHEBI:28667 (ChEBI)
11-deoxy-13,14-dihydro-15-keto-11,16-cyclo-PGE2*Metabolite
11-hydroxy-9,15-dioxo-prost-5-en-1,20-dioic acid*Metabolite
11a-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoic acidMetaboliteCHEBI:73965 (ChEBI)
12-15d-J2-IsoPMetaboliteLMFA03110090 (LIPID MAPS) Iso-Prostaglandin H2
12-A2-IsoPMetaboliteLMFA03110248 (LIPID MAPS) Iso-Prostaglandin H2
12-D2-IsoKMetabolite
12-D2-IsoPMetaboliteLMFA03110085 (LIPID MAPS) Iso-Prostaglandin H2
12-Dioxolane-IsoPMetabolite
12-E2-IsoKMetabolite
12-E2-IsoPMetaboliteLMFA03110190 (LIPID MAPS) Iso-Prostaglandin H2
12-F2-IsoPMetaboliteLMFA03110042 (LIPID MAPS) Iso-Prostaglandin H2
12-F3-IsoPMetabolite
12-G2-IsoPMetaboliteIso-Prostaglandin G2
12-G3-IsoPMetabolite
12-H2-IsoPMetaboliteIso-Prostaglandin H2
12-H3-IsoPMetabolite
12-J2-IsoPMetaboliteLMFA03110087 (LIPID MAPS) Iso-Prostaglandin H2
12-TxA2-IsoPMetabolite
12-TxB2-IsoPMetabolite
12-oxo-RvE1MetaboliteCHEBI:165264 (ChEBI)
13,14-dihydro-15-keto-PGA2MetaboliteCHEBI:89315 (ChEBI) 8: Prostanoid Metabolites as Biomarkers in Human Disease Helena Idborg; Sven-Christian Pawelzik. 2022. PubMed 36005592.
13,14-dihydro-15-keto-PGD2 MetaboliteCHEBI:72603 (ChEBI) DK-PGD2
13,14-dihydro-15-keto-PGE2MetaboliteCHEBI:15550 (ChEBI) PGEM= Metabolites downstream of PGE2
13,14-dihydro-PGE2*Metabolite
13,14-dihydro-PGF2aMetabolite88346 (ChEBI)
13-D4-NeuroPMetaboliteLMFA04010218 (LIPID MAPS)
13-E4-NeuroPMetaboliteLMFA04010346 (LIPID MAPS)
13-F4-NeuroPMetaboliteLMFA04010003 (LIPID MAPS)
13-G4-NeuroP*Metabolite
13-H4-NeuroP*Metabolite
13R-HpDPA*Metabolite
13S,14S-epoxy-maresinMetaboliteCHEBI:131958 (ChEBI) (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid
14-D4-NeuroPMetaboliteLMFA04010234 (LIPID MAPS)
14-E4-NeuroPMetaboliteLMFA04010362 (LIPID MAPS)
14-F4-NeuroPMetaboliteLMFA04010004 (LIPID MAPS)
14-G4-NeuroP*Metabolite
14-H4-NeuroPMetaboliteHMDB0062292 (HMDB)
14-dihomo-F2-IsoPMetaboliteLMFA03110331 (LIPID MAPS)
14s-HpDHAMetaboliteCHEBI:136526 (ChEBI)
15-15d-J2-IsoPMetaboliteIso-Prostaglandin H2
15-A2-IsoPMetaboliteLMFA03110138 (LIPID MAPS) Iso-Prostaglandin H2
15-D2-IsoKMetabolite=LGD2
15-D2-IsoPMetaboliteLMFA03110099 (LIPID MAPS) Iso-Prostaglandin H2
15-E2-IsoKMetabolite=LGE2
15-E2-IsoPMetaboliteIso-Prostaglandin H2
15-F2-IsoPMetabolite27415-26-5 (CAS) = 8-iso-PGF2a
15-F3-IsoPMetaboliteCHEBI:157746 (ChEBI) = 8-epi PGF3
15-G2-IsoPMetabolite
15-G3-IsoPMetabolite= 8-epi PGF3
15-H2-IsoPMetaboliteIso-Prostaglandin H2 =PGH2
15-H3-IsoPMetabolite= 8-epi PGF3
15-J2-IsoPMetaboliteLMFA03110101 (LIPID MAPS) Iso-Prostaglandin H2
15-TxA2-IsoPMetabolite
15-TxB2-IsoPMetabolite
15-deoxy-Δ12,14-PGD2MetaboliteCHEBI:63999 (ChEBI) =15d-PGJ2
15-deoxy-Δ12,14-PGJ2Metabolite34159 (ChEBI) =15d-PGJ2
15-hydroxy PG dehydrogenase*

prostaglandin Δreductase*

β-oxidase*		GeneProductLumped reaction
15-keto-13,14-dihydro-8-iso-PGF2aMetabolite
15-keto-13,14-dihydro-PGE1Metabolite134499 (ChEBI)
15-keto-13,14-dihydro-PGE1MetaboliteCHEBI:134499 (ChEBI)
15-keto-13,14-dihydro-PGF2aMetabolite63976 (ChEBI)
15-keto-8-iso-PGF2a Metabolite
15-keto-PGD2MetaboliteCHEBI:15557 (ChEBI)
15-keto-PGE1Metabolite22973-19-9 (CAS)
15-keto-PGE2Metabolite15547 (ChEBI)
15-keto-PGF2aMetaboliteCHEBI:28442 (ChEBI)
15-keto-PGI2MetaboliteCHEBI:15556 (ChEBI) =15-dehydro-Prostaglandin I2
15-ketoprostaglandin reductaseGeneProduct1.3.1.48 (Enzyme Nomenclature)
15R-HpEPEPathwayvia acetalyted cox2
15S-HEPEMetaboliteCHEBI:88347 (ChEBI)
15S-HpEPEMetaboliteCHEBI:165266 (ChEBI)
15S-hydroxy-5S-HpEPE*Metabolite
15Δ-trans PD1Metabolite
16-oxo-RvD2MetaboliteCHEBI:138281 (ChEBI)
16R/S,17S-dihydroxy-DHAMetabolite
16S,17S-epoxyprotectinsMetabolite
17-D4-NeuroPMetaboliteLMFA04010250 (LIPID MAPS) = 17-F4c-NP
17-E4-NeuroPMetaboliteLMFA04010378 (LIPID MAPS) = 17-F4c-NP
17-F4-NeuroPMetaboliteLMFA04010002 (LIPID MAPS) = 17-F4c-NP
17-G4-NeuroP*Metabolite= 17-F4c-NP
17-H4-NeuroP*Metabolite= 17-F4c-NP
17-dihomo-F2-IsoPMetaboliteLMFA03110347 (LIPID MAPS)
17-oxo-RvD1MetaboliteCHEBI:132800 (ChEBI)
17R-HDHAMetaboliteCHEBI:91137 (ChEBI)
17R-HpDHAMetaboliteCHEBI:138590 (ChEBI)
17S-HDHAMetaboliteCHEBI:138640 (ChEBI)
17S-HpDHAMetaboliteCHEBI:136113 (ChEBI)
17S-HpDPAMetaboliteCHEBI:136118 (ChEBI)
18-F3-IsoPMetabolite
18-G3-IsoPMetabolite
18-H3-IsoPMetabolite
18-oxo-RvE1MetaboliteCHEBI:131617 (ChEBI)
18R-HpEPEMetaboliteCHEBI:138565 (ChEBI)
18S-HpEPE*Metabolite
18S-RvE1MetaboliteCHEBI:137038 (ChEBI)
18S-RvE2MetaboliteCHEBI:137034 (ChEBI)
19-OH-6-keto-PGF1aMetabolite172589 (ChEBI)
19-OH-PGE1Metabolite55123-67-6 (CAS)
19-OH-PGE2MetaboliteCHEBI:165313 (ChEBI)
19-OH-PGH2*Metabolite
19-hydroxy-RvE1MetaboliteCHEBI:165268 (ChEBI)
2,3 dinor-6-keto-PGF1a*Metabolite73944 (ChEBI)
2,3-Dinor-Thromboxane B2MetaboliteCHEBI:89991 (ChEBI)
2,3-dinor 6-keto pentanor*Metabolite
2,3-dinor-11β-PGF2*MetaboliteCHEBI:165323 (ChEBI)
2,3-dinor-5,6-dihydro-8-IsoPGF2aMetabolite
2,3-dinor-8-IsoPGF2aMetabolite
20-D4-NeuroPMetaboliteLMFA04010266 (LIPID MAPS)
20-E4-NeuroPMetaboliteLMFA04010394 (LIPID MAPS)
20-F4-NeuroPMetaboliteLMFA04010001 (LIPID MAPS)
20-G4-NeuroP*Metabolite
20-H4-NeuroP*Metabolite
20-OH-LTB4MetaboliteCHEBI:15646 (ChEBI)
20-carboxy-RvE1*Metabolite
20-hydroxy-RvE1MetaboliteCHEBI:165269 (ChEBI)
4,13-diketo-7,9-dihydroxy-2,3-dinor prostanoic acid*MetaboliteLumped reaction
4-D4-NeuroPMetaboliteLMFA04010154 (LIPID MAPS)
4-E4-NeuroPMetaboliteLMFA04010282 (LIPID MAPS)
4-F4-NeuroPMetaboliteLMFA04010008 (LIPID MAPS)
4-G4-NeuroP*Metabolite
4-H4-NeuroP*Metabolite
4S,5-epoxy-17R-HDHAMetaboliteCHEBI:187528 (ChEBI)
4S,5-epoxy-17S-hydroxy-HDHAMetaboliteCHEBI:138647 (ChEBI)
4S-hydroperoxy-17S-HDHAMetaboliteCHEBI:138641 (ChEBI)
5(S)-HETEMetaboliteCHEBI:28209 (ChEBI)
5-15d-J2-IsoPMetaboliteLMFA03110075 (LIPID MAPS) Iso-Prostaglandin H2
5-A2-IsoPMetaboliteLMFA03110257 (LIPID MAPS) Iso-Prostaglandin H2
5-D2-IsoKMetabolite
5-D2-IsoPMetaboliteLMFA03110070 (LIPID MAPS) Iso-Prostaglandin H2
5-E2-IsoKMetabolite
5-E2-IsoPMetaboliteLMFA03110174 (LIPID MAPS) Iso-Prostaglandin H2
5-F2-IsoPMetaboliteLMFA03110039 (LIPID MAPS) Iso-Prostaglandin H2
5-F3-IsoPMetabolite
5-G2-IsoPMetaboliteIso-Prostaglandin G2
5-G3-IsoPMetabolite
5-H2-IsoPMetaboliteIso-Prostaglandin H2
5-H3-IsoPMetabolite
5-HPETEMetaboliteHMDB11135 (HMDB)
5-J2-IsoPMetaboliteLMFA03110072 (LIPID MAPS) Iso-Prostaglandin H2
5-TxA2-IsoPMetabolite
5-TxB2-IsoPMetabolite
5-series leukotrienesPathway
5S,12R,18R-TriHEPE*Metabolite
5S,12S,18R-TriHEPE*Metabolite
5S,6R,18R-TriHEPE*Metabolite
5S,6S,18R-TriHEPE*Metabolite
5S,6S-epoxy-18R-HEPEMetaboliteCHEBI:132219 (ChEBI)
5S,6S-epoxy-18S-HEPEMetaboliteCHEBI:138490 (ChEBI)
5S-hydroxyperoxy-18R-HEPEMetaboliteCHEBI:81562 (ChEBI)
5S-hydroxyperoxy-18S-HEPEMetaboliteCHEBI:91287 (ChEBI)
5α,7α-dihydroxy-11-keto tetranor-prostane-1,16-dioic acid*Metabolite
6,15-Diketo-13,14-dihydro-2,3-dinor PGF1a*Metabolite6,15-Diketo-13,14-dihydro-2,3-dinor PGF1a = 15 kd dinor
6,15-Diketo-13,14-dihydro-PGF1a*MetaboliteCHEBI:72595 (ChEBI)
6,15-diketo PGF1aMetabolite
6-keto-PGE1Metabolite28269 (ChEBI)
6-keto-PGF1aMetabolite28158 (ChEBI)
6-trans-LTB4MetaboliteCHEBI:63981 (ChEBI)
7,8-epoxy-13R-HDPA*Metabolite
7-D4-NeuroPMetaboliteLMFA04010170 (LIPID MAPS)
7-E4-NeuroPMetaboliteLMFA04010298 (LIPID MAPS)
7-F4-NeuroPMetaboliteLMFA04010007 (LIPID MAPS)
7-G4-NeuroP*Metabolite
7-H4-NeuroP*Metabolite
7-dihomo-F2-IsoPMetabolite7-F2t-dihomo-IsoP (LIPID MAPS)
7-hydroperoxy-13R-HpDPA*Metabolite
7-oxo-RvD2MetaboliteCHEBI:138279 (ChEBI)
7S,17S-diHpDPAMetaboliteCHEBI:140248 (ChEBI)
7S,8-epoxy-17R-HDHAMetaboliteCHEBI:138613 (ChEBI)
7S,8-epoxy-17S-HDHAMetabolite53477500 (PubChem-compound)
7S,8R-epoxy-17S-HDPA*Metabolite
7S-hydroperoxy-17S-HDHAMetaboliteCHEBI:140245 (ChEBI)
7α-hydroxy-5,11-diketo-tetranorprosta-1,16-dioc acid*Metabolite
8-15d-J2-IsoPMetaboliteLMFA03110062 (LipidBank) Iso-Prostaglandin H2
8-A2-IsoPMetaboliteIso-Prostaglandin H2
8-D2-IsoKMetabolite
8-D2-IsoPMetaboliteLMFA03110057 (LIPID MAPS) Iso-Prostaglandin H2
8-Dioxolane-IsoPMetabolite
8-E2-IsoKMetabolite
8-E2-IsoPMetaboliteLMFA03110003 (LIPID MAPS) Iso-Prostaglandin H2
8-F2-IsoPMetabolite8-F2t-IsoP (LIPID MAPS)
8-F3-IsoPMetabolite
8-G2-IsoPMetaboliteIso-Prostaglandin G2
8-G3-IsoPMetabolite
8-H2-IsoPMetaboliteIso-Prostaglandin H2
8-H3-IsoPMetabolite
8-J2-IsoPMetaboliteLMFA03110059 (LIPID MAPS) Iso-Prostaglandin H2
8-TxA2-IsoPMetabolite
8-iso-13,14-dihydro-15-keto-PGE2*Metabolite
8-oxo-RvD1MetaboliteCHEBI:132797 (ChEBI)
9,15-dideoxy-Δ9,12,14-PGD2*Metabolite
9-deoxy-Δ12-PGD2*Metabolite175297 (ChEBI)
9-hydroxyprostaglandin dehydrogenase*GeneProduct
9a, 11a-dihydroxy-11-keto-2,3,4,5-tetranorprostane-1,16-dioic acid*Metabolite
9alpha,11alpha-PGF2aMetaboliteCHEBI:15553 (ChEBI)
9alpha,11beta-PGF2Metabolite15553 (ChEBI)
9α, 11β-dihydroxy-15-oxo-2,3,18,19-tetranorprost-5-ene-1,20-dioic acid*Metabolite
ABCC4GeneProductENSG00000125257 (Ensembl)
AKR1B1GeneProductENSG00000085662 (Ensembl) =aldo-keto reductase family 1 member B
AKR1C3GeneProductENSG00000196139 (Ensembl) =NADPH-dependent PGD2 11-ketoreductase

=aldo-keto reductase family 1 member C3

=EC 1.1.1.188
ALOX12 GeneProductENSG00000108839 (Ensembl) Enzyme 12LOX
ALOX12GeneProductENSG00000108839 (Ensembl)
ALOX15 GeneProductENSG00000161905 (Ensembl) Enzyme:LOX15
ALOX15BGeneProductENSG00000179593 (Ensembl) =15-LOX-2 =arachidonate 15-lipoxygenase type B
ALOX15GeneProductENSG00000161905 (Ensembl)
ALOX5GeneProductENSG00000012779 (Ensembl)
AT-RvD1MetaboliteCHEBI:138179 (ChEBI)
AT-RvD2 MetaboliteCHEBI:138614 (ChEBI)
AT-RvD3MetaboliteCHEBI:138615 (ChEBI)
AT-RvD4MetaboliteCHEBI:138616 (ChEBI)
Adrenic acid (22:4,w6)Metabolite53487 (ChEBI)
Albumin-mediated degradationComplex
Arachidonic Acid (20:4,w6)Metabolite15843 (ChEBI)
Beta-oxidation
CMKLR1ComplexENSG00000174600 (Ensembl) =ChemR23
CYP4F8GeneProductENSG00000186526 (Ensembl) =cytochrome P450 family 4 subfamily F member 8
CYP8A1GeneProductENSG00000124212 (Ensembl) =prostaglandin I2 synthase =PTGIS
Ca2+MetaboliteCHEBI:29108 (ChEBI) calcium
Carbonyl reductase*GeneProduct
Cell Cycle Arrest Senescence
CysLT1RProteinENSG00000173198 (Ensembl) =cysteinyl leukotriene type 1 receptor
Cytosolic phospholipase A2ProteinP47712 (Uniprot-TrEMBL)
DH-15d-Δ12,14-PGD2MetaboliteCHEBI:165317 (ChEBI)
DH-PGD2*Metabolite
DH-PGE2MetaboliteCHEBI:185711 (ChEBI)
DH-PGF1a*Metabolite
DH-PGF2aMetaboliteCHEBI:183014 (ChEBI)
DH-PGG2*Metabolite
DH-PGH2*Metabolite
DH-PGI2MetaboliteCHEBI:165328 (ChEBI)
DH-PGJ2MetaboliteCHEBI:165318 (ChEBI)
DH-TxA2*Metabolite
DH-TxB*Metabolite
DNA damage-induced senescence Oncogene-induced senescence
DPEP1 GeneProductENSG00000015413 (Ensembl) dipeptidase 1
DPEP1GeneProductENSG00000015413 (Ensembl) =Human microsomal dipeptidase (MDP, formerly referred to as dehydropeptidase-I or renal dipeptidase) [EC 3.4.13.11]
DPEP2GeneProductENSG00000167261 (Ensembl)
DehydraseGeneProduct
Dehydration
Dehydration*
Dihomo-15d-PGJ2Metabolite16061095 (PubChem-compound) =1a,1b-dihomo-15-deoxy-Δ12,14-prostaglandin J2
Dihomo-y-linolenic acid (DGLA) (20:3,w6)MetaboliteCHEBI:53486 (ChEBI) = 8,11,14-Eicosatrienoic acid =DGLA
Dinor-4,13-diketo-7,9-dihydroxy-prostan-1,18-dioic acid*Metabolite
Dinor-4,13-diketo-7,9-dihydroxy-prostanoic acid*Metabolite
Dinor-4-keto-7,9,13-trihydroxy-prosta-11,12-enoic acid*Metabolite
Docosahexaenoic acid (DHA) (22:6,w3)MetaboliteCHEBI:36005 (ChEBI)
Docosapentaenoic acid (DPA) (22:5,w3)MetaboliteCHEBI:53488 (ChEBI)
EETsPathway
ELOVL2GeneProductENSG00000197977 (Ensembl)
ELOVL5GeneProductENSG00000012660 (Ensembl) fatty acid elongase 5
Eicosadienoic acid (20:2,w6)MetaboliteCHEBI:73731 (ChEBI)
Eicosapentaenoic acid (EPA) (20:5,w3)MetaboliteCHEBI:28364 (ChEBI)
Eicosatetraenoic acid (ETA) (20:4,w3)MetaboliteCHEBI:166893 (ChEBI)
Eicosatrienoic acid (20:3,w3)Metabolite5312529 (PubChem-compound)
ElongaseGeneProduct
Enzymatic Epoxidation
Enzymatic HydrolysisProtein
Enzymatic dehydrogenationGeneProduct
Enzymatic β and w oxidation*
Excretion
Excretion via urine
FADS1GeneProductENSG00000149485 (Ensembl) Δ5-Desaturase
FADS2GeneProductENSG00000134824 (Ensembl)
FLAPGeneProductENSG00000132965 (Ensembl) gene = ALOX5AP FLAP= 5-lipoxygenase activating protein
FPR2 GeneProductENSG00000171049 (Ensembl) =formyl peptide receptor 2 =ALX
Free radical-catalyzed peroxidation
GGT1GeneProductENSG00000100031 (Ensembl)
GGT5GeneProductENSG00000099998 (Ensembl) =gamma-glutamyltransferase 5
GGTGeneProductENSG00000100031 (Ensembl) gamma-glutamyltransferase 1
GPR32GeneProductENSG00000142511 (Ensembl) =G protein-coupled receptor 32 =RVDR1
GPx-4ProteinENSG00000167468 (Ensembl) Glutathione Peroxidase 4
GSTM4s/LTC4sGeneProductENSG00000168765 (Ensembl) glutathione S-transferase mu 4
GiComplex
GqComplex
GsComplexPGI2 binding to the associated IP receptor (coupled to Gs) leads to an activation of the AC and thus to an increase of intracellular cAMP. Its elevation downregulates store-mediated calcium entry, calcium mobilization and secretion, as well as platelet adhesion to subendothelial collagen via integrin α2β1. The cAMP increase further results in an activation of protein kinase-A (PKA) and in principle, in an inhibition of platelet activation. Analogous to cAMP, PKA activity has been associated with a reduced Ca2+ release from intra-platelet stores
H-PGDS GeneProductENSG00000163106 (Ensembl)
HETEsPathway
HPGD GeneProductENSG00000164120 (Ensembl) 15-PGDH=15-hydroxy-prostaglandin dehydrogenase
HPGDGeneProductENSG00000164120 (Ensembl)
Hydrolase*GeneProduct
Hydrolysis (Unknown Hydrolase)Protein
Hydrolysis*GeneProduct
IP3ComplexCHEBI:16595 (ChEBI)
Irradiation-induced Senescence
Irradiation-induced Senescence Oncogene-induced senescence (RAS)
Irradiation-induced senescence
IsofuranesPathway
L-PGDS GeneProductENSG00000107317 (Ensembl)
LGD2MetaboliteCHEBI:34820 (ChEBI) Levuglandin D2
LGE2MetaboliteCHEBI:34821 (ChEBI) Levuglandin E2
LGR6 receptorMetabolite
LTA4MetaboliteCHEBI:15651 (ChEBI)
LTA4HGeneProductENSG00000111144 (Ensembl)
LTB4MetaboliteCHEBI:15647 (ChEBI)
LTC4MetaboliteCHEBI:16978 (ChEBI)
LTC4SGeneProductENSG00000213316 (Ensembl)
LTD4MetaboliteCHEBI:28666 (ChEBI)
LTE4MetaboliteCHEBI:15650 (ChEBI)
Leukotriene 3-seriesPathway
Linoleic acid (LA) (18:2,w6)Metabolite17351 (ChEBI) LA (18:2 w6)
LipoxinsPathway
Lipoxins

Eoxins Protectins Resolvins

Maresins		Pathway
MAPK cascadeMetabolite
MCTR1MetaboliteCHEBI:138202 (ChEBI) (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid
MCTR2 MetaboliteCHEBI:138206 (ChEBI) (13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid
MCTR3 MetaboliteCHEBI:138209 (ChEBI) (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid
Maresin 1MetaboliteCHEBI:138249 (ChEBI) 7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic acid
Maresin 2MetaboliteCHEBI:138248 (ChEBI) (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid
MaresinsPathway
Membrane phospholipidsMetaboliteCHEBI:16247 (ChEBI)
Mitochondrial dysfunction-associated senescence Oncogene-induced senescence
Mitochondrial dysfunction-associated senescence Oncogene-induced senescence(RAS)
Mitochondrial dysfunction-associated senescence

Oncogene-induced senescence(RAS)

Mitochondrial dysfunction-associated senescence

Oncogene-induced senescence(RAS)

Irradiation-induced senescence
Neurofuranes
Non-enzymatic
Non-enzymatic degradation
Non-enzymatic HydrolysisProtein
Non-enzymatic dehydration
Non-enzymatic hydrolysis
Non-enzymatic,albumin-mediated degradation
Oncogene-induced senescence

DNA damage-induced senescence Oxidative stress-induced senescence Replicative senescence

Irradiation-induced senescence
Oncogene-induced senescence(RAS)
Osbond acid (22:5,w6)MetaboliteCHEBI:65136 (ChEBI) =docosapentaenoic acid (DPAω6, 22:5)
P450GeneProduct
PAI-1ProteinENSG00000106366 (Ensembl) Gene: SERPINE1
PDXMetabolite138653 (ChEBI) (4Z,7Z,10S,11E,13Z,15E,17S,19Z)-10,17-dihydroxydocosahexaenoic acid
PG-9KRGeneProductENSG00000159228 (Ensembl) PG-9KR= Prostaglandin-9-ketoreductase
PGA IsomeraseGeneProduct
PGA1Metabolite14152-28-4 (CAS)
PGA2Metabolite27820 (ChEBI) PGA2=Prostaglandin A2
PGB1MetaboliteCHEBI:27624 (ChEBI)
PGB2Metabolite28099 (ChEBI) PGB2=Prostaglandin B2
PGC IsomeraseGeneProduct
PGC1MetaboliteCHEBI:15546 (ChEBI)
PGC2Metabolite27555 (ChEBI) PGC2=Prostaglandin C2
PGD1Metabolite27696 (ChEBI)
PGD2Metabolite15555 (ChEBI)
PGD3MetaboliteCHEBI:34939 (ChEBI)
PGDSGeneProduct5.3.99.2 (Enzyme Nomenclature)
PGE 19-hydroxylaseGeneProduct
PGE1Metabolite15544 (ChEBI)
PGE2Metabolite15551 (ChEBI)
PGE3MetaboliteCHEBI:28031 (ChEBI)
PGESGeneProduct5.3.99.3 (Enzyme Nomenclature)
PGF1aMetabolite28852 (ChEBI)
PGF3aMetaboliteCHEBI:36075 (ChEBI)
PGFSGeneProduct1.1.1.188 (Enzyme Nomenclature) =Prostaglandin F synthase
PGG1Metabolite133739 (ChEBI)
PGG2Metabolite27647 (ChEBI) Prostaglandin G2 is abbreviated as PGG2
PGG3MetaboliteCHEBI:134406 (ChEBI)
PGH1Metabolite91133 (ChEBI)
PGH2Metabolite15554 (ChEBI) PGH2 is the abbreviation of PGG2
PGH3MetaboliteCHEBI:134407 (ChEBI)
PGI1*Metabolite
PGI2MetaboliteCHEBI:15552 (ChEBI) Synonym for PGI2 is "Prostacyclin"
PGI3Metabolite
PGISGeneProduct5.3.99.4 (Enzyme Nomenclature)
PGJ2Metabolite27485 (ChEBI)
PPARγComplex
PRAK/MAPKAPK5Metabolite
PTGDR2 ComplexENSG00000183134 (Ensembl) =prostaglandin D2 receptor 2 =DP2
PTGDRComplexENSG00000168229 (Ensembl) =prostaglandin D2 receptor =DP1
PTGER1ComplexENSG00000160951 (Ensembl) =prostaglandin E receptor 1 =EP1
PTGER2ComplexENSG00000125384 (Ensembl) =prostaglandin E receptor 2 =EP2
PTGER3 ComplexENSG00000050628 (Ensembl) =prostaglandin E receptor 3 =EP3
PTGER4 ComplexENSG00000171522 (Ensembl) =prostaglandin E receptor 4 =EP4
PTGES GeneProductENSG00000148344 (Ensembl) =microsomal prostaglandin E synthase 1 (mPGES-1)
PTGES2 GeneProductENSG00000148334 (Ensembl) =microsomal prostaglandin E synthase 2 (PTGES2)
PTGES3 GeneProductENSG00000110958 (Ensembl) =prostaglandin E synthase 3 (cPGES)
PTGFR ComplexENSG00000122420 (Ensembl) Prostaglandin F receptor : FP

Activation of FP by PGF2α results in the IP3 and DAG formation as well as in the mobilization of Ca2+.

PTGIRComplexENSG00000160013 (Ensembl) prostaglandin I2 receptor
PTGS1GeneProductENSG00000095303 (Ensembl) =Prostaglandin-endoperoxide synthase 1 =cyclooxygenase (COX)
PTGS2GeneProductAlternatively, RvDs biosynthesis can be initiated by the aspirin-dependent acetylated COX-2 enzyme to give the 17R-series RvDs. In fact, acetylated COX-2 in the presence of aspirin acts as a modified dioxygenase by introducing an oxygen molecule with opposite stereochemistry. The RvDs biosynthesized through aspirin and acetylated COX-2 also undergo lipid oxidation catalysed by 15-LO and 5-LO, epoxidation, and hydrolysis processes, forming AT-RvDs
PTGS2GeneProductENSG00000073756 (Ensembl)
Paracrine senescence
Peroxidase
Peroxidase*GeneProduct
Phospholipase (cPLA2α)GeneProduct
Prostaglandin F synthase
Prostaglandin [c]Metabolite
Prostaglandin [e]Metabolite
Protectin D1Metabolite195348 (ChEBI)
Protectin D2Metabolite
RASMetabolite
RORalphaMetabolite
ROSMetabolite26523 (ChEBI)
Radiation-induced senescence
Radiation-induced senescence Oncogene-induced senescence(RAS)
RbGeneProductENSG00000139687 (Ensembl)
Reduction
Reduction*
Replicative senescence
Replicative senescence

Radiation-induced senescence Mtochondrial dysfunction-associated senescence

Oncogene-induced senescence		Pathway
RvD1(n-3 DPA)*Metabolite
RvD1MetaboliteCHEBI:81564 (ChEBI)
RvD2(n-3 DPA)*Metabolite
RvD2MetaboliteCHEBI:81565 (ChEBI)
RvD3MetaboliteCHEBI:138648 (ChEBI)
RvD4MetaboliteCHEBI:138649 (ChEBI)
RvD5Metabolite
RvD5(n-3 DPA)*Metabolite
RvD6MetaboliteCHEBI:138643 (ChEBI)
RvE1MetaboliteCHEBI:81559 (ChEBI)
RvE2MetaboliteCHEBI:81560 (ChEBI)
RvE3MetaboliteCHEBI:138542 (ChEBI)
RvE4Metabolite1025684-60-9 (CAS)
RvT1MetaboliteCHEBI:137011 (ChEBI)
RvT2MetaboliteCHEBI:137018 (ChEBI)
RvT3MetaboliteCHEBI:137019 (ChEBI)
RvT4MetaboliteCHEBI:137020 (ChEBI)
SASPPathway
SASPPathwayWP3391 (WikiPathways)
SEH
SIRT1GeneProductENSG00000096717 (Ensembl)
SLCO2A1GeneProductENSG00000174640 (Ensembl)
Senescence phenotypePathway
SenescencePathwayWP615 (WikiPathways)
Spontaneous hydrolysis
Stearidonic acid (SDA) (18:4,w3)MetaboliteCHEBI:32389 (ChEBI)
TBXA2RComplexENSG00000006638 (Ensembl) =thromboxane A2 receptor
TBXAS1GeneProductENSG00000059377 (Ensembl) =CYP5A1
TXASGeneProduct5.3.99.5 (Enzyme Nomenclature)
TxA1*Metabolite
TxA3Metabolite
TxAMetaboliteCHEBI:15627 (ChEBI)
TxB1Metabolite71668258 (PubChem-compound)
TxBMetaboliteCHEBI:28728 (ChEBI)
Unknown
a-Linolenic acid (ALA) (18:3,w3)MetaboliteCHEBI:27432 (ChEBI) IUPAC Name: (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid
alpha-tetranor-15-keto-13,14-dihydro-8-iso-PGF2aMetabolite
cAMPMetaboliteCHEBI:17489 (ChEBI) PGI2 binding to the associated IP receptor (coupled to Gs) leads to an activation of the AC and thus to an increase of intracellular cAMP. Its elevation downregulates store-mediated calcium entry, calcium mobilization and secretion, as well as platelet adhesion to subendothelial collagen via integrin α2β1. The cAMP increase further results in an activation of protein kinase-A (PKA) and in principle, in an inhibition of platelet activation. Analogous to cAMP, PKA activity has been associated with a reduced Ca2+ release from intra-platelet stores
elongation

delta6 desaturation

beta-oxidation
epoxide hydrolysis
h15-LOX1Protein
p21GeneProductENSG00000124762 (Ensembl) Gene: CDKN1A
p38 MAPKGeneProductENSG00000185386 (Ensembl)
p53GeneProduct
p53MetaboliteCHEBI:77731 (ChEBI)
p53GeneProductENSG00000141510 (Ensembl)
p53S37Metabolite
w-hydroxylase*
y-linolenic acid (GLA) (18:3,w6)Metabolite28661 (ChEBI) GLA(18:3 w6)
Δ12-PGD2Metabolite
Δ12-PGJ2MetaboliteCHEBI:28130 (ChEBI) Synonym: 9-Deoxy-delta(9,12)-13,14-dihydro PGD2
Δ13-reductaseGeneProduct1.3.1.48 (Enzyme Nomenclature) =15-oxoprostaglandin-Δ13-reductase
Δ6-trans-12-epi-leukotriene B4MetaboliteCHEBI:63982 (ChEBI)
Δ9-Elongase*
β and ω oxidation*
β-oxidase*GeneProduct
β-oxidationComplex
β-oxidation*

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5424"
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