IL19 signaling (Homo sapiens)

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Promote the proliferation and invasion of lung fibroblastsCardioprotection in dnCREB miceReceptorLung CancerLigand IL19Figure LegendA2B ReceptorCYIn A549cellsIn bronchialepithelial cellsIn HepG2cellsStat3Y705IL192JAK1Y1035Y1034STAT3 Y705IL195NFKBIAPIL198SOCS1 MAPK3PIL193MAPK3Y204T202MAPK1 Y187T185RELA RELA NUMMP9IL197IL1912IL199IL1911MAPK1PSTAT3Y705SOCS5STAT3STAT1Y701STAT3S727STAT3 Y705IL196RAC1 GTPIL20RBSTAT3Y705IL191IL194NFKB1S536CCNB1AKT1S473TGFB1MAPK8T183Y185CXCR4MMP1Akt1S473Mapk8T183Y185Stat3Y705Mapk14Y180T182Tgfb1Casp3 Casp9Ccl2TNFAIL10IL1913IL20RBSTAT3Y705MUC5ACTGFB1ACTA2IL20RBIL20RAIL20RAIL20RBIL20RAIL20RBIL20RAIL20RBIL20RAIL20RBIL20RACardiac dysfunction; Heart failureAllergic rhinitisSquamous cell carcinomaMAPK14T180 Y182MAP2K1 PMAP2K2PAngiogenesisIntimal hyperplasiaGranulopoiesisChronic RhinosinusitisAcute kidney injuryIdiopathic pulmonary fibrosis Pathogenesis of asthma and chronic obstructive pulmonary diseaseIL48TNFA8IL4RTNFRCCL11 STAT6PSTAT3PMAPK14PIL133IL13RIL17RIL173IL193SMAD3S425Immunological orMechanical injuryVascular SmoothMuscle cellsIL197CYNUSOCS5COL1A1 Ligand IL4Ligand TNFALigand IL13Ligand IL17MAPK3T202Y204Mapk3T202Y204Mapk1T185Y187MAPK1 T185Y187MAPK3T202Y204MAPK1 Y187T185 IL-19 secreted from osteocytes Tumor-cell induced IL-19 secretion by osteoclastsIL20RAIL20RBCleavageAdenosineIL1910TNFA10MonocytesTGFBR1TGFBR2IL191TNFAIL1BIL191IL20RAIL20RBOthersSuppression of IL-4-inducedeotaxin production in human nasal fibroblastsIL20RAIL20RBProliferation, migrationand colony formationin CE81T cellsInduces the MMP9 production by activating ERK and NFκB pathwayin HNECsIL-19 inducesSTAT3-dependentproduction of MUC5ACAssociated with EC Proliferation, enhanced cell spreading, promotionof EC cord structure formation andmicrovessel formationLigand TGFB1Apoptosis inM-1 cells In granulocyte-monocyte progenitor cells and promyelocyte/myelocytesInvolves in theautocrine-negativefeedback to diminish the vascularresponse to injuryProliferation ofIL20RB+ tumor cellsLigand AdenosinInflammation responds in human monocytic cell lineCell survival, cytokine expression and apoptosis Involed in the development of elevated intraocular pressure in response to inflammationMolecular AssociationDownregulationUpregulationLeads to phosphorylationCytoplasmPhosphositeCYTransportNucleusNUProteinGTPPLeads to through indirect/multiple reactionsIndirect regulation of gene / protein expressionIndirect inhibitionGTPase-activating protein Direct regulation of gene / protein expressionIn M-1cellsProteinmRNAProtein/ GeneProtein/ Gene


Description

Schematic representation of IL-19 signaling pathway

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Bibliography

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  1. Hsu YH, Li HH, Sung JM, Chen WT, Hou YC, Chang MS; ''Interleukin-19 mediates tissue damage in murine ischemic acute kidney injury.''; PLoS One, 2013 PubMed Europe PMC Scholia
  2. Bruns DR, Ghincea AR, Ghincea CV, Azuma YT, Watson PA, Autieri MV, Walker LA; ''Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner.''; World J Cardiol, 2017 PubMed Europe PMC Scholia
  3. Li X, Huang J, Chen X, Lai X, Huang Z, Li Y, Li S, Chang L, Zhang G; ''''; , PubMed Europe PMC Scholia
  4. Wang Y, Sun S, Wang K, Zhang M, Li M, Zan Y, Huang Q, Wu S, Zhao W, Xu W, Wu J; ''Interleukin-19 Aggravates Pulmonary Fibrosis via Activating Fibroblast through TGF-β/Smad Pathway.''; Mediators Inflamm, 2022 PubMed Europe PMC Scholia
  5. He Y, Luo W, Liu Y, Wang Y, Ma C, Wu Q, Tian P, He D, Jia Z, Lv X, Ma YS, Yang H, Xu K, Zhang X, Xiao Y, Zhang P, Liang Y, Fu D, Yao F, Hu G; ''IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer.''; J Clin Invest, 2022 PubMed Europe PMC Scholia
  6. Jain S, Gabunia K, Kelemen SE, Panetti TS, Autieri MV; ''The anti-inflammatory cytokine interleukin 19 is expressed by and angiogenic for human endothelial cells.''; Arterioscler Thromb Vasc Biol, 2011 PubMed Europe PMC Scholia
  7. Tian Y, Sommerville LJ, Cuneo A, Kelemen SE, Autieri MV; ''Expression and suppressive effects of interleukin-19 on vascular smooth muscle cell pathophysiology and development of intimal hyperplasia.''; Am J Pathol, 2008 PubMed Europe PMC Scholia
  8. Higashino M, Takabayashi T, Takahashi N, Okamoto M, Narita N, Kojima A, Hyo S, Kawata R, Takenaka H, Fujieda S; ''Interleukin-19 downregulates interleukin-4-induced eotaxin production in human nasal fibroblasts.''; Allergol Int, 2011 PubMed Europe PMC Scholia
  9. Keller KE, Yang YF, Sun YY, Walter MR, Wirtz MK; ''Analysis of interleukin-20 receptor complexes in trabecular meshwork cells and effects of cytokine signaling in anterior segment perfusion culture.''; Mol Vis, 2019 PubMed Europe PMC Scholia
  10. Zhong H, Wu Y, Belardinelli L, Zeng D; ''A2B adenosine receptors induce IL-19 from bronchial epithelial cells, resulting in TNF-alpha increase.''; Am J Respir Cell Mol Biol, 2006 PubMed Europe PMC Scholia
  11. Hsing CH, Kwok FA, Cheng HC, Li CF, Chang MS; ''Inhibiting interleukin-19 activity ameliorates esophageal squamous cell carcinoma progression.''; PLoS One, 2013 PubMed Europe PMC Scholia
  12. Xiao M, Zhang W, Liu W, Mao L, Yang J, Hu L, Zhang S, Zheng Y, Liu A, Song Q, Li Y, Xiao G, Zou Z, Bai X; ''Osteocytes regulate neutrophil development through IL-19: a potent cytokine for neutropenia treatment.''; Blood, 2021 PubMed Europe PMC Scholia
  13. Lai X, Li X, Chang L, Chen X, Huang Z, Bao H, Huang J, Yang L, Wu X, Wang Z, Bellanti JA, Zheng SG, Zhang G; ''IL-19 Up-Regulates Mucin 5AC Production in Patients With Chronic Rhinosinusitis via STAT3 Pathway.''; Front Immunol, 2019 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129674view00:45, 22 May 2024EweitzModified title
127701view01:17, 23 November 2023EweitzOntology Term : 'Interleukin mediated signaling pathway' added !
127700view01:17, 23 November 2023EweitzOntology Term : 'interleukin-19 signaling pathway' added !
127699view01:16, 23 November 2023EweitzModified title
127461view12:45, 6 October 2023JmillanacostaChanged data nodes for graphical shapes in legend
127458view19:40, 4 October 2023Khanspersupdated legend to graphical lines
127418view09:49, 1 October 2023EgonwConverted three interactions that are not mim-conversions not a regular Arrow
127405view11:41, 30 September 2023EgonwAll WikiPathways content is CC0
127404view11:37, 30 September 2023IsabelWassinkOntology Term : 'signaling pathway' added !
127374view23:31, 24 September 2023Rex D A BModified title
127373view23:29, 24 September 2023Rex D A BNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACTA2Protein59 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
Akt1Protein11651 (Entrez Gene)
CCL11 Protein6356 (Entrez Gene)
CCNB1Protein891 (Entrez Gene)
COL1A1 Protein1277 (Entrez Gene)
CXCR4Protein7852 (Entrez Gene)
Casp3 Protein12367 (Entrez Gene)
Casp9Protein12371 (Entrez Gene)
Ccl2Protein20296 (Entrez Gene)
IL10Protein16176 (Entrez Gene)
IL13 Protein29949 (Entrez Gene)
IL13RProtein53832 (Entrez Gene)
IL17 Protein29949 (Entrez Gene)
IL17RProtein53832 (Entrez Gene)
IL19 Protein29949 (Entrez Gene)
IL19Protein29949 (Entrez Gene)
IL19Protein29949 (NCBI Protein)
IL1BProtein16176 (Entrez Gene)
IL20RAProtein53832 (Entrez Gene)
IL20RBProtein53833 (Entrez Gene)
IL4 Protein3565 (Entrez Gene)
IL4RProtein3566 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
MAP2K1 Protein
MAP2K2Protein
MAPK1 Protein
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MMP1Protein4312 (Entrez Gene)
MMP9Protein
MUC5ACProtein4586 (Entrez Gene)
Mapk1Protein26413 (Entrez Gene)
Mapk14Protein26416 (Entrez Gene)
Mapk3Protein26417 (Entrez Gene)
Mapk8Protein26419 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NFKBIAProtein
Protein0 (Entrez Gene)
RAC1 Protein5879 (Entrez Gene)
RELA Protein
SMAD3 Protein20848 (Entrez Gene)
SOCS1 GeneProduct8651 (Entrez Gene)
SOCS5Protein9655 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3 Protein6774 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT6Protein6778 (Entrez Gene)
Stat3Protein20848 (Entrez Gene)
TGFB1Protein21803 (Entrez Gene)
TGFB1Protein7040 (Entrez Gene)
TGFBR1Protein21803 (Entrez Gene)
TGFBR2Protein21803 (Entrez Gene)
TNFA Protein29949 (Entrez Gene)
TNFAProtein7124 (Entrez Gene)
TNFRProtein7132 (Entrez Gene)
Tgfb1Protein7040 (Entrez Gene)

Annotated Interactions

No annotated interactions

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