PGK1, PKM2, KHKC/KHKA acting as protein kinases (Homo sapiens)

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Bibliography

1. Jiang Y, Wang Y, Wang T, Hawke DH, Zheng Y, Li X, Zhou Q, Majumder S, Bi E, Liu DX, Huang S, Lu Z; ''PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells.''; Nat Commun, 2014 PubMed Europe PMC Scholia
2. He CL, Bian YY, Xue Y, Liu ZX, Zhou KQ, Yao CF, Lin Y, Zou HF, Luo FX, Qu YY, Zhao JY, Ye ML, Zhao SM, Xu W; ''Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1.''; Sci Rep, 2016 PubMed Europe PMC Scholia
3. Liang J, Cao R, Wang X, Zhang Y, Wang P, Gao H, Li C, Yang F, Zeng R, Wei P, Li D, Li W, Yang W; ''Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2.''; Cell Res, 2017 PubMed Europe PMC Scholia
4. Li X, Qian X, Lu Z; ''Fructokinase A acts as a protein kinase to promote nucleotide synthesis.''; Cell Cycle, 2016 PubMed Europe PMC Scholia
5. Qian X, Li X, Cai Q, Zhang C, Yu Q, Jiang Y, Lee JH, Hawke D, Wang Y, Xia Y, Zheng Y, Jiang BH, Liu DX, Jiang T, Lu Z; ''Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy.''; Mol Cell, 2017 PubMed Europe PMC Scholia
6. Cheng TY, Yang YC, Wang HP, Tien YW, Shun CT, Huang HY, Hsiao M, Hua KT; ''Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein.''; Oncogene, 2018 PubMed Europe PMC Scholia
7. Xia L, Qin K, Wang XR, Wang XL, Zhou AW, Chen GQ, Lu Y; ''Pyruvate kinase M2 phosphorylates H2AX and promotes genomic instability in human tumor cells.''; Oncotarget, 2017 PubMed Europe PMC Scholia
8. Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Alfred Yung WK, Lu Z; ''PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.''; Cell, 2012 PubMed Europe PMC Scholia
9. Li X, Qian X, Peng LX, Jiang Y, Hawke DH, Zheng Y, Xia Y, Lee JH, Cote G, Wang H, Wang L, Qian CN, Lu Z; ''A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation.''; Nat Cell Biol, 2016 PubMed Europe PMC Scholia
10. Jiang Y, Li X, Yang W, Hawke DH, Zheng Y, Xia Y, Aldape K, Wei C, Guo F, Chen Y, Lu Z; ''PKM2 regulates chromosome segregation and mitosis progression of tumor cells.''; Mol Cell, 2014 PubMed Europe PMC Scholia
11. Li X, Zheng Y, Lu Z; ''PGK1 is a new member of the protein kinome.''; Cell Cycle, 2016 PubMed Europe PMC Scholia
12. Gao X, Wang H, Yang JJ, Liu X, Liu ZR; ''Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase.''; Mol Cell, 2012 PubMed Europe PMC Scholia
13. Wei Y, Wang D, Jin F, Bian Z, Li L, Liang H, Li M, Shi L, Pan C, Zhu D, Chen X, Hu G, Liu Y, Zhang CY, Zen K; ''Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23.''; Nat Commun, 2017 PubMed Europe PMC Scholia
14. Li X, Jiang Y, Meisenhelder J, Yang W, Hawke DH, Zheng Y, Xia Y, Aldape K, He J, Hunter T, Wang L, Lu Z; ''Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis.''; Mol Cell, 2016 PubMed Europe PMC Scholia
15. Yang W, Lu Z; ''Pyruvate kinase M2 at a glance.''; J Cell Sci, 2015 PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
1,3-BPG	Metabolite	HMDB0001270 (HMDB)
3-PG	Metabolite	HMDB0000807 (HMDB)
AKT1S1	Protein	Q96B36 (Uniprot-TrEMBL)
Apoptosis	Pathway	WP2507 (WikiPathways)
Autophage	Pathway
Bcl2	Protein	Q9JJV8 (Uniprot-TrEMBL)
Beclin1	Protein	Q14457 (Uniprot-TrEMBL)
Bub3	Protein	O43684 (Uniprot-TrEMBL)
Cell invasion	Pathway
Cytokinesis	Pathway
De Novo nucleic acid synthesis	Pathway
Exosome secretion	Pathway
F1-P	Metabolite	HMDB0060467 (HMDB)
Fructose	Metabolite	HMDB0000660 (HMDB)
Gene transcription	Pathway
Genomic instability	Pathway
Glucose	Metabolite	HMDB0000122 (HMDB)
H2AX	Protein	P16104 (Uniprot-TrEMBL)
H3	Protein	P84243 (Uniprot-TrEMBL)
KHKA	GeneProduct	P50053 (Uniprot-TrEMBL)
KHKC	GeneProduct	P50053 (Uniprot-TrEMBL)
Lactate	Metabolite	HMDB0000190 (HMDB)
MLC2	Protein	P10916 (Uniprot-TrEMBL)
Mitochondrial pyruvate metabolism	Pathway
Mitosis	Pathway
PAK2	Protein	Q13177 (Uniprot-TrEMBL)
PDHK1	Protein	Q15118 (Uniprot-TrEMBL)
PEP	Metabolite	HMDB0000263 (HMDB)
PGK1	GeneProduct	P00558 (Uniprot-TrEMBL)
PKM2	GeneProduct	P14618 (Uniprot-TrEMBL)
PRPS1	Protein	P60891 (Uniprot-TrEMBL)
Pyruvate	Metabolite	HMDB0000243 (HMDB)
SNAP-23	Protein	O00161 (Uniprot-TrEMBL)
STAT3	Protein	P40763 (Uniprot-TrEMBL)
mTOR1 activation	Pathway

Annotated Interactions

No annotated interactions